KR20230041081A - 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도 - Google Patents

비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도 Download PDF

Info

Publication number
KR20230041081A
KR20230041081A KR1020237008221A KR20237008221A KR20230041081A KR 20230041081 A KR20230041081 A KR 20230041081A KR 1020237008221 A KR1020237008221 A KR 1020237008221A KR 20237008221 A KR20237008221 A KR 20237008221A KR 20230041081 A KR20230041081 A KR 20230041081A
Authority
KR
South Korea
Prior art keywords
testosterone
gel
treatment
subjects
max
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020237008221A
Other languages
English (en)
Korean (ko)
Inventor
웨인 크레프너
시오반 포가티
워너 오브레거
파울 조제 피에르 마리 메스
Original Assignee
에이세러스 바이오파마 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에이세러스 바이오파마 인크. filed Critical 에이세러스 바이오파마 인크.
Priority to KR1020247037387A priority Critical patent/KR20240162608A/ko
Publication of KR20230041081A publication Critical patent/KR20230041081A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237008221A 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도 Ceased KR20230041081A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247037387A KR20240162608A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161486324P 2011-05-15 2011-05-15
US61/486,324 2011-05-15
US201161486634P 2011-05-16 2011-05-16
US61/486,634 2011-05-16
KR1020217036024A KR20210135003A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
PCT/IB2012/001112 WO2012156820A1 (en) 2011-05-15 2012-05-15 Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217036024A Division KR20210135003A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247037387A Division KR20240162608A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도

Publications (1)

Publication Number Publication Date
KR20230041081A true KR20230041081A (ko) 2023-03-23

Family

ID=46579248

Family Applications (10)

Application Number Title Priority Date Filing Date
KR1020237008221A Ceased KR20230041081A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020187038088A Active KR102088038B1 (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020247037387A Pending KR20240162608A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020207028301A Ceased KR20200118228A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020137033181A Ceased KR20140045400A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020207006630A Ceased KR20200028503A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020217007047A Active KR102568894B1 (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020217036024A Ceased KR20210135003A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020137033180A Ceased KR20140033408A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020197029484A Ceased KR20190117803A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도

Family Applications After (9)

Application Number Title Priority Date Filing Date
KR1020187038088A Active KR102088038B1 (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020247037387A Pending KR20240162608A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020207028301A Ceased KR20200118228A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020137033181A Ceased KR20140045400A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020207006630A Ceased KR20200028503A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020217007047A Active KR102568894B1 (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020217036024A Ceased KR20210135003A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도
KR1020137033180A Ceased KR20140033408A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템
KR1020197029484A Ceased KR20190117803A (ko) 2011-05-15 2012-05-15 비내용 테스토스테론 바이오-접착제 겔 제형 및 남성의 성선기능저하증을 치료하기 위한 그의 용도

Country Status (16)

Country Link
EP (3) EP2709588B1 (https=)
JP (9) JP2014513716A (https=)
KR (10) KR20230041081A (https=)
CN (4) CN110613679A (https=)
AR (2) AR089553A1 (https=)
AU (11) AU2012257490A1 (https=)
BR (2) BR112013029332A2 (https=)
CA (3) CA2836398C (https=)
DK (1) DK2714006T3 (https=)
EA (1) EA201391701A1 (https=)
ES (1) ES2859784T3 (https=)
IL (2) IL229400A0 (https=)
MX (4) MX395212B (https=)
PL (1) PL2714006T4 (https=)
WO (2) WO2012156822A1 (https=)
ZA (2) ZA201309265B (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
AR086400A1 (es) 2011-05-13 2013-12-11 Trimel Pharmaceuticals Corp Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
BR112013029332A2 (pt) * 2011-05-15 2021-06-01 Trimel Biopharma Srl formulações de gel bioadesivas de testosterona intranasais e uso das mesmas para tratar hipogonadismo de indivíduo do sexo masculino
US8971800B2 (en) * 2011-05-31 2015-03-03 Qualcomm Incorporated Methods and apparatus for improving NFC activation and data exchange reporting mechanisms
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150297733A1 (en) * 2012-11-14 2015-10-22 Trimel Biopharma Srl Controlled release topical testosterone formulations and methods
WO2014093818A2 (en) * 2012-12-14 2014-06-19 Bioject, Inc. Use of a novel subcutaneous needle-free technique to deliver testosterone in hypogonadal men
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
JP6338658B2 (ja) * 2013-10-07 2018-06-06 アンタレス・ファーマ・インコーポレーテッド テストステロンの針補助ジェット注射を通じたヘマトクリット調節
EP4062918A1 (en) 2014-02-19 2022-09-28 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
EP3145489A1 (en) 2014-05-22 2017-03-29 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
WO2016123317A1 (en) * 2015-01-28 2016-08-04 Prometheon Pharma, Llc Topical formulations of growth factors
EP4233873A3 (en) * 2015-06-29 2023-10-18 Lyra Therapeutics, Inc. Implantable scaffolds for treatment of sinusitis
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
BR102015020878B1 (pt) * 2015-08-28 2019-08-27 F B M Ind Farmaceutica Ltda formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona.
MX393613B (es) 2016-01-07 2025-03-24 Viramal Ltd Composiciones de gel para administracion transdermica para maximizar las concentraciones de farmaco en el estrato corneo y suero, y metodos de uso de las mismas.
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017187262A1 (en) 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system
KR102433459B1 (ko) * 2016-06-02 2022-08-17 아세러스 랩스 인코포레이티드 칸나비노이드의 반고체 및 점성 액체 비강 제형
US11903951B2 (en) 2016-06-03 2024-02-20 M et P Pharma AG Nasal pharmaceutical compositions with a porous excipient
KR20190109452A (ko) * 2017-01-20 2019-09-25 엠 이티 피 파마 아게 대기 오염 물질에의 노출 위험을 감소시키기 위한 비강 약학적 조성물
EP3641424B1 (en) * 2017-06-17 2022-05-04 LG Electronics Inc. Method for registering a user equipment with a network slice in a wireless communication system and user equipment therefor
EP3710086A4 (en) 2017-11-17 2021-11-17 Koska Family Limited SYSTEMS AND PROCEDURES FOR LIQUID DISPENSER
CA3083757A1 (en) * 2017-11-27 2019-05-31 Aska Pharmaceutical Co., Ltd. Powder preparation for nasal administration
CA3090262A1 (en) * 2018-02-02 2019-08-08 Aytu Bioscience, Inc. Methods of testosterone therapy
WO2019175290A1 (en) 2018-03-13 2019-09-19 Beckley Canopy Therapeutics Limited Cannabis or cannabis derived compositions for promoting cessation of chemical dependence
US12544511B2 (en) 2018-06-20 2026-02-10 Koska Family Limited Systems and methods for pre-filled dual-chamber medical agent delivery
CN108771622B (zh) * 2018-07-11 2022-01-07 尹振图 一种自闭式针形滴嘴及眼药水瓶
AU2019365255B2 (en) 2018-10-26 2025-06-12 Viramal Limited Mucoadhesive gel composition
EP3659583B1 (en) 2018-11-30 2023-06-07 Viramal Limited A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent
US20200170962A1 (en) 2018-11-30 2020-06-04 F. Markus Leweke Nasal cannabidiol compositions
CN113365635A (zh) * 2018-12-14 2021-09-07 阿克罗斯生物制药公司 睾酮的活性酯衍生物、组合物和其用途
USD1052082S1 (en) 2020-06-01 2024-11-19 Koska Family Limited Sealed fluid container
CN112121049B (zh) * 2020-08-28 2022-02-01 嘉兴市第一医院 顺式阿曲库铵在制备治疗男性性腺功能减退症的药物中的应用
CA3198930A1 (en) * 2020-11-19 2022-05-27 Acousia Therapeutics Gmbh Non-aqueous gel composition
GB202307501D0 (en) * 2023-05-19 2023-07-05 Lawley Pharmaceuticals Pty Ltd Process for preparing dispensable testosterone cream

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082881A (en) * 1976-12-23 1978-04-04 E. R. Squibb & Sons, Inc. Topical and other type pharmaceutical formulations containing isosorbide carrier
DE4214953C2 (de) 1992-05-06 1995-05-18 Arrowdean Ltd Arzneimittel zur Erhöhung des Testosteronspiegels
US5756071A (en) 1992-06-03 1998-05-26 Arrowdean Limited Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier
DE4405898A1 (de) * 1994-02-18 1995-08-24 Schering Ag Transdermale therapeutische Systeme enthaltend Sexualsteroide
US5576071A (en) 1994-11-08 1996-11-19 Micron Technology, Inc. Method of reducing carbon incorporation into films produced by chemical vapor deposition involving organic precursor compounds
JP2000514065A (ja) * 1997-07-03 2000-10-24 アルザ コーポレイション ドラッグデリバリーディバイスとその製造法
JP4139860B2 (ja) * 1997-11-10 2008-08-27 ストラカン インターナショナル リミティッド 浸透増強および刺激減少システム
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
DE10064950A1 (de) * 2000-12-23 2002-07-11 Impetus Ag Basel Thixotropes Nasenspray
JP2005505587A (ja) * 2001-10-12 2005-02-24 シーエヌエス・インコーポレーテッド 含水性の点鼻ゲル及びその塗布装置
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
ATE534373T1 (de) * 2003-10-10 2011-12-15 Antares Pharma Ipl Ag Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut
ATE319426T1 (de) * 2003-11-11 2006-03-15 Mattern Udo Nasenformulierung mit kontrollierter freisetzung von sexualhormonen
JP5002462B2 (ja) * 2004-12-09 2012-08-15 バイエル・アニマル・ヘルス・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 酸によるグルココルチコイドエステルの安定化
CA2610708C (en) * 2005-06-03 2013-10-08 Acrux Dds Pty Ltd Method and composition for transdermal drug delivery
EP1790343A1 (en) * 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
CN101099742A (zh) * 2006-07-06 2008-01-09 上海富海科申药业有限公司 能够减少皮肤刺激的睾酮凝胶制剂
CA2664427C (en) * 2006-10-04 2012-06-05 M & P Patent Aktiengesellschaft Controlled release delivery system for nasal application of neurotransmitters
BRPI0809124A8 (pt) * 2007-03-23 2015-11-24 Unimed Pharmaceuticals Llc Composições e métodos para tratamento de hipogonadismo pediátrico
EP2191833B1 (en) * 2007-09-20 2013-02-13 Shiseido Company, Ltd. Transdermally absorbable preparation
EP2949361B1 (en) * 2007-11-13 2017-03-22 Athenion AG C-19 steroids for treating cellulite
GB0807605D0 (en) * 2008-04-28 2008-06-04 Diurnal Ltd Lipid composition
BR112013029332A2 (pt) * 2011-05-15 2021-06-01 Trimel Biopharma Srl formulações de gel bioadesivas de testosterona intranasais e uso das mesmas para tratar hipogonadismo de indivíduo do sexo masculino

Also Published As

Publication number Publication date
JP2014515038A (ja) 2014-06-26
JP2022078222A (ja) 2022-05-24
JP6152092B2 (ja) 2017-06-28
MX363561B (es) 2019-03-27
IL229400A0 (en) 2014-01-30
MX2019003340A (es) 2019-07-04
AR089553A1 (es) 2014-09-03
CN103796636A (zh) 2014-05-14
AR086409A1 (es) 2013-12-11
AU2020267162B2 (en) 2022-06-09
BR112013029336B1 (pt) 2021-11-30
JP2021001206A (ja) 2021-01-07
EP2709588B1 (en) 2021-08-25
KR20200118228A (ko) 2020-10-14
BR112013029332A2 (pt) 2021-06-01
EP2714006A1 (en) 2014-04-09
EP3977982A1 (en) 2022-04-06
JP2020073469A (ja) 2020-05-14
WO2012156820A9 (en) 2014-02-20
EP2714006B1 (en) 2020-12-09
AU2019203067A1 (en) 2019-05-23
KR20240162608A (ko) 2024-11-15
KR20140045400A (ko) 2014-04-16
BR112013029336A2 (pt) 2020-08-11
KR20140033408A (ko) 2014-03-18
JP2020079257A (ja) 2020-05-28
CA2836398A1 (en) 2012-11-22
ZA201309264B (en) 2015-09-30
EA201391701A1 (ru) 2014-04-30
AU2012257490A1 (en) 2013-12-19
WO2012156822A1 (en) 2012-11-22
KR20200028503A (ko) 2020-03-16
ES2859784T3 (es) 2021-10-04
CN109481394B (zh) 2023-05-05
CA3034552C (en) 2023-02-07
ZA201309265B (en) 2016-01-27
MX2020008599A (es) 2022-08-31
CN109481394A (zh) 2019-03-19
MX2013013388A (es) 2014-09-15
MX2013013369A (es) 2014-10-17
PL2714006T3 (pl) 2021-08-16
AU2020210227A1 (en) 2020-08-20
JP2018199701A (ja) 2018-12-20
CN103796636B (zh) 2019-04-05
CA2836398C (en) 2021-12-14
JP6594924B2 (ja) 2019-10-23
AU2012257492A1 (en) 2013-12-19
JP7017254B2 (ja) 2022-02-08
AU2017204182A1 (en) 2017-07-20
DK2714006T3 (da) 2021-03-15
CA2836405C (en) 2021-09-07
EP2709588A1 (en) 2014-03-26
WO2012156820A1 (en) 2012-11-22
JP2022105175A (ja) 2022-07-12
KR20210029849A (ko) 2021-03-16
IL229401A0 (en) 2014-01-30
CN103813784A (zh) 2014-05-21
CA2836405A1 (en) 2012-11-22
AU2024216312A1 (en) 2024-10-24
JP2014513716A (ja) 2014-06-05
PL2714006T4 (pl) 2021-08-16
KR102088038B1 (ko) 2020-03-13
KR20190117803A (ko) 2019-10-16
AU2019201618A1 (en) 2019-04-18
JP2017160204A (ja) 2017-09-14
KR102568894B1 (ko) 2023-08-21
AU2017203470A1 (en) 2017-06-22
CN110613679A (zh) 2019-12-27
AU2020267162A1 (en) 2020-12-03
MX395212B (es) 2025-03-21
KR20210135003A (ko) 2021-11-11
MX374398B (es) 2025-03-06
AU2019203400A1 (en) 2019-08-01
KR20190006194A (ko) 2019-01-17
AU2022202402A1 (en) 2022-05-12
CA3034552A1 (en) 2012-11-22

Similar Documents

Publication Publication Date Title
AU2022202402A1 (en) Intranasal testosterone gel formulations and use thereof for treating male hypogonadism
US20250064831A1 (en) Controlled release topical testosterone formulations and methods
US20250009756A1 (en) Male Testosterone Titration Methods, Male Intranasal Testosterone Bio-Adhesive Gel Formulations and Use Thereof for Treating Hypogonadism and TRT
US20260108531A1 (en) Methods of Treating Hypogonadism with Transnasal Testosterone Bio-adhesive Gel Formulations in Males with Allergic Rhinitis and Methods for Preventing an Allergic Rhinitis Event
WO2014080282A2 (en) One-and two-point titration methods to determine daily treatment regimens to treat hypogonadism or male testosterone deficiency with an intranasal testosterone bio-adhesive gel, and primary and secondary efficacy and safety endpoints
HK1263036B (en) Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism
HK1263036A1 (en) Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism
HK1196287B (en) Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism
HK1196287A (en) Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20230308

Application number text: 1020217036024

Filing date: 20211103

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20231204

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20240610

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20231204

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I