JP2022110118A5 - - Google Patents
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- JP2022110118A5 JP2022110118A5 JP2022082105A JP2022082105A JP2022110118A5 JP 2022110118 A5 JP2022110118 A5 JP 2022110118A5 JP 2022082105 A JP2022082105 A JP 2022082105A JP 2022082105 A JP2022082105 A JP 2022082105A JP 2022110118 A5 JP2022110118 A5 JP 2022110118A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- linker
- pharmaceutical composition
- psma
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 14
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 7
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- -1 thionocarbonyl Chemical group 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 230000001717 pathogenic effect Effects 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000006356 alkylene carbonyl group Chemical group 0.000 claims 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000005599 alkyl carboxylate group Chemical group 0.000 claims 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024095014A JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95648907P | 2007-08-17 | 2007-08-17 | |
| US60/956,489 | 2007-08-17 | ||
| US7435808P | 2008-06-20 | 2008-06-20 | |
| US61/074,358 | 2008-06-20 | ||
| JP2021019732A JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019732A Division JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024095014A Division JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022110118A JP2022110118A (ja) | 2022-07-28 |
| JP2022110118A5 true JP2022110118A5 (enExample) | 2023-03-01 |
| JP7609824B2 JP7609824B2 (ja) | 2025-01-07 |
Family
ID=40378553
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521210A Pending JP2010536790A (ja) | 2007-08-17 | 2008-08-15 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2014125603A Active JP5902237B2 (ja) | 2007-08-17 | 2014-06-18 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2016046076A Pending JP2016153410A (ja) | 2007-08-17 | 2016-03-09 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2017223872A Active JP6596479B2 (ja) | 2007-08-17 | 2017-11-21 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2018100343A Active JP6625690B2 (ja) | 2007-08-17 | 2018-05-25 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2019179190A Active JP6838118B2 (ja) | 2007-08-17 | 2019-09-30 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2021019732A Active JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2022082105A Active JP7609824B2 (ja) | 2007-08-17 | 2022-05-19 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
| JP2024095014A Pending JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521210A Pending JP2010536790A (ja) | 2007-08-17 | 2008-08-15 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2014125603A Active JP5902237B2 (ja) | 2007-08-17 | 2014-06-18 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2016046076A Pending JP2016153410A (ja) | 2007-08-17 | 2016-03-09 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2017223872A Active JP6596479B2 (ja) | 2007-08-17 | 2017-11-21 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2018100343A Active JP6625690B2 (ja) | 2007-08-17 | 2018-05-25 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2019179190A Active JP6838118B2 (ja) | 2007-08-17 | 2019-09-30 | Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法 |
| JP2021019732A Active JP7079355B2 (ja) | 2007-08-17 | 2021-02-10 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024095014A Pending JP2024117783A (ja) | 2007-08-17 | 2024-06-12 | Ｐｓｍａ結合性リガンド－リンカー結合体及び使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (24) | US9193763B2 (enExample) |
| EP (7) | EP3858347A3 (enExample) |
| JP (9) | JP2010536790A (enExample) |
| CN (2) | CN102014956B (enExample) |
| AU (1) | AU2008289108C1 (enExample) |
| CA (1) | CA2696627C (enExample) |
| DK (1) | DK2187965T3 (enExample) |
| ES (1) | ES2768224T3 (enExample) |
| HK (1) | HK1212588A1 (enExample) |
| HU (1) | HUE047200T2 (enExample) |
| IL (1) | IL203998A (enExample) |
| NZ (2) | NZ600085A (enExample) |
| PL (1) | PL2187965T3 (enExample) |
| PT (1) | PT2187965T (enExample) |
| SI (1) | SI2187965T1 (enExample) |
| WO (1) | WO2009026177A1 (enExample) |
Families Citing this family (129)
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| CA2527196C (en) | 2003-05-30 | 2012-10-16 | Purdue Research Foundation | Diagnostic method for atherosclerosis |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| PT3699162T (pt) * | 2006-11-08 | 2022-10-11 | Molecular Insight Pharm Inc | Heterodímeros de ácido glutâmico |
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