|
WO1993013101A1
(fr)
|
1991-12-27 |
1993-07-08 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
|
|
WO1998017276A1
(en)
|
1996-10-25 |
1998-04-30 |
Merck & Co., Inc. |
Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
|
|
DE69940958D1
(de)
|
1998-12-23 |
2009-07-16 |
Glaxo Group Ltd |
Bestimmungsmethode fur liganden der nuklearen rezeptoren
|
|
ATE381542T1
(de)
|
2001-08-13 |
2008-01-15 |
Phenex Pharmaceuticals Ag |
Nr1h4-kern-rezeptor-bindende verbindungen
|
|
WO2004048349A1
(en)
|
2002-11-22 |
2004-06-10 |
Smithkline Beecham Corporation |
Farnesoid x receptor agonists
|
|
WO2006006490A1
(ja)
|
2004-07-08 |
2006-01-19 |
Ono Pharmaceutical Co., Ltd. |
スピロ化合物
|
|
WO2007076260A2
(en)
|
2005-12-19 |
2007-07-05 |
Smithkline Beecham Corporation |
Farnesoid x receptor agonists
|
|
CA2640476A1
(en)
|
2006-02-03 |
2007-08-16 |
Eli Lilly And Company |
Compounds and methods for modulating fx-receptors
|
|
TW200812982A
(en)
|
2006-05-24 |
2008-03-16 |
Lilly Co Eli |
Compounds and methods for modulating FXR
|
|
CN101448791B
(zh)
|
2006-05-24 |
2011-11-16 |
伊莱利利公司 |
Fxr激动剂
|
|
EP1894924A1
(en)
|
2006-08-29 |
2008-03-05 |
Phenex Pharmaceuticals AG |
Heterocyclic FXR binding compounds
|
|
EP1894928A1
(en)
|
2006-08-29 |
2008-03-05 |
PheneX Pharmaceuticals AG |
Heterocyclic fxr binding compounds
|
|
CL2007003035A1
(es)
|
2006-10-24 |
2008-05-16 |
Smithkline Beechman Corp |
Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos,
|
|
EP2108017A2
(en)
|
2007-01-30 |
2009-10-14 |
Biogen Idec MA, Inc. |
Imidazolone compounds as tgf-beta family type i receptors, alk5 and/or alk4 antagonists
|
|
KR20100038102A
(ko)
|
2007-06-13 |
2010-04-12 |
글락소스미스클라인 엘엘씨 |
파네소이드 ｘ 수용체 작용제
|
|
MX2009013946A
(es)
|
2007-07-02 |
2010-03-10 |
Glaxosmithkline Llc |
Agonistas del receptor de farnesoide x.
|
|
WO2009009059A1
(en)
|
2007-07-09 |
2009-01-15 |
Biogen Idec Ma Inc. |
Spiro compounds as antagonists of tgf-beta
|
|
TW200906823A
(en)
|
2007-07-16 |
2009-02-16 |
Lilly Co Eli |
Compounds and methods for modulating FXR
|
|
CN101910151A
(zh)
|
2007-10-22 |
2010-12-08 |
先灵公司 |
双环杂环衍生物及其作为gpr119活性调节剂的用途
|
|
EP2128158A1
(en)
|
2008-05-26 |
2009-12-02 |
Phenex Pharmaceuticals AG |
Heterocyclic cyclopropyl-substituted FXR binding compounds
|
|
US20110230493A1
(en)
|
2008-11-21 |
2011-09-22 |
Pfizer Inc. |
1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide Compounds as FAAH Inhibitors
|
|
EP2289883A1
(en)
|
2009-08-19 |
2011-03-02 |
Phenex Pharmaceuticals AG |
Novel FXR (NR1H4) binding and activity modulating compounds
|
|
US8440710B2
(en)
|
2009-10-15 |
2013-05-14 |
Hoffmann-La Roche Inc. |
HSL inhibitors useful in the treatment of diabetes
|
|
WO2012087521A1
(en)
|
2010-12-20 |
2012-06-28 |
Irm Llc |
Compositions and methods for modulating farnesoid x receptors
|
|
EP2655368A1
(en)
*
|
2010-12-20 |
2013-10-30 |
Irm Llc |
Compositions and methods for modulating farnesoid x receptors
|
|
CU24152B1
(es)
*
|
2010-12-20 |
2016-02-29 |
Irm Llc |
1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
|
|
EP2545964A1
(en)
|
2011-07-13 |
2013-01-16 |
Phenex Pharmaceuticals AG |
Novel FXR (NR1H4) binding and activity modulating compounds
|
|
IN2014DN09346A
(https=)
|
2012-06-13 |
2015-07-17 |
Hoffmann La Roche |
|
|
EP2903985A1
(en)
|
2012-10-03 |
2015-08-12 |
Advinus Therapeutics Limited |
Spirocyclic compounds, compositions and medicinal applications thereof
|
|
EP3034501A1
(en)
*
|
2014-12-17 |
2016-06-22 |
Gilead Sciences, Inc. |
Hydroxy containing FXR (NR1H4) modulating compounds
|
|
EP3034499A1
(en)
|
2014-12-17 |
2016-06-22 |
Gilead Sciences, Inc. |
Novel FXR (NR1H4) modulating compounds
|
|
MX2017008057A
(es)
|
2014-12-18 |
2017-09-28 |
Novartis Ag |
Derivados de azabiciclooctano como agonistas de fxr para el uso en el tratamiento de enfermedades hepaticas y gastrointestinales.
|
|
CN106146483A
(zh)
|
2015-04-23 |
2016-11-23 |
上海迪诺医药科技有限公司 |
杂环类法尼酯衍生物x受体调节剂
|
|
CN106946867B
(zh)
*
|
2016-01-06 |
2019-11-12 |
广州市恒诺康医药科技有限公司 |
Fxr受体调节剂及其制备方法和用途
|
|
WO2017133521A1
(zh)
|
2016-02-01 |
2017-08-10 |
山东轩竹医药科技有限公司 |
Fxr受体激动剂
|
|
CN107021958A
(zh)
|
2016-02-01 |
2017-08-08 |
山东轩竹医药科技有限公司 |
Fxr受体激动剂
|
|
MX384205B
(es)
|
2016-02-22 |
2025-03-14 |
Novartis Ag |
Metodos para usar agonistas de fxr.
|
|
ES2862194T3
(es)
|
2016-02-22 |
2021-10-07 |
Novartis Ag |
Métodos para usar agonistas del FXR
|
|
US10080741B2
(en)
|
2016-04-26 |
2018-09-25 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as FXR agonists and methods of use thereof
|
|
WO2017189663A1
(en)
|
2016-04-26 |
2017-11-02 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as fxr agonists and methods of use thereof
|
|
WO2017189651A1
(en)
|
2016-04-26 |
2017-11-02 |
Enanta Pharmaceuticals, Inc. |
Isoxazole derivatives as fxr agonists and methods of use thereof
|
|
WO2017201155A1
(en)
|
2016-05-18 |
2017-11-23 |
Enanta Pharmaceuticals, Inc. |
lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
|
|
MX385718B
(es)
|
2016-06-13 |
2025-03-18 |
Gilead Sciences Inc |
Compuestos moduladores de fxr (nr1h4).
|
|
AR108711A1
(es)
|
2016-06-13 |
2018-09-19 |
Gilead Sciences Inc |
Compuestos moduladores de fxr (nr1h4)
|
|
CN108430998B
(zh)
|
2016-09-28 |
2021-07-09 |
四川科伦博泰生物医药股份有限公司 |
氮杂双环衍生物及其制备方法和用途
|
|
CN106632294A
(zh)
|
2016-12-15 |
2017-05-10 |
宁波百纳西药业有限公司 |
一种螺环化合物及其药物用途
|