JP2021532757A5 - - Google Patents

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Publication number
JP2021532757A5
JP2021532757A5 JP2021504769A JP2021504769A JP2021532757A5 JP 2021532757 A5 JP2021532757 A5 JP 2021532757A5 JP 2021504769 A JP2021504769 A JP 2021504769A JP 2021504769 A JP2021504769 A JP 2021504769A JP 2021532757 A5 JP2021532757 A5 JP 2021532757A5
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JP2021504769A
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JP2021532757A (ja
JP7584401B2 (ja
JPWO2020028039A5 (https=
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Priority to JP2022113740A priority patent/JP7584474B2/ja
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JP2021504769A 2018-07-30 2019-07-17 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法 Active JP7584401B2 (ja)

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JP2022113739A JP7584473B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2022113740A JP7584474B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2024105200A JP2024114921A (ja) 2018-07-30 2024-06-28 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法

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US201862712199P 2018-07-30 2018-07-30
US62/712,199 2018-07-30
US201862712327P 2018-07-31 2018-07-31
US62/712,327 2018-07-31
PCT/US2019/042151 WO2020028039A1 (en) 2018-07-30 2019-07-17 Engineered glycosyltransferases and steviol glycoside glucosylation methods

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JP2022113740A Division JP7584474B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2022113739A Division JP7584473B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2024105200A Division JP2024114921A (ja) 2018-07-30 2024-06-28 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法

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JP2021532757A JP2021532757A (ja) 2021-12-02
JP2021532757A5 true JP2021532757A5 (https=) 2023-03-22
JPWO2020028039A5 JPWO2020028039A5 (https=) 2023-03-22
JP7584401B2 JP7584401B2 (ja) 2024-11-15

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JP2021504769A Active JP7584401B2 (ja) 2018-07-30 2019-07-17 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2022113740A Active JP7584474B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2022113739A Active JP7584473B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2024105200A Pending JP2024114921A (ja) 2018-07-30 2024-06-28 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法

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JP2022113739A Active JP7584473B2 (ja) 2018-07-30 2022-07-15 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
JP2024105200A Pending JP2024114921A (ja) 2018-07-30 2024-06-28 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法

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US (3) US11760981B2 (https=)
EP (1) EP3830106A4 (https=)
JP (4) JP7584401B2 (https=)
KR (1) KR20210040408A (https=)
CN (2) CN121538193A (https=)
AU (2) AU2019314181B2 (https=)
BR (1) BR112021001661A8 (https=)
CA (1) CA3108268A1 (https=)
IL (2) IL280302B2 (https=)
MX (1) MX2021001260A (https=)
SG (1) SG11202100470WA (https=)
TW (1) TW202019951A (https=)
WO (1) WO2020028039A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3497222T (pt) 2016-08-12 2022-02-09 Amyris Inc Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos
KR102905512B1 (ko) 2017-02-03 2025-12-29 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
IL280302B2 (en) 2018-07-30 2025-09-01 Codexis Inc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside
CN111621482B (zh) * 2020-06-30 2022-04-29 浙江工业大学 一种草铵膦脱氢酶突变体、基因工程菌及一锅法多酶同步定向进化方法
EP4176070A1 (en) 2020-07-03 2023-05-10 c-LEcta GmbH One-pot cell-free glycosylation process
CN112760302B (zh) * 2020-12-23 2022-08-26 中化健康产业发展有限公司 一种能够催化莱鲍迪苷A生成莱鲍迪苷D的糖基转移酶StUGT
US20240368661A1 (en) * 2021-02-17 2024-11-07 Arzeda Corp. Compositions and methods for producing rebaudioside d
WO2022253282A1 (zh) * 2021-06-01 2022-12-08 弈柯莱生物科技(上海)股份有限公司 一种糖基转移酶及其应用
CN115418358B (zh) * 2021-06-01 2024-01-30 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
CN115449514B (zh) * 2021-06-08 2023-09-29 弈柯莱生物科技(上海)股份有限公司 一种β-1,2-糖基转移酶及其应用
CN113462670B (zh) * 2021-08-23 2023-03-24 兴化格林生物制品有限公司 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法
CN115725528B (zh) * 2021-08-30 2024-01-12 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
CN116555210B (zh) * 2022-01-30 2025-06-13 弈柯莱生物科技(集团)股份有限公司 糖基转移酶及其在制备莱鲍迪苷e中的应用
CN119256080A (zh) * 2022-05-23 2025-01-03 苏州引航生物科技有限公司 微生物来源的蔗糖合酶及其应用
CA3266431A1 (en) * 2022-09-02 2024-03-07 Arzeda Corp. Compositions and methods for producing rebaudioside m
CN120858181A (zh) 2022-12-05 2025-10-28 泰特和莱尔解决方案美国公司 获得甜菊醇糖苷的方法
WO2025039672A1 (zh) * 2023-08-24 2025-02-27 弈柯莱生物科技(集团)股份有限公司 莱鲍迪苷M的制备方法和β-1,2-葡萄糖基转移酶在其中的应用
KR102840622B1 (ko) * 2024-10-22 2025-08-01 주식회사 삼양사 Udp-글루코실트랜스퍼라제 변이체, udp-글루코실트랜스퍼라제 변이체 융합효소 및 이의 스테비올 배당체 생산 용도

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
WO1995033836A1 (en) 1994-06-03 1995-12-14 Novo Nordisk Biotech, Inc. Phosphonyldipeptides useful in the treatment of cardiovascular diseases
ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP1717322B1 (en) 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6265201B1 (en) 1997-01-17 2001-07-24 Regents Of The University Of Minnesota DNA molecules and protein displaying improved triazine compound degrading ability
DK1036198T3 (da) 1997-12-08 2013-01-02 California Inst Of Techn Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser
IL138800A0 (en) 1998-04-02 2001-10-31 Tellus Genetic Resources Inc A method of identifying a plant with a lesion in a gene sequence
NZ507591A (en) 1998-05-01 2002-03-28 Maxygen Inc Optimization of pest resistance genes using DNA shuffling
WO1999065927A2 (en) 1998-06-17 1999-12-23 Maxygen, Inc. Method for producing polynucleotides with desired properties
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
WO2000009682A1 (en) 1998-08-12 2000-02-24 Maxygen, Inc. Dna shuffling of monooxygenase genes for production of industrial chemicals
CA2345203A1 (en) 1998-10-07 2000-04-13 Maxygen Inc. Dna shuffling to produce nucleic acids for mycotoxin detoxification
EP1129184A1 (en) 1998-11-10 2001-09-05 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimation of plant phenotypes
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7702464B1 (en) 2001-08-21 2010-04-20 Maxygen, Inc. Method and apparatus for codon determining
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US8457903B1 (en) 1999-01-19 2013-06-04 Codexis Mayflower Holdings, Llc Method and/or apparatus for determining codons
EP1130093A1 (en) 1999-01-19 2001-09-05 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7873477B1 (en) 2001-08-21 2011-01-18 Codexis Mayflower Holdings, Llc Method and system using systematically varied data libraries
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
JP2003524394A (ja) 1999-02-11 2003-08-19 マキシジェン, インコーポレイテッド ハイスループット質量分析法
CA2362737A1 (en) 1999-03-05 2000-09-08 Maxygen, Inc. Recombination of insertion modified nucleic acids
US6703240B1 (en) 1999-04-13 2004-03-09 Maxygar, Inc. Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6519065B1 (en) 1999-11-05 2003-02-11 Jds Fitel Inc. Chromatic dispersion compensation device
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
IL150291A0 (en) 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
EP1272967A2 (en) 2000-03-30 2003-01-08 Maxygen, Inc. In silico cross-over site selection
JP2004508011A (ja) 2000-04-03 2004-03-18 マキシジェン, インコーポレイテッド スブチリシン変異体
US7049485B2 (en) 2000-10-20 2006-05-23 Board Of Trustees Of Michigan State University Transgenic plants containing ligninase and cellulase which degrade lignin and cellulose to fermentable sugars
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
EP1493027B1 (en) 2002-03-01 2014-10-15 Codexis Mayflower Holdings, LLC Methods, systems, and software for identifying functional bio-molecules
US7620500B2 (en) 2002-03-09 2009-11-17 Maxygen, Inc. Optimization of crossover points for directed evolution
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
EP1654354A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
EP2155869A2 (en) 2007-05-30 2010-02-24 Danisco US, INC., Genencor Division Variants of an alpha-amylase with improved production levels in fermentation processes
US8093028B2 (en) 2007-07-24 2012-01-10 Wisconsin Alumni Research Foundation Engineered glycosyltransferases with expanded substrate specificity
US8768871B2 (en) 2008-02-12 2014-07-01 Codexis, Inc. Method of generating an optimized, diverse population of variants
US8504498B2 (en) 2008-02-12 2013-08-06 Codexis, Inc. Method of generating an optimized, diverse population of variants
WO2009149577A1 (en) 2008-06-13 2009-12-17 Givaudan Sa Methods of identifying modulators of the bitter taste receptor tas2r44
EP3023494B1 (en) 2008-06-13 2018-11-28 Codexis, Inc. Method of synthesizing polynucleotide variants
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
ES2592377T3 (es) 2008-10-03 2016-11-29 Morita Kagaku Kogyo Co., Ltd. Nuevos glucósidos de esteviol
US8753861B2 (en) 2008-11-11 2014-06-17 Danisco Us Inc. Protease comprising one or more combinable mutations
US11155888B2 (en) 2010-03-12 2021-10-26 Purecircle Usa Inc. Stevia composition, production method and uses
US20150344512A1 (en) 2011-12-19 2015-12-03 Purecircle Usa Inc. Methods of purifying steviol glycosides and uses of the same
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
EP2575432B1 (en) 2010-06-02 2019-08-14 Evolva, Inc. Recombinant production of steviol glycosides
US9029426B2 (en) 2010-12-13 2015-05-12 Purecircle Sdn Bhd Highly soluble Rebaudioside D
US20140030381A1 (en) 2011-02-17 2014-01-30 Purecircle Usa Inc. Glucosyl stevia composition
US8733641B1 (en) 2011-06-14 2014-05-27 Digital Processing Systems, LLC. Electronic kiosk system and method for dispensing medical smart cards and managing healthcare information and services
EP2726651B1 (en) 2011-06-28 2018-11-07 Codexis, Inc. Protein variant generation by region shuffling
CA3128532A1 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
EP4124245A1 (en) 2011-12-19 2023-02-01 The Coca-Cola Company Beverage comprising rebaudioside x
MX355028B (es) 2012-01-23 2018-03-28 Dsm Ip Assets Bv Produccion de diterpeno.
US10000783B2 (en) 2012-03-16 2018-06-19 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
WO2013159055A1 (en) 2012-04-20 2013-10-24 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
MX395285B (es) 2012-05-22 2025-03-25 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
TW201402599A (zh) 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
MX2015003684A (es) 2012-09-25 2015-06-15 Cargill Inc Mezclas de esteviosidos.
EP2928321A1 (en) 2012-12-05 2015-10-14 Evolva SA Steviol glycoside compositions sensory properties
US20140171519A1 (en) 2012-12-19 2014-06-19 Indra Prakash Compositions and methods for improving rebaudioside x solubility
EP4414988A3 (en) 2013-01-31 2024-11-06 Codexis, Inc. Methods, systems, and software for identifying bio-molecules using models of multiplicative form
MY199452A (en) 2013-02-06 2023-10-30 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
BR112015019160A2 (pt) 2013-02-11 2017-08-22 Dalgaard Mikkelsen Michael Produção de glicosídeos de esteviol em hospedeiros recombinantes
KR101404728B1 (ko) 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
US20140322389A1 (en) 2013-03-14 2014-10-30 Indra Prakash Beverages containing rare sugars
US20140272068A1 (en) 2013-03-14 2014-09-18 Indra Prakash Beverages containing rare sugars
WO2014153000A1 (en) 2013-03-14 2014-09-25 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
US20160029677A1 (en) 2013-03-15 2016-02-04 The Coca-Cola Company Novel glucosyl steviol glycosides, their compositions and their purification
EP2970354B1 (en) 2013-03-15 2018-05-30 The Coca-Cola Company Steviol glycosides and their compositions
US20140342044A1 (en) 2013-05-14 2014-11-20 Pepsico, Inc. Compositions and Comestibles
US20140342043A1 (en) 2013-05-14 2014-11-20 Pepsico, Inc. Rebaudioside Sweetener Compositions and Food Products Sweetened with Same
CA2912347A1 (en) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Extracellular diterpene production
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
US10905146B2 (en) 2013-07-12 2021-02-02 The Coca-Cola Company Compositions for improving rebaudioside M solubility
EP3021689B1 (en) 2013-07-15 2021-03-24 DSM IP Assets B.V. Diterpene production
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US20160235102A1 (en) 2013-09-23 2016-08-18 Almendra Americas, LLC Sweetener composition, sweetener products, and methods of sweetening
AU2014342939B2 (en) 2013-11-01 2018-03-22 Conagen Inc. Recombinant production of steviol glycosides
CN106471128A (zh) 2014-01-28 2017-03-01 百事可乐公司 一种酶法制备瑞鲍迪甙m的方法
US20150223505A1 (en) 2014-02-12 2015-08-13 Purecircle Usa Inc. Stevia composition, production method and uses
US10609942B2 (en) 2015-01-06 2020-04-07 James and Carol May Family, LLLP Compositions and methods for sweeteners
US10772346B2 (en) 2014-02-21 2020-09-15 James and Carol May Family, LLLP Compositions and methods for the solubilization of stevia glycosides
WO2015152707A1 (en) 2014-04-02 2015-10-08 Purecircle Sdn Bhd Compounds produced from stevia and process for producing the same
US20180020709A1 (en) 2014-04-16 2018-01-25 Purecircle Usa Inc. Rebaudioside m biosynthetic production and recovery methods
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
GB2526383B (en) 2014-05-20 2018-01-31 Tate & Lyle Ingredients Americas Llc Improved sweetener
US10357052B2 (en) 2014-06-16 2019-07-23 Sweet Green Fields USA LLC Rebaudioside A and stevioside with improved solubilities
US10485256B2 (en) 2014-06-20 2019-11-26 Sweet Green Fields International Co., Limited Stevia sweetener with improved solubility with a cyclodextrin
CN104151378A (zh) 2014-08-12 2014-11-19 济南汉定生物工程有限公司 一种甜菊糖甙rm的提纯方法
EP3683315A1 (en) 2014-08-19 2020-07-22 Purecircle SDN BHD Method for preparing rebaudioside m
WO2016036980A1 (en) 2014-09-03 2016-03-10 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
IL234525B (en) 2014-09-08 2018-05-31 Unavoo Food Tech Ltd The composition containing a filler and a flavoring agent and its use
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
ES2903031T3 (es) 2014-09-11 2022-03-30 Pepsico Inc Potenciador de dulzor
EP4166010A1 (en) 2014-09-19 2023-04-19 PureCircle SDN BHD High-purity steviol glycosides
KR101765369B1 (ko) 2014-09-19 2017-08-08 한국과학기술원 돌외 유래의 신규한 당전이효소 및 이의 용도
BR112017006163B1 (pt) * 2014-10-03 2022-04-05 Conagen Inc Produto de consumo oral e método para adoçar o mesmo
EP3204506B1 (en) 2014-10-08 2022-01-12 DSM IP Assets B.V. Steviol glycoside production
CN107109453A (zh) 2014-11-05 2017-08-29 马努斯生物合成股份有限公司 甜菊醇糖苷的微生物产生
US20160165941A1 (en) 2014-11-21 2016-06-16 Flipn'Sweet, LLC Sugar substitute compositions comprising digestion resistent soluble fiber
US20170258121A1 (en) 2014-11-24 2017-09-14 Cargill, Incorporated Glycoside compositions
CN107249356B (zh) 2014-12-17 2021-08-06 嘉吉公司 用于口服摄入或使用的甜菊醇糖苷化合物、组合物以及用于增强甜菊醇糖苷溶解度的方法
EP3245196A4 (en) 2015-01-13 2018-06-13 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
EP3250686A1 (en) 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
CA3220591A1 (en) 2015-03-11 2016-09-15 Morita Kagaku Kogyo Co., Ltd. Sweetner composition and food containing same
WO2016146711A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
CA2979957A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
KR102569053B1 (ko) * 2015-04-14 2023-08-21 코나겐 인크. 조작된 전체 세포 촉매를 사용한 비칼로리 감미료의 제조
CA2985669C (en) 2015-05-20 2022-05-03 Cargill, Incorporated Glycoside compositions
US10612065B2 (en) 2015-05-29 2020-04-07 Cargill, Incorporated Heat treatment to produce glycosides
EP3303552A4 (en) 2015-05-29 2019-01-16 Cargill, Incorporated FERMENTATION METHOD FOR THE PRODUCTION OF STEVIOL GLYCOSIDES WITH MULTIPHASE SUPPLY
EP3303553B1 (en) 2015-05-29 2022-07-27 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high ph
CN105200098A (zh) 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 一种利用酿酒酵母酶法制备瑞鲍迪甙m的方法
US10517321B2 (en) 2015-07-10 2019-12-31 Sweet Green Fields USA LLC Compositions of steviol multiglycosylated derivatives and stevia components
CN107820394A (zh) 2015-07-10 2018-03-20 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷组合物
US11124535B2 (en) 2015-07-10 2021-09-21 Dsm Ip Assets B.V. Steviol glycoside composition
US10844414B2 (en) 2015-08-06 2020-11-24 Cargill, Incorporated Methods for producing steviol glycosides in engineered yeast
US20190203244A1 (en) 2015-08-20 2019-07-04 Pepsico, Inc. Preparation of rebaudioside m in a single reaction vessel
WO2017053980A1 (en) 2015-09-25 2017-03-30 The Coca-Cola Company Steviol glycoside blends, compositions and methods
EP4190172B1 (en) 2015-10-02 2025-11-26 The Coca-Cola Company Sweetener composition comprising steviol glycoside sweeteners with improved flavor profiles
US20170105432A1 (en) 2015-10-16 2017-04-20 Senomyx, Inc. Sweetener and flavor enhancer formulations
WO2017068017A1 (en) 2015-10-23 2017-04-27 Dsm Ip Assets B.V. Low sugar flavoured yogurt
US11647771B2 (en) 2015-10-26 2023-05-16 Purecircle Usa Inc. Steviol glycoside compositions
WO2017093895A1 (en) 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
EP3387136B1 (en) 2015-12-10 2022-01-05 Evolva SA Production of steviol glycosides in recombinant hosts
PL3393258T3 (pl) 2015-12-24 2026-02-23 Danone Us, Llc Sposób wytwarzania odcedzanego fermentowanego produktu mlecznego z zastosowaniem laktazy
CN108777992A (zh) 2016-01-07 2018-11-09 谱赛科美国股份有限公司 高溶解性甜菊醇糖苷
US20190021382A1 (en) 2016-03-01 2019-01-24 Wm. Wrigley Jr. Company Long-lasting sweetener formulations
US20170258120A1 (en) 2016-03-09 2017-09-14 Merisant US, Inc. Liquid sweetener compositions
WO2017156432A1 (en) 2016-03-10 2017-09-14 Chromocell Corporation Steviol glycoside esters
US11149050B2 (en) 2016-03-14 2021-10-19 Purecircle Usa Inc. Highly soluble steviol glycosides
US20190116835A1 (en) 2016-03-28 2019-04-25 The Coca-Cola Company Sweetness and Taste Improvement of Steviol Glycoside or Mogroside Sweeteners with Flavonids
CN109152393A (zh) 2016-03-31 2019-01-04 三得利控股株式会社 含有甜菊的饮料
ES2980286T3 (es) 2016-03-31 2024-09-30 Suntory Holdings Ltd Bebida que contiene estevia
AU2017246876B2 (en) 2016-04-06 2021-09-23 The Coca-Cola Company Sweetness and taste improvement of steviol glycoside or mogroside sweeteners
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017189778A1 (en) 2016-04-26 2017-11-02 Chromocell Corporation Methods, compounds, and compositions, for modulating sweet taste
US20190124953A1 (en) 2016-04-29 2019-05-02 Pepsico, Inc. Novel steviol glycosides blends
US11985995B2 (en) 2016-05-10 2024-05-21 The Coca-Cola Company Methods of freeze drying compositions containing rebaudioside M and rebaudioside D
WO2017207484A1 (en) * 2016-05-31 2017-12-07 Universiteit Gent Mutant sucrose synthases and their uses
US20170352267A1 (en) 2016-06-02 2017-12-07 GM Global Technology Operations LLC Systems for providing proactive infotainment at autonomous-driving vehicles
BR112018076109B1 (pt) 2016-06-14 2022-11-01 Purecircle Usa Inc Processo para produzir uma composição de glicosídeos de esteviol, composição adoçante, composição de paladar, ingrediente alimentar e alimento, bebida, produto cosmético e farmacêutico
US20190127772A1 (en) * 2016-06-15 2019-05-02 Codexis, Inc. Enzymatic glycosylation of steviol glycosides and other compounds with glucose-1-phosphate
CN108135238A (zh) 2016-08-04 2018-06-08 百事可乐公司 甜味剂组合物
WO2018029272A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
CA3033243A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
PT3497222T (pt) 2016-08-12 2022-02-09 Amyris Inc Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos
US10085472B2 (en) 2016-08-29 2018-10-02 Pepsico, Inc. Compositions comprising rebaudioside J
KR102905512B1 (ko) * 2017-02-03 2025-12-29 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
CN106866757B (zh) 2017-03-16 2020-06-26 诸城市浩天药业有限公司 甜菊糖m苷晶型及制备方法和用途
US20170354175A1 (en) 2017-05-15 2017-12-14 Senomyx, Inc. Sweetener composition
CA3103514A1 (en) * 2018-07-09 2020-01-16 Codexis, Inc. Engineered galactose oxidase variant enzymes
IL280302B2 (en) 2018-07-30 2025-09-01 Codexis Inc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside

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