JP2022105175A5 - - Google Patents
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- Publication number
- JP2022105175A5 JP2022105175A5 JP2022076671A JP2022076671A JP2022105175A5 JP 2022105175 A5 JP2022105175 A5 JP 2022105175A5 JP 2022076671 A JP2022076671 A JP 2022076671A JP 2022076671 A JP2022076671 A JP 2022076671A JP 2022105175 A5 JP2022105175 A5 JP 2022105175A5
- Authority
- JP
- Japan
- Prior art keywords
- testosterone
- gel formulation
- pharmaceutically acceptable
- mixture
- testosterone gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 122
- 239000000203 mixture Substances 0.000 claims 63
- 229960003604 testosterone Drugs 0.000 claims 61
- 238000009472 formulation Methods 0.000 claims 51
- 238000000034 method Methods 0.000 claims 13
- 239000003981 vehicle Substances 0.000 claims 9
- 238000009792 diffusion process Methods 0.000 claims 6
- 206010002261 Androgen deficiency Diseases 0.000 claims 5
- 206010058359 Hypogonadism Diseases 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 5
- 238000009165 androgen replacement therapy Methods 0.000 claims 5
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 5
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940126601 medicinal product Drugs 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000003906 humectant Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486324P | 2011-05-15 | 2011-05-15 | |
| US61/486,324 | 2011-05-15 | ||
| US201161486634P | 2011-05-16 | 2011-05-16 | |
| US61/486,634 | 2011-05-16 | ||
| JP2020012807A JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020012807A Division JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022105175A JP2022105175A (ja) | 2022-07-12 |
| JP2022105175A5 true JP2022105175A5 (https=) | 2022-10-06 |
Family
ID=46579248
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510901A Expired - Fee Related JP6152092B2 (ja) | 2011-05-15 | 2012-05-15 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022076671A Pending JP2022105175A (ja) | 2011-05-15 | 2022-05-06 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Family Applications Before (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510901A Expired - Fee Related JP6152092B2 (ja) | 2011-05-15 | 2012-05-15 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP2709588B1 (https=) |
| JP (9) | JP6152092B2 (https=) |
| KR (10) | KR102568894B1 (https=) |
| CN (4) | CN103813784A (https=) |
| AR (2) | AR086409A1 (https=) |
| AU (11) | AU2012257490A1 (https=) |
| BR (2) | BR112013029336B1 (https=) |
| CA (3) | CA2836398C (https=) |
| DK (1) | DK2714006T3 (https=) |
| EA (1) | EA201391701A1 (https=) |
| ES (1) | ES2859784T3 (https=) |
| IL (2) | IL229400A0 (https=) |
| MX (4) | MX2013013369A (https=) |
| PL (1) | PL2714006T3 (https=) |
| WO (2) | WO2012156822A1 (https=) |
| ZA (2) | ZA201309265B (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR086400A1 (es) | 2011-05-13 | 2013-12-11 | Trimel Pharmaceuticals Corp | Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| KR102568894B1 (ko) * | 2011-05-15 | 2023-08-21 | 에이세러스 바이오파마 인크. | 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템 |
| US8971800B2 (en) * | 2011-05-31 | 2015-03-03 | Qualcomm Incorporated | Methods and apparatus for improving NFC activation and data exchange reporting mechanisms |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2014076569A2 (en) * | 2012-11-14 | 2014-05-22 | Trimel Biopharma Srl | Controlled release topical testosterone formulations and methods |
| WO2014093818A2 (en) * | 2012-12-14 | 2014-06-19 | Bioject, Inc. | Use of a novel subcutaneous needle-free technique to deliver testosterone in hypogonadal men |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| US11160751B2 (en) * | 2013-10-07 | 2021-11-02 | Antares Pharma, Inc. | Hematocrit modulation through needle assisted jet injection of testosterone |
| WO2015127012A1 (en) * | 2014-02-19 | 2015-08-27 | Wotton Paul K | Needle assisted jet injection administration of testosterone compositions |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| RU2016141135A (ru) | 2014-07-29 | 2018-08-28 | Терапьютиксмд, Инк. | Трансдермальный крем |
| WO2016123317A1 (en) * | 2015-01-28 | 2016-08-04 | Prometheon Pharma, Llc | Topical formulations of growth factors |
| EP4233873A3 (en) * | 2015-06-29 | 2023-10-18 | Lyra Therapeutics, Inc. | Implantable scaffolds for treatment of sinusitis |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| BR102015020878B1 (pt) * | 2015-08-28 | 2019-08-27 | F B M Ind Farmaceutica Ltda | formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona. |
| ES2949053T3 (es) * | 2016-01-07 | 2023-09-25 | Viramal Ltd | Composiciones de gel para administración transdérmica para maximizar las concentraciones de fármaco en el estrato córneo y suero, y métodos de uso de las mismas |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| MX2018012967A (es) | 2016-04-25 | 2019-03-06 | Koska Family Ltd | Sistema de suministro medico. |
| UY37271A (es) * | 2016-06-02 | 2017-11-30 | Acerus Pharmaceuticals Corp | Composiciones nasales de cannabinoides |
| EP3463375A1 (en) * | 2016-06-03 | 2019-04-10 | M Et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
| CN110461340A (zh) * | 2017-01-20 | 2019-11-15 | 马特恩制药股份公司 | 用于降低暴露于空气污染物的风险的鼻用药物组合物 |
| US10764951B2 (en) | 2017-06-17 | 2020-09-01 | Lg Electronics Inc. | Registration method of user terminal in wireless communication system and apparatus therefor |
| KR102639913B1 (ko) | 2017-11-17 | 2024-02-23 | 코스카 패밀리 리미티드 | 유체 전달 매니폴드를 위한 시스템 및 방법 |
| AU2018371435B2 (en) * | 2017-11-27 | 2023-12-14 | Aska Pharmaceutical Co., Ltd. | Powder preparation for nasal administration |
| AU2019215163A1 (en) * | 2018-02-02 | 2020-08-20 | Acerus Biopharma Inc. | Methods of testosterone therapy |
| WO2019175290A1 (en) | 2018-03-13 | 2019-09-19 | Beckley Canopy Therapeutics Limited | Cannabis or cannabis derived compositions for promoting cessation of chemical dependence |
| US12544511B2 (en) | 2018-06-20 | 2026-02-10 | Koska Family Limited | Systems and methods for pre-filled dual-chamber medical agent delivery |
| CN108771622B (zh) * | 2018-07-11 | 2022-01-07 | 尹振图 | 一种自闭式针形滴嘴及眼药水瓶 |
| BR112021007877A2 (pt) | 2018-10-26 | 2021-08-03 | Viramal Limited | composição em gel mucoadesiva |
| US20200170962A1 (en) | 2018-11-30 | 2020-06-04 | F. Markus Leweke | Nasal cannabidiol compositions |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| KR20210131305A (ko) * | 2018-12-14 | 2021-11-02 | 아세러스 바이오파마 인크. | 테스토스테론의 활성 에스테르 유도체, 조성물 및 그의 용도 |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| CN112121049B (zh) * | 2020-08-28 | 2022-02-01 | 嘉兴市第一医院 | 顺式阿曲库铵在制备治疗男性性腺功能减退症的药物中的应用 |
| CN116600787A (zh) * | 2020-11-19 | 2023-08-15 | 阿库西亚医疗有限责任公司 | 非水性凝胶组合物 |
| GB202307501D0 (en) * | 2023-05-19 | 2023-07-05 | Lawley Pharmaceuticals Pty Ltd | Process for preparing dispensable testosterone cream |
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| DE4214953C2 (de) | 1992-05-06 | 1995-05-18 | Arrowdean Ltd | Arzneimittel zur Erhöhung des Testosteronspiegels |
| US5756071A (en) | 1992-06-03 | 1998-05-26 | Arrowdean Limited | Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier |
| DE4405898A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
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| EP1896038B1 (en) * | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Method and composition for testosterone transdermal delivery |
| EP1790343A1 (en) * | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| CN101099742A (zh) * | 2006-07-06 | 2008-01-09 | 上海富海科申药业有限公司 | 能够减少皮肤刺激的睾酮凝胶制剂 |
| WO2008040488A1 (en) * | 2006-10-04 | 2008-04-10 | M & P Patent Aktiengesellschaft | Controlled release delivery system for nasal application of neurotransmitters |
| JP2010521519A (ja) * | 2007-03-23 | 2010-06-24 | ユニメッド・ファーマシューティカルズ・エルエルシー | 小児性腺機能低下症の治療用組成物及び治療方法 |
| US8507467B2 (en) * | 2007-09-20 | 2013-08-13 | Shiseido Company, Ltd. | Transdermally absorbable preparation |
| PL2500062T3 (pl) * | 2007-11-13 | 2015-12-31 | Curadis Gmbh | Steroidy C-19 do określonych zastosowań terapeutycznych |
| GB0807605D0 (en) * | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| KR102568894B1 (ko) * | 2011-05-15 | 2023-08-21 | 에이세러스 바이오파마 인크. | 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템 |
-
2012
- 2012-05-15 KR KR1020217007047A patent/KR102568894B1/ko active Active
- 2012-05-15 PL PL12748245T patent/PL2714006T3/pl unknown
- 2012-05-15 WO PCT/IB2012/001127 patent/WO2012156822A1/en not_active Ceased
- 2012-05-15 KR KR1020137033180A patent/KR20140033408A/ko not_active Ceased
- 2012-05-15 CN CN201280035162.8A patent/CN103813784A/zh active Pending
- 2012-05-15 KR KR1020207006630A patent/KR20200028503A/ko not_active Ceased
- 2012-05-15 MX MX2013013369A patent/MX2013013369A/es unknown
- 2012-05-15 AU AU2012257490A patent/AU2012257490A1/en not_active Abandoned
- 2012-05-15 JP JP2014510901A patent/JP6152092B2/ja not_active Expired - Fee Related
- 2012-05-15 CA CA2836398A patent/CA2836398C/en active Active
- 2012-05-15 BR BR112013029336-5A patent/BR112013029336B1/pt active IP Right Grant
- 2012-05-15 EA EA201391701A patent/EA201391701A1/ru unknown
- 2012-05-15 MX MX2013013388A patent/MX363561B/es unknown
- 2012-05-15 DK DK12748245.3T patent/DK2714006T3/da active
- 2012-05-15 KR KR1020237008221A patent/KR20230041081A/ko not_active Ceased
- 2012-05-15 WO PCT/IB2012/001112 patent/WO2012156820A1/en not_active Ceased
- 2012-05-15 CN CN201280035150.5A patent/CN103796636B/zh not_active Expired - Fee Related
- 2012-05-15 MX MX2019003340A patent/MX374398B/es active IP Right Grant
- 2012-05-15 EP EP12738595.3A patent/EP2709588B1/en active Active
- 2012-05-15 CA CA2836405A patent/CA2836405C/en active Active
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2013
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2017
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2018
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2024
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