JP2021508697A5 - - Google Patents

Download PDF

Info

Publication number
JP2021508697A5
JP2021508697A5 JP2020535541A JP2020535541A JP2021508697A5 JP 2021508697 A5 JP2021508697 A5 JP 2021508697A5 JP 2020535541 A JP2020535541 A JP 2020535541A JP 2020535541 A JP2020535541 A JP 2020535541A JP 2021508697 A5 JP2021508697 A5 JP 2021508697A5
Authority
JP
Japan
Prior art keywords
composition
compound according
cancer
alkyl
motomeko
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020535541A
Other languages
English (en)
Japanese (ja)
Other versions
JP7304863B2 (ja
JP2021508697A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/067961 external-priority patent/WO2019133878A1/en
Publication of JP2021508697A publication Critical patent/JP2021508697A/ja
Publication of JP2021508697A5 publication Critical patent/JP2021508697A5/ja
Priority to JP2023104912A priority Critical patent/JP2023123696A/ja
Application granted granted Critical
Publication of JP7304863B2 publication Critical patent/JP7304863B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020535541A 2017-12-29 2018-12-28 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤 Active JP7304863B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023104912A JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762611620P 2017-12-29 2017-12-29
US62/611,620 2017-12-29
PCT/US2018/067961 WO2019133878A1 (en) 2017-12-29 2018-12-28 Heterobifunctional inhibitors of e-selectin and galectin-3

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023104912A Division JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

Publications (3)

Publication Number Publication Date
JP2021508697A JP2021508697A (ja) 2021-03-11
JP2021508697A5 true JP2021508697A5 (cg-RX-API-DMAC7.html) 2022-01-11
JP7304863B2 JP7304863B2 (ja) 2023-07-07

Family

ID=65139264

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020535541A Active JP7304863B2 (ja) 2017-12-29 2018-12-28 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤
JP2023104912A Withdrawn JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023104912A Withdrawn JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

Country Status (9)

Country Link
US (1) US11548908B2 (cg-RX-API-DMAC7.html)
EP (1) EP3732186A1 (cg-RX-API-DMAC7.html)
JP (2) JP7304863B2 (cg-RX-API-DMAC7.html)
KR (1) KR20200104889A (cg-RX-API-DMAC7.html)
CN (1) CN111566117A (cg-RX-API-DMAC7.html)
AU (1) AU2018395417B2 (cg-RX-API-DMAC7.html)
BR (1) BR112020013198A2 (cg-RX-API-DMAC7.html)
CA (1) CA3085356A1 (cg-RX-API-DMAC7.html)
WO (1) WO2019133878A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118373810A (zh) 2018-12-27 2024-07-23 糖模拟物有限公司 抑制c-糖苷的半乳凝素-3
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2021011435A1 (en) 2019-07-12 2021-01-21 Magnani John L Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
WO2021021994A1 (en) * 2019-07-31 2021-02-04 Glycomimetics, Inc. Use of highly potent multimeric e-selectin antagonists for treating sickle cell disease
WO2021022132A1 (en) 2019-07-31 2021-02-04 Magnani John L Use of e-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts
WO2021034796A1 (en) * 2019-08-20 2021-02-25 Glycomimetics, Inc. Process for preparing an e-selectin inhibitor intermediate
WO2021195465A1 (en) 2020-03-27 2021-09-30 Magnani John L Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
JP2023527411A (ja) 2020-05-31 2023-06-28 グリコミメティクス， インコーポレイテッド がん細胞の負荷を減少させ、正常な造血を保護するための化合物および方法
AU2021292458A1 (en) 2020-06-14 2023-01-19 GlycoMimetics Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting
CA3206500A1 (en) * 2021-02-18 2022-08-25 Indranath Ghosh Process for preparing an e-selectin inhibitor intermediate
CN113229815B (zh) * 2021-05-17 2022-07-08 庞尔亮 一种兽医用牲畜疫病检测装置
US20240269157A1 (en) 2021-08-03 2024-08-15 Glycomimetics, Inc. Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting

Family Cites Families (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7409399A (nl) 1973-07-19 1975-01-21 Rhone Poulenc Sa Werkwijze ter bereiding van thermostabiele har- sen en voorwerpen geheel of gedeeltelijk be- staande uit deze harsen.
US4471057A (en) 1981-06-30 1984-09-11 The Wistar Institute Detection of colorectal carcinoma
DK17885D0 (da) 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
US4876199A (en) 1985-04-04 1989-10-24 Fred Hutchinson Cancer Research Center Hybridomas producing monoclonal antibodies to mono-, di-, and trifucosylated type 2 chain
US4851511A (en) 1986-01-30 1989-07-25 Fred Hutchinson Cancer Research Center Monoclonal antibody that specifically binds to disialosyl Lea
US4925796A (en) 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
DE3787403D1 (de) 1986-05-09 1993-10-21 Pulverer Gerhard Verwendung von spezifischen Monosacchariden zur Herstellung eines Arzneimittels zur Verhinderung von Metastasen maligner Tumore.
US5538724A (en) 1987-08-11 1996-07-23 The Board Of Trustees For The Leland Stanford Junior Univ. Method of control leukocyte extravasation
US5079353A (en) 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
DK455088D0 (da) 1988-08-12 1988-08-12 Symbicom Ab Syntetiske receptoranaloger
US5632991A (en) 1988-11-14 1997-05-27 Brigham & Women's Hospital Antibodies specific for E-selectin and the uses thereof
EP0381310A1 (en) 1989-01-30 1990-08-08 The Biomembrane Institute Monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides and method for production thereof
US5464778A (en) 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
US5272263A (en) 1989-04-28 1993-12-21 Biogen, Inc. DNA sequences encoding vascular cell adhesion molecules (VCAMS)
EP0583799A1 (en) 1989-05-23 1994-02-23 Otsuka Pharmaceutical Co., Ltd. Monoclonal antibodies to ELAM-1 sialoglycoprotein antigen on the surface of activated endothelial cells
US6033665A (en) 1989-09-27 2000-03-07 Elan Pharmaceuticals, Inc. Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
US6280932B1 (en) 1990-06-11 2001-08-28 Gilead Sciences, Inc. High affinity nucleic acid ligands to lectins
US6001988A (en) 1990-06-11 1999-12-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US5576305A (en) 1990-06-15 1996-11-19 Cytel Corporation Intercellular adhesion mediators
AU8007791A (en) 1990-06-15 1992-01-07 Cytel Corporation Intercellular adhesion mediators
US5753631A (en) 1990-06-15 1998-05-19 Cytel Corporation Intercellular adhesion mediators
US6387884B1 (en) 1990-06-18 2002-05-14 Stanford University Leukocyte homing modulation
US6391857B1 (en) 1990-06-18 2002-05-21 Stanford University Methods and compositions for endothelial binding
EP0544815A1 (en) 1990-07-17 1993-06-09 The Board Of Regents Of The University Of Oklahoma Peptides from the GMP-140 lectinbindingdomain and selectin binding ligands on carbonhydrates
US5143712A (en) 1990-07-30 1992-09-01 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US5211937A (en) 1990-07-30 1993-05-18 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US5648344A (en) 1990-07-30 1997-07-15 Glycomed Incorporated Methods of treating inflammation using selection binding compounds
US5789573A (en) 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
NZ240316A (en) 1990-10-25 1996-12-20 Univ Michigan Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells
CZ96893A3 (en) 1990-11-23 1993-12-15 Gen Hospital Corp Inhibition of adhesive protein cells and their carbohydrates interaction
US5151360A (en) 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US6309639B1 (en) 1991-02-05 2001-10-30 The Board Of Regents Of The University Of Oklahoma Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
US6124267A (en) 1991-02-05 2000-09-26 Southpac Trust Internationals, Inc. O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
WO1992016640A1 (en) 1991-03-18 1992-10-01 The Scripps Research Institute Oligosaccharide enzyme substrates and inhibitors: methods and compositions
US6121233A (en) 1991-04-19 2000-09-19 John L. Magnani Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules
US5318890A (en) 1991-05-06 1994-06-07 The Regents Of The University Of California Assays for inhibitors of leukocyte adhesion
AU660995B2 (en) 1991-05-06 1995-07-13 Genentech Inc. Glycam-1 (Sgp 50), a selectin ligand
US5580858A (en) 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
US5646123A (en) 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
US5352670A (en) 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
JPH07507040A (ja) 1991-09-10 1995-08-03 セントコー，インコーポレイテッド セレクチンによって介在される炎症のペプチド阻害剤
US5268364A (en) 1991-12-12 1993-12-07 The Biomembrane Institute Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
AU3914393A (en) 1991-12-18 1994-03-15 Board Of Regents Of The University Of Oklahoma, The Peptide inhibitors of inflammation mediated by selectins
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5620864A (en) 1992-06-29 1997-04-15 Health Research, Inc. Acceptor for fucosyl transferase
US5591835A (en) 1992-06-29 1997-01-07 Glycomed Incorporated Substituted lactose derivatives
CA2100412A1 (en) 1992-07-15 1994-01-16 Yutaka Yamada Glycolipid derivatives
CA2144180A1 (en) 1992-09-08 1994-03-17 George A. Heavner Peptide inhibitors of cellular adhesion
US5519008A (en) 1992-09-10 1996-05-21 Glycomed Incorporated Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
US5695752A (en) 1992-09-11 1997-12-09 The Regents Of The University Of California Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor
WO1994006442A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation
US5843707A (en) 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
US6277975B1 (en) 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
EP0601417A3 (de) 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung
US5710123A (en) 1992-12-18 1998-01-20 Centocor, Inc. Peptide inhibitors of selectin binding
JP3887011B2 (ja) 1992-12-29 2007-02-28 ジェネンテク，インコーポレイテッド ＩＦＮ−γインヒビターによる炎症性腸疾患の処置
US5412123A (en) 1993-02-08 1995-05-02 Glycomed Incorporated Anthraquinone and anthracene derivatives as inhibitors of the cell-adhesion molecules of the immune system
US5763413A (en) 1993-03-04 1998-06-09 Mect Corporation Lewis-associated compound, process for producing the same, and anti-inflammatory
US5527890A (en) 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
EP0700301B1 (en) 1993-05-05 1999-09-01 Affymax Technologies N.V. Peptides and compounds that bind to elam-1
US5854218A (en) 1993-05-14 1998-12-29 Cytel Corporation Sialyl Lex analogues as inhibitors of cellular adhesion
US5811404A (en) 1993-05-14 1998-09-22 Cytel Corporation Sialyl Lex analogues as inhibitors of cellular adhesion
US5527785A (en) 1993-05-14 1996-06-18 The Regents Of The University Of California Selectin receptor modulating compositions
SE9301677L (sv) 1993-05-14 1994-11-18 Kurt G I Nilsson Syntesmetod
EP0698031A4 (en) 1993-05-14 1997-07-09 Cytel Corp SIALYL LE x ANALOGUES AS INHIBITORS OF CELLULAR ADHESION
US5856300A (en) 1994-05-12 1999-01-05 T Cell Sciences, Inc. Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
DK0730608T3 (da) 1993-05-17 2002-07-22 Avant Immunotherapeutics Inc Præparater omfattende komplementrelaterede proteiner og carbohydrater og fremgangsmåder til fremstilling og anvendelse af præparaterne
US5976540A (en) 1993-05-17 1999-11-02 T Cell Sciences, Inc. Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
US5646248A (en) 1993-06-08 1997-07-08 La Jolla Cancer Research Foundation E-selection binding soluble lamp-1 polypeptide
US5789385A (en) 1993-06-16 1998-08-04 Glycomed Incorporated Sialyl Lewisx mimetics containing phenyl backbones
US5658880A (en) 1993-06-16 1997-08-19 Glycomed Incorporated Sialic acid/fucose based medicaments
US5837689A (en) 1993-06-16 1998-11-17 Glycomed Incorporated Sialyl lewis-x mimetics containing naphthyl backbones
US5750508A (en) 1993-06-16 1998-05-12 Glycomed Incorporated Sialic acid/fucose based medicaments
US5679321A (en) 1993-06-17 1997-10-21 Glycomed Incorporated Sialic acid/fucose based medicaments
DK76193D0 (da) 1993-06-25 1993-06-25 Astra Ab Kulhydratderivater
US5559103A (en) 1993-07-21 1996-09-24 Cytel Corporation Bivalent sialyl X saccharides
US5508387A (en) 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
WO1995005830A1 (en) 1993-08-20 1995-03-02 The Regents Of The University Of California Polyanion anti-inflammatory agents
US5464815A (en) 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
WO1995010296A1 (en) 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5783693A (en) 1993-11-19 1998-07-21 The Regents Of The University Of California Methods for synthesizing sulfated disaccharide inhibitors of selectins
WO1995014787A1 (en) 1993-11-22 1995-06-01 Centocor, Inc. Peptide inhibitors of selecting binding
US5663151A (en) 1994-03-04 1997-09-02 Bristol-Myers Squibb Company Sulfated α-glycolipid derivatives as cell adhesion inhibitors
DE4408248A1 (de) 1994-03-11 1995-09-14 Hoechst Ag Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
EP0671409A3 (de) 1994-03-11 1996-06-12 Hoechst Ag Malonsäurederivate mit antiadhäsiven Eigenschaften.
HUT77345A (hu) 1994-04-29 1998-03-30 Texas Biotechnology Corporation E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények
US5444050A (en) 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5486536A (en) 1994-08-15 1996-01-23 The Regents Of The University Of Michigan Sulfatides as anti-inflammatory compounds
JPH0899989A (ja) 1994-09-30 1996-04-16 Akira Hasegawa 新規糖脂質誘導体およびその製造用中間体
DE4436164A1 (de) 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
US5686426A (en) 1994-11-17 1997-11-11 Bristol-Myers Squibb Company Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US5639734A (en) 1994-12-20 1997-06-17 Esko; Jeffrey D. Disaccharide inflammation inhibitors and uses thereof
EP0801071A4 (en) 1994-12-28 1999-01-13 Sumitomo Pharma LEWIS DERIVATIVE X AND PRODUCTION METHOD THEREOF
US20020040008A1 (en) 1995-01-24 2002-04-04 Wagner Denisa D. Method for treating and preventing atherosclerosis
US5527936A (en) 1995-02-17 1996-06-18 E. I. Du Pont De Nemours And Company Hydrosilylation of unsaturated compounds
GB9504065D0 (en) 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
GB9511357D0 (en) 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
US5736533A (en) 1995-06-07 1998-04-07 Neose Technologies, Inc. Bacterial inhibition with an oligosaccharide compound
WO1996040942A1 (en) 1995-06-07 1996-12-19 Cytel Corporation Humanized antibodies to e-selectin
IT1290779B1 (it) 1995-06-26 1998-12-10 Antonio Sacchetti Procedimento per il potenziamento delle attivita' terapeutiche di sostanze naturali (vitamine, minerali, erbe, fitopreparati, alimenti)
AU707474B2 (en) 1995-06-29 1999-07-08 Novartis Ag Diglycosylated 1,2-diols as mimetics of sialyl-lewis X and sialyl-lewis A
US5876715A (en) 1995-08-17 1999-03-02 The Biomembrane Institute Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof
DE19532902A1 (de) 1995-09-06 1997-03-13 Hoechst Ag Neuartige Glycomimetika als Selektin-Antagonisten und daraus hergestellte entzündungshemmend wirkende Arzneimittel
DE19537334A1 (de) 1995-10-09 1997-04-10 Hoechst Ag Antiadhäsive Piperidin- und Pyrrolidin-Carbonsäuren
WO1997014707A1 (en) 1995-10-18 1997-04-24 Cytel Corporation SIALYL Lex ANALOGUES AS INHIBITORS OF CELLULAR ADHESION
EP0859005A1 (en) 1995-10-26 1998-08-19 Kanebo, Ltd. Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same
US5747463A (en) 1995-11-13 1998-05-05 Bristol-Myers Squibb Company Malonate derivatives of glycolipids as cell adhesion inhibitors
JPH09176047A (ja) 1995-12-25 1997-07-08 Unitika Ltd 外用医薬製剤
DE19602355A1 (de) 1996-01-24 1997-07-31 Hoechst Ag Mehrfach fucosylierte Dicarbonsäuren mit antiadhäsiven Eigenschaften
DE69738731D1 (de) 1996-01-30 2008-07-10 Glycomimetics Inc SIALYL-LEWISa UND SIALYL-LEWISx EPITOPE ANALOGE
DE69737496D1 (de) 1996-01-30 2007-05-03 Glycomimetics Inc SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE
AU718317B2 (en) 1996-03-01 2000-04-13 Regents Of The University Of California, The Inhibition of selectin binding
US5710023A (en) 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
US6344545B1 (en) 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US5654412A (en) 1996-05-29 1997-08-05 Glycomed Incorporated Processes for the synthesis of sialyl Lewisx compounds
US5994402A (en) 1996-06-05 1999-11-30 Rotstein; Ori D. Anti-inflammatory and anti-pyretic method
US5919768A (en) 1996-06-26 1999-07-06 Texas Biotechnology Corporation Di- and trivalent small molecule selectin inhibitors
SK15699A3 (en) 1996-08-08 1999-07-12 Novartis Ag Modified oligosaccharides, process for their preparation and pharmaceutical composition containing them
US5830871A (en) 1996-10-28 1998-11-03 The Scripps Research Institute Inhibitors of E-, P- and L-selectin binding
GB9618520D0 (en) 1996-09-05 1996-10-16 Chiroscience Ltd Compounds and their therapeutic use
US6592872B1 (en) 1996-09-17 2003-07-15 The United States Of America As Represented By The Department Of Health And Human Services Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein
WO1998013058A1 (en) 1996-09-27 1998-04-02 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
DE19643764A1 (de) 1996-09-30 1998-04-02 Bayer Ag Glycokonjugate von modifizierten Camptothecin-Derivaten (20-0-Verknüpfung)
US6110897A (en) 1996-10-10 2000-08-29 Glycorex Ab Antiinflammatory cell adhesion inhibitors
US6043348A (en) 1996-11-13 2000-03-28 Lawman; Michael J. P. Antibody recognizing a small subset of human hematopoietic cells
DE19654180A1 (de) 1996-12-23 1998-06-25 Hoechst Ag Phosphane, Verfahren zu ihrer Herstellung und ihre Verwendung in Metallkomplexen
EP1019064A4 (en) 1997-02-28 2006-11-08 Univ California Inhibition of cell-cell binding by lipid assemblies
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
SE9701127D0 (sv) 1997-03-26 1997-03-26 Karolinska Innovations Ab Antigenic fusionprotein carrying GALal, 3GAL epitopes
JP3720520B2 (ja) 1997-03-27 2005-11-30 タカラバイオ株式会社 糖と標的物との相互作用の測定方法
US6413760B1 (en) 1997-04-15 2002-07-02 Genetics Institute, Inc. Highly purified mocarhagin cobra venom protease polynucleotides endcoding same and related proteases and therapeutic uses thereof
US5916910A (en) 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
US6193973B1 (en) 1997-08-22 2001-02-27 B. David Tuttle Dietary supplement for boosting energy and increasing muscular strength
US5948628A (en) 1997-09-05 1999-09-07 The Board Of Regents Of The University Of Oklahoma Methods of screening for compounds which mimic galectin-1
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
WO1999043356A1 (en) 1998-02-25 1999-09-02 Hsc Research Development Limited Partnership Antibiotic-ligand conjugates and methods of use thereof
WO1999043353A2 (en) 1998-02-26 1999-09-02 Boehringer Ingelheim Pharmaceuticals, Inc. Combination anti-selectin and immunosuppressant therapy
US6458777B1 (en) 1998-03-13 2002-10-01 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
CA2245224A1 (en) 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
US6365365B1 (en) 1998-03-20 2002-04-02 The Regents Of The University Of California Method of determining whether an agent modulates glycosyl sulfotransferase-3
US6265192B1 (en) 1998-03-20 2001-07-24 The Regents Of The University Of California Glycosly sulfortransferase-3
US6037333A (en) 1998-05-07 2000-03-14 Trustees Of Tufts College Microbe-inhibiting compositions
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
EP1087996B1 (en) 1998-06-16 2007-01-17 The Board of Regents of The University of Oklahoma Glycosulfopeptides and methods of synthesis and use thereof
US6004815A (en) 1998-08-13 1999-12-21 The Regents Of The University Of California Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells
WO2000017216A1 (fr) 1998-09-21 2000-03-30 Otsuka Pharmaceutical Co., Ltd. Derives de carboxymethylgalactose
US6960566B1 (en) 1998-11-06 2005-11-01 The Wister Institute of Anatomy and Biology Compositions and methods for treatment of cancer
DE69941031D1 (de) 1998-11-12 2009-08-06 Novolytics Inc Zusammensetzungen und verfahren zur erzeugung von gefässeokklusion
WO2000035945A1 (en) 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
AU4692400A (en) 1999-05-03 2000-11-17 Smithkline Beecham Corporation Cxcr-4 receptor antagonists - thrombopoietin mimetics
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
US7204981B2 (en) 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
AU2001249622B2 (en) 2000-03-30 2007-06-07 Massachusetts Institute Of Technology RNA sequence-specific mediators of RNA interference
DE60118362T2 (de) 2000-05-19 2007-05-24 The Center for Blood Research, Inc., Boston VERFAHREN ZUR BEHANDLUNG VON HÄMOSTATISCHEN STÖRUNGEN DURCH LöSLICHES P-SELECTIN
US20020165178A1 (en) 2000-06-28 2002-11-07 Christian Schetter Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
WO2002022820A1 (en) 2000-09-12 2002-03-21 Genetics Institute, Llc Inhibition of stenosis or restenosis by p-selectin antagonists
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
AU2002219828A1 (en) 2000-11-14 2002-05-27 The General Hospital Corporation Blockade of T cell migration into epithelial GVHD target tissues
JP4262480B2 (ja) 2000-11-29 2009-05-13 ブラッコ インターナショナル ビー．ヴイ． 結合能を有するシアリル・ルイスｘ類似物
US20020132220A1 (en) 2000-12-27 2002-09-19 Berens Kurt L. Use of selectin antagonists in organ preservation solutions
SE0100172D0 (sv) 2001-01-22 2001-01-22 Ulf Nilsson New inhibitors against galectins
US7754219B2 (en) 2001-03-28 2010-07-13 President And Fellows Of Harvard College Methods of delivery of exogenous proteins to the cytosol and uses thereof
US20030198639A1 (en) 2002-04-16 2003-10-23 Frenette Paul S. Methods of treating sickle cell disease
US7087212B2 (en) 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
WO2003032925A2 (en) 2001-10-19 2003-04-24 Cummings Richard D Glycosulfopeptide inhibitors and methods of use thereof
AU2002357072A1 (en) 2001-12-07 2003-06-23 Centocor, Inc. Pseudo-antibody constructs
CN102153540A (zh) 2001-12-21 2011-08-17 阿诺麦德股份有限公司 具有强效的与趋化因子受体结合的杂环化合物
US20030186942A1 (en) 2002-01-16 2003-10-02 Crooks Peter A. Compounds of use in the treatment of epilepsy, seizure, and electroconvulsive disorders
FR2835527B1 (fr) 2002-02-05 2004-03-12 Centre Nat Rech Scient Synthese de molecules de type inositolphosphate glycanne: traitement des troubles de la proliferation cellulaire et des desordres metaboliques caracterises par une resistance a l'insuline
US20040072796A1 (en) 2002-04-18 2004-04-15 Embury Stephen H. Method and composition for preventing pain in sickle cell patients
AUPS213802A0 (en) 2002-05-03 2002-06-06 Alchemia Pty Ltd Disaccharides for drug discovery
US7060685B2 (en) 2002-05-16 2006-06-13 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
JP2006502986A (ja) 2002-07-03 2006-01-26 グリコミメティクス， インコーポレイテッド 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法
CA2504755C (en) 2002-10-11 2010-12-14 University Of Maryland Biotechnology Institute Carbohydrate-based synthetic vaccines for hiv
AU2003301209A1 (en) 2002-12-20 2004-07-22 Glycomimetics, Inc. Oligosaccharides and conjugates thereof for the treatement of pseudomonas bacteria infection
US6844125B2 (en) 2003-03-20 2005-01-18 Kabushiki Kaisha Toshiba Combination of developing agents, image forming apparatus, and method for forming image
US7332334B2 (en) 2003-04-18 2008-02-19 Oklahoma Medical Research Foundation Hematopoietic stem cells treated by in vitro fucosylation and methods of use
US20040219158A1 (en) 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7772192B2 (en) 2003-06-03 2010-08-10 The Regents Of The University Of California Compositions and methods for treatment of disease with acetylated disaccharides
US20050054614A1 (en) 2003-08-14 2005-03-10 Diacovo Thomas G. Methods of inhibiting leukocyte accumulation
US7041226B2 (en) 2003-11-04 2006-05-09 Lexmark International, Inc. Methods for improving flow through fluidic channels
WO2005046597A2 (en) 2003-11-07 2005-05-26 Brigham And Womens's Hospital, Inc. Antibodies to cd44 glycoforms and uses thereof
WO2005051920A2 (en) 2003-11-19 2005-06-09 Glycomimetics, Inc. Specific antagonist for both e- and p-selectins
US20050187171A1 (en) 2003-11-19 2005-08-25 Glycomimetics, Inc. Glycomimetic antagonists for both E-and P-selectins
ES2300877T3 (es) 2003-12-18 2008-06-16 Unibioscreen S.A. Derivados de esteroides glucosilados con actividad antimigratoria.
BRPI0417750A (pt) 2003-12-23 2007-04-10 Progen Ind Ltd composto da fórmula; composição farmacêutica ou veterinária; uso do composto, e método para prevenção e tratamento na área de glicosaminoglicano (gag) miméticos
GB0404434D0 (en) 2004-02-27 2004-03-31 Novartis Ag Organic compounds
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
SE0401301D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
WO2005116088A2 (en) 2004-05-25 2005-12-08 The Johns Hopkins University Methods and compositions for treating diseases and disorders associated with siglec-8 expressing cells
WO2006002382A2 (en) 2004-06-24 2006-01-05 The Scripps Research Institute Arrays with cleavable linkers
WO2006017180A2 (en) 2004-07-09 2006-02-16 Progenics Pharmaceuticals, Inc. Glycopeptide dimers and uses thereof
TW200616968A (en) 2004-08-27 2006-06-01 Ono Pharmaceutical Co Compound having basic substituent and application thereof
WO2006062946A2 (en) 2004-12-06 2006-06-15 University Of Florida Research Foundation, Inc. Incorporation of bone marrow derived stem cells in tumors
US8008312B2 (en) 2005-01-07 2011-08-30 Emory University CXCR4 antagonists for the treatment of HIV infection
RU2007130077A (ru) 2005-01-07 2009-02-20 Эмори Юниверсити (Us) Антагонисты cxcr4 и их применение для лечения вич-инфекции
US20080287469A1 (en) 2005-02-17 2008-11-20 Diacovo Thomas G Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation
WO2006105019A1 (en) 2005-03-25 2006-10-05 Wisconsin Alumni Research Foundation Compounds and methods for treating seizure disorders
ES2334708T3 (es) 2005-05-04 2010-03-15 F. Hoffmann-La Roche Ag (3,4-dihidro-quinazolin-2-il)-(2-ariloxi-etil)-aminas que tienen una actividad sobre el receptor 5-ht.
US20090036386A1 (en) 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
US7504515B2 (en) 2005-05-26 2009-03-17 Vertex Pharmaceuticals Incorporated Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4- (oxazol-5-yl)phenyl) ureido)phenyl) ethylcarbamate
US20060287253A1 (en) 2005-06-17 2006-12-21 Kriegler Steven M Compounds and methods for treating seizure disorders
JP2009507209A (ja) 2005-07-22 2009-02-19 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア ヘパリン組成物およびセレクチン阻害
AU2006280101B2 (en) 2005-08-09 2012-06-28 Glycomimetics, Inc. Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
JP2009504184A (ja) 2005-08-15 2009-02-05 ザ・スクリプス・リサーチ・インステイチユート コレステロールオゾン化産物の作用の相殺によるアテローム性動脈硬化症の治療および予防のために有用な治療薬を同定する方法
US20080234294A1 (en) 2005-08-18 2008-09-25 Novartis Ag Cxcr4 Binding Molecules
EP2264043B1 (en) 2005-09-02 2017-11-08 GlycoMimetics, Inc. Heterobifunctional pan-selectin inhibitors
CA2663633A1 (en) 2005-09-14 2007-03-22 Lai-Xi Wang Synthetic polyvalent carbohydrates as components of microbicides
WO2007106886A2 (en) 2006-03-15 2007-09-20 Trustees Of Tufts College Fluorinated carbohydrates and their use in tumor visualization, tissue engineering, and cancer chemotherapy
WO2007143052A1 (en) 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
WO2007146188A2 (en) 2006-06-07 2007-12-21 The Board Of Trustees Of The Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
WO2008002449A2 (en) 2006-06-23 2008-01-03 Glycomimetics, Inc. Glycomimetic inhibitors of siglec-8
WO2008008852A2 (en) 2006-07-11 2008-01-17 Emory University Cxcr4 antagonists including heteroatoms for the treatment of medical disorders
US20080227799A1 (en) 2006-07-11 2008-09-18 Liotta Dennis C CXCR4 Antagonists Including Heteroatoms for the Treatment of Medical Disorders
JP2009543802A (ja) 2006-07-11 2009-12-10 エモリー・ユニバーシテイ 医学的疾患の治療のためのジアジン及びトリアジン構造を含むｃｘｃｒ４アンタゴニスト
WO2008011094A2 (en) 2006-07-18 2008-01-24 Robert Sackstein Cytokine induction of selectin ligands on cells
GB0614947D0 (en) 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
JP5298020B2 (ja) 2006-10-12 2013-09-25 グリコミメティクス， インコーポレイテッド ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換
US20080306098A1 (en) 2006-11-06 2008-12-11 Mutz Mitchell W Pharmacokinetics of protease inhibitors and other drugs
US20100145032A1 (en) 2007-01-18 2010-06-10 Suomen Punainen Risti, Veripalelu Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof
WO2008100453A1 (en) 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
EP1964846A1 (en) 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
US20080261978A1 (en) 2007-03-08 2008-10-23 Clark Michael P Chemokine receptor modulators
US20090054334A1 (en) 2007-05-23 2009-02-26 Mutz Mitchell W Combinatorial improvement of bifunctional drug properties
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
EP2184349A4 (en) 2007-08-08 2011-10-26 Kyowa Hakko Kirin Co Ltd ISOLATED CELL MASS
EP2211913A4 (en) 2007-10-12 2010-12-22 Transmolecular Inc SYSTEMIC ADMINISTRATION OF CHLOROTOXIN AGENTS FOR THE DIAGNOSIS AND TREATMENT OF TUMORS
FI20070853A0 (fi) 2007-11-09 2007-11-09 Glykos Finland Oy Glykaania sitovat monoklonaaliset vasta-aineet
US9486497B2 (en) 2007-12-10 2016-11-08 The University Of Queensland Treatment of immunocompromised conditions
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
JP5706815B2 (ja) 2008-04-08 2015-04-22 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ トリテルペンであるサポニン、その合成法および使用
ES2611206T3 (es) 2008-05-16 2017-05-05 Galecto Biotech Ab Derivados de di-(3-deoxi-3-1H-1,2,3-triazol-1-il)-beta-D-galacto-iranosil)sulfano como inhibidores de galectina-3
CN102088983B (zh) 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
WO2010025416A1 (en) 2008-08-29 2010-03-04 Genzyme Corporation Cxcr4 antagonists for kidney injury
WO2010040710A1 (en) 2008-10-08 2010-04-15 Wittycell Vaccine composition for use against influenza
US20100240773A1 (en) 2009-03-23 2010-09-23 Kenneth Korzekwa Multifunctional linkers
FI20095459A0 (fi) 2009-04-24 2009-04-24 Suomen Punainen Risti Veripalv Uusia määritysmenetelmiä
WO2010126435A1 (en) 2009-04-28 2010-11-04 Forskarpatent I Syd Ab Novel galactoside inhibitors of galectins
US8410066B2 (en) 2009-05-01 2013-04-02 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
WO2010132315A1 (en) 2009-05-13 2010-11-18 Endgenitor Technologies, Inc. Enhanced hematopoietic stem cell engraftment
WO2011002673A1 (en) 2009-07-01 2011-01-06 Temple University - Of The Commonwealth System Of Higher Education Leptin agonist and methods of use
WO2011019419A1 (en) 2009-08-11 2011-02-17 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Carbohydrate-mediated tumor targeting
WO2011120314A1 (zh) 2010-04-02 2011-10-06 西安交通大学 一种作为抗肿瘤药物的联苯化合物及其制备方法
AU2011237629B2 (en) 2010-04-07 2015-09-17 Glycomimetics, Inc. Glycomimetic compounds and methods to inhibit infection by HIV
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
US20130261070A1 (en) 2010-10-04 2013-10-03 John L. Magnani Anti-epileptogenic agents
FI20106031A0 (fi) 2010-10-06 2010-10-06 Suomen Punainen Risti Veripalv Menetelmä solujen eristämiseksi ja menetelmällä eristetty solupopulaatio
WO2012061662A1 (en) * 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
US9243021B2 (en) 2012-10-31 2016-01-26 Galecto Biotech Ab Galactoside inhibitor of galectins
WO2012151576A1 (en) 2011-05-05 2012-11-08 Robert Sackstein Methods of treating complications and disorders associated with g-csf administration
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
EP2620443A1 (en) 2012-01-25 2013-07-31 Galecto Biotech AB Novel galactoside inhibitors of galectins
WO2013170985A1 (en) 2012-05-18 2013-11-21 Boettger Erik C New aminoglycoside antibiotics targeting bacterial 16s ribosomal rna lacking ototoxicity
EP2859112A4 (en) 2012-06-08 2015-10-28 Glycom As PROCESS FOR THE PREPARATION OF OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION
US9238644B2 (en) 2012-08-17 2016-01-19 Cancer Therapeutics Crc Pty Limited VEGFR3 inhibitors
GB201214736D0 (en) 2012-08-17 2012-10-03 Isis Innovation Inflammation imaging and therapy
RS64329B1 (sr) 2012-10-23 2023-08-31 Synaffix Bv Modifikovano antitelo, konjugat antitela i postupak za njihovo pripremanje
CA2888527A1 (en) 2012-10-31 2014-05-08 Glycomimetics, Inc. E-selectin antagonists compounds and methods of use
CA2884802A1 (en) 2012-10-31 2014-05-08 Galecto Biotech Ab Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis
JP6366598B2 (ja) 2012-11-15 2018-08-01 タフツ ユニバーシティー ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット
ES2668045T3 (es) * 2012-12-07 2018-05-16 Glycomimetics, Inc. Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas
GB2511137A (en) 2013-02-26 2014-08-27 Glykos Finland Oy Chelator Molecule
WO2014153009A2 (en) 2013-03-14 2014-09-25 The Regents Of The University Of California, A California Corporation Thiosaccharide mucolytic agents
WO2014149837A1 (en) 2013-03-15 2014-09-25 Glycomimetics, Inc. Compounds and methods to enhance the oral availability of glycomimetics
WO2014177771A1 (en) 2013-05-02 2014-11-06 Glykos Finland Oy Conjugates of a glycoprotein or a glycan with a toxic payload
WO2015019284A2 (en) 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
CA2925119A1 (en) 2013-09-30 2015-04-02 Glycomimetics, Inc. Methods and compositions for treating and/or preventing mucositis
US20160333043A1 (en) 2014-01-17 2016-11-17 Glycomimetics, Inc. E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose
US20170095496A1 (en) 2014-04-08 2017-04-06 Galecto Biotech Ab Galactoside inhibitors for new uses
FR3020952B1 (fr) 2014-05-14 2017-09-08 Adocia Formulation a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique
CN106460024B (zh) 2014-06-27 2021-10-01 格礼卡姆股份公司 寡糖的制备
EP3415522A1 (en) 2014-07-09 2018-12-19 Galecto Biotech AB Novel hybrid galactoside inhibitor of galectins
CA2961672A1 (en) 2014-09-19 2016-03-24 Emory University Saccharide analogs and agents for the diagnosis and therapy of bacterial infections
US10519181B2 (en) 2014-12-03 2019-12-31 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
EP3245216B1 (en) 2015-01-16 2019-12-11 Galecto Biotech AB Novel galactoside inhibitor of galectins
US10774102B2 (en) * 2015-01-30 2020-09-15 Galecto Biotech Ab Galactoside inhibitor of galectins
WO2016164394A1 (en) 2015-04-08 2016-10-13 Glycomimetics, Inc. 2-halo-galactose-containing selectin antagonists
WO2016180483A1 (en) 2015-05-12 2016-11-17 Galecto Biotech Ab Once-daily treatment of pulmonary fibrosis
WO2017019770A1 (en) 2015-07-27 2017-02-02 Wayne State University Compositions and methods relating to galectin detection
JP2018522040A (ja) 2015-08-03 2018-08-09 グリコミメティクス， インコーポレイテッド 増強された再構成能および寿命を有するｔ細胞の動員および使用のための方法
JP6892859B2 (ja) 2015-11-09 2021-06-23 ガレクト・バイオテック・エイビイ 新規ガラクトシドによるガレクチン阻害剤
WO2017095904A1 (en) * 2015-12-02 2017-06-08 Glycomimetics, Inc. Heterobifunctional pan-selectin antagonists having a triazole linker
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
EP3522931A1 (en) 2016-10-07 2019-08-14 GlycoMimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体

Similar Documents

Publication Publication Date Title
JP2021508697A5 (cg-RX-API-DMAC7.html)
JP2020510054A5 (cg-RX-API-DMAC7.html)
JP2019529518A5 (cg-RX-API-DMAC7.html)
JP2020528889A5 (cg-RX-API-DMAC7.html)
JP2019518766A5 (cg-RX-API-DMAC7.html)
JP2020164547A5 (cg-RX-API-DMAC7.html)
JP2019519598A5 (cg-RX-API-DMAC7.html)
RU2017112048A (ru) Синергистические комбинации ауристана
JP2019518071A5 (cg-RX-API-DMAC7.html)
JP2020506951A5 (cg-RX-API-DMAC7.html)
JP2014525464A5 (cg-RX-API-DMAC7.html)
JP2019514882A5 (cg-RX-API-DMAC7.html)
JP2016506916A5 (cg-RX-API-DMAC7.html)
JP2019515952A5 (cg-RX-API-DMAC7.html)
JP2019501204A5 (cg-RX-API-DMAC7.html)
JP2019529444A5 (cg-RX-API-DMAC7.html)
JP2019504898A5 (cg-RX-API-DMAC7.html)
JP2014533699A5 (cg-RX-API-DMAC7.html)
JP2010540556A5 (cg-RX-API-DMAC7.html)
US20200297693A1 (en) Glucose conjugates of triptolide, analogs and uses thereof
JP2020097631A5 (cg-RX-API-DMAC7.html)
JP2007508238A5 (cg-RX-API-DMAC7.html)
JP2012509279A5 (cg-RX-API-DMAC7.html)
JP2012526766A5 (cg-RX-API-DMAC7.html)
JP2009541225A5 (cg-RX-API-DMAC7.html)