JP2021512865A5 - - Google Patents
Info
- Publication number
- JP2021512865A5 JP2021512865A5 JP2020541571A JP2020541571A JP2021512865A5 JP 2021512865 A5 JP2021512865 A5 JP 2021512865A5 JP 2020541571 A JP2020541571 A JP 2020541571A JP 2020541571 A JP2020541571 A JP 2020541571A JP 2021512865 A5 JP2021512865 A5 JP 2021512865A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- compound according
- alkyl
- heteroaryl
- divalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024083049A JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862625153P | 2018-02-01 | 2018-02-01 | |
| US62/625,153 | 2018-02-01 | ||
| PCT/US2019/016362 WO2019152848A1 (en) | 2018-02-01 | 2019-02-01 | Lipid-like nanocomplexes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083049A Division JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512865A JP2021512865A (ja) | 2021-05-20 |
| JP2021512865A5 true JP2021512865A5 (enExample) | 2022-02-03 |
| JP7497045B2 JP7497045B2 (ja) | 2024-06-10 |
Family
ID=67478550
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020541571A Active JP7497045B2 (ja) | 2018-02-01 | 2019-02-01 | 脂質様ナノ複合体及びその使用 |
| JP2024083049A Active JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083049A Active JP7650112B2 (ja) | 2018-02-01 | 2024-05-22 | 脂質様ナノ複合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12133855B2 (enExample) |
| EP (1) | EP3746129A4 (enExample) |
| JP (2) | JP7497045B2 (enExample) |
| KR (1) | KR102904334B1 (enExample) |
| CN (1) | CN111954542A (enExample) |
| AU (1) | AU2019215157B2 (enExample) |
| BR (1) | BR112020015796A2 (enExample) |
| CA (1) | CA3089826A1 (enExample) |
| IL (1) | IL276322B2 (enExample) |
| MX (1) | MX429255B (enExample) |
| WO (1) | WO2019152848A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108368028B (zh) | 2015-10-28 | 2021-09-03 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
| US12678515B2 (en) | 2015-12-30 | 2026-07-14 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| IL276322B2 (en) | 2018-02-01 | 2024-12-01 | Tufts College | Lipid-like nanocomplexes and uses thereof |
| CA3116576A1 (en) | 2018-10-18 | 2020-04-23 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| MX2022006854A (es) | 2019-12-04 | 2022-11-30 | Orna Therapeutics Inc | Composiciones y metodos de arn circular. |
| JP7716112B2 (ja) * | 2020-03-02 | 2025-07-31 | トラスティーズ オブ タフツ カレッジ | 免疫細胞へのｉｎ ｖｉｖｏでのｍＲＮＡ送達のためのイミダゾール系合成リピドイド |
| US20240245805A1 (en) | 2020-03-20 | 2024-07-25 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| KR20230005367A (ko) * | 2020-05-04 | 2023-01-09 | 트러스티즈 오브 터프츠 칼리지 | 뇌 전달을 위한 합성 지질-유사 물질 |
| EP4164647A4 (en) * | 2020-06-12 | 2024-07-24 | Trustees Of Tufts College | Ph-responsive lipidoid nanoparticles for intracellular mrna delivery |
| KR20230051172A (ko) | 2020-07-16 | 2023-04-17 | 아퀴타스 테라퓨틱스 인크. | 지질 나노 입자에 사용하기 위한 양이온성 지질 |
| IL303434A (en) * | 2020-12-07 | 2023-08-01 | Tufts College | Lipidoid preparations and methods of using them |
| JP2024504636A (ja) * | 2021-01-15 | 2024-02-01 | トラスティーズ オブ タフツ カレッジ | ｍＲＮＡの標的化送達のための脂質ナノ粒子 |
| CN117769428A (zh) * | 2021-04-30 | 2024-03-26 | 塔夫茨大学信托人 | 用于治疗疾病和病症的类脂质纳米颗粒 |
| CN113402404B (zh) | 2021-04-30 | 2022-03-11 | 苏州科锐迈德生物医药科技有限公司 | 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN113387825A (zh) * | 2021-06-10 | 2021-09-14 | 福州大学 | 长链烷基酯胺类化合物或含氟长链烷基酯胺类化合物及其公斤级制备方法 |
| AU2022288705A1 (en) | 2021-06-10 | 2023-12-07 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| US20250268828A1 (en) | 2021-09-30 | 2025-08-28 | Orna Therapeutics, Inc. | Lipid Nanoparticle Compositions for Delivering Circular Polynucleotides |
| WO2023081526A1 (en) | 2021-11-08 | 2023-05-11 | Orna Therapeutics, Inc. | Lipid nanoparticle compositions for delivering circular polynucleotides |
| CN114163345B (zh) * | 2021-12-15 | 2022-07-26 | 武汉滨会生物科技股份有限公司 | 一种可离子化脂质化合物及核酸体外细胞转染试剂 |
| CN114191561B (zh) * | 2021-12-15 | 2022-08-02 | 武汉滨会生物科技股份有限公司 | 一种可离子化脂质化合物在核酸药物递送系统中的应用 |
| WO2023114943A2 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| CA3242399A1 (en) * | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Fluorinated cationic lipids for use in lipid nanoparticles |
| CN116813493B (zh) * | 2022-03-21 | 2026-04-28 | 苏州科锐迈德生物医药科技有限公司 | 一种脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN114716355B (zh) * | 2022-04-02 | 2023-09-05 | 华南理工大学 | 一种脂质化合物、包含其的组合物及应用 |
| CN114773217B (zh) * | 2022-06-20 | 2022-10-18 | 深圳市瑞吉生物科技有限公司 | 用于递送核酸的阳离子脂质化合物和组合物及用途 |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| WO2024077232A2 (en) * | 2022-10-07 | 2024-04-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for t cell targeted delivery of therapeutic agents and activation of t cells |
| WO2024102730A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Lipids and nanoparticle compositions for delivering polynucleotides |
| WO2024102762A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Lipids and lipid nanoparticle compositions for delivering polynucleotides |
| TW202428289A (zh) | 2022-11-08 | 2024-07-16 | 美商歐納醫療公司 | 環狀rna組合物 |
| CN116063245B (zh) * | 2022-12-05 | 2024-09-10 | 南开大学 | 一种中心可降解的mRNA脂质体纳米粒子及其制备方法和应用 |
| KR102758330B1 (ko) * | 2023-02-22 | 2025-01-23 | 주식회사 서지넥스 | 황화물을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자 |
| WO2024205657A2 (en) | 2023-03-29 | 2024-10-03 | Orna Therapeutics, Inc. | Lipids and lipid nanoparticle compositions for delivering polynucleotides |
| KR102902665B1 (ko) * | 2024-11-29 | 2025-12-22 | 이화여자대학교 산학협력단 | 에틸렌글리콜을 포함한 생분해성 이온화 지질 및 이를 이용한 약물 전달용 지질나노입자 |
| CN119320334A (zh) * | 2024-12-19 | 2025-01-17 | 国家纳米科学中心 | 具有三维空间结构的可电离脂质化合物及制备方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE682393C (de) | 1933-04-14 | 1939-10-13 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung quaternaerer Stickstoffverbindungen |
| US4275236A (en) | 1979-12-26 | 1981-06-23 | Sherex Chemical Company, Inc. | Tertiary di-(β-hydroxy organo) amine oxides and their preparation |
| EP0863749A2 (en) * | 1995-11-30 | 1998-09-16 | Vical Incorporated | Complex cationic lipids |
| US5994317A (en) * | 1996-04-09 | 1999-11-30 | Vical Incorporated | Quaternary cytofectins |
| JP4087637B2 (ja) | 2001-04-23 | 2008-05-21 | 信越化学工業株式会社 | エステル構造を有する新規第三級アミン化合物及びその製造方法 |
| FR2873376B1 (fr) * | 2004-07-23 | 2006-11-24 | Tetrahedron Sas | Nouveaux seleno-hydroxyacides et leurs derives, applications en nutrition, cosmetique et pharmacie |
| CA2841881A1 (en) | 2011-07-12 | 2013-01-17 | General Electric Company | Polymer and method for removing undesirable elements from aqueous solutions |
| CN103131227B (zh) | 2013-02-23 | 2015-05-13 | 北京化工大学 | 一种抗生物垢涂层的制备方法 |
| WO2014134445A1 (en) * | 2013-02-28 | 2014-09-04 | Tufts Unversity | Disulfide compounds for delivery of pharmaceutical agents |
| WO2014186366A1 (en) * | 2013-05-13 | 2014-11-20 | Tufts University | Nanocomplexes for delivery of saporin |
| US10888622B2 (en) | 2013-05-14 | 2021-01-12 | Trustees Of Tufts College | Nanocomplexes of modified peptides or proteins |
| WO2014210356A1 (en) | 2013-06-26 | 2014-12-31 | Massachusetts Institute Of Technology | Multi-tailed lipids and uses thereof |
| EP3170676B1 (en) | 2014-07-17 | 2020-09-09 | Toppan Printing Co., Ltd. | Thermal transfer image receiving sheet and method for producing same |
| WO2017176974A1 (en) | 2016-04-06 | 2017-10-12 | Ohio State Innovation Foundation | Biodegradable amino-ester nanomaterials for nucleic acid delivery |
| US20190336611A1 (en) | 2016-06-09 | 2019-11-07 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| WO2018022292A1 (en) | 2016-07-26 | 2018-02-01 | Trustees Of Tufts College | Antibody-conjugated nanoparticles and medical uses thereof |
| IL276322B2 (en) | 2018-02-01 | 2024-12-01 | Tufts College | Lipid-like nanocomplexes and uses thereof |
-
2019
- 2019-02-01 IL IL276322A patent/IL276322B2/en unknown
- 2019-02-01 MX MX2020007944A patent/MX429255B/es unknown
- 2019-02-01 US US16/966,368 patent/US12133855B2/en active Active
- 2019-02-01 CA CA3089826A patent/CA3089826A1/en active Pending
- 2019-02-01 JP JP2020541571A patent/JP7497045B2/ja active Active
- 2019-02-01 WO PCT/US2019/016362 patent/WO2019152848A1/en not_active Ceased
- 2019-02-01 BR BR112020015796-1A patent/BR112020015796A2/pt not_active Application Discontinuation
- 2019-02-01 KR KR1020207024651A patent/KR102904334B1/ko active Active
- 2019-02-01 EP EP19747806.8A patent/EP3746129A4/en active Pending
- 2019-02-01 AU AU2019215157A patent/AU2019215157B2/en not_active Expired - Fee Related
- 2019-02-01 CN CN201980023529.6A patent/CN111954542A/zh active Pending
-
2023
- 2023-06-02 US US18/205,096 patent/US20230405022A1/en active Pending
-
2024
- 2024-05-22 JP JP2024083049A patent/JP7650112B2/ja active Active
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