MX2021006398A - Expansión de células asesinas naturales y células ilc3 con compuestos aromáticos novedosos. - Google Patents

Expansión de células asesinas naturales y células ilc3 con compuestos aromáticos novedosos.

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Publication number
MX2021006398A
MX2021006398A MX2021006398A MX2021006398A MX2021006398A MX 2021006398 A MX2021006398 A MX 2021006398A MX 2021006398 A MX2021006398 A MX 2021006398A MX 2021006398 A MX2021006398 A MX 2021006398A MX 2021006398 A MX2021006398 A MX 2021006398A
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MX
Mexico
Prior art keywords
cells
ilc3
natural killer
expansion
cell
Prior art date
Application number
MX2021006398A
Other languages
English (en)
Inventor
Lin Kang
Xuan Guo
Xiaokui Zhang
Vanessa Voskinarian-Berse
Robert J Hariri
Der Touw William Van
Original Assignee
Celularity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celularity Inc filed Critical Celularity Inc
Publication of MX2021006398A publication Critical patent/MX2021006398A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
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  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente descripción se proporcionan métodos para producir células asesinas naturales (NK) y/o células ILC3 mediante el uso de un método de expansión y diferenciación de tres etapas con medios que comprenden factores movilizadores de células madre. En la presente descripción también se proporcionan métodos para suprimir la proliferación de células tumorales mediante el uso de las células NK y/o células ILC3 y las poblaciones de células NK y/o células ILC3 producidas mediante los métodos de tres etapas descritos en la presente descripción, así como también métodos para tratar individuos que tienen cáncer o una infección viral, que comprende administrar las células NK y/o células ILC3 y las poblaciones de células NK y/o células ILC3 producidas mediante los métodos de tres etapas descritos en la presente descripción a un individuo que tiene el cáncer o la infección viral.
MX2021006398A 2018-11-30 2019-11-29 Expansión de células asesinas naturales y células ilc3 con compuestos aromáticos novedosos. MX2021006398A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862774114P 2018-11-30 2018-11-30
PCT/US2019/063876 WO2020113182A1 (en) 2018-11-30 2019-11-29 Expansion of natural killer cells and ilc3 cells with novel aromatic compounds

Publications (1)

Publication Number Publication Date
MX2021006398A true MX2021006398A (es) 2021-07-15

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MX2021006398A MX2021006398A (es) 2018-11-30 2019-11-29 Expansión de células asesinas naturales y células ilc3 con compuestos aromáticos novedosos.

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Country Link
US (1) US20230028680A1 (es)
EP (1) EP3887508A1 (es)
JP (1) JP2022511786A (es)
KR (1) KR20210111762A (es)
CN (1) CN113454207A (es)
AU (1) AU2019387491A1 (es)
BR (1) BR112021010245A2 (es)
CA (1) CA3119427A1 (es)
EA (1) EA202191508A1 (es)
MX (1) MX2021006398A (es)
PH (1) PH12021551241A1 (es)
SG (1) SG11202105213XA (es)
WO (1) WO2020113182A1 (es)

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WO2020252464A1 (en) * 2019-06-14 2020-12-17 Celularity Inc. Populations of natural killer cells for treating cancers
WO2021016621A1 (en) * 2019-07-25 2021-01-28 Celularity Inc. Populations of natural killer cells comprising a cd38 chimeric antigen receptor
WO2021155312A1 (en) * 2020-01-29 2021-08-05 Celularity Inc. Placental derived natural killer cells for treatment of coronavirus infections
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
US20240082398A1 (en) * 2021-01-15 2024-03-14 City Of Hope Methods of preparing and expanding type i innate lymphoid cells and therapeutic uses thereof
WO2023278628A1 (en) * 2021-06-29 2023-01-05 Celularity Inc. Human placental hematopoietic stem cell derived natural killer cells in acute myeloid leukemia (aml) remission with minimal residual disease (mrd) or relapsed/refractory aml
JPWO2023038037A1 (es) * 2021-09-08 2023-03-16

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CA3119427A1 (en) 2020-06-04
EP3887508A1 (en) 2021-10-06
KR20210111762A (ko) 2021-09-13
WO2020113182A1 (en) 2020-06-04
AU2019387491A1 (en) 2021-05-27
BR112021010245A2 (pt) 2021-08-17
PH12021551241A1 (en) 2021-11-03
JP2022511786A (ja) 2022-02-01
CN113454207A (zh) 2021-09-28
EA202191508A1 (ru) 2021-09-21
US20230028680A1 (en) 2023-01-26
SG11202105213XA (en) 2021-06-29

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