ES2894802T3 - Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular - Google Patents

Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular Download PDF

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Publication number
ES2894802T3
ES2894802T3 ES16849594T ES16849594T ES2894802T3 ES 2894802 T3 ES2894802 T3 ES 2894802T3 ES 16849594 T ES16849594 T ES 16849594T ES 16849594 T ES16849594 T ES 16849594T ES 2894802 T3 ES2894802 T3 ES 2894802T3
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English (en)
Spanish (es)
Inventor
Kevin Gene Peters
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Aerpio Pharmaceuticals Inc
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Aerpio Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES16849594T 2015-09-23 2016-09-22 Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular Active ES2894802T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222481P 2015-09-23 2015-09-23
PCT/US2016/053107 WO2017053566A1 (en) 2015-09-23 2016-09-22 Methods of treating intraocular pressure with activators of tie-2

Publications (1)

Publication Number Publication Date
ES2894802T3 true ES2894802T3 (es) 2022-02-15

Family

ID=58276474

Family Applications (2)

Application Number Title Priority Date Filing Date
ES16849594T Active ES2894802T3 (es) 2015-09-23 2016-09-22 Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular
ES21191499T Active ES2981607T3 (es) 2015-09-23 2016-09-22 Activadores de Tie-2 para uso en el tratamiento de la presión intraocular

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES21191499T Active ES2981607T3 (es) 2015-09-23 2016-09-22 Activadores de Tie-2 para uso en el tratamiento de la presión intraocular

Country Status (15)

Country Link
US (3) US10952992B2 (enExample)
EP (3) EP4414032A3 (enExample)
JP (3) JP6959924B2 (enExample)
KR (1) KR20180054677A (enExample)
CN (2) CN108290057A (enExample)
AU (2) AU2016326510C1 (enExample)
BR (1) BR112018005499A2 (enExample)
CA (1) CA2998673C (enExample)
ES (2) ES2894802T3 (enExample)
IL (1) IL258150B (enExample)
MX (2) MX387804B (enExample)
MY (1) MY194736A (enExample)
PH (1) PH12018500658A1 (enExample)
SG (1) SG10201912000WA (enExample)
WO (1) WO2017053566A1 (enExample)

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US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
ES2894802T3 (es) 2015-09-23 2022-02-15 Aerpio Pharmaceuticals Inc Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular
BR112019001206A2 (pt) 2016-07-20 2019-06-25 Aerpio Therapeutics Inc anticorpos monoclonais humanizados que visam ve-ptp (hptp-ss)
CN113286580A (zh) * 2018-07-13 2021-08-20 西北大学 青光眼中的ve-ptp抑制
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EP3962482A4 (en) 2019-04-29 2023-01-11 EyePoint Pharmaceuticals, Inc. TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL
US11413242B2 (en) 2019-06-24 2022-08-16 EyePoint Pharmaceuticals, Inc. Formulations of Tie-2 activators and methods of use thereof
WO2021086904A1 (en) 2019-10-29 2021-05-06 Aerpio Pharmaceuticals, Inc. Small molecule activators of tie-2
JP2023510747A (ja) * 2020-01-08 2023-03-15 アイポイント ファーマシューティカルズ, インコーポレイテッド Tie-2活性化物質とプロスタグランジンの組み合わせおよびその使用

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AU2022202618B2 (en) 2023-12-14
JP2024061772A (ja) 2024-05-08
SG10201912000WA (en) 2020-02-27
WO2017053566A1 (en) 2017-03-30
BR112018005499A2 (pt) 2018-10-09
AU2016326510B2 (en) 2022-03-10
IL258150B (en) 2021-06-30
US20170079959A1 (en) 2017-03-23
PH12018500658A1 (en) 2018-10-01
KR20180054677A (ko) 2018-05-24
CA2998673C (en) 2023-12-12
MY194736A (en) 2022-12-15
CN108290057A (zh) 2018-07-17
EP3977994C0 (en) 2024-04-24
US20230398100A1 (en) 2023-12-14
JP2022000482A (ja) 2022-01-04
US12171751B2 (en) 2024-12-24
AU2022202618A1 (en) 2022-05-12
NZ740730A (en) 2024-07-26
EP4414032A3 (en) 2024-11-06
EP3352856B1 (en) 2021-08-18
AU2016326510C1 (en) 2024-06-27
NZ780430A (en) 2024-09-27
US10952992B2 (en) 2021-03-23
CN113713101A (zh) 2021-11-30
EP4414032A2 (en) 2024-08-14
JP2018528273A (ja) 2018-09-27
IL258150A (en) 2018-05-31
JP7451472B2 (ja) 2024-03-18
EP3352856A4 (en) 2019-05-01
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