JP2022524951A5 - - Google Patents

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Publication number
JP2022524951A5
JP2022524951A5 JP2021549951A JP2021549951A JP2022524951A5 JP 2022524951 A5 JP2022524951 A5 JP 2022524951A5 JP 2021549951 A JP2021549951 A JP 2021549951A JP 2021549951 A JP2021549951 A JP 2021549951A JP 2022524951 A5 JP2022524951 A5 JP 2022524951A5
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JP
Japan
Prior art keywords
sting
protein
immunostimulatory
human
modified
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Pending
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JP2021549951A
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English (en)
Japanese (ja)
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JP2022524951A (ja
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Priority claimed from PCT/US2020/020240 external-priority patent/WO2020176809A1/en
Publication of JP2022524951A publication Critical patent/JP2022524951A/ja
Publication of JP2022524951A5 publication Critical patent/JP2022524951A5/ja
Priority to JP2025227194A priority Critical patent/JP2026058346A/ja
Pending legal-status Critical Current

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JP2021549951A 2019-02-27 2020-02-27 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌 Pending JP2022524951A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025227194A JP2026058346A (ja) 2019-02-27 2025-12-03 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962811521P 2019-02-27 2019-02-27
US62/811,521 2019-02-27
US201962828990P 2019-04-03 2019-04-03
US62/828,990 2019-04-03
US201962934478P 2019-11-12 2019-11-12
US62/934,478 2019-11-12
US202062962140P 2020-01-16 2020-01-16
US62/962,140 2020-01-16
PCT/US2020/020240 WO2020176809A1 (en) 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025227194A Division JP2026058346A (ja) 2019-02-27 2025-12-03 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌

Publications (2)

Publication Number Publication Date
JP2022524951A JP2022524951A (ja) 2022-05-11
JP2022524951A5 true JP2022524951A5 (https=) 2023-03-06

Family

ID=70277449

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Application Number Title Priority Date Filing Date
JP2021549951A Pending JP2022524951A (ja) 2019-02-27 2020-02-27 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌
JP2025227194A Pending JP2026058346A (ja) 2019-02-27 2025-12-03 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025227194A Pending JP2026058346A (ja) 2019-02-27 2025-12-03 腫瘍、腫瘍常在免疫細胞および腫瘍微小環境にコロニー形成するよう操作した免疫刺激性細菌

Country Status (12)

Country Link
US (1) US20220135980A1 (https=)
EP (1) EP3931210A1 (https=)
JP (2) JP2022524951A (https=)
KR (1) KR20220004959A (https=)
CN (1) CN113748124A (https=)
AU (2) AU2020229875B2 (https=)
BR (1) BR112021016728A2 (https=)
CA (2) CA3176660A1 (https=)
IL (1) IL285608A (https=)
MX (1) MX2021010273A (https=)
SG (1) SG11202108459QA (https=)
WO (1) WO2020176809A1 (https=)

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CN112444629B (zh) * 2020-12-09 2023-09-29 青岛科技大学 基于发夹核酸分子信号放大线路的外泌体检测方法及应用
CN112852698B (zh) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用
KR20230172456A (ko) * 2021-02-09 2023-12-22 유니버시티 오브 매사추세츠 침입하고 자율적으로 용해하도록 설계된 치료 단백질의 세포내 전달 및 이의 사용 방법
EP4313109A1 (en) * 2021-03-31 2024-02-07 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
CN113249382B (zh) * 2021-04-12 2023-05-12 右江民族医学院 下调TRIM56基因表达的siRNA及其应用
BR112023022681A2 (pt) * 2021-04-30 2024-01-23 Kalivir Immunotherapeutics Inc Vírus oncolíticos para expressão modificada de mhc
CN113549621B (zh) * 2021-07-14 2022-07-19 山西大学 一种增强细菌中外源蛋白活性和表达的最小启动子
WO2023064755A2 (en) * 2021-10-11 2023-04-20 University Of Florida Research Foundation, Incorporated A novel poultry salmonella vaccine and diagnostic methodology to control foodborne salmonellosis
WO2023086796A2 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
IL318055A (en) * 2022-07-08 2025-02-01 Viromissile Inc ONCOLYTIC VACCINIA VIRUSES AND RECOMBINANT VIRUSES AND METHODS OF USE THEREOF
CN115356320B (zh) * 2022-10-20 2023-01-17 上海诚益生物科技有限公司 基于均相时间分辨荧光技术的体外rig-i激活检测的方法
WO2024107827A1 (en) * 2022-11-16 2024-05-23 The Broad Institute, Inc. Therapeutic exploitation of sting channel activity
CN119798461B (zh) * 2024-09-19 2025-12-19 兰州大学 一种鼠伤寒沙门氏菌鞭毛蛋白衍生物与塞内卡病毒抗原的融合蛋白及其应用
CN119280432B (zh) * 2024-10-14 2025-06-24 汕头大学医学院 一种工程化减毒柯萨奇b3病毒载体在制备用于治疗外伤性颅脑损伤的药物中的应用

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