JP2022105175A5 - - Google Patents
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- Publication number
- JP2022105175A5 JP2022105175A5 JP2022076671A JP2022076671A JP2022105175A5 JP 2022105175 A5 JP2022105175 A5 JP 2022105175A5 JP 2022076671 A JP2022076671 A JP 2022076671A JP 2022076671 A JP2022076671 A JP 2022076671A JP 2022105175 A5 JP2022105175 A5 JP 2022105175A5
- Authority
- JP
- Japan
- Prior art keywords
- testosterone
- gel formulation
- pharmaceutically acceptable
- mixture
- testosterone gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 122
- 239000000203 mixture Substances 0.000 claims 63
- 229960003604 testosterone Drugs 0.000 claims 61
- 238000009472 formulation Methods 0.000 claims 51
- 238000000034 method Methods 0.000 claims 13
- 239000003981 vehicle Substances 0.000 claims 9
- 238000009792 diffusion process Methods 0.000 claims 6
- 206010002261 Androgen deficiency Diseases 0.000 claims 5
- 206010058359 Hypogonadism Diseases 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 5
- 238000009165 androgen replacement therapy Methods 0.000 claims 5
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 5
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940126601 medicinal product Drugs 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000003906 humectant Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486324P | 2011-05-15 | 2011-05-15 | |
| US61/486,324 | 2011-05-15 | ||
| US201161486634P | 2011-05-16 | 2011-05-16 | |
| US61/486,634 | 2011-05-16 | ||
| JP2020012807A JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020012807A Division JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022105175A JP2022105175A (ja) | 2022-07-12 |
| JP2022105175A5 true JP2022105175A5 (https=) | 2022-10-06 |
Family
ID=46579248
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2014510901A Expired - Fee Related JP6152092B2 (ja) | 2011-05-15 | 2012-05-15 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022076671A Pending JP2022105175A (ja) | 2011-05-15 | 2022-05-06 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Family Applications Before (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2014510901A Expired - Fee Related JP6152092B2 (ja) | 2011-05-15 | 2012-05-15 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP2709588B1 (https=) |
| JP (9) | JP2014513716A (https=) |
| KR (10) | KR20230041081A (https=) |
| CN (4) | CN110613679A (https=) |
| AR (2) | AR089553A1 (https=) |
| AU (11) | AU2012257490A1 (https=) |
| BR (2) | BR112013029332A2 (https=) |
| CA (3) | CA2836398C (https=) |
| DK (1) | DK2714006T3 (https=) |
| EA (1) | EA201391701A1 (https=) |
| ES (1) | ES2859784T3 (https=) |
| IL (2) | IL229400A0 (https=) |
| MX (4) | MX395212B (https=) |
| PL (1) | PL2714006T4 (https=) |
| WO (2) | WO2012156822A1 (https=) |
| ZA (2) | ZA201309265B (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| AR086400A1 (es) | 2011-05-13 | 2013-12-11 | Trimel Pharmaceuticals Corp | Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| BR112013029332A2 (pt) * | 2011-05-15 | 2021-06-01 | Trimel Biopharma Srl | formulações de gel bioadesivas de testosterona intranasais e uso das mesmas para tratar hipogonadismo de indivíduo do sexo masculino |
| US8971800B2 (en) * | 2011-05-31 | 2015-03-03 | Qualcomm Incorporated | Methods and apparatus for improving NFC activation and data exchange reporting mechanisms |
| US8633178B2 (en) | 2011-11-23 | 2014-01-21 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150297733A1 (en) * | 2012-11-14 | 2015-10-22 | Trimel Biopharma Srl | Controlled release topical testosterone formulations and methods |
| WO2014093818A2 (en) * | 2012-12-14 | 2014-06-19 | Bioject, Inc. | Use of a novel subcutaneous needle-free technique to deliver testosterone in hypogonadal men |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| JP6338658B2 (ja) * | 2013-10-07 | 2018-06-06 | アンタレス・ファーマ・インコーポレーテッド | テストステロンの針補助ジェット注射を通じたヘマトクリット調節 |
| EP4062918A1 (en) | 2014-02-19 | 2022-09-28 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
| EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| RU2016141135A (ru) | 2014-07-29 | 2018-08-28 | Терапьютиксмд, Инк. | Трансдермальный крем |
| WO2016123317A1 (en) * | 2015-01-28 | 2016-08-04 | Prometheon Pharma, Llc | Topical formulations of growth factors |
| EP4233873A3 (en) * | 2015-06-29 | 2023-10-18 | Lyra Therapeutics, Inc. | Implantable scaffolds for treatment of sinusitis |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| BR102015020878B1 (pt) * | 2015-08-28 | 2019-08-27 | F B M Ind Farmaceutica Ltda | formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona. |
| MX393613B (es) | 2016-01-07 | 2025-03-24 | Viramal Ltd | Composiciones de gel para administracion transdermica para maximizar las concentraciones de farmaco en el estrato corneo y suero, y metodos de uso de las mismas. |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2017187262A1 (en) | 2016-04-25 | 2017-11-02 | Marc Andrew Koska | Medical delivery system |
| KR102433459B1 (ko) * | 2016-06-02 | 2022-08-17 | 아세러스 랩스 인코포레이티드 | 칸나비노이드의 반고체 및 점성 액체 비강 제형 |
| US11903951B2 (en) | 2016-06-03 | 2024-02-20 | M et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
| KR20190109452A (ko) * | 2017-01-20 | 2019-09-25 | 엠 이티 피 파마 아게 | 대기 오염 물질에의 노출 위험을 감소시키기 위한 비강 약학적 조성물 |
| EP3641424B1 (en) * | 2017-06-17 | 2022-05-04 | LG Electronics Inc. | Method for registering a user equipment with a network slice in a wireless communication system and user equipment therefor |
| EP3710086A4 (en) | 2017-11-17 | 2021-11-17 | Koska Family Limited | SYSTEMS AND PROCEDURES FOR LIQUID DISPENSER |
| CA3083757A1 (en) * | 2017-11-27 | 2019-05-31 | Aska Pharmaceutical Co., Ltd. | Powder preparation for nasal administration |
| CA3090262A1 (en) * | 2018-02-02 | 2019-08-08 | Aytu Bioscience, Inc. | Methods of testosterone therapy |
| WO2019175290A1 (en) | 2018-03-13 | 2019-09-19 | Beckley Canopy Therapeutics Limited | Cannabis or cannabis derived compositions for promoting cessation of chemical dependence |
| US12544511B2 (en) | 2018-06-20 | 2026-02-10 | Koska Family Limited | Systems and methods for pre-filled dual-chamber medical agent delivery |
| CN108771622B (zh) * | 2018-07-11 | 2022-01-07 | 尹振图 | 一种自闭式针形滴嘴及眼药水瓶 |
| AU2019365255B2 (en) | 2018-10-26 | 2025-06-12 | Viramal Limited | Mucoadhesive gel composition |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| US20200170962A1 (en) | 2018-11-30 | 2020-06-04 | F. Markus Leweke | Nasal cannabidiol compositions |
| CN113365635A (zh) * | 2018-12-14 | 2021-09-07 | 阿克罗斯生物制药公司 | 睾酮的活性酯衍生物、组合物和其用途 |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| CN112121049B (zh) * | 2020-08-28 | 2022-02-01 | 嘉兴市第一医院 | 顺式阿曲库铵在制备治疗男性性腺功能减退症的药物中的应用 |
| CA3198930A1 (en) * | 2020-11-19 | 2022-05-27 | Acousia Therapeutics Gmbh | Non-aqueous gel composition |
| GB202307501D0 (en) * | 2023-05-19 | 2023-07-05 | Lawley Pharmaceuticals Pty Ltd | Process for preparing dispensable testosterone cream |
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| EP2191833B1 (en) * | 2007-09-20 | 2013-02-13 | Shiseido Company, Ltd. | Transdermally absorbable preparation |
| EP2949361B1 (en) * | 2007-11-13 | 2017-03-22 | Athenion AG | C-19 steroids for treating cellulite |
| GB0807605D0 (en) * | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| BR112013029332A2 (pt) * | 2011-05-15 | 2021-06-01 | Trimel Biopharma Srl | formulações de gel bioadesivas de testosterona intranasais e uso das mesmas para tratar hipogonadismo de indivíduo do sexo masculino |
-
2012
- 2012-05-15 BR BR112013029332-2A patent/BR112013029332A2/pt not_active Application Discontinuation
- 2012-05-15 CN CN201910982324.2A patent/CN110613679A/zh active Pending
- 2012-05-15 MX MX2020008599A patent/MX395212B/es unknown
- 2012-05-15 AU AU2012257490A patent/AU2012257490A1/en not_active Abandoned
- 2012-05-15 CN CN201280035150.5A patent/CN103796636B/zh not_active Expired - Fee Related
- 2012-05-15 MX MX2013013369A patent/MX2013013369A/es unknown
- 2012-05-15 JP JP2014510900A patent/JP2014513716A/ja active Pending
- 2012-05-15 CN CN201280035162.8A patent/CN103813784A/zh active Pending
- 2012-05-15 WO PCT/IB2012/001127 patent/WO2012156822A1/en not_active Ceased
- 2012-05-15 KR KR1020237008221A patent/KR20230041081A/ko not_active Ceased
- 2012-05-15 EA EA201391701A patent/EA201391701A1/ru unknown
- 2012-05-15 JP JP2014510901A patent/JP6152092B2/ja not_active Expired - Fee Related
- 2012-05-15 MX MX2019003340A patent/MX374398B/es active IP Right Grant
- 2012-05-15 CA CA2836398A patent/CA2836398C/en active Active
- 2012-05-15 KR KR1020187038088A patent/KR102088038B1/ko active Active
- 2012-05-15 DK DK12748245.3T patent/DK2714006T3/da active
- 2012-05-15 CN CN201811198846.5A patent/CN109481394B/zh active Active
- 2012-05-15 EP EP12738595.3A patent/EP2709588B1/en active Active
- 2012-05-15 KR KR1020247037387A patent/KR20240162608A/ko active Pending
- 2012-05-15 AU AU2012257492A patent/AU2012257492A1/en not_active Abandoned
- 2012-05-15 KR KR1020207028301A patent/KR20200118228A/ko not_active Ceased
- 2012-05-15 CA CA2836405A patent/CA2836405C/en active Active
- 2012-05-15 WO PCT/IB2012/001112 patent/WO2012156820A1/en not_active Ceased
- 2012-05-15 KR KR1020137033181A patent/KR20140045400A/ko not_active Ceased
- 2012-05-15 KR KR1020207006630A patent/KR20200028503A/ko not_active Ceased
- 2012-05-15 KR KR1020217007047A patent/KR102568894B1/ko active Active
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2013
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2017
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2018
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