JP2021520349A5 - - Google Patents
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- JP2021520349A5 JP2021520349A5 JP2020553633A JP2020553633A JP2021520349A5 JP 2021520349 A5 JP2021520349 A5 JP 2021520349A5 JP 2020553633 A JP2020553633 A JP 2020553633A JP 2020553633 A JP2020553633 A JP 2020553633A JP 2021520349 A5 JP2021520349 A5 JP 2021520349A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021199945A JP2022022391A (ja) | 2018-04-03 | 2021-12-09 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| JP2023167564A JP2023165937A (ja) | 2018-04-03 | 2023-09-28 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652284P | 2018-04-03 | 2018-04-03 | |
| US62/652,284 | 2018-04-03 | ||
| US201862656297P | 2018-04-11 | 2018-04-11 | |
| US62/656,297 | 2018-04-11 | ||
| US201862657605P | 2018-04-13 | 2018-04-13 | |
| US62/657,605 | 2018-04-13 | ||
| US201862741683P | 2018-10-05 | 2018-10-05 | |
| US62/741,683 | 2018-10-05 | ||
| PCT/US2019/025655 WO2019195471A1 (en) | 2018-04-03 | 2019-04-03 | Ret inhibitor for use in treating cancer having a ret alteration |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021199945A Division JP2022022391A (ja) | 2018-04-03 | 2021-12-09 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| JP2023167564A Division JP2023165937A (ja) | 2018-04-03 | 2023-09-28 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520349A JP2021520349A (ja) | 2021-08-19 |
| JP2021520349A5 true JP2021520349A5 (enExample) | 2021-09-30 |
| JP7422084B2 JP7422084B2 (ja) | 2024-01-25 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020553633A Active JP7422084B2 (ja) | 2018-04-03 | 2019-04-03 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| JP2021199945A Pending JP2022022391A (ja) | 2018-04-03 | 2021-12-09 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| JP2023167564A Withdrawn JP2023165937A (ja) | 2018-04-03 | 2023-09-28 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021199945A Pending JP2022022391A (ja) | 2018-04-03 | 2021-12-09 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| JP2023167564A Withdrawn JP2023165937A (ja) | 2018-04-03 | 2023-09-28 | Ret変化を有する癌の処置において使用するためのret阻害剤 |
Country Status (26)
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|---|---|
| US (5) | US20210100795A1 (enExample) |
| EP (2) | EP4353317A3 (enExample) |
| JP (3) | JP7422084B2 (enExample) |
| KR (1) | KR20200139749A (enExample) |
| AU (1) | AU2019247766A1 (enExample) |
| BR (1) | BR112020020273A2 (enExample) |
| CA (1) | CA3096043A1 (enExample) |
| CL (1) | CL2020002544A1 (enExample) |
| CR (1) | CR20200522A (enExample) |
| DK (1) | DK3773589T3 (enExample) |
| ES (1) | ES2970041T3 (enExample) |
| FI (1) | FI3773589T3 (enExample) |
| HR (1) | HRP20240124T1 (enExample) |
| HU (1) | HUE065374T2 (enExample) |
| IL (1) | IL277629A (enExample) |
| LT (1) | LT3773589T (enExample) |
| MX (1) | MX2020010417A (enExample) |
| MY (1) | MY203645A (enExample) |
| PE (1) | PE20210096A1 (enExample) |
| PL (1) | PL3773589T3 (enExample) |
| PT (1) | PT3773589T (enExample) |
| RS (1) | RS65127B1 (enExample) |
| SG (1) | SG11202009681YA (enExample) |
| SI (1) | SI3773589T1 (enExample) |
| WO (1) | WO2019195471A1 (enExample) |
| ZA (1) | ZA202006072B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| EA038890B1 (ru) | 2015-11-02 | 2021-11-03 | Блюпринт Медсинс Корпорейшн | Ингибиторы ret |
| CA3096043A1 (en) | 2018-04-03 | 2019-10-10 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| US11666570B2 (en) * | 2019-07-11 | 2023-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnosis and regulation of epidermal differentiation and cancer cell activity |
| KR20230017234A (ko) | 2020-05-29 | 2023-02-03 | 블루프린트 메디신즈 코포레이션 | 프랄세티닙의 고체 형태 |
| US11946935B2 (en) * | 2020-08-25 | 2024-04-02 | Regents Of The University Of Minnesota | Circulating tumor markers for meningiomas |
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|---|---|---|---|---|
| AU2001237041B9 (en) | 2000-02-17 | 2005-07-28 | Amgen Inc. | Kinase inhibitors |
| JP2005535675A (ja) | 2002-07-24 | 2005-11-24 | ユニバーシティ・オブ・シンシナティ | 変異型retキナーゼ関連疾患を処置するための4−(4−メチルピペラジン−1−イルメチル)−n−[4−メチル−3−(4−ピリジン−3−イル)ピリミジン−2−イルアミノ]フェニル]−ベンズアミド |
| DK1696920T3 (en) | 2003-12-19 | 2015-01-19 | Plexxikon Inc | RELATIONS AND PROCEDURES FOR THE DEVELOPMENT OF LAW MODULATORS |
| US8227455B2 (en) | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
| KR20080019213A (ko) | 2005-05-09 | 2008-03-03 | 아칠리온 파르마세우티칼스 인코포레이티드 | 티아졸 화합물 및 그 사용방법 |
| US20100047777A1 (en) | 2005-05-26 | 2010-02-25 | The Johns Hopkins University | Methods for identifying mutations in coding and non-coding dna |
| WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
| US20090227598A1 (en) | 2006-01-24 | 2009-09-10 | Buser-Doepner Carolyn A | Ret Tyrosine Kinase Inhibition |
| CA2652442C (en) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| US20090048214A1 (en) | 2006-11-15 | 2009-02-19 | Rigel Pharmaceuticals, Inc | Methods for Treating Renal Tumors Using 2, 4-Pyrimidinediamine Drug and Prodrug Compounds |
| WO2009003136A1 (en) | 2007-06-26 | 2008-12-31 | Rigel Pharmaceuticals, Inc. | Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders |
| BRPI0814818A2 (pt) | 2007-07-09 | 2019-09-10 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito anti-proliferativo e um efeito inibitório de mtor quinase em uma animal de sangue quente, método para tratar doenças, e, composição farmacêutica |
| CN101801958B (zh) | 2007-07-19 | 2014-01-29 | 默沙东公司 | 作为蛋白质激酶抑制剂的杂环酰胺化合物 |
| WO2009100536A1 (en) | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
| EP2313091A4 (en) | 2008-07-14 | 2012-04-04 | Univ Kingston | PHARMACEUTICAL COMPOSITIONS WITH RET-HEMMERN AND METHOD FOR THE TREATMENT OF CANCER |
| EP2411011A4 (en) | 2009-03-24 | 2012-08-15 | Msd Kk | NEW AMINO-PYRIDINE DERIVATIVES WITH SELECTIVE AURORA A INHIBITION |
| EP2440052A4 (en) | 2009-06-08 | 2013-01-23 | Abraxis Bioscience Llc | TRIAZINE DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF |
| BRPI1011319A2 (pt) | 2009-06-09 | 2016-06-21 | California Capital Equity Llc | derivados de triazina benzil-substituídos e suas aplicações terapêuticas |
| US20120316137A1 (en) | 2009-10-30 | 2012-12-13 | Ariad Pharmaceuticals, Inc. | Methods and Compositions for Treating Cancer |
| WO2011060295A1 (en) | 2009-11-13 | 2011-05-19 | Genosco | Kinase inhibitors |
| EP2740742B1 (en) | 2011-08-04 | 2018-03-14 | National Cancer Center | Fusion gene of kif5b gene and ret gene, and method for determining effectiveness of cancer treatment targeting fusion gene |
| WO2013028817A1 (en) | 2011-08-23 | 2013-02-28 | Foundation Medicine , Inc. | Novel kif5b-ret fusion molecules and uses thereof |
| MX370814B (es) | 2011-09-02 | 2020-01-08 | Univ California | Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas. |
| US20130096136A1 (en) | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| US10023855B2 (en) | 2011-10-31 | 2018-07-17 | Macrogen, Inc. | Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker |
| US8841450B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2824099A4 (en) | 2012-03-09 | 2015-11-11 | Carna Biosciences Inc | NOVEL TRIAZINE DERIVATIVE |
| JP2015109806A (ja) | 2012-03-22 | 2015-06-18 | アステラス製薬株式会社 | 新規ret融合体の検出法 |
| KR102090944B1 (ko) | 2012-04-25 | 2020-03-19 | 라퀄리아 파마 인코포레이티드 | Ttx-s 차단제로서의 피롤로피리디논 유도체 |
| AU2013259267A1 (en) | 2012-05-10 | 2014-11-06 | Synta Pharmaceuticals Corp. | Treating cancer with Hsp90 inhibitory compounds |
| US8802697B2 (en) | 2012-07-11 | 2014-08-12 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| JPWO2014017491A1 (ja) | 2012-07-26 | 2016-07-11 | 国立研究開発法人国立がん研究センター | Cep55遺伝子とret遺伝子との融合遺伝子 |
| US20140121239A1 (en) | 2012-09-07 | 2014-05-01 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| SG11201502211QA (en) | 2012-09-25 | 2015-05-28 | Chugai Pharmaceutical Co Ltd | Ret inhibitor |
| ES2755772T3 (es) | 2012-11-07 | 2020-04-23 | Nerviano Medical Sciences Srl | Pirimidinil y piridinilpirrolopiridinonas sustituidas, proceso para su preparación y su uso como inhibidores de cinasas |
| TWI629266B (zh) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | 纖維母細胞生長因子受體之抑制劑 |
| MX2015010354A (es) | 2013-02-25 | 2015-10-09 | Squibb Bristol Myers Co | Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| PE20151538A1 (es) | 2013-03-15 | 2015-11-18 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos como inhibidores de reorganizado durante la transfeccion (ret) |
| WO2014147640A2 (en) | 2013-03-19 | 2014-09-25 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation of anagliptin |
| WO2015006875A1 (en) | 2013-07-18 | 2015-01-22 | Methylgene Inc. | Process for the preparation of substituted pyrimidines |
| US20150057335A1 (en) | 2013-08-20 | 2015-02-26 | National Cancer Center | Novel fusion genes identified in lung cancer |
| WO2015058129A1 (en) | 2013-10-17 | 2015-04-23 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| ES2683127T3 (es) | 2013-10-17 | 2018-09-25 | Blueprint Medicines Corporation | Composiciones útiles para tratar trastornos relacionados con la KIT |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| WO2016022569A1 (en) | 2014-08-04 | 2016-02-11 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| US9879021B2 (en) | 2014-09-10 | 2018-01-30 | Glaxosmithkline Intellectual Property Development Limited | Compounds as rearranged during transfection (RET) inhibitors |
| PL3191450T3 (pl) | 2014-09-10 | 2019-08-30 | Glaxosmithkline Intellectual Property Development Limited | Pochodne pirydonu jako inhibitory kinazy rearanżowanej podczas transfekcji (ret) |
| CA2967125C (en) | 2014-11-14 | 2022-10-25 | Nerviano Medical Sciences S.R.L. | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| CN104844567B (zh) | 2015-04-23 | 2017-03-29 | 暨南大学 | 一种中间体1‑(3‑氯‑2‑吡啶基)‑3‑溴‑1h‑5‑吡唑甲酸的合成方法 |
| DK3322706T3 (da) | 2015-07-16 | 2021-02-01 | Array Biopharma Inc | Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer |
| MX2018001032A (es) | 2015-07-24 | 2018-11-09 | Blueprint Medicines Corp | Compuestos utiles para el tratamiento de trastornos relacionados con kit y pdgfr. |
| CN108137607B (zh) | 2015-08-26 | 2021-04-06 | 缆图药品公司 | 适用于治疗与ntrk相关的病症的化合物和组合物 |
| CN105255927B (zh) | 2015-09-30 | 2018-07-27 | 温州医科大学附属第一医院 | 一种kiaa1217-ret融合基因 |
| EA038890B1 (ru) | 2015-11-02 | 2021-11-03 | Блюпринт Медсинс Корпорейшн | Ингибиторы ret |
| MA43163A (fr) | 2015-11-02 | 2018-09-12 | Five Prime Therapeutics Inc | Polypeptides à domaine extracellulaire cd80 et leur utilisation dans le traitement du cancer |
| EP3371220A2 (en) | 2015-11-02 | 2018-09-12 | Janssen Pharmaceutica NV | Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof |
| CA3005741A1 (en) | 2015-11-19 | 2017-05-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| MA43416A (fr) | 2015-12-11 | 2018-10-17 | Regeneron Pharma | Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3 |
| WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
| AR107912A1 (es) | 2016-03-17 | 2018-06-28 | Blueprint Medicines Corp | Inhibidores de ret |
| MX379513B (es) | 2016-04-01 | 2025-03-11 | Signal Pharm Llc | Compuestos de aminopurina sustituida, composiciones de estos y métodos de tratamiento con estos. |
| SG11201808878UA (en) | 2016-04-15 | 2018-11-29 | Cancer Research Tech Ltd | Heterocyclic compounds as ret kinase inhibitors |
| EP3442535B1 (en) | 2016-04-15 | 2022-06-01 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
| EP3442977B1 (en) | 2016-04-15 | 2023-06-28 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| CN110022900A (zh) | 2016-09-08 | 2019-07-16 | 蓝图药品公司 | 成纤维细胞生长因子受体4抑制剂与细胞周期蛋白依赖性激酶抑制剂的组合 |
| JP2018052878A (ja) | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| CN106749231B (zh) | 2016-10-09 | 2019-03-01 | 南京纳丁菲医药科技有限公司 | 萘啶化合物和药物组合物及它们的应用 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) * | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| US10799503B2 (en) | 2016-12-01 | 2020-10-13 | Ignyta, Inc. | Methods for the treatment of cancer |
| CA3049136C (en) | 2017-01-18 | 2022-06-14 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| WO2018213329A1 (en) * | 2017-05-15 | 2018-11-22 | Blueprint Medicines Corporation | Combinations of ret inhibitors and mtorc1 inhibitors and uses thereof for the treatment of cancer mediated by aberrant ret activity |
| ES2968421T3 (es) | 2017-06-23 | 2024-05-09 | San Diego State Univ Research Foundation | Atropisomerismo para la selectividad potenciada de inhibidor de cinasa |
| CN109180677A (zh) | 2017-06-30 | 2019-01-11 | 厦门大学 | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 |
| AU2018298443B2 (en) | 2017-07-07 | 2024-11-21 | Medicover Public Co Ltd | Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers |
| CN107980784B (zh) | 2017-12-13 | 2020-05-26 | 中国农业大学 | 5-氨基吡唑类化合物在调节植物生长方面的应用 |
| KR102814342B1 (ko) | 2017-12-19 | 2025-05-29 | 터닝 포인트 테라퓨틱스, 인크. | 질병 치료용 대환식 화합물 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| WO2019143994A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| CA3087354C (en) | 2018-01-18 | 2023-01-03 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CN108341782A (zh) | 2018-03-30 | 2018-07-31 | 南京哈柏医药科技有限公司 | 3-氨基-5-甲基吡唑的合成工艺 |
| CA3096043A1 (en) | 2018-04-03 | 2019-10-10 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| EP3833372A4 (en) | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
| CN111440151A (zh) | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
| CN111362923A (zh) | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
| KR20230017234A (ko) | 2020-05-29 | 2023-02-03 | 블루프린트 메디신즈 코포레이션 | 프랄세티닙의 고체 형태 |
| JP2023501757A (ja) | 2020-05-29 | 2023-01-18 | ブループリント メディシンズ コーポレイション | プラルセチニブ薬学的組成物 |
| EP4255892A1 (en) | 2020-12-04 | 2023-10-11 | Blueprint Medicines Corporation | Method of preparing pralsetinib |
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