|
US645503A
(en)
|
1899-05-11 |
1900-03-13 |
Timothy Francis Crowley |
Cutter-gage for ice-cream, & c.
|
|
US953924A
(en)
|
1909-06-28 |
1910-04-05 |
Dow Wire & Iron Works |
Sliding door.
|
|
US20030040463A1
(en)
|
1996-04-05 |
2003-02-27 |
Wiegand Stanley J. |
TIE-2 ligands, methods of making and uses thereof
|
|
AU5154098A
(en)
|
1996-10-31 |
1998-05-22 |
Duke University |
Soluble tie2 receptor
|
|
US5919813C1
(en)
|
1998-03-13 |
2002-01-29 |
Univ Johns Hopkins Med |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
|
|
US5980929A
(en)
|
1998-03-13 |
1999-11-09 |
Johns Hopkins University, School Of Medicine |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
CA2368670C
(en)
|
1999-03-26 |
2012-06-05 |
Chitra Suri |
Modulation of vascular permeability by means of tie2 receptor activators
|
|
EP1046715A1
(en)
|
1999-04-23 |
2000-10-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
|
|
US6897201B2
(en)
*
|
2000-08-21 |
2005-05-24 |
Inspire Pharmaceuticals, Inc. |
Compositions and methods for the treatment of glaucoma or ocular hypertension
|
|
AU2002335085A1
(en)
|
2001-10-25 |
2003-05-06 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
AU2003229627A1
(en)
|
2002-04-08 |
2003-10-20 |
Max-Planck-Gesellschaft Zur |
Ve-ptp as regulator of ve-cadherin mediated processes or disorders
|
|
AU2003231098A1
(en)
|
2002-04-25 |
2003-11-10 |
University Of Connecticut Health Center |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
AR046510A1
(es)
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
HUE029852T2
(en)
|
2004-03-15 |
2017-04-28 |
Janssen Pharmaceutica Nv |
Opioid receptor modulators
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
EP1771474B1
(en)
|
2004-07-20 |
2010-01-27 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
|
EP1819355A4
(en)
|
2004-09-28 |
2009-08-12 |
Genexel Sein Inc |
METHOD OF USE OF A CHIMERIC COILED COIL MOLECULE
|
|
ES2371083T3
(es)
|
2004-12-21 |
2011-12-27 |
Medimmune Limited |
Anticuerpos dirigidos contra la angiopoyetina-2 y usos de los mismos.
|
|
US7893040B2
(en)
|
2005-07-22 |
2011-02-22 |
Oculis Ehf |
Cyclodextrin nanotechnology for ophthalmic drug delivery
|
|
WO2007033216A2
(en)
|
2005-09-12 |
2007-03-22 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
TW200744567A
(en)
*
|
2005-09-23 |
2007-12-16 |
Alcon Inc |
Phenylethylamine analogs and their use for treating glaucoma
|
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
|
EP2518083A3
(en)
|
2005-12-15 |
2012-12-05 |
Medimmune Limited |
Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or FLTL antagonist for treating cancer
|
|
EP2596807B1
(en)
|
2006-03-08 |
2015-12-16 |
Archemix LLC |
Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders
|
|
KR101482483B1
(ko)
|
2006-04-07 |
2015-01-15 |
에르피오 세러퓨틱스 인코포레이티드 |
인간 단백질 타이로신 포스파타아제 베타(hptp베타)에 결합하는 항체 및 그의 용도
|
|
DE102006016426A1
(de)
*
|
2006-04-07 |
2007-10-11 |
Merck Patent Gmbh |
Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
*
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8957022B2
(en)
|
2006-10-27 |
2015-02-17 |
Sunnybrook Health Sciences Centre |
Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
US9403789B2
(en)
|
2008-02-21 |
2016-08-02 |
Sequoia Pharmaceuticals, Inc. |
Benzofuran-containing amino acid inhibitors of cytochrome P450
|
|
CA2838846C
(en)
|
2009-01-12 |
2018-06-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating brain edema
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
WO2010097800A1
(en)
*
|
2009-02-26 |
2010-09-02 |
Muhammad Abdulrazik |
Synergistic combination of bioactive compounds for lowering of intraocular pressure
|
|
CN102340993A
(zh)
|
2009-03-03 |
2012-02-01 |
爱尔康研究有限公司 |
向眼部递送受体酪氨酸激酶抑制性(RTKi)化合物的药物组合物
|
|
AU2010221369B2
(en)
|
2009-03-03 |
2014-03-13 |
Alcon Research, Ltd. |
Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
|
|
ES2726946T3
(es)
|
2009-07-06 |
2019-10-10 |
Aerpio Therapeutics Inc |
Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
US20140010805A1
(en)
|
2010-07-12 |
2014-01-09 |
Karen Curd |
Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer
|
|
NZ610230A
(en)
|
2010-10-07 |
2015-07-31 |
Aerpio Therapeutics Inc |
Compositions and methods for treating ocular edema, neovascularization and related diseases
|
|
US20180092883A1
(en)
|
2010-10-07 |
2018-04-05 |
Aerpio Therapeutics, Inc. |
Phosphatase inhibitors for treating ocular diseases
|
|
CN103249422A
(zh)
|
2010-12-02 |
2013-08-14 |
丸善制药株式会社 |
Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物
|
|
CA2850830A1
(en)
|
2011-10-13 |
2013-04-18 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome and cancer
|
|
AU2012323849B2
(en)
|
2011-10-13 |
2017-04-20 |
EyePoint, Inc. |
Treatment of ocular disease
|
|
US20130190324A1
(en)
|
2011-12-23 |
2013-07-25 |
The Regents Of The University Of Colorado, A Body Corporate |
Topical ocular drug delivery
|
|
AU2013245630A1
(en)
|
2012-04-13 |
2014-10-30 |
The Johns Hopkins University |
Treatment of ischemic retinopathies
|
|
LT3495387T
(lt)
|
2012-07-13 |
2021-11-25 |
Roche Glycart Ag |
Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti
|
|
WO2014022455A1
(en)
|
2012-07-31 |
2014-02-06 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions for in vivo induction of pancreatic beta cell formation
|
|
US10519226B2
(en)
|
2012-10-11 |
2019-12-31 |
Ascendis Pharma Opthalmology Division A/S |
VEGF neutralizing prodrugs for the treatment of ocular conditions
|
|
KR102467714B1
(ko)
|
2012-11-08 |
2022-11-16 |
클리어사이드 바이오메디컬, 인코포레이드 |
인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
|
|
WO2014079709A1
(en)
|
2012-11-23 |
2014-05-30 |
Ab Science |
Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
GB2516561B
(en)
|
2013-03-15 |
2016-03-09 |
Aerpio Therapeutics Inc |
Compositions, formulations and methods for treating ocular diseases
|
|
ES2743509T3
(es)
|
2013-04-11 |
2020-02-19 |
Sunnybrook Res Inst |
Métodos, usos y composiciones de agonistas de Tie2
|
|
EP3010526A1
(en)
|
2013-06-20 |
2016-04-27 |
Novartis AG |
Use of a vegf antagonist in treating macular edema
|
|
US20160137717A1
(en)
|
2013-06-20 |
2016-05-19 |
Gabriela Burian |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
US20160151410A1
(en)
|
2013-07-02 |
2016-06-02 |
The Trustees Of Columbia University In The City Of New York |
Clearance of bioactive lipids from membrane structures by cyclodextrins
|
|
BR112016000282A2
(pt)
|
2013-07-11 |
2017-12-12 |
Novartis Ag |
uso de antagonista de vegf em tratamento de retinopatia da prematuridade
|
|
WO2015004616A1
(en)
|
2013-07-11 |
2015-01-15 |
Novartis Ag |
Use of a vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients
|
|
US9828422B2
(en)
|
2013-07-29 |
2017-11-28 |
Samsung Electronics Co., Ltd. |
Anti-Ang2 antibody
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
TR201905773T4
(tr)
|
2013-10-01 |
2019-05-21 |
Sphingotec Gmbh |
Bir majör advers kardiyak olayla karşılaşma riskinin tahmin edilmesi için bir usul.
|
|
AU2014342162B2
(en)
|
2013-11-01 |
2020-01-02 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietin-based interventions for treating cerebral malaria
|
|
EP3116503A4
(en)
|
2014-03-14 |
2017-08-23 |
Aerpio Therapeutics, Inc. |
Hptp-beta inhibitors
|
|
US10071850B2
(en)
|
2014-04-04 |
2018-09-11 |
Daizo Corporation |
Discharge container
|
|
WO2015152416A1
(ja)
|
2014-04-04 |
2015-10-08 |
国立大学法人東北大学 |
眼圧降下剤
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
US9539245B2
(en)
|
2014-08-07 |
2017-01-10 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of Tie-2
|
|
US20160082129A1
(en)
|
2014-09-24 |
2016-03-24 |
Aerpio Therapeutics, Inc. |
VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector
|
|
TWI738632B
(zh)
|
2014-11-07 |
2021-09-11 |
瑞士商諾華公司 |
穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
MY194736A
(en)
*
|
2015-09-23 |
2022-12-15 |
Aerpio Therapeutics Inc |
Methods of treating intraocular pressure with activators of tie-2
|
|
WO2020223209A1
(en)
*
|
2019-04-29 |
2020-11-05 |
Aerpio Pharmaceuticals, Inc. |
Tie-2 activators targeting the schlemm's canal
|