JP2011507933A5 - - Google Patents
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- Publication number
- JP2011507933A5 JP2011507933A5 JP2010540130A JP2010540130A JP2011507933A5 JP 2011507933 A5 JP2011507933 A5 JP 2011507933A5 JP 2010540130 A JP2010540130 A JP 2010540130A JP 2010540130 A JP2010540130 A JP 2010540130A JP 2011507933 A5 JP2011507933 A5 JP 2011507933A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- targeting agent
- use according
- cell
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 40
- 230000008685 targeting Effects 0.000 claims 35
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 239000003795 chemical substances by application Substances 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000012636 effector Substances 0.000 claims 5
- 230000009919 sequestration Effects 0.000 claims 5
- 239000003463 adsorbent Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 3
- 229940124549 vasodilator Drugs 0.000 claims 3
- 239000003071 vasodilator agent Substances 0.000 claims 3
- 210000000601 blood cell Anatomy 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 229960001389 doxazosin Drugs 0.000 claims 2
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001289 prazosin Drugs 0.000 claims 2
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 claims 2
- 229960001693 terazosin Drugs 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000002616 plasmapheresis Methods 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 238000011285 therapeutic regimen Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1663007P | 2007-12-26 | 2007-12-26 | |
| US1661307P | 2007-12-26 | 2007-12-26 | |
| PCT/EP2008/068268 WO2009080831A1 (en) | 2007-12-26 | 2008-12-23 | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241327A Division JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507933A JP2011507933A (ja) | 2011-03-10 |
| JP2011507933A5 true JP2011507933A5 (enExample) | 2012-02-16 |
Family
ID=40459778
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540130A Pending JP2011507933A (ja) | 2007-12-26 | 2008-12-23 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
| JP2014241327A Pending JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014241327A Pending JP2015038158A (ja) | 2007-12-26 | 2014-11-28 | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9011864B2 (enExample) |
| EP (1) | EP2238169A1 (enExample) |
| JP (2) | JP2011507933A (enExample) |
| AR (1) | AR069979A1 (enExample) |
| TW (1) | TWI524897B (enExample) |
| WO (1) | WO2009080831A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004224925C1 (en) * | 2004-08-30 | 2011-07-21 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| ES2475201T3 (es) * | 2007-12-26 | 2014-07-10 | Biotest Ag | Agentes dirigidos contra CD138 y usos de los mismos |
| PL2242772T3 (pl) * | 2007-12-26 | 2015-05-29 | Biotest Ag | Immunokonjugaty nakierowane na CD138 i ich zastosowanie |
| US9446146B2 (en) * | 2007-12-26 | 2016-09-20 | Biotest Ag | Methods and agents for improving targeting of CD138 expressing tumor cells |
| CA2761120A1 (en) * | 2009-05-06 | 2010-11-11 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| EP2589609A1 (en) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| US10117932B2 (en) | 2011-12-08 | 2018-11-06 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| CN105339498A (zh) * | 2013-03-07 | 2016-02-17 | 贝勒医学院 | 癌症中靶向cd138 |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| HUE050159T2 (hu) | 2013-12-17 | 2020-11-30 | Genentech Inc | Anti-CD3 antitestek és alkalmazási eljárások |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| AU2016274989A1 (en) * | 2015-06-12 | 2017-11-02 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| US10323094B2 (en) | 2015-06-16 | 2019-06-18 | Genentech, Inc. | Humanized and affinity matured antibodies to FcRH5 and methods of use |
| EP3310811B1 (en) | 2015-06-16 | 2021-06-16 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| EP3541843A1 (en) | 2016-11-15 | 2019-09-25 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| IL320863A (en) | 2017-10-02 | 2025-07-01 | Visterra Inc | Antibodies to CD138 and their uses |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| CR20200391A (es) | 2018-02-08 | 2020-10-19 | Genentech Inc | Moléculas biespecíficas de unión al antígeno y métodos de uso |
| JP7585231B2 (ja) * | 2019-04-29 | 2024-11-18 | イミュノジェン， インコーポレイテッド | 抗ｃｄ１２３免疫複合体を含む治療的組み合わせ |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| BR112021025421A2 (pt) | 2019-06-17 | 2022-02-01 | Visterra Inc | Moléculas de anticorpo humanizado para cd138 e os usos dos mesmos |
| CR20220330A (es) | 2019-12-13 | 2022-08-04 | Genentech Inc | Anticuerpos anti-ly6g6d y métodos de uso. |
| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック， インコーポレイテッド | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬 |
| WO2022098638A2 (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| EP4240493A2 (en) | 2020-11-04 | 2023-09-13 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| KR20240007171A (ko) | 2021-05-14 | 2024-01-16 | 제넨테크, 인크. | 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법 |
| AU2023254206A1 (en) | 2022-04-13 | 2024-10-17 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| GB202313214D0 (en) * | 2023-08-30 | 2023-10-11 | Iksuda Therapeutics Ltd | Co-administration of antibody-drug conjugate |
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| EP2551282A3 (en) | 2005-03-23 | 2013-02-13 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
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-
2008
- 2008-12-23 US US12/342,180 patent/US9011864B2/en not_active Expired - Fee Related
- 2008-12-23 JP JP2010540130A patent/JP2011507933A/ja active Pending
- 2008-12-23 AR ARP080105722A patent/AR069979A1/es unknown
- 2008-12-23 WO PCT/EP2008/068268 patent/WO2009080831A1/en not_active Ceased
- 2008-12-23 EP EP08864283A patent/EP2238169A1/en not_active Ceased
- 2008-12-24 TW TW097150429A patent/TWI524897B/zh not_active IP Right Cessation
-
2014
- 2014-11-28 JP JP2014241327A patent/JP2015038158A/ja active Pending
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