JP2015504072A5 - - Google Patents
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- Publication number
- JP2015504072A5 JP2015504072A5 JP2014551313A JP2014551313A JP2015504072A5 JP 2015504072 A5 JP2015504072 A5 JP 2015504072A5 JP 2014551313 A JP2014551313 A JP 2014551313A JP 2014551313 A JP2014551313 A JP 2014551313A JP 2015504072 A5 JP2015504072 A5 JP 2015504072A5
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- JP
- Japan
- Prior art keywords
- composition
- compound
- cell
- compound according
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 28
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 230000006907 apoptotic process Effects 0.000 claims 6
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- NNJPGOLRFBJNIW-HNNXBMFYSA-N (-)-demecolcine Chemical compound C1=C(OC)C(=O)C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-HNNXBMFYSA-N 0.000 claims 2
- 108010006654 Bleomycin Proteins 0.000 claims 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 2
- 108010076667 Caspases Proteins 0.000 claims 2
- 102000011727 Caspases Human genes 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 2
- NNJPGOLRFBJNIW-UHFFFAOYSA-N Demecolcine Natural products C1=C(OC)C(=O)C=C2C(NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-UHFFFAOYSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
- 229940009456 adriamycin Drugs 0.000 claims 2
- 230000001640 apoptogenic effect Effects 0.000 claims 2
- 229960001561 bleomycin Drugs 0.000 claims 2
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
- 229940127093 camptothecin Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 229960001338 colchicine Drugs 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229960000684 cytarabine Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960004039 finasteride Drugs 0.000 claims 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 2
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims 2
- 229960000390 fludarabine Drugs 0.000 claims 2
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 229960004857 mitomycin Drugs 0.000 claims 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 2
- 229960001156 mitoxantrone Drugs 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000001235 sensitizing effect Effects 0.000 claims 2
- 229960001603 tamoxifen Drugs 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960000303 topotecan Drugs 0.000 claims 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
- 229960003048 vinblastine Drugs 0.000 claims 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
- 229960004528 vincristine Drugs 0.000 claims 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 2
- LFIPKBDLYATZMF-UBHSHLNASA-N (2s)-1-[(2s)-2-cyclohexyl-2-[[(2s)-2-(methylamino)propanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C1([C@H](NC(=O)[C@H](C)NC)C(=O)N2[C@@H](CCC2)C(O)=O)CCCCC1 LFIPKBDLYATZMF-UBHSHLNASA-N 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261582760P | 2012-01-03 | 2012-01-03 | |
| US61/582,760 | 2012-01-03 | ||
| PCT/US2013/020124 WO2013103703A1 (en) | 2012-01-03 | 2013-01-03 | Inhibitors of iap |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096425A Division JP2015199738A (ja) | 2012-01-03 | 2015-05-11 | Ｉａｐの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504072A JP2015504072A (ja) | 2015-02-05 |
| JP2015504072A5 true JP2015504072A5 (enExample) | 2015-03-26 |
| JP5747137B2 JP5747137B2 (ja) | 2015-07-08 |
Family
ID=48695302
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014551313A Active JP5747137B2 (ja) | 2012-01-03 | 2013-01-03 | Ｉａｐの阻害剤 |
| JP2015096425A Pending JP2015199738A (ja) | 2012-01-03 | 2015-05-11 | Ｉａｐの阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096425A Pending JP2015199738A (ja) | 2012-01-03 | 2015-05-11 | Ｉａｐの阻害剤 |
Country Status (41)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2755614T3 (enExample) | 2012-01-03 | 2018-03-31 | ||
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN109705191B (zh) * | 2017-10-25 | 2022-04-29 | 广东东阳光药业有限公司 | Iap抑制剂及其在药物中的应用 |
| IL274598B2 (en) | 2017-11-13 | 2025-01-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | SMAC mimetics used as IAP inhibitors and their use |
| CN112533898A (zh) | 2018-07-31 | 2021-03-19 | 日商泛美克斯股份有限公司 | 杂环化合物 |
| US20220402935A1 (en) | 2019-07-31 | 2022-12-22 | Fimecs, Inc. | Heterocyclic compound |
| US20230029259A1 (en) * | 2019-12-02 | 2023-01-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents |
| EP4093394A1 (en) | 2020-01-20 | 2022-11-30 | Astrazeneca AB | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| AU2022463015A1 (en) | 2021-10-22 | 2024-05-09 | Tract Pharmaceuticals, Inc. | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CN117110469B (zh) * | 2023-08-18 | 2025-12-09 | 中国检验检疫科学研究院 | 一种测定防脱发类化妆品中禁用组分的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526988A (en) | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| DE69830577T2 (de) | 1997-04-15 | 2006-05-04 | Genentech, Inc., South San Francisco | Halo-alkoxycarbonylverbindungen |
| CA2570321C (en) * | 2004-07-02 | 2013-10-08 | Genentech, Inc. | Inhibitors of iap |
| KR20120127754A (ko) * | 2004-12-20 | 2012-11-23 | 제넨테크, 인크. | Ｉａｐ의 피롤리딘 억제제 |
| US8044209B2 (en) | 2006-10-12 | 2011-10-25 | Novartis Ag | Pyrrolydine derivatives as IAP inhibitors |
| NZ598890A (en) | 2007-04-30 | 2013-10-25 | Genentech Inc | Inhibitors of iap |
| NO2755614T3 (enExample) * | 2012-01-03 | 2018-03-31 | ||
| USD690416S1 (en) | 2012-12-12 | 2013-09-24 | Pharmajet, Inc. | Needle-free syringe |
-
2012
- 2012-09-13 NO NO12832667A patent/NO2755614T3/no unknown
-
2013
- 2013-01-02 AR ARP130100006A patent/AR089623A1/es not_active Application Discontinuation
- 2013-01-03 SM SM20180352T patent/SMT201800352T1/it unknown
- 2013-01-03 MY MYPI2014001966A patent/MY178390A/en unknown
- 2013-01-03 JP JP2014551313A patent/JP5747137B2/ja active Active
- 2013-01-03 UA UAA201408260A patent/UA114417C2/uk unknown
- 2013-01-03 PT PT161896618T patent/PT3133073T/pt unknown
- 2013-01-03 ME MEP-2016-235A patent/ME02526B/me unknown
- 2013-01-03 SI SI201330343A patent/SI2800749T1/sl unknown
- 2013-01-03 CN CN201380012308.1A patent/CN104159897A/zh active Pending
- 2013-01-03 ES ES13733613.7T patent/ES2594856T3/es active Active
- 2013-01-03 PL PL13733613T patent/PL2800749T3/pl unknown
- 2013-01-03 PE PE2014001069A patent/PE20142182A1/es active IP Right Grant
- 2013-01-03 HU HUE16189661A patent/HUE037760T2/hu unknown
- 2013-01-03 TW TW102100188A patent/TWI503318B/zh active
- 2013-01-03 LT LTEP13733613.7T patent/LT2800749T/lt unknown
- 2013-01-03 WO PCT/US2013/020124 patent/WO2013103703A1/en not_active Ceased
- 2013-01-03 RU RU2016124658A patent/RU2728789C2/ru active
- 2013-01-03 DK DK16189661.8T patent/DK3133073T3/en active
- 2013-01-03 AU AU2013202780A patent/AU2013202780B2/en active Active
- 2013-01-03 DK DK13733613.7T patent/DK2800749T3/en active
- 2013-01-03 HR HRP20161381TT patent/HRP20161381T1/hr unknown
- 2013-01-03 RU RU2014130171/04A patent/RU2593259C2/ru active
- 2013-01-03 LT LTEP16189661.8T patent/LT3133073T/lt unknown
- 2013-01-03 ES ES16189661.8T patent/ES2672809T3/es active Active
- 2013-01-03 EP EP16189661.8A patent/EP3133073B1/en active Active
- 2013-01-03 CN CN201711212712.XA patent/CN107915728B/zh active Active
- 2013-01-03 TR TR2018/08088T patent/TR201808088T4/tr unknown
- 2013-01-03 ME MEP-2018-161A patent/ME03084B/me unknown
- 2013-01-03 CA CA2861637A patent/CA2861637C/en active Active
- 2013-01-03 KR KR1020147021597A patent/KR101553792B1/ko active Active
- 2013-01-03 PT PT137336137T patent/PT2800749T/pt unknown
- 2013-01-03 KR KR1020157014670A patent/KR101855566B1/ko active Active
- 2013-01-03 MX MX2014007895A patent/MX336294B/es unknown
- 2013-01-03 HU HUE13733613A patent/HUE031305T2/hu unknown
- 2013-01-03 PL PL16189661T patent/PL3133073T3/pl unknown
- 2013-01-03 NZ NZ627480A patent/NZ627480A/en not_active IP Right Cessation
- 2013-01-03 KR KR1020187012124A patent/KR101917992B1/ko active Active
- 2013-01-03 SG SG11201403784QA patent/SG11201403784QA/en unknown
- 2013-01-03 HK HK15104538.4A patent/HK1203949A1/xx unknown
- 2013-01-03 RS RS20160910A patent/RS55327B1/sr unknown
- 2013-01-03 SI SI201331047T patent/SI3133073T1/en unknown
- 2013-01-03 EP EP13733613.7A patent/EP2800749B1/en active Active
- 2013-01-03 BR BR112014016637-4A patent/BR112014016637B1/pt active IP Right Grant
- 2013-01-03 RS RS20180755A patent/RS57438B1/sr unknown
- 2013-01-03 US US13/733,244 patent/US8716236B2/en active Active
-
2014
- 2014-05-05 US US14/269,739 patent/US9238675B2/en active Active
- 2014-06-26 IL IL242314A patent/IL242314A/en active IP Right Grant
- 2014-06-26 IL IL233386A patent/IL233386A/en active IP Right Grant
- 2014-07-01 CL CL2014001770A patent/CL2014001770A1/es unknown
- 2014-07-02 PH PH12014501534A patent/PH12014501534B1/en unknown
- 2014-07-25 ZA ZA2014/05535A patent/ZA201405535B/en unknown
- 2014-07-25 CO CO14161919A patent/CO7020915A2/es unknown
- 2014-07-31 CR CR20140367A patent/CR20140367A/es not_active Application Discontinuation
- 2014-07-31 EC ECIEPI201411792A patent/ECSP14011792A/es unknown
- 2014-08-03 MA MA37254A patent/MA35895B1/fr unknown
-
2015
- 2015-05-08 PH PH12015501038A patent/PH12015501038A1/en unknown
- 2015-05-11 JP JP2015096425A patent/JP2015199738A/ja active Pending
- 2015-12-18 US US14/974,140 patent/US9586991B2/en active Active
-
2016
- 2016-10-06 SM SM201600357T patent/SMT201600357B/it unknown
- 2016-12-07 CY CY20161101257T patent/CY1118371T1/el unknown
-
2017
- 2017-01-31 US US15/420,817 patent/US20170136084A1/en not_active Abandoned
-
2018
- 2018-06-22 CY CY20181100652T patent/CY1120355T1/el unknown
- 2018-06-26 HR HRP20180976TT patent/HRP20180976T1/hr unknown
-
2019
- 2019-04-02 US US16/372,940 patent/US11096982B2/en active Active
-
2021
- 2021-08-03 US US17/392,724 patent/US11963994B2/en active Active
- 2021-09-17 AR ARP210102590A patent/AR123542A2/es not_active Application Discontinuation
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