IL258150B - Methods for treating intraocular pressure with angiopoietin-1 receptor activators - Google Patents

Methods for treating intraocular pressure with angiopoietin-1 receptor activators

Info

Publication number
IL258150B
IL258150B IL258150A IL25815018A IL258150B IL 258150 B IL258150 B IL 258150B IL 258150 A IL258150 A IL 258150A IL 25815018 A IL25815018 A IL 25815018A IL 258150 B IL258150 B IL 258150B
Authority
IL
Israel
Prior art keywords
activators
tie
methods
intraocular pressure
treating intraocular
Prior art date
Application number
IL258150A
Other languages
English (en)
Hebrew (he)
Other versions
IL258150A (en
Original Assignee
Aerprio Therapeutics Llc
Aerpio Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerprio Therapeutics Llc, Aerpio Pharmaceuticals Inc filed Critical Aerprio Therapeutics Llc
Publication of IL258150A publication Critical patent/IL258150A/en
Publication of IL258150B publication Critical patent/IL258150B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL258150A 2015-09-23 2018-03-15 Methods for treating intraocular pressure with angiopoietin-1 receptor activators IL258150B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222481P 2015-09-23 2015-09-23
PCT/US2016/053107 WO2017053566A1 (en) 2015-09-23 2016-09-22 Methods of treating intraocular pressure with activators of tie-2

Publications (2)

Publication Number Publication Date
IL258150A IL258150A (en) 2018-05-31
IL258150B true IL258150B (en) 2021-06-30

Family

ID=58276474

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258150A IL258150B (en) 2015-09-23 2018-03-15 Methods for treating intraocular pressure with angiopoietin-1 receptor activators

Country Status (15)

Country Link
US (3) US10952992B2 (enExample)
EP (3) EP3977994B1 (enExample)
JP (3) JP6959924B2 (enExample)
KR (1) KR20180054677A (enExample)
CN (2) CN113713101B (enExample)
AU (2) AU2016326510C1 (enExample)
BR (1) BR112018005499A2 (enExample)
CA (1) CA2998673C (enExample)
ES (2) ES2894802T3 (enExample)
IL (1) IL258150B (enExample)
MX (2) MX387804B (enExample)
MY (1) MY194736A (enExample)
PH (1) PH12018500658A1 (enExample)
SG (1) SG10201912000WA (enExample)
WO (1) WO2017053566A1 (enExample)

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Also Published As

Publication number Publication date
JP7451472B2 (ja) 2024-03-18
EP3352856A1 (en) 2018-08-01
EP3352856B1 (en) 2021-08-18
AU2016326510C1 (en) 2024-06-27
CN113713101B (zh) 2023-07-28
JP2018528273A (ja) 2018-09-27
EP4414032A2 (en) 2024-08-14
EP4414032A3 (en) 2024-11-06
MY194736A (en) 2022-12-15
MX2021010915A (es) 2021-10-01
AU2016326510B2 (en) 2022-03-10
JP6959924B2 (ja) 2021-11-05
CA2998673C (en) 2023-12-12
US20170079959A1 (en) 2017-03-23
US20230398100A1 (en) 2023-12-14
AU2022202618A1 (en) 2022-05-12
EP3977994B1 (en) 2024-04-24
EP3977994C0 (en) 2024-04-24
CN108290057A (zh) 2018-07-17
AU2016326510A1 (en) 2018-04-12
US12171751B2 (en) 2024-12-24
SG10201912000WA (en) 2020-02-27
US20210386713A1 (en) 2021-12-16
JP2024061772A (ja) 2024-05-08
ES2894802T3 (es) 2022-02-15
AU2022202618B2 (en) 2023-12-14
NZ780430A (en) 2024-09-27
US11666558B2 (en) 2023-06-06
EP3977994A1 (en) 2022-04-06
IL258150A (en) 2018-05-31
ES2981607T3 (es) 2024-10-09
CA2998673A1 (en) 2017-03-30
PH12018500658A1 (en) 2018-10-01
US10952992B2 (en) 2021-03-23
WO2017053566A1 (en) 2017-03-30
CN113713101A (zh) 2021-11-30
JP2022000482A (ja) 2022-01-04
MX2018003542A (es) 2018-11-09
KR20180054677A (ko) 2018-05-24
NZ740730A (en) 2024-07-26
MX387804B (es) 2025-03-19
BR112018005499A2 (pt) 2018-10-09
EP3352856A4 (en) 2019-05-01

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