JP2021530432A - メタセシス反応におけるn−キレート化ルテニウム錯体の使用 - Google Patents
メタセシス反応におけるn−キレート化ルテニウム錯体の使用 Download PDFInfo
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- JP2021530432A JP2021530432A JP2020558468A JP2020558468A JP2021530432A JP 2021530432 A JP2021530432 A JP 2021530432A JP 2020558468 A JP2020558468 A JP 2020558468A JP 2020558468 A JP2020558468 A JP 2020558468A JP 2021530432 A JP2021530432 A JP 2021530432A
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- alkyl
- optionally
- aryl
- alkoxy
- independently
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- 239000012327 Ruthenium complex Substances 0.000 title claims abstract description 5
- 238000005649 metathesis reaction Methods 0.000 title description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 23
- 238000006798 ring closing metathesis reaction Methods 0.000 claims abstract description 10
- 238000005686 cross metathesis reaction Methods 0.000 claims abstract description 9
- 238000005865 alkene metathesis reaction Methods 0.000 claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 80
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 69
- 125000003118 aryl group Chemical group 0.000 claims description 52
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 51
- 239000003446 ligand Substances 0.000 claims description 46
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 45
- 125000003545 alkoxy group Chemical group 0.000 claims description 38
- 125000005843 halogen group Chemical group 0.000 claims description 38
- -1 sulfone amide Chemical class 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 33
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 29
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 29
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 23
- 150000003457 sulfones Chemical class 0.000 claims description 19
- 239000011541 reaction mixture Substances 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- 125000002015 acyclic group Chemical group 0.000 claims description 6
- 150000001408 amides Chemical class 0.000 claims description 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 5
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims description 4
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 229940125904 compound 1 Drugs 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 150000003568 thioethers Chemical class 0.000 claims description 4
- ADLVDYMTBOSDFE-UHFFFAOYSA-N 5-chloro-6-nitroisoindole-1,3-dione Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC2=C1C(=O)NC2=O ADLVDYMTBOSDFE-UHFFFAOYSA-N 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 125000003367 polycyclic group Chemical group 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 2
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- SKTCDJAMAYNROS-UHFFFAOYSA-N methoxycyclopentane Chemical compound COC1CCCC1 SKTCDJAMAYNROS-UHFFFAOYSA-N 0.000 claims description 2
- 125000004437 phosphorous atom Chemical group 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 description 40
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 28
- 239000002243 precursor Substances 0.000 description 26
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 20
- 238000005481 NMR spectroscopy Methods 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 229910052757 nitrogen Inorganic materials 0.000 description 15
- 229910052786 argon Inorganic materials 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 11
- 230000015572 biosynthetic process Effects 0.000 description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 description 9
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 7
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 7
- 229910000175 cerite Inorganic materials 0.000 description 7
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 7
- 239000011949 solid catalyst Substances 0.000 description 7
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 description 6
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 239000012043 crude product Substances 0.000 description 6
- 239000003480 eluent Substances 0.000 description 6
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 6
- 229910052707 ruthenium Inorganic materials 0.000 description 6
- 239000000741 silica gel Substances 0.000 description 6
- 229910002027 silica gel Inorganic materials 0.000 description 6
- 238000004440 column chromatography Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000004817 gas chromatography Methods 0.000 description 5
- 125000005842 heteroatom Chemical group 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 4
- IAFQYUQIAOWKSB-UHFFFAOYSA-N Ethyl undecanoate Chemical compound CCCCCCCCCCC(=O)OCC IAFQYUQIAOWKSB-UHFFFAOYSA-N 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 4
- 229910019854 Ru—N Inorganic materials 0.000 description 4
- 150000001721 carbon Chemical group 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- CAMHHLOGFDZBBG-UHFFFAOYSA-N epoxidized methyl oleate Natural products CCCCCCCCC1OC1CCCCCCCC(=O)OC CAMHHLOGFDZBBG-UHFFFAOYSA-N 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 125000002524 organometallic group Chemical group 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 235000011007 phosphoric acid Nutrition 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- LYUUVYQGUMRKOV-UHFFFAOYSA-N Diethyl diallylmalonate Chemical compound CCOC(=O)C(CC=C)(CC=C)C(=O)OCC LYUUVYQGUMRKOV-UHFFFAOYSA-N 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Natural products CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 2
- YMWUJEATGCHHMB-DICFDUPASA-N dichloromethane-d2 Chemical compound [2H]C([2H])(Cl)Cl YMWUJEATGCHHMB-DICFDUPASA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N o-dihydroxy-benzene Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N ortho-hydroxybenzaldehyde Natural products OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007152 ring opening metathesis polymerisation reaction Methods 0.000 description 2
- 150000003303 ruthenium Chemical class 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 description 1
- 238000004679 31P NMR spectroscopy Methods 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 1
- FXNFFCMITPHEIT-UHFFFAOYSA-N Ethyl 10-undecenoate Chemical compound CCOC(=O)CCCCCCCCC=C FXNFFCMITPHEIT-UHFFFAOYSA-N 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- RBFQJDQYXXHULB-UHFFFAOYSA-N arsane Chemical compound [AsH3] RBFQJDQYXXHULB-UHFFFAOYSA-N 0.000 description 1
- 150000001502 aryl halides Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000001649 bromium compounds Chemical class 0.000 description 1
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- SLLGVCUQYRMELA-UHFFFAOYSA-N chlorosilicon Chemical compound Cl[Si] SLLGVCUQYRMELA-UHFFFAOYSA-N 0.000 description 1
- 229940060799 clarus Drugs 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 150000001913 cyanates Chemical class 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
- 125000005956 isoquinolyl group Chemical group 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 125000003566 oxetanyl group Chemical group 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003003 phosphines Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003304 ruthenium compounds Chemical class 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000010421 standard material Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 229910052714 tellurium Inorganic materials 0.000 description 1
- PORWMNRCUJJQNO-UHFFFAOYSA-N tellurium atom Chemical compound [Te] PORWMNRCUJJQNO-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2265—Carbenes or carbynes, i.e.(image)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2265—Carbenes or carbynes, i.e.(image)
- B01J31/2269—Heterocyclic carbenes
- B01J31/2273—Heterocyclic carbenes with only nitrogen as heteroatomic ring members, e.g. 1,3-diarylimidazoline-2-ylidenes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
Description
トルエン(10ml)中のS1(0.240g、1.0ミリモル)の溶液に、トルエン(50μl)中の所定量の対応する触媒(前駆体)を、指定温度で1回で添加した。適切な間隔で、反応混合物の試料を取り、そこに3滴のエチルビニルエーテルを添加して触媒を失活させた。試料は、ガスクロマトグラフィーによって分析した。
トルエン(8.3mL)中のS3(1.062g、5.0ミリモル、1モル当量)、アクリロニトリル(0.655mL、10.0ミリモル、2モル当量)およびステアリン酸メチル(内標準)の溶液に、トルエン(50μl)中の適切な触媒(前駆体)(100ppm)の溶液を、アルゴン下、85℃で、1回で添加した。反応混合物を1時間撹拌した。反応中に、アルゴンの流れを溶液を通して通過させた。試料を取り、そこに3滴のエチルビニルエーテルを添加して触媒を失活させた。試料は、ガスクロマトグラフィーによって分析した。
S3(3.00g、14.13ミリモル)およびステアリン酸メチル(内標準)に、トルエン(50μl)中の適切な触媒(前駆体)(30ppm)の溶液を、アルゴン下、85℃で、1回で添加した。反応混合物を1時間撹拌した。反応中に、アルゴンの流れを溶液を通して通過させた。試料を取り、そこに3滴のエチルビニルエーテルを添加して触媒を失活させた。試料は、ガスクロマトグラフィーによって分析した。
1H NMR (CD2Cl2, 600 MHz): δ = 18.70 (s, 1H), 7.50 (t, J = 7.5 Hz, 1H), 7.31-7.23 (m, 3H), 7.19 (t, J = 7.4 Hz, 1H), 7.05 (br s, 4H), 6.99 (br s, 2H), 6.90 (d, J = 7.5 Hz, 1H), 6.74 (d, J = 7.3 Hz, 1H), 4.10 (s, 4H), 3.90-3.00 (br m, 3H), 2.90-2.00 (br m, 19H), 1.73 (s, 3H)。
13C NMR (CD2Cl2, 150 MHz): δ = 313.4, 313.3, 213.4, 148.9, 139.0, 134.0, 132.6, 132.5, 131.6, 129.8, 129.1, 129.0, 128.4, 128.3, 127.3, 60.0, 43.1, 32.4, 29.6, 23.3, 21.4, 14.4。
1H NMR (CD2Cl2, 600 MHz): δ = 18.61 (s, 1H), 7.60-6.30 (m, 18H), 4.60-1.50 (m, 28H)。
13C NMR (CD2Cl2, 150 MHz): δ = 315.3, 213.2, 149.5, 139.0, 135.4, 134.6, 132.3, 131.0, 129.9, 129.1, 127.9, 127.8, 126.1, 58.8, 34.7, 22.9, 21.3, 14.4。
1H NMR (CD2Cl2, 600 MHz): δ = 18.61 (s, 1H), 7.70-6.70 (m, 14H), 6.57 (d, J = 7.7 Hz, 1H), 4.80-2.30 (br m, 11H), 2.20-0.20 (br m, 28H)。
13C NMR (CD2Cl2, 150 MHz): δ = 307.0, 215.5, 149.6, 148.1, 133.9, 132.7, 131.5, 129.9, 128.9, 128.7, 128.4, 128.3, 127.5, 124.9, 60.1, 55.1, 43.6, 29.2, 27.0, 23.9。
1H NMR (CD2Cl2, 600 MHz): δ = 18.33 (s, 1H), 7.80-6.95 (m, 12H), 6.95-6.30 (m, 7H), 6.05 (d, J = 7.7 Hz, 1H), 4.60-2.60 (br m, 14H), 2.0-0.20 (br m, 24H) 。
13C NMR (CD2Cl2, 150 MHz): δ = 311.0, 215.6, 148.6, 135.9, 132.8, 132.6, 130.0, 129.6, 128.6, 127.4, 127.4, 126.9, 126.4, 124.4, 62.2, 59.3, 57.4, 55.7, 32.4, 29.6, 27.8, 26.4, 23.7, 23.3, 14.4。
1H NMR (CD2Cl2, 600 MHz): δ = 19.15 (s, 1H), 7.90-6.70 (m, 9H), 4.45-4.05 (m, 2H), 2.40-2.26 (m, 3H), 2.12-1.90 (m, 8H), 1.88-1.58 (m, 16H), 1.36-1.16 (m, 11H)。
13C NMR (CD2Cl2, 150 MHz): δ = 295.5, 148.2, 134.3, 133.2, 132.8, 132.4, 129.9, 129.1, 128.7, 128.6, 126.5, 63.1, 43.8, 35.2 (d, J = 20.3 Hz), 30.7, 28.5 (d, J = 10.0 Hz), 27.0, 26.9。
31P NMR (CD2Cl2, 243 MHz): δ = 35.6。
1H NMR (CD2Cl2, 600 MHz): δ = 19.14 (d, J = 10.2 Hz, 1H), 8.00-6.80 (m, 14H), 4.33 (d, J = 14.0 Hz, 2H), 4.20-2.90 (br m, 2H), 2.39-2.26 (m, 3H), 2.05-1.60 (m, 22H), 1.38-1.16 (m, 10H) 。
13C NMR (CD2Cl2, 150 MHz): δ = 297.7, 148.9, 134.6, 133.0, 132.7, 129.6, 129.2, 128.6, 126.6, 60.2, 34.8 (d, J = 20.3 Hz), 30.2, 28.5 (d, J = 9.8 Hz), 27.0。
31P NMR (CD2Cl2, 243 MHz): δ = 34.5。
1H NMR (CDCl3, 600 MHz): δ = 7.49-7.45 (m, 2H), 7.43-7.38 (m, 2H), 7.36-7.32 (m, 1H), 7.21-7.14 (m, 3H), 7.06-7.03 (m, 1H), 3.76 (s, 2H), 3.71 (s, 2H), 2.97 (t, J = 5.9 Hz, 2H), 2.82 (t, J = 5.9 Hz, 2H) 。
13C NMR (CDCl3, 150 MHz): δ = 138.4, 134.9, 134.3, 129.0, 128.6, 128.2, 127.0, 126.5, 126.0, 125.5, 62.7, 56.1, 50.6, 29.3。
1H NMR (CDCl3, 600 MHz): δ = 7.53 (dd, J = 7.5; 1.6 Hz, 1H), 7.35-7.27 (m, 5H), 7.26-7.19 (m, 3H), 7.17 (dd, J = 17.5; 10.9 Hz, 1H), 5.65 (dd, J = 17.6; 1.5 Hz, 1H), 5.26 (dd, J = 11.0; 1.5 Hz, 1H), 3.55 (s, 2H), 3.51 (s, 2H), 2.14 (s, 3H) 。
13C NMR (CDCl3, 150 MHz): δ =139.4, 137.7, 136.2, 134.9, 130.4, 129.0, 128.1, 127.3, 126.9, 125.6, 114.8, 62.1, 60.0, 42.0。
1H NMR (CDCl3, 600 MHz): δ = 7.56-7.52 (m, 1H), 7.50-7.46 (m, 1H), 7.43-7.39 (m, 4H), 7.38-7.34 (m, 4H), 7.31-7.25 (m, 4H), 7.05 (dd, J = 17.4; 10.9 Hz, 1H), 5.64 (dd, J = 17.4; 1.6 Hz, 1H), 5.25 (dd, J = 10.9; 1.6 Hz, 1H), 3.64 (s, 2H), 3.57 (s, 4H) 。
13C NMR (CDCl3, 150 MHz): δ = 139.4, 137.6, 136.4, 135.1, 130.3, 129.0, 128.1, 127.4, 127.2, 126.9, 125.6, 114.5, 58.2, 56.1, 26.9。
Claims (12)
- 式1
R1は水素原子またはC5〜C24アリール、C1〜C25アルキル、C4〜C25ヘテロアリール、C7〜C24アラルキルを表し、これらは、任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は互いに連結して環を形成することができ;
R2は、C5〜C24アリール、C4〜C25ヘテロアリール、C7〜C24アラルキルを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して環式系を形成することができ;
a、b、c、dは、独立して水素原子、ハロゲン原子、C1〜C25アルキル、C1〜C25ペルフルオロアルキル、C3〜C7シクロアルキル、C1〜C25アルコキシ、C5〜C24アリール、C7〜C24アラルキル、C5〜C25ヘテロアリール、3〜12員ヘテロ環を表し、ここで、アルキル基は互いに連結して環を形成することができ;独立してアルコキシ基(−OR’)、チオエーテル(−SR’)、ニトロ(−NO2)、シアノ(−CN)、アミド(−CONR’R’’)、カルボキシルおよびエステル(−COOR’)、スルホン(−SO2R’)、スルホンアミド(−SO2NR’R’’)、ホルミルおよびケトン(−COR’)を表すこともでき、ここで、置換基R’およびR’’は、独立して以下:C1〜C25アルキル、C1〜C25ペルフルオロアルキル、C5〜C24アリール、C5〜C25ヘテロアリール、C5〜C24ペルフルオロアリールの意味を有し;
Lは、中性配位子、例えば、P(R’)3基(式中、R’は、独立してC1〜C6アルキル、C3〜C8シクロアルキル、C5〜C24アリール、C7〜C24アラルキル、C5〜C24ペルフルオロアリールを表し、2つの置換基R’は互いに連結して、環にリン原子を含有するシクロアルキル環を形成することができる)を表す、
または、Lは、式2aまたは2b:
各R5、R6、R7、R8、R9、R10は、独立して水素原子、C1〜C12アルキル、C3〜C12シクロアルキル、C5〜C20アリール、もしくはC5〜C20ヘテロアリールを表し、これは、任意選択で少なくとも1つのC1〜C12アルキル、C1〜C12ペルフルオロアルキル、C1〜C12アルコキシもしくはハロゲン原子で置換され、R5、R6、R7、R8、R9、R10基は、任意選択で相互接続してC4〜C10環式系もしくはC4〜C12多環式系を形成することができる)のいわゆるN−ヘテロ環式カルベン配位子を含む群から独立して選択される]のルテニウム錯体の、
例えば、閉環メタセシス(RCM)、ホモメタセシス(自己−CM)またはクロスメタセシス(CM)から選択される反応を含む、オレフィンメタセシス反応での使用。 - 式1
X1およびX2が、ハロゲン原子を表し;
LがP(R’)3基[式中、R’はC3〜C8シクロアルキルを表す]を表す、またはLが式2aまたは2b[式中、置換基R3、R4、R5、R6、R7、R8、R9、R10は上に規定される通りである]の配位子を表し;
R1が、水素原子またはC5〜C24アリール、C4〜C25ヘテロアリール、C7〜C24アラルキルを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して環式系を形成することができ;
R2が、C5〜C24アリール、C4〜C25ヘテロアリールを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は互いに連結して環を形成することができ;
a、b、c、dが、独立して水素原子、アルコキシ(−OR’)、チオエーテル(−SR’)、ニトロ(−NO2)、シアノ(−CN)、アミド(−CONR’R’’)、カルボキシルおよびエステル(−COOR’)、スルホン(−SO2R’)、スルホンアミド(−SO2NR’R’’)、ホルミルおよびケトン(−COR’)基を表し、ここで、置換基R’およびR’’は、独立して以下:C1〜C25アルキル、C1〜C25ペルフルオロアルキル、C5〜C24アリール、C5〜C25ヘテロアリール、C5〜C24ペルフルオロアリールの意味を有する、
請求項1に記載の使用。 - 式1
X1およびX2が、ハロゲン原子を表し;
Lが、P(R’)3基[式中、R’はC3〜C8シクロアルキルを表す]を表す;または、
Lが、式2a[式中、各R3およびR4は、独立してC1〜C12アルキル、C3〜C12シクロアルキル、C5〜C20アリールを表し、これは任意選択で少なくとも1つのC1〜C12アルキル、C1〜C12ペルフルオロアルキル、C2〜C12アルコキシで置換され、各R5、R6、R7、R8は、独立して水素原子、C1〜C12アルキル、C3〜C12シクロアルキル、C5〜C20アリール、もしくはC5〜C20ヘテロアリールを表し、これは任意選択で少なくとも1つのC1〜C12アルキル、C1〜C12ペルフルオロアルキル、C1〜C12アルコキシもしくはハロゲン原子で置換され、R5、R6、R7、R8基は、任意選択で相互接続してC4〜C10環式系もしくはC4〜C12多環式系を形成することができる]の配位子を表し;
R1が、水素原子またはC5〜C24アリール、C4〜C25ヘテロアリールを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して環式系を形成することができ;
R2が、C5〜C24アリール、C4〜C25ヘテロアリールを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でC1〜C12ペルフルオロアルキル、任意選択でC1〜C12アルコキシ、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して非環式系を形成することができ;
a、b、c、dが、独立して水素原子、アルコキシ(−OR’)、ニトロ(−NO2)、アミド(−CONR’R’’)、エステル(−COOR’)、スルホン(−SO2R’)、スルホンアミド(−SO2NR’R’’)基を表し、ここで、置換基R’およびR’’は、独立して以下:C1〜C25アルキル、C5〜C24アリールの意味を有する、
請求項1または2に記載の使用。 - 式1
Lが、P(R’)3基[式中、R’はC3〜C8シクロアルキルを表す]を表す;または
Lが、式2a[式中、各R3およびR4は、独立してC5〜C20アリールを表し、これは任意選択で少なくとも1つのC1〜C12アルキルで置換され、各R5、R6、R7、R8は、独立して水素原子を表す]の配位子を表し;
R1が水素原子またはC5〜C24アリール、C4〜C24ヘテロアリールを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して環式系を形成することができ;
R2が、C5〜C24アリールまたはC4〜C24ヘテロアリールを表し、これらは任意選択で少なくとも1つのC1〜C12アルキル、任意選択でハロゲン原子で置換され、ここで、アルキル基は相互接続して環式系を形成することができ;
a、b、c、dが、独立して水素原子、アルコキシ基(−OR’)を表し、ここで、置換基R’は、独立してC1〜C25アルキル、C5〜C24アリールを表す、
請求項1から3のいずれか一項に記載の使用。 - 式1
Lが、トリシクロヘキシルホスフィンを表す;または
Lが、式2a[式中、各R3およびR4は、独立してC5〜C20アリールを表し、これは任意選択で少なくとも1つのC1〜C12アルキルで置換され、各R5、R6、R7、R8は独立して水素原子を表す]の配位子を表し;
R1が、水素原子、C5〜C24アリールまたはC4〜C25ヘテロアリールを表し、これらは任意選択で少なくとも1種のハロゲン原子で置換され;
R2が、C5〜C24アリールまたはC4〜C25ヘテロアリールを表し、これらは任意選択で少なくとも1種のハロゲン原子で置換され;
a、b、c、dが、独立して水素原子、アルコキシ基(−OR’)を表し、ここで、置換基R’は独立してC1〜C25アルキルを表す、
請求項1から4のいずれか一項に記載の使用。 - 反応が、有機溶媒、例えば、トルエン、ベンゼン、メシチレン、ジクロロメタン、酢酸エチル、酢酸メチル、テトラブチルメチルエーテル、シクロペンチルメチルエーテル中、または溶媒なしで実行される、請求項1から6のいずれか一項に記載の使用。
- 反応が、0〜150℃の温度で実行される、請求項1から7のいずれか一項に記載の使用。
- 反応が、20〜120℃の温度で実行される、請求項1から8のいずれか一項に記載の使用。
- 反応が、1分〜24時間実行される、請求項1から9のいずれか一項に記載の使用。
- 化合物1が、0.5モル%以下の量で使用される、請求項1から10のいずれか一項に記載の使用。
- 化合物1が、固体形態および/または有機溶媒中の溶液の形態で反応混合物に添加される、請求項1から11のいずれか一項に記載の使用。
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PL426318A PL426318A1 (pl) | 2018-07-12 | 2018-07-12 | Zastosowanie N-chelatujących kompleksów rutenu w reakcji metatezy |
PLPL426318 | 2018-07-12 | ||
PCT/IB2019/055864 WO2020012370A1 (en) | 2018-07-12 | 2019-07-10 | Use of n-chelating ruthenium complexes in the metathesis reaction |
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JP2021530432A true JP2021530432A (ja) | 2021-11-11 |
JP2021530432A5 JP2021530432A5 (ja) | 2021-12-23 |
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US (1) | US20210237045A1 (ja) |
EP (1) | EP3820609B1 (ja) |
JP (1) | JP2021530432A (ja) |
KR (1) | KR20210030938A (ja) |
CA (1) | CA3096337A1 (ja) |
PL (2) | PL426318A1 (ja) |
WO (1) | WO2020012370A1 (ja) |
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KR102536751B1 (ko) * | 2020-04-07 | 2023-05-24 | 주식회사 엘지화학 | 촉매 조성물, 이를 포함하는 세척액 조성물 및 이를 이용한 중합장치의 세척방법 |
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Publication number | Publication date |
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CA3096337A1 (en) | 2020-01-16 |
EP3820609B1 (en) | 2023-06-28 |
PL426318A1 (pl) | 2020-01-13 |
EP3820609A1 (en) | 2021-05-19 |
US20210237045A1 (en) | 2021-08-05 |
WO2020012370A1 (en) | 2020-01-16 |
PL3820609T3 (pl) | 2023-10-16 |
KR20210030938A (ko) | 2021-03-18 |
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