HK1255330A1 - 適用於治療與ntrk相關的病症的化合物和組合物 - Google Patents

適用於治療與ntrk相關的病症的化合物和組合物

Info

Publication number
HK1255330A1
HK1255330A1 HK18114466.6A HK18114466A HK1255330A1 HK 1255330 A1 HK1255330 A1 HK 1255330A1 HK 18114466 A HK18114466 A HK 18114466A HK 1255330 A1 HK1255330 A1 HK 1255330A1
Authority
HK
Hong Kong
Prior art keywords
ntrk
compounds
compositions useful
disorders related
treating disorders
Prior art date
Application number
HK18114466.6A
Other languages
English (en)
Inventor
史蒂文‧M‧翁勞斯基
娜塔莎‧布魯杰孟
昌德拉塞卡．V．曼德拉
尼爾．比富爾科
Original Assignee
藍圖藥品公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 藍圖藥品公司 filed Critical 藍圖藥品公司
Publication of HK1255330A1 publication Critical patent/HK1255330A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
HK18114466.6A 2015-08-26 2018-11-13 適用於治療與ntrk相關的病症的化合物和組合物 HK1255330A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562210264P 2015-08-26 2015-08-26
PCT/US2016/048698 WO2017035354A1 (en) 2015-08-26 2016-08-25 Compounds and compositions useful for treating disorders related to ntrk

Publications (1)

Publication Number Publication Date
HK1255330A1 true HK1255330A1 (zh) 2019-08-16

Family

ID=56896780

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114466.6A HK1255330A1 (zh) 2015-08-26 2018-11-13 適用於治療與ntrk相關的病症的化合物和組合物

Country Status (17)

Country Link
US (2) US10017512B2 (zh)
EP (1) EP3341374A1 (zh)
JP (1) JP6877407B2 (zh)
KR (1) KR20180043810A (zh)
CN (1) CN108137607B (zh)
AR (1) AR105836A1 (zh)
AU (1) AU2016311426B2 (zh)
BR (1) BR112018003588A2 (zh)
CA (1) CA2995997A1 (zh)
HK (1) HK1255330A1 (zh)
IL (1) IL257702A (zh)
MX (1) MX2018002407A (zh)
PH (1) PH12018500397A1 (zh)
RU (1) RU2744974C2 (zh)
TW (1) TW201713665A (zh)
WO (1) WO2017035354A1 (zh)
ZA (1) ZA201801881B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
WO2014160521A1 (en) 2013-03-15 2014-10-02 Blueprint Medicines Corporation Piperazine derivatives and their use as kit modulators
PL3057969T3 (pl) 2013-10-17 2018-11-30 Blueprint Medicines Corporation Kompozycje użyteczne do leczenia zaburzeń związanych z KIT
EP3060560A1 (en) 2013-10-25 2016-08-31 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
KR20180048635A (ko) 2015-07-24 2018-05-10 블루프린트 메디신즈 코포레이션 Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물
CA2995997A1 (en) 2015-08-26 2017-03-02 Blueprint Medicines Corporation Compounds and compositions useful for treating disorders related to ntrk
US10030005B2 (en) 2015-11-02 2018-07-24 Blueprint Medicines Corporation Inhibitors of RET
CN108431008A (zh) 2015-11-19 2018-08-21 蓝图药品公司 可用于治疗与ntrk相关的病症的化合物和组合物
WO2017161269A1 (en) 2016-03-17 2017-09-21 Blueprint Medicines Corporation Inhibitors of ret receptor tyrosine kinases
EP3442977B1 (en) 2016-04-15 2023-06-28 Blueprint Medicines Corporation Inhibitors of activin receptor-like kinase
WO2018017983A1 (en) 2016-07-22 2018-01-25 Blueprint Medicines Corporation Compounds useful for treating disorders related to ret
WO2018022761A1 (en) 2016-07-27 2018-02-01 Blueprint Medicines Corporation Substituted cyclopentane-amides for treating disorders related to ret
US11040979B2 (en) 2017-03-31 2021-06-22 Blueprint Medicines Corporation Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
KR102619444B1 (ko) 2017-08-23 2023-12-29 치아타이 티안큉 파마수티컬 그룹 주식회사 아미노피라졸 및 피리미딘을 함유하는 마크로사이클 및 그의 약학적 조성물 및 용도
EP3697786B1 (en) 2017-10-18 2022-08-31 Blueprint Medicines Corporation Substituted pyrrolopyridines as inhibitors of activin receptor-like kinase
WO2019152982A1 (en) * 2018-02-05 2019-08-08 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic compounds as ep4 antagonists
JP2021519297A (ja) * 2018-03-28 2021-08-10 フォチョン・ファーマシューティカルズ・リミテッドＦｏｃｈｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｌｔｄ． Ｔｒｋキナーゼ阻害剤としての大環状化合物
WO2019195471A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
TW202045480A (zh) * 2019-02-27 2020-12-16 美商費洛醫療公司 化合物及使用方法
WO2020210669A1 (en) 2019-04-12 2020-10-15 Blueprint Medicines Corporation Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making
CN113408945B (zh) * 2021-07-15 2023-03-24 广西中烟工业有限责任公司 一种烤烟纯度的检测方法、装置、电子设备及存储介质

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251911B1 (en) * 1996-10-02 2001-06-26 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
PL224879B1 (pl) 2002-09-04 2017-02-28 Pharmacopeia Drug Discovery Inc Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US7329662B2 (en) 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
EA012873B1 (ru) * 2004-04-02 2009-12-30 Оси Фармасьютикалз, Инк. 6,6-бициклические кольцевые замещенные гетеробициклические ингибиторы протеинкиназ
CA2563699C (en) * 2004-04-23 2014-03-25 Exelixis, Inc. Kinase modulators and method of use
WO2009032694A1 (en) * 2007-08-28 2009-03-12 Dana Farber Cancer Institute Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis
SI2350071T1 (sl) 2008-10-22 2014-05-30 Array Biopharma, Inc. Substituirane pirazolo(1,5-a)pirimidinske spojine kot Trk kinazni inhibitorji
WO2011139273A1 (en) * 2010-05-05 2011-11-10 Vertex Pharmaceuticals Incorporated 4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
CN102241678B (zh) 2011-04-26 2014-10-29 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
JP6223451B2 (ja) * 2012-08-31 2017-11-01 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト がんの診断及び治療方法
CN104837832B (zh) 2012-10-05 2019-04-26 里格尔药品股份有限公司 Gdf-8抑制剂
AU2013337277B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel NTRK1 fusion molecules and uses thereof
TWI629266B (zh) 2012-12-28 2018-07-11 藍印藥品公司 纖維母細胞生長因子受體之抑制劑
CN105377845B (zh) * 2013-02-01 2017-11-24 拜耳制药股份公司 取代的吡唑并嘧啶基氨基‑吲唑类
CN103965199B (zh) 2013-02-02 2017-07-07 广东东阳光药业有限公司 一种芳杂环化合物、包含它的药物组合物及其用途
MY182036A (en) 2013-02-21 2021-01-18 Sunshine Lake Pharma Co Ltd Heteroaromatic compounds as pi3 kinase modulators
KR20150130491A (ko) 2013-03-13 2015-11-23 제넨테크, 인크. 피라졸로 화합물 및 그것의 용도
WO2014160521A1 (en) 2013-03-15 2014-10-02 Blueprint Medicines Corporation Piperazine derivatives and their use as kit modulators
GB2515785A (en) * 2013-07-03 2015-01-07 Redx Pharma Ltd Compounds
US9334263B2 (en) 2013-10-17 2016-05-10 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
PL3057969T3 (pl) 2013-10-17 2018-11-30 Blueprint Medicines Corporation Kompozycje użyteczne do leczenia zaburzeń związanych z KIT
EP3060560A1 (en) 2013-10-25 2016-08-31 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
WO2015157093A1 (en) 2014-04-08 2015-10-15 Rigel Pharmaceuticals, Inc. 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use
WO2016022569A1 (en) 2014-08-04 2016-02-11 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
EP3233863B1 (en) 2014-12-15 2024-04-10 CMG Pharmaceutical Co., Ltd. Fused ring heteroaryl compounds and their use as trk inhibitors
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
EP3259264B1 (en) 2015-02-20 2022-07-27 Rigel Pharmaceuticals, Inc. Gdf-8 inhibitors
KR20180048635A (ko) 2015-07-24 2018-05-10 블루프린트 메디신즈 코포레이션 Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물
CA2995997A1 (en) 2015-08-26 2017-03-02 Blueprint Medicines Corporation Compounds and compositions useful for treating disorders related to ntrk
US10030005B2 (en) 2015-11-02 2018-07-24 Blueprint Medicines Corporation Inhibitors of RET
CN108431008A (zh) 2015-11-19 2018-08-21 蓝图药品公司 可用于治疗与ntrk相关的病症的化合物和组合物
WO2017161269A1 (en) 2016-03-17 2017-09-21 Blueprint Medicines Corporation Inhibitors of ret receptor tyrosine kinases
EP3442977B1 (en) 2016-04-15 2023-06-28 Blueprint Medicines Corporation Inhibitors of activin receptor-like kinase
WO2018017983A1 (en) 2016-07-22 2018-01-25 Blueprint Medicines Corporation Compounds useful for treating disorders related to ret
WO2018022761A1 (en) 2016-07-27 2018-02-01 Blueprint Medicines Corporation Substituted cyclopentane-amides for treating disorders related to ret
WO2018049233A1 (en) 2016-09-08 2018-03-15 Nicolas Stransky Inhibitors of the fibroblast growth factor receptor in combination with cyclin-dependent kinase inhibitors
CN107844168B (zh) 2017-11-23 2020-12-01 英业达科技有限公司 主板组件及其卡扣装置

Also Published As

Publication number Publication date
AU2016311426B2 (en) 2021-05-20
AR105836A1 (es) 2017-11-15
IL257702A (en) 2018-04-30
MX2018002407A (es) 2018-11-29
PH12018500397A1 (en) 2018-08-29
CN108137607B (zh) 2021-04-06
BR112018003588A2 (pt) 2018-09-25
US10017512B2 (en) 2018-07-10
RU2018110379A (ru) 2019-09-27
TW201713665A (zh) 2017-04-16
EP3341374A1 (en) 2018-07-04
US20190169194A1 (en) 2019-06-06
AU2016311426A1 (en) 2018-04-05
JP6877407B2 (ja) 2021-05-26
CA2995997A1 (en) 2017-03-02
ZA201801881B (en) 2019-05-29
US20170066773A1 (en) 2017-03-09
US11046697B2 (en) 2021-06-29
CN108137607A (zh) 2018-06-08
KR20180043810A (ko) 2018-04-30
RU2744974C2 (ru) 2021-03-17
RU2018110379A3 (zh) 2019-12-26
JP2018528200A (ja) 2018-09-27
WO2017035354A1 (en) 2017-03-02

Similar Documents

Publication Publication Date Title
HK1259453A1 (zh) 可用於治療與ntrk相關的病症的化合物和組合物
HK1255330A1 (zh) 適用於治療與ntrk相關的病症的化合物和組合物
IL291533A (en) Compounds and preparations including them for the treatment of diseases of the central nervous system
HK1252741A1 (zh) 用於治療神經疾病的組合物和方法
HK1255103A1 (zh) 可用於治療與kit和pdgfr相關的病症的化合物
PT3206493T (pt) Composições e métodos para tratamento de transtornos do snc
LT3224269T (lt) Kompozicijos ir būdai, skirti cns sutrikimams gydyti
SG11201705093UA (en) Composition for treating il-6-related diseases
PL3250210T3 (pl) Kompozycje i sposoby leczenia zaburzeń OUN
HUE044021T2 (hu) Akne kezelésére szolgáló készítmény
IL249640A0 (en) Preparations for the treatment of nosebleeds
IL250114A0 (en) Methods and compositions for the treatment of hiv-related diseases
GB201612043D0 (en) Composition for treatment of disorders
HK1248130A1 (zh) 用於治療疼痛的組合物
PL3273997T3 (pl) Kompozycja do leczenia nieżytu nosa