BR112018072701A2 - métodos de tratamento de leucemia mieloide aguda e mieloma múltiplo usando células exterminadoras naturais - Google Patents

métodos de tratamento de leucemia mieloide aguda e mieloma múltiplo usando células exterminadoras naturais

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Publication number
BR112018072701A2
BR112018072701A2 BR112018072701-6A BR112018072701A BR112018072701A2 BR 112018072701 A2 BR112018072701 A2 BR 112018072701A2 BR 112018072701 A BR112018072701 A BR 112018072701A BR 112018072701 A2 BR112018072701 A2 BR 112018072701A2
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Brazil
Prior art keywords
cells
methods
myeloid leukemia
natural killer
acute myeloid
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BR112018072701-6A
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English (en)
Inventor
Alan Fischkoff Steven
Herzberg Uri
Kang Lin
Murphy Brian
Nordberg Andrea
Voskinarian-Berse Vanessa
Wilson Keith
Zhang Xiaokui
Myint Han
Hussein Mohamed
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Celularity, Inc.
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Publication date
Application filed by Celularity, Inc. filed Critical Celularity, Inc.
Publication of BR112018072701A2 publication Critical patent/BR112018072701A2/pt

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    • A61K38/20—Interleukins [IL]
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Abstract

são aqui fornecidos métodos de tratamento da leucemia mieloide aguda (aml) e do mieloma múltiplo (mm) por administração de uma quantidade eficaz de uma população celular compreendendo células exterminadoras naturais, nas quais a população celular compreendendo células exterminadoras naturais é produzida por um método de três estágios compreendendo a cultura de uma população de células-tronco ou progenitoras hematopoéticas em meios compreendendo fatores de mobilização de células-tronco, por exemplo, métodos de três estágios de produção de células nk em meios compreendendo fatores de mobilização de células-tronco partindo de células-tronco hematopoéticas ou progenitoras de células placentárias, por exemplo perfusado placentário (por exemplo, perfusado placentário humano) ou outros tecidos, por exemplo, sangue do cordão umbilical ou sangue periférico. além disso, são aqui fornecidos métodos de utilização das células nk produzidas pelos métodos de três estágios aqui proporcionados para suprimir a proliferação de células de leucemia mieloide aguda. em certas modalidades, as células nk produzidas pelos métodos de três estágios aqui descritos são utilizadas em combinação com il-2.
BR112018072701-6A 2016-05-07 2017-05-05 métodos de tratamento de leucemia mieloide aguda e mieloma múltiplo usando células exterminadoras naturais BR112018072701A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662333186P 2016-05-07 2016-05-07
US201662333187P 2016-05-07 2016-05-07
US62/333,187 2016-05-07
US62/333,186 2016-05-07
US201662415918P 2016-11-01 2016-11-01
US201662415954P 2016-11-01 2016-11-01
US62/415,954 2016-11-01
US62/415,918 2016-11-01
PCT/US2017/031255 WO2017196657A1 (en) 2016-05-07 2017-05-05 Methods of treating acute myeloid leukemia and multiple myeloma using natural killer cells

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BR112018072701A2 true BR112018072701A2 (pt) 2019-02-19

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US (1) US11180731B2 (pt)
EP (1) EP3452063A4 (pt)
JP (2) JP2019519486A (pt)
KR (1) KR20190005964A (pt)
CN (1) CN109843304A (pt)
AU (2) AU2017262581A1 (pt)
BR (1) BR112018072701A2 (pt)
CA (1) CA3023239A1 (pt)
CO (1) CO2018012923A2 (pt)
IL (1) IL262775A (pt)
MX (1) MX2018013565A (pt)
NZ (1) NZ747910A (pt)
SG (2) SG10201912837RA (pt)
WO (1) WO2017196657A1 (pt)
ZA (1) ZA201807431B (pt)

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AU2019215034C1 (en) 2018-02-01 2022-01-06 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
WO2020252464A1 (en) * 2019-06-14 2020-12-17 Celularity Inc. Populations of natural killer cells for treating cancers
CN111727961B (zh) * 2020-08-10 2020-12-01 医微细胞生物技术(广州)有限公司 一种牙髓干细胞冻存液及其冻存方法
TW202237826A (zh) 2020-11-30 2022-10-01 瑞士商克里斯珀醫療股份公司 基因編輯的自然殺手細胞
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
CN114015653A (zh) * 2021-12-15 2022-02-08 山东省齐鲁干细胞工程有限公司 一种冻存脐带血来源的nk细胞及其制备方法

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JPH07135969A (ja) * 1993-11-18 1995-05-30 Rikagaku Kenkyusho ナチュラルキラー細胞の前駆細胞及びその分化増殖法
PE20100362A1 (es) * 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
WO2012128622A1 (en) * 2011-03-18 2012-09-27 Ipd-Therapeutics B.V. Generation of nk cells and nk-cell progenitors
SG11201404241SA (en) * 2012-01-27 2014-08-28 Univ Montreal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
CA2864283C (en) 2012-02-08 2020-11-03 Jan Spanholtz Ex vivo nk cell differentiation from cd34+ hematopoietic cells
CA2881792C (en) * 2012-08-13 2024-02-27 Anthrogenesis Corporation Natural killer cells and uses thereof
CN106459914B (zh) * 2014-05-15 2020-11-06 新加坡国立大学 经修饰的自然杀伤细胞及其用途

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EP3452063A1 (en) 2019-03-13
KR20190005964A (ko) 2019-01-16
JP2022095927A (ja) 2022-06-28
MX2018013565A (es) 2019-08-21
SG10201912837RA (en) 2020-02-27
CA3023239A1 (en) 2017-11-16
WO2017196657A1 (en) 2017-11-16
US11180731B2 (en) 2021-11-23
EP3452063A4 (en) 2020-01-08
AU2022287584A1 (en) 2023-02-02
CO2018012923A2 (es) 2018-12-14
NZ747910A (en) 2023-02-24
US20190153389A1 (en) 2019-05-23
JP2019519486A (ja) 2019-07-11
ZA201807431B (en) 2021-09-29
IL262775A (en) 2018-12-31
SG11201809858RA (en) 2018-12-28
AU2017262581A1 (en) 2019-01-03
CN109843304A (zh) 2019-06-04

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