|
US645503A
(en)
|
1899-05-11 |
1900-03-13 |
Timothy Francis Crowley |
Cutter-gage for ice-cream, & c.
|
|
US953924A
(en)
|
1909-06-28 |
1910-04-05 |
Dow Wire & Iron Works |
Sliding door.
|
|
US20030040463A1
(en)
|
1996-04-05 |
2003-02-27 |
Wiegand Stanley J. |
TIE-2 ligands, methods of making and uses thereof
|
|
WO1998018914A1
(en)
|
1996-10-31 |
1998-05-07 |
Duke University |
Soluble tie2 receptor
|
|
US5980929A
(en)
|
1998-03-13 |
1999-11-09 |
Johns Hopkins University, School Of Medicine |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
|
|
US5919813C1
(en)
|
1998-03-13 |
2002-01-29 |
Univ Johns Hopkins Med |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
PT1165115E
(pt)
|
1999-03-26 |
2003-10-31 |
Univ California |
Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2
|
|
EP1046715A1
(en)
|
1999-04-23 |
2000-10-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
|
|
US6897201B2
(en)
*
|
2000-08-21 |
2005-05-24 |
Inspire Pharmaceuticals, Inc. |
Compositions and methods for the treatment of glaucoma or ocular hypertension
|
|
US7052695B2
(en)
|
2001-10-25 |
2006-05-30 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of treating hypertension
|
|
WO2003084565A2
(en)
|
2002-04-08 |
2003-10-16 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Ve-ptp as regulator of ve-cadherin mediated processes or disorders
|
|
RU2376029C2
(ru)
|
2002-04-25 |
2009-12-20 |
Юниверсити Оф Коннектикут Хелт Сентер |
Применение белков теплового шока для улучшения терапевтического эффекта невакцинного лечебного воздействия
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
AR046510A1
(es)
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
SI1725537T1
(sl)
|
2004-03-15 |
2011-11-30 |
Janssen Pharmaceutica Nv |
Nove spojine kot modulatorji opioidnih receptorjev
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
CN101044164A
(zh)
|
2004-07-20 |
2007-09-26 |
健泰科生物技术公司 |
血管生成素样4蛋白抑制剂，组合，以及其用途
|
|
EP2457578B1
(en)
|
2004-09-28 |
2015-08-19 |
Aprogen, Inc. |
Chimeric molecule comprising angiopoietin-1 and a coiled-coil domain for use in treating penile erectile dysfunction
|
|
EP2284194A1
(en)
|
2004-12-21 |
2011-02-16 |
AstraZeneca AB |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
US7893040B2
(en)
|
2005-07-22 |
2011-02-22 |
Oculis Ehf |
Cyclodextrin nanotechnology for ophthalmic drug delivery
|
|
WO2007033216A2
(en)
|
2005-09-12 |
2007-03-22 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
TW200744567A
(en)
*
|
2005-09-23 |
2007-12-16 |
Alcon Inc |
Phenylethylamine analogs and their use for treating glaucoma
|
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
|
CN101370519B
(zh)
|
2005-12-15 |
2013-07-24 |
阿斯利康(瑞典)有限公司 |
治疗癌症的促血管生成素-2拮抗剂和VEGF-A、KDR和/或Flt1拮抗剂的组合
|
|
SI1991275T1
(sl)
|
2006-03-08 |
2015-03-31 |
Archemix Llc |
Komplement vezavni aptameri in sredstva proti C5, uporabni pri zdravljenju očesnih motenj
|
|
MX2008012991A
(es)
|
2006-04-07 |
2008-10-17 |
Procter & Gamble |
Anticuerpos que ligan proteina tirosina fosfatasa humana beta (hptpbeta) y los usos de estos.
|
|
DE102006016426A1
(de)
|
2006-04-07 |
2007-10-11 |
Merck Patent Gmbh |
Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
*
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
CA2693383C
(en)
|
2006-10-27 |
2017-03-28 |
Sunnybrook Health Sciences Center |
Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
US9403789B2
(en)
|
2008-02-21 |
2016-08-02 |
Sequoia Pharmaceuticals, Inc. |
Benzofuran-containing amino acid inhibitors of cytochrome P450
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
PL2385763T3
(pl)
|
2009-01-12 |
2018-09-28 |
Aerpio Therapeutics, Inc. |
Sposoby leczenia zespołu nieszczelności naczyń
|
|
WO2010097800A1
(en)
|
2009-02-26 |
2010-09-02 |
Muhammad Abdulrazik |
Synergistic combination of bioactive compounds for lowering of intraocular pressure
|
|
JP5583145B2
(ja)
|
2009-03-03 |
2014-09-03 |
アルコン リサーチ， リミテッド |
レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物
|
|
KR20110130454A
(ko)
|
2009-03-03 |
2011-12-05 |
알콘 리서치, 리미티드 |
리셉터 티로신 키나제 저해(ＲＴＫｉ) 화합물을 눈에 전달하기 위한 약학 조성물
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
EP3556367A1
(en)
|
2009-07-06 |
2019-10-23 |
Aerpio Therapeutics, Inc. |
Benzosulfonamide derivatives, compositions thereof, and their use in the treatment of cancer or metastasis
|
|
KR20130045341A
(ko)
|
2010-07-12 |
2013-05-03 |
쓰레솔드 파마슈티컬스, 인코포레이티드 |
암 치료를 위한 저산소증 활성 프로드러그와 항혈관형성제의 투여
|
|
SG189177A1
(en)
|
2010-10-07 |
2013-05-31 |
Akebia Therapeutics Inc |
Compositions and methods for treating ocular edema, neovascularization and related diseases
|
|
US20180092883A1
(en)
|
2010-10-07 |
2018-04-05 |
Aerpio Therapeutics, Inc. |
Phosphatase inhibitors for treating ocular diseases
|
|
EP2857032A3
(en)
|
2010-12-02 |
2015-07-15 |
Maruzen Pharmaceuticals Co., Ltd. |
Tie2 activator, vascular endothelial growth factor (vegf) inhibitor, anti-angiogenic agent, agent for maturing blood vessels, agent for normalizing blood vessels, agent for stabilizing blood vessels, and pharmaceutical composition
|
|
EP2766043A4
(en)
|
2011-10-13 |
2015-06-10 |
Aerpio Therapeutics Inc |
METHOD FOR THE TREATMENT OF CAPILLARY LECKSYNDROME AND CANCER
|
|
JP2014532072A
(ja)
|
2011-10-13 |
2014-12-04 |
エアピオ セラピューティックス， インコーポレイテッド |
眼疾患の治療
|
|
US20130190324A1
(en)
|
2011-12-23 |
2013-07-25 |
The Regents Of The University Of Colorado, A Body Corporate |
Topical ocular drug delivery
|
|
EP2836232A4
(en)
|
2012-04-13 |
2016-03-16 |
Univ Johns Hopkins |
TREATMENT OF ISCHEMIC RETINOPATHY
|
|
HRP20181595T1
(hr)
|
2012-07-13 |
2018-12-14 |
Roche Glycart Ag |
Bispecifična anti-vegf/anti-ang-2 protutijela i njihova upotreba u liječenju očnih krvožilnih bolesti
|
|
DK2880167T3
(en)
|
2012-07-31 |
2018-07-30 |
Univ Texas |
METHODS AND COMPOSITIONS FOR IN VIVO-INDUCTION OF PANCREAS BETA CELL CREATION
|
|
CN104755103A
(zh)
|
2012-10-11 |
2015-07-01 |
阿森迪斯药物眼科部股份有限公司 |
用于治疗眼病症的中和vegf的前药
|
|
EP4566672A3
(en)
|
2012-11-08 |
2025-08-13 |
Clearside Biomedical Inc. |
Methods for the treatment of ocular disease in human subjects
|
|
WO2014079709A1
(en)
|
2012-11-23 |
2014-05-30 |
Ab Science |
Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections
|
|
EP2967066B1
(en)
|
2013-03-15 |
2019-10-23 |
Aerpio Therapeutics, Inc. |
Compositions, formulations and methods for treating ocular diseases
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
ES2743509T3
(es)
|
2013-04-11 |
2020-02-19 |
Sunnybrook Res Inst |
Métodos, usos y composiciones de agonistas de Tie2
|
|
EP3010525A1
(en)
|
2013-06-20 |
2016-04-27 |
Novartis AG |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
EP3010526A1
(en)
|
2013-06-20 |
2016-04-27 |
Novartis AG |
Use of a vegf antagonist in treating macular edema
|
|
WO2015002893A1
(en)
|
2013-07-02 |
2015-01-08 |
The Trustees Of Columbia University In The City Of New York |
Clearance of bioactive lipids from membrane structures by cyclodextrins
|
|
EP3019527A2
(en)
|
2013-07-11 |
2016-05-18 |
Novartis AG |
Use of a vegf antagonist in treating retinopathy of prematurity
|
|
CN105377891A
(zh)
|
2013-07-11 |
2016-03-02 |
诺华股份有限公司 |
Vegf拮抗剂在治疗儿童患者的脉络膜视网膜新生血管和通透性疾病中的应用
|
|
US9902767B2
(en)
|
2013-07-29 |
2018-02-27 |
Samsung Electronics Co., Ltd. |
Method of blocking vascular leakage using an anti-ANG2 antibody
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
ES2731531T3
(es)
|
2013-10-01 |
2019-11-15 |
Sphingotec Gmbh |
Método para predecir el riesgo de experimentar un episodio cardiaco adverso grave
|
|
SI3062811T1
(sl)
|
2013-11-01 |
2020-07-31 |
Regeneron Pharmaceuticals, Inc. |
Posegi na podlagi angiopoietina za zdravljenje cerebralne malarije
|
|
WO2015138882A1
(en)
|
2014-03-14 |
2015-09-17 |
Aerpio Therapeutics, Inc. |
Hptp-beta inhibitors
|
|
JP2015199733A
(ja)
*
|
2014-04-04 |
2015-11-12 |
国立大学法人東北大学 |
眼圧降下剤
|
|
JP6603653B2
(ja)
|
2014-04-04 |
2019-11-06 |
株式会社ダイゾー |
吐出容器
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
WO2016022813A1
(en)
|
2014-08-07 |
2016-02-11 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of tie-2
|
|
WO2016049183A1
(en)
|
2014-09-24 |
2016-03-31 |
Aerpio Therapeutics, Inc. |
Ve-ptp extracellular domain antibodies delivered by a gene therapy vector
|
|
TWI761959B
(zh)
|
2014-11-07 |
2022-04-21 |
瑞士商諾華公司 |
治療眼部疾病之方法
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
WO2017053566A1
(en)
|
2015-09-23 |
2017-03-30 |
Aerpio Therapeutics, Inc. |
Methods of treating intraocular pressure with activators of tie-2
|
|
AU2020264969B2
(en)
*
|
2019-04-29 |
2025-06-05 |
EyePoint Pharmaceuticals, Inc. |
Tie-2 activators targeting the schlemm's canal
|