JP2023501539A5 - - Google Patents

Info

Publication number
JP2023501539A5
JP2023501539A5 JP2022527167A JP2022527167A JP2023501539A5 JP 2023501539 A5 JP2023501539 A5 JP 2023501539A5 JP 2022527167 A JP2022527167 A JP 2022527167A JP 2022527167 A JP2022527167 A JP 2022527167A JP 2023501539 A5 JP2023501539 A5 JP 2023501539A5
Authority
JP
Japan
Prior art keywords
sting
sequence
modified
protein
bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022527167A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023501539A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/060307 external-priority patent/WO2021097144A2/en
Publication of JP2023501539A publication Critical patent/JP2023501539A/ja
Publication of JP2023501539A5 publication Critical patent/JP2023501539A5/ja
Priority to JP2025017602A priority Critical patent/JP2025081374A/ja
Priority to JP2025184585A priority patent/JP2026021469A/ja
Pending legal-status Critical Current

Links

JP2022527167A 2019-11-12 2020-11-12 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用 Pending JP2023501539A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2025017602A JP2025081374A (ja) 2019-11-12 2025-02-05 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
JP2025184585A JP2026021469A (ja) 2019-11-12 2025-10-31 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962934503P 2019-11-12 2019-11-12
US62/934,503 2019-11-12
US202062962162P 2020-01-16 2020-01-16
US62/962,162 2020-01-16
US202062990404P 2020-03-16 2020-03-16
US62/990,404 2020-03-16
PCT/US2020/060307 WO2021097144A2 (en) 2019-11-12 2020-11-12 Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2025017602A Division JP2025081374A (ja) 2019-11-12 2025-02-05 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
JP2025184585A Division JP2026021469A (ja) 2019-11-12 2025-10-31 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用

Publications (2)

Publication Number Publication Date
JP2023501539A JP2023501539A (ja) 2023-01-18
JP2023501539A5 true JP2023501539A5 (https=) 2023-11-20

Family

ID=73740563

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022527167A Pending JP2023501539A (ja) 2019-11-12 2020-11-12 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
JP2025017602A Pending JP2025081374A (ja) 2019-11-12 2025-02-05 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
JP2025184585A Pending JP2026021469A (ja) 2019-11-12 2025-10-31 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2025017602A Pending JP2025081374A (ja) 2019-11-12 2025-02-05 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
JP2025184585A Pending JP2026021469A (ja) 2019-11-12 2025-10-31 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用

Country Status (9)

Country Link
EP (2) EP4613276A3 (https=)
JP (3) JP2023501539A (https=)
KR (1) KR20220113943A (https=)
AU (1) AU2020382614B2 (https=)
BR (1) BR112022009139A2 (https=)
CA (2) CA3177479A1 (https=)
IL (1) IL292836A (https=)
MX (1) MX2022005705A (https=)
WO (1) WO2021097144A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7340591B2 (ja) * 2018-07-11 2023-09-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
JP2023501539A (ja) * 2019-11-12 2023-01-18 アクティム・セラピューティクス・インコーポレイテッド 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用
IL300447A (en) 2020-08-12 2023-04-01 Actym Therapeutics Inc Bacteria-based ingredients that stimulate the immune system, treatments and platforms for delivering RNA
CN112852698B (zh) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用
CN113249382B (zh) * 2021-04-12 2023-05-12 右江民族医学院 下调TRIM56基因表达的siRNA及其应用
EP4398919A4 (en) * 2021-09-10 2026-03-11 Univ Minnesota SALMONELLA MODIFIED FOR NON-TOXIC TUMOR COLONIZATION
WO2023086796A2 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
JP2024547212A (ja) * 2022-01-10 2024-12-26 シェンチェン シンセティカ パイオニアリング カンパニー リミテッド 抗腫瘍活性を有する改変された細菌
CN114410812B (zh) * 2022-01-24 2024-05-10 河北科技师范学院 一种鉴别鸡群对沙门氏菌易感性的snp位点、筛选及应用
CN114457159B (zh) * 2022-02-24 2023-09-19 珠海圣美生物诊断技术有限公司 一种检测肿瘤细胞或肿瘤细胞碎片的方法
CN115089701A (zh) * 2022-05-09 2022-09-23 吉林大学 含有水凝胶式缓释载体的靶向肿瘤疫苗试剂盒
WO2025106484A1 (en) * 2023-11-14 2025-05-22 The Regents Of The University Of California Listeria variants and methods of use thereof
WO2025254287A1 (ko) * 2024-06-03 2025-12-11 씨제이제일제당 (주) 신규한 프로모터 및 이의 용도

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3847770A (en) 1972-04-10 1974-11-12 Continental Can Co Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3936354A (en) 1974-04-29 1976-02-03 Lapointe Jean Rock Anti-tumour product of bacterial origin
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4769027A (en) 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6190657B1 (en) 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
CN1253551C (zh) 1997-09-10 2006-04-26 维昂药品公司 减毒的遗传修饰肿瘤靶向细菌
JP2001010973A (ja) 1999-06-29 2001-01-16 Dnavec Research Inc がんワクチン
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
CA2386806A1 (en) 1999-10-04 2001-04-12 Vion Pharmaceuticals, Inc. Non-invasive tumor imaging by tumor-targeted bacteria
AU2001227889A1 (en) 2000-01-14 2001-07-24 The United States of America, represented by The Secretary, Department of Health & Human Services Oligodeoxynucleotide and its use to induce an immune response
WO2003045153A1 (en) 2001-11-21 2003-06-05 The Johns Hopkins University Combination bacteriolytic therapy for the treatment of tumors
WO2003065787A2 (en) 2002-02-06 2003-08-14 Johns Hopkins University School Of Medicine Methods and compositions for the targeting of a systemic immune response to specific organs or tissues
US20070298012A1 (en) 2003-12-16 2007-12-27 Ivan King Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
WO2006004992A1 (en) 2004-06-29 2006-01-12 Anticancer, Inc. Cancer selective auxotrophs
US20090123426A1 (en) 2004-12-17 2009-05-14 Chiang Li Compositions for Bacterial Mediated Gene Silencing and Methods of Using the Same
US8426375B2 (en) 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
JP4842749B2 (ja) * 2006-04-19 2011-12-21 花王株式会社 組換え微生物
CN1974759B (zh) 2006-07-26 2010-06-09 吉林大学 运载重组质粒的减毒沙门氏菌及其在抗肿瘤中的应用
US8241844B2 (en) 2008-10-03 2012-08-14 Ralph Clark, legal representative Methods and compositions for modulating an immune response with immunogenic oligonucleotides
US20120009153A1 (en) 2009-08-13 2012-01-12 Hongnian Guo Compositions for bacterial mediated gene silencing and methods of using the same
WO2012149364A1 (en) 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
EP2620159A1 (en) 2012-01-24 2013-07-31 Institut Pasteur Improved cancer treatment by immunotherapy with bcg or antigenically related non-pathogenic mycobacteria
CN103374538B (zh) 2012-04-27 2017-12-01 山东新创生物科技有限公司 包含戈氏梭菌(Clostridiumghonii)的衍生细菌菌株的组合物及其使用方法
ES2391108B1 (es) 2012-07-26 2013-10-07 Universitat Autonoma De Barcelona Uso de mycobacterium brumae para el tratamiento del cáncer de vejiga
US9539290B2 (en) 2012-12-24 2017-01-10 Anticancer Inc. Individualized bacterial treatment of pancreatic cancer
DK2986311T3 (en) 2013-04-18 2019-02-25 Tilt Biotherapeutics Oy IMPROVED ADOPTIVE CELL THERAPY
WO2015002969A1 (en) 2013-07-03 2015-01-08 City Of Hope Anticancer combinations
US10987432B2 (en) 2013-09-05 2021-04-27 The University Of Hong Kong Therapeutic delivery and expression system, methods and uses thereof
HUE035875T2 (hu) 2013-10-25 2018-06-28 Psioxus Therapeutics Ltd Heterológ géneket tartalmazó onkolitikus adenovírusok
WO2015153639A1 (en) 2014-03-31 2015-10-08 The Johns Hopkins University Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-ctla-4 and/or anti-pd-1 antibodies to treat solid tumor malignancies
WO2016025582A2 (en) 2014-08-12 2016-02-18 Forbes Neil S Targeting epigenetic regulators using a bacterial delivery system
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
US20160206666A1 (en) 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
ES2881384T3 (es) 2015-05-13 2021-11-29 Synlogic Operating Co Inc Bacterias manipuladas para reducir la hiperfenilalaninemia
WO2016210373A2 (en) * 2015-06-24 2016-12-29 Synlogic, Inc. Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof
US11273184B2 (en) 2015-08-31 2022-03-15 Synlogic Operating Company, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
WO2017043815A1 (en) 2015-09-08 2017-03-16 Sillajen, Inc. Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof
WO2017156349A1 (en) 2016-03-10 2017-09-14 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
AU2017290828A1 (en) 2016-06-30 2019-01-24 Virogin Biotech Canada Ltd Pseudotyped oncolytic viral delivery of therapeutic polypeptides
CN110402145A (zh) 2016-10-26 2019-11-01 莫得纳特斯公司 用于增强免疫应答的信使核糖核酸及其使用方法
BR112019013863A2 (pt) * 2017-01-06 2020-03-03 Synlogic Operating Company, Inc. Micro-organismos programados para produzir moduladores imunes e terapêuticos anticâncer em células tumorais
SG11201906552WA (en) 2017-01-25 2019-08-27 Tessa Therapeutics Pte Ltd TGF-ß DECOY RECEPTOR
WO2018191619A1 (en) * 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EP4599893A3 (en) 2017-04-14 2025-11-05 CG Oncology, Inc. Cg0070 for treating bcg resistant bladder carcinoma in situ
CN108795832B (zh) * 2017-04-26 2021-05-14 江苏恒瑞医药股份有限公司 一种内源l-门冬酰胺酶ii基因敲除的宿主菌、其制备方法及其应用
EP3652318A1 (en) 2017-07-11 2020-05-20 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
WO2019035901A1 (en) * 2017-08-15 2019-02-21 University Of Miami COMPOSITIONS AND METHODS FOR STING PROTEIN MODULATION
WO2019183117A1 (en) * 2018-03-19 2019-09-26 Multivir Inc. Methods and compositions comprising genetically engineered vaccines for the treatment and prevention of cancer
JP7340591B2 (ja) 2018-07-11 2023-09-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
WO2020172462A1 (en) 2019-02-22 2020-08-27 Arizona Board Of Regents On Behalf Of Arizona State University Tumor-navigating, self-eradicating, trail-armed salmonella for precision cancer therapy
US11717542B2 (en) 2019-02-22 2023-08-08 Arizona Board Of Regents On Behalf Of Arizona State University Using tumor-navigating Salmonella to modulate tumor metabolism
JP2023501539A (ja) * 2019-11-12 2023-01-18 アクティム・セラピューティクス・インコーポレイテッド 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用

Similar Documents

Publication Publication Date Title
JP2023501539A5 (https=)
JP2022524951A5 (https=)
Conlon et al. Cytokines in the treatment of cancer
JP7574243B2 (ja) 抗cd70キメラ抗原受容体
US11123369B2 (en) Bispecific CAR T-cells for solid tumor targeting
AU2020382614B2 (en) Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
Homey et al. Chemokines: agents for the immunotherapy of cancer?
JP2023539454A5 (https=)
US20050053579A1 (en) Novel synthetic chimeric fusion transgene with immuno-therapeutic uses
US11992504B2 (en) Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment
IL310711B2 (en) Modulating polypeptide expression through a novel system for modifying gene expression
KR20180057723A (ko) 항-cd30 키메라성 항원 수용체
Burkart et al. Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters
CA3128350A1 (en) Microenvironment sensors to regulate engineered gene expression
AU2018277294A1 (en) Oncolytic virus and method
JP2025500373A5 (https=)
Tüting et al. Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: studies with the model tumor antigen β-galactosidase and the BALB/c Meth A p53 tumor-specific antigen
US20250352647A1 (en) Method for enhancing durability of immune cell
Heuer et al. Neuroblastoma cells expressing mature IL-18, but not proIL-18, induce a strong and immediate antitumor immune response
CN1871025B (zh) 基于印记位点调节物兄弟(boris)的预防性癌症疫苗
Qin et al. Human lymphotoxin has at least equal antitumor activity in comparison to human tumor necrosis factor but is less toxic in mice
Dezfouli et al. Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNγ primed and IFNβ treated B7‐1+ B16‐F10 melanoma cells
Selinsky et al. Soluble tumor necrosis factor receptor type I enhances tumor development and persistence in vivo
US20240261401A1 (en) Engineered immune cells, compositions and methods thereof
JP2006096663A (ja) 癌遺伝子ワクチン