CN113748124A - 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌 - Google Patents

工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌 Download PDF

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CN113748124A
CN113748124A CN202080031041.0A CN202080031041A CN113748124A CN 113748124 A CN113748124 A CN 113748124A CN 202080031041 A CN202080031041 A CN 202080031041A CN 113748124 A CN113748124 A CN 113748124A
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immunostimulatory
protein
cancer
sting
bacterium
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C·D·萨诺斯
L·H·格利克曼
J·斯科博
A·C·M·扬内洛
H·基欧
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Aktim Treatment Ltd
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Aktim Treatment Ltd
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CN202080031041.0A 2019-02-27 2020-02-27 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌 Pending CN113748124A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962811521P 2019-02-27 2019-02-27
US62/811,521 2019-02-27
US201962828990P 2019-04-03 2019-04-03
US62/828,990 2019-04-03
US201962934478P 2019-11-12 2019-11-12
US62/934,478 2019-11-12
US202062962140P 2020-01-16 2020-01-16
US62/962,140 2020-01-16
PCT/US2020/020240 WO2020176809A1 (en) 2019-02-27 2020-02-27 Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment

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CN113748124A true CN113748124A (zh) 2021-12-03

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CN202080031041.0A Pending CN113748124A (zh) 2019-02-27 2020-02-27 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌

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US (1) US20220135980A1 (https=)
EP (1) EP3931210A1 (https=)
JP (2) JP2022524951A (https=)
KR (1) KR20220004959A (https=)
CN (1) CN113748124A (https=)
AU (2) AU2020229875B2 (https=)
BR (1) BR112021016728A2 (https=)
CA (2) CA3176660A1 (https=)
IL (1) IL285608A (https=)
MX (1) MX2021010273A (https=)
SG (1) SG11202108459QA (https=)
WO (1) WO2020176809A1 (https=)

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CN112852698A (zh) * 2021-01-30 2021-05-28 军事科学院军事医学研究院军事兽医研究所 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用
CN115356320A (zh) * 2022-10-20 2022-11-18 上海诚益生物科技有限公司 基于均相时间分辨荧光技术的体外rig-i激活检测的方法
CN119280432A (zh) * 2024-10-14 2025-01-10 汕头大学医学院 一种工程化减毒柯萨奇b3病毒载体在制备用于治疗外伤性颅脑损伤的药物中的应用
CN119798461A (zh) * 2024-09-19 2025-04-11 兰州大学 一种鼠伤寒沙门氏菌鞭毛蛋白衍生物与塞内卡病毒抗原的融合蛋白及其应用

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JP7340591B2 (ja) * 2018-07-11 2023-09-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
KR102327091B1 (ko) * 2020-06-18 2021-11-16 전남대학교 산학협력단 암의 치료용 살모넬라 균주 및 이의 용도
IL300447A (en) 2020-08-12 2023-04-01 Actym Therapeutics Inc Bacteria-based ingredients that stimulate the immune system, treatments and platforms for delivering RNA
CN112444629B (zh) * 2020-12-09 2023-09-29 青岛科技大学 基于发夹核酸分子信号放大线路的外泌体检测方法及应用
KR20230172456A (ko) * 2021-02-09 2023-12-22 유니버시티 오브 매사추세츠 침입하고 자율적으로 용해하도록 설계된 치료 단백질의 세포내 전달 및 이의 사용 방법
EP4313109A1 (en) * 2021-03-31 2024-02-07 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
CN113249382B (zh) * 2021-04-12 2023-05-12 右江民族医学院 下调TRIM56基因表达的siRNA及其应用
BR112023022681A2 (pt) * 2021-04-30 2024-01-23 Kalivir Immunotherapeutics Inc Vírus oncolíticos para expressão modificada de mhc
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