MX2021010273A - Bacterias inmunoestimuladoras modificadas para colonizar tumores, celulas inmunitarias residentes de tumor y el microentorno tumoral. - Google Patents

Bacterias inmunoestimuladoras modificadas para colonizar tumores, celulas inmunitarias residentes de tumor y el microentorno tumoral.

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Publication number
MX2021010273A
MX2021010273A MX2021010273A MX2021010273A MX2021010273A MX 2021010273 A MX2021010273 A MX 2021010273A MX 2021010273 A MX2021010273 A MX 2021010273A MX 2021010273 A MX2021010273 A MX 2021010273A MX 2021010273 A MX2021010273 A MX 2021010273A
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MX
Mexico
Prior art keywords
tumor
bacteria
immune cells
modified
immunostimulatory bacteria
Prior art date
Application number
MX2021010273A
Other languages
English (en)
Spanish (es)
Inventor
Laura Hix Glickman
Christopher D Thanos
Justin Skoble
Alexandre Charles Michel Iannello
Haixing Kehoe
Original Assignee
Actym Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actym Therapeutics Inc filed Critical Actym Therapeutics Inc
Publication of MX2021010273A publication Critical patent/MX2021010273A/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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  • Gastroenterology & Hepatology (AREA)
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  • Immunology (AREA)
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MX2021010273A 2019-02-27 2020-02-27 Bacterias inmunoestimuladoras modificadas para colonizar tumores, celulas inmunitarias residentes de tumor y el microentorno tumoral. MX2021010273A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962811521P 2019-02-27 2019-02-27
US201962828990P 2019-04-03 2019-04-03
US201962934478P 2019-11-12 2019-11-12
US202062962140P 2020-01-16 2020-01-16
PCT/US2020/020240 WO2020176809A1 (en) 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

Publications (1)

Publication Number Publication Date
MX2021010273A true MX2021010273A (es) 2021-09-23

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ID=70277449

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Application Number Title Priority Date Filing Date
MX2021010273A MX2021010273A (es) 2019-02-27 2020-02-27 Bacterias inmunoestimuladoras modificadas para colonizar tumores, celulas inmunitarias residentes de tumor y el microentorno tumoral.

Country Status (12)

Country Link
US (1) US20220135980A1 (https=)
EP (1) EP3931210A1 (https=)
JP (2) JP2022524951A (https=)
KR (1) KR20220004959A (https=)
CN (1) CN113748124A (https=)
AU (2) AU2020229875B2 (https=)
BR (1) BR112021016728A2 (https=)
CA (2) CA3176660A1 (https=)
IL (1) IL285608A (https=)
MX (1) MX2021010273A (https=)
SG (1) SG11202108459QA (https=)
WO (1) WO2020176809A1 (https=)

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JP7340591B2 (ja) * 2018-07-11 2023-09-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
KR102327091B1 (ko) * 2020-06-18 2021-11-16 전남대학교 산학협력단 암의 치료용 살모넬라 균주 및 이의 용도
IL300447A (en) 2020-08-12 2023-04-01 Actym Therapeutics Inc Bacteria-based ingredients that stimulate the immune system, treatments and platforms for delivering RNA
CN112444629B (zh) * 2020-12-09 2023-09-29 青岛科技大学 基于发夹核酸分子信号放大线路的外泌体检测方法及应用
CN112852698B (zh) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用
KR20230172456A (ko) * 2021-02-09 2023-12-22 유니버시티 오브 매사추세츠 침입하고 자율적으로 용해하도록 설계된 치료 단백질의 세포내 전달 및 이의 사용 방법
EP4313109A1 (en) * 2021-03-31 2024-02-07 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
CN113249382B (zh) * 2021-04-12 2023-05-12 右江民族医学院 下调TRIM56基因表达的siRNA及其应用
BR112023022681A2 (pt) * 2021-04-30 2024-01-23 Kalivir Immunotherapeutics Inc Vírus oncolíticos para expressão modificada de mhc
CN113549621B (zh) * 2021-07-14 2022-07-19 山西大学 一种增强细菌中外源蛋白活性和表达的最小启动子
WO2023064755A2 (en) * 2021-10-11 2023-04-20 University Of Florida Research Foundation, Incorporated A novel poultry salmonella vaccine and diagnostic methodology to control foodborne salmonellosis
WO2023086796A2 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
IL318055A (en) * 2022-07-08 2025-02-01 Viromissile Inc ONCOLYTIC VACCINIA VIRUSES AND RECOMBINANT VIRUSES AND METHODS OF USE THEREOF
CN115356320B (zh) * 2022-10-20 2023-01-17 上海诚益生物科技有限公司 基于均相时间分辨荧光技术的体外rig-i激活检测的方法
WO2024107827A1 (en) * 2022-11-16 2024-05-23 The Broad Institute, Inc. Therapeutic exploitation of sting channel activity
CN119798461B (zh) * 2024-09-19 2025-12-19 兰州大学 一种鼠伤寒沙门氏菌鞭毛蛋白衍生物与塞内卡病毒抗原的融合蛋白及其应用
CN119280432B (zh) * 2024-10-14 2025-06-24 汕头大学医学院 一种工程化减毒柯萨奇b3病毒载体在制备用于治疗外伤性颅脑损伤的药物中的应用

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