JP2021501220A5

JP2021501220A5 -

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Publication number: JP2021501220A5
Authority: JP; Japan
Prior art keywords: methoxy; cyclopropyl; isoxazole; octane; bicyclo
Prior art date: 2018-10-31
Legal status : Granted

Application number

JP2020544333A

Other languages

English (en)

Japanese (ja)

Other versions

JP7212693B2 (ja

JP2021501220A (ja

Filing date

2018-10-31

Publication date

2021-11-11

2018-10-31 Application filed filed Critical

2018-10-31 Priority claimed from PCT/US2018/058315 external-priority patent/WO2019089667A1/en

2021-01-14 Publication of JP2021501220A publication Critical patent/JP2021501220A/ja

2021-11-11 Publication of JP2021501220A5 publication Critical patent/JP2021501220A5/ja

2023-01-25 Application granted granted Critical

2023-01-25 Publication of JP7212693B2 publication Critical patent/JP7212693B2/ja

Status Active legal-status Critical Current

2038-10-31 Anticipated expiration legal-status Critical

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-1 C 2-4 alquinylene Chemical group 0.000 claims 196
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 64
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 57
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 42
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 37
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 32
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 31
SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 24
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 21
229920002554 vinyl polymer Polymers 0.000 claims 21
125000001072 heteroaryl group Chemical group 0.000 claims 19
125000000217 alkyl group Chemical group 0.000 claims 18
239000005711 Benzoic acid Substances 0.000 claims 17
235000010233 benzoic acid Nutrition 0.000 claims 17
229910052760 oxygen Inorganic materials 0.000 claims 15
150000001875 compounds Chemical class 0.000 claims 14
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 14
RAYMXZBXQCGRGX-UHFFFAOYSA-N quinoline-5-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=N1 RAYMXZBXQCGRGX-UHFFFAOYSA-N 0.000 claims 14
150000003839 salts Chemical class 0.000 claims 13
239000012453 solvate Substances 0.000 claims 13
229910052717 sulfur Inorganic materials 0.000 claims 13
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 12
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 11
125000003545 alkoxy group Chemical group 0.000 claims 11
125000001188 haloalkyl group Chemical group 0.000 claims 11
125000000623 heterocyclic group Chemical group 0.000 claims 11
125000002768 hydroxyalkyl group Chemical group 0.000 claims 11
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
NDMFETHQFUOIQX-UHFFFAOYSA-N 1-(3-chloropropyl)imidazolidin-2-one Chemical compound ClCCCN1CCNC1=O NDMFETHQFUOIQX-UHFFFAOYSA-N 0.000 claims 10
125000004183 alkoxy alkyl group Chemical group 0.000 claims 10
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 10
125000004103 aminoalkyl group Chemical group 0.000 claims 10
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 10
LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 claims 10
125000003118 aryl group Chemical group 0.000 claims 9
125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 9
125000005843 halogen group Chemical group 0.000 claims 9
229910052739 hydrogen Inorganic materials 0.000 claims 9
239000001257 hydrogen Substances 0.000 claims 9
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
ORSZGLLQNYSMNO-UHFFFAOYSA-N 1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC=N2 ORSZGLLQNYSMNO-UHFFFAOYSA-N 0.000 claims 8
125000004474 heteroalkylene group Chemical group 0.000 claims 8
229910052757 nitrogen Inorganic materials 0.000 claims 8
229940081066 picolinic acid Drugs 0.000 claims 8
125000002947 alkylene group Chemical group 0.000 claims 7
125000004452 carbocyclyl group Chemical group 0.000 claims 7
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 7
125000004438 haloalkoxy group Chemical group 0.000 claims 7
235000019260 propionic acid Nutrition 0.000 claims 7
HMVYYTRDXNKRBQ-UHFFFAOYSA-N 1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC=N1 HMVYYTRDXNKRBQ-UHFFFAOYSA-N 0.000 claims 6
125000003282 alkyl amino group Chemical group 0.000 claims 6
NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 6
239000008194 pharmaceutical composition Substances 0.000 claims 6
NIPZZXUFJPQHNH-UHFFFAOYSA-N pyrazine-2-carboxylic acid Chemical compound OC(=O)C1=CN=CC=N1 NIPZZXUFJPQHNH-UHFFFAOYSA-N 0.000 claims 6
NAXDZGAMYZVHKL-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CN=1 NAXDZGAMYZVHKL-UHFFFAOYSA-N 0.000 claims 5
JMBRGSSMPFVXEZ-UHFFFAOYSA-N bicyclo[2.2.2]octane-4-carboxamide Chemical compound C1CC2CCC1(C(=O)N)CC2 JMBRGSSMPFVXEZ-UHFFFAOYSA-N 0.000 claims 5
125000004076 pyridyl group Chemical group 0.000 claims 5
125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 4
DMPZJACLHDWUFS-UHFFFAOYSA-N 1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC=C2N=CSC2=C1 DMPZJACLHDWUFS-UHFFFAOYSA-N 0.000 claims 4
FWZOJLZJEACICV-UHFFFAOYSA-N 2-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=C1SC(=N2)C12CCC(CC1)(CC2)C=CC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 FWZOJLZJEACICV-UHFFFAOYSA-N 0.000 claims 4
PVGLYQXOHNMBFM-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=CC=1)OC PVGLYQXOHNMBFM-UHFFFAOYSA-N 0.000 claims 4
QNCUSMLZWUPDEV-UHFFFAOYSA-N 4-[5-[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)C=CC12CCC(CC1)(C2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 QNCUSMLZWUPDEV-UHFFFAOYSA-N 0.000 claims 4
YCAPXSMYWUQRGA-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-6-methoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC(=C1)OC)C(=O)O YCAPXSMYWUQRGA-UHFFFAOYSA-N 0.000 claims 4
FCASJJSUWLUYHQ-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=NC=C(C(=O)O)C=C1 FCASJJSUWLUYHQ-UHFFFAOYSA-N 0.000 claims 4
206010016654 Fibrosis Diseases 0.000 claims 4
YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims 4
230000004761 fibrosis Effects 0.000 claims 4
125000005842 heteroatom Chemical group 0.000 claims 4
TUKDVVKJZVLVTD-UHFFFAOYSA-N imidazo[1,2-a]pyridine-7-carboxylic acid Chemical compound C1=C(C(=O)O)C=CN2C=CN=C21 TUKDVVKJZVLVTD-UHFFFAOYSA-N 0.000 claims 4
WHOCKNWCRFHEMH-UHFFFAOYSA-N imidazo[1,2-a]pyridine-8-carboxylic acid Chemical compound OC(=O)C1=CC=CN2C=CN=C12 WHOCKNWCRFHEMH-UHFFFAOYSA-N 0.000 claims 4
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 4
208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
HRSDPDBQVZHCRC-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine-3-carboxylic acid Chemical compound C1=CC=CC2=C(C(=O)O)C=NN21 HRSDPDBQVZHCRC-UHFFFAOYSA-N 0.000 claims 4
MJLYHUGEXSTFAI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F MJLYHUGEXSTFAI-UHFFFAOYSA-N 0.000 claims 3
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
MRAAWNFQBGUXFU-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=NC=C(C(=O)O)C=1 MRAAWNFQBGUXFU-UHFFFAOYSA-N 0.000 claims 3
125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 3
239000002253 acid Substances 0.000 claims 3
229910052799 carbon Inorganic materials 0.000 claims 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
125000000753 cycloalkyl group Chemical group 0.000 claims 3
235000001968 nicotinic acid Nutrition 0.000 claims 3
239000011664 nicotinic acid Substances 0.000 claims 3
206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 3
125000003566 oxetanyl group Chemical group 0.000 claims 3
125000004043 oxo group Chemical group O=* 0.000 claims 3
125000003226 pyrazolyl group Chemical group 0.000 claims 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
GZJDYOXXKYAXMN-UHFFFAOYSA-N 1,3-benzothiazole-7-carboxamide Chemical compound NC(=O)C1=CC=CC2=C1SC=N2 GZJDYOXXKYAXMN-UHFFFAOYSA-N 0.000 claims 2
MIKSITSFBHXCLH-UHFFFAOYSA-N 1-[3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1C=C(C=CC=1)C1(CC1)C(=O)O)O MIKSITSFBHXCLH-UHFFFAOYSA-N 0.000 claims 2
GIKNQEQASOSMSW-UHFFFAOYSA-N 1-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]-5-(difluoromethyl)pyrazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1N=CC(=C1C(F)F)C(=O)O GIKNQEQASOSMSW-UHFFFAOYSA-N 0.000 claims 2
KNOCEIYOPWHYEO-UHFFFAOYSA-N 1-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]pyrazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1N=CC(=C1)C(=O)O KNOCEIYOPWHYEO-UHFFFAOYSA-N 0.000 claims 2
WTHSRRCOVIDHTL-AATRIKPKSA-N 1-chloro-7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(Cl)=N1 WTHSRRCOVIDHTL-AATRIKPKSA-N 0.000 claims 2
QVJYKNGWBFDKHY-MDZDMXLPSA-N 1-cyclopentyloxy-7-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]isoquinoline-3-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CCCC2)=N1 QVJYKNGWBFDKHY-MDZDMXLPSA-N 0.000 claims 2
MBGAXGKHADNKCF-UHFFFAOYSA-N 1-cyclopropyl-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=NN(C2CC2)C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 MBGAXGKHADNKCF-UHFFFAOYSA-N 0.000 claims 2
XXCHIJLFLLIORN-UHFFFAOYSA-N 2-[2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]phenyl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=C(C=CC=C1)CC(=O)O XXCHIJLFLLIORN-UHFFFAOYSA-N 0.000 claims 2
HYRHTCHZQGGIKB-UHFFFAOYSA-N 2-[2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridin-4-yl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=CC(=C1)CC(=O)O HYRHTCHZQGGIKB-UHFFFAOYSA-N 0.000 claims 2
FGCVFKBIRAIUQW-UHFFFAOYSA-N 2-[3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]phenyl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C=CC=1)CC(=O)O FGCVFKBIRAIUQW-UHFFFAOYSA-N 0.000 claims 2
XFLKGOONVOYBFA-HWKANZROSA-N 2-[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridin-2-yl]oxyacetic acid Chemical compound OC(=O)COC1=NC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 XFLKGOONVOYBFA-HWKANZROSA-N 0.000 claims 2
FJKTYOCVARPTJW-CMDGGOBGSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O FJKTYOCVARPTJW-CMDGGOBGSA-N 0.000 claims 2
KUYRKEJGTQEKGR-AATRIKPKSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O KUYRKEJGTQEKGR-AATRIKPKSA-N 0.000 claims 2
ZKPKAYSICPSPTO-VOTSOKGWSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O ZKPKAYSICPSPTO-VOTSOKGWSA-N 0.000 claims 2
PTJCDGHSTQTFSN-ONEGZZNKSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC=C(N=1)C(=O)O PTJCDGHSTQTFSN-ONEGZZNKSA-N 0.000 claims 2
JQQWRDCKPWBLAV-SNAWJCMRSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC(=C(N=1)C)C(=O)O JQQWRDCKPWBLAV-SNAWJCMRSA-N 0.000 claims 2
SKBPSMAZVQMNKE-ONEGZZNKSA-N 2-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=C(C=C2C(=O)O)C(F)(F)F SKBPSMAZVQMNKE-ONEGZZNKSA-N 0.000 claims 2
FJKTYOCVARPTJW-HJWRWDBZSA-N 2-[4-[(Z)-2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)\C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O FJKTYOCVARPTJW-HJWRWDBZSA-N 0.000 claims 2
FWZOJLZJEACICV-KTKRTIGZSA-N 2-[4-[(Z)-2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)\C=C/C12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O FWZOJLZJEACICV-KTKRTIGZSA-N 0.000 claims 2
LIEOVZYAUKNHAY-ZHACJKMWSA-N 2-[4-[4-[(E)-2-[3-(3-chloro-5-methoxypyridin-4-yl)-5-cyclopropyl-1,2-oxazol-4-yl]ethenyl]-2-oxabicyclo[2.2.2]octan-1-yl]phenyl]-2-methylpropanoic acid Chemical compound ClC=1C=NC=C(C=1C1=NOC(=C1/C=C/C12COC(CC1)(CC2)C1=CC=C(C=C1)C(C(=O)O)(C)C)C1CC1)OC LIEOVZYAUKNHAY-ZHACJKMWSA-N 0.000 claims 2
IRHZURAXYGPNPQ-BUHFOSPRSA-N 2-[4-[4-[(E)-2-[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]ethenyl]-2-oxabicyclo[2.2.2]octan-1-yl]phenyl]-2-methylpropanamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)/C=C/C12COC(CC1)(CC2)C1=CC=C(C=C1)C(C(=O)N)(C)C IRHZURAXYGPNPQ-BUHFOSPRSA-N 0.000 claims 2
YSZGMJHOCCDXMA-BUHFOSPRSA-N 2-[4-[4-[(E)-2-[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]ethenyl]-2-oxabicyclo[2.2.2]octan-1-yl]phenyl]-2-methylpropanenitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)/C=C/C12COC(CC1)(CC2)C1=CC=C(C=C1)C(C#N)(C)C YSZGMJHOCCDXMA-BUHFOSPRSA-N 0.000 claims 2
LTXMRHLVRKYATJ-BUHFOSPRSA-N 2-[4-[4-[(E)-2-[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]ethenyl]-2-oxabicyclo[2.2.2]octan-1-yl]phenyl]-2-methylpropanoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)/C=C/C12COC(CC1)(CC2)C1=CC=C(C=C1)C(C(=O)O)(C)C LTXMRHLVRKYATJ-BUHFOSPRSA-N 0.000 claims 2
FNMVSJWDWYCICG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,2-difluoro-1-methylcyclopropyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1(C(C1)(F)F)C)COC12CCC(CC1)(CC2)C1=NC=2C=CC=C(C=2C=C1)C(=O)O FNMVSJWDWYCICG-UHFFFAOYSA-N 0.000 claims 2
GRWMHEKFBZLRJM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(S2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 GRWMHEKFBZLRJM-UHFFFAOYSA-N 0.000 claims 2
BJKMSEZRHFONSI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-3H-benzimidazole-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC2=C(N1)C=CC(=C2)C(=O)O BJKMSEZRHFONSI-UHFFFAOYSA-N 0.000 claims 2
CFLWZKKOSLLPFS-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]pyridine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1C=C(C(=O)O)C=CN=1 CFLWZKKOSLLPFS-UHFFFAOYSA-N 0.000 claims 2
VJSAXAGDGVUHLQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12COC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O VJSAXAGDGVUHLQ-UHFFFAOYSA-N 0.000 claims 2
GXWUJQPIBXQGMQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC=2C=CC=C(C=2CC1)C(=O)O GXWUJQPIBXQGMQ-UHFFFAOYSA-N 0.000 claims 2
WLLQLLQIMFKEHZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC2=CC=C(C=C2CC1)C(=O)O WLLQLLQIMFKEHZ-UHFFFAOYSA-N 0.000 claims 2
ZBRXAPRGIYZWBP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]bicyclo[2.2.2]octane-1-carbonyl]-3,4-dihydro-1H-isoquinoline-8-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(=O)N1CC2=C(C=CC=C2CC1)C(=O)O ZBRXAPRGIYZWBP-UHFFFAOYSA-N 0.000 claims 2
UGALHDBBHDUBMX-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O UGALHDBBHDUBMX-UHFFFAOYSA-N 0.000 claims 2
OKIYJIPJCMIEJY-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC=C2C(=O)O OKIYJIPJCMIEJY-UHFFFAOYSA-N 0.000 claims 2
ZSSCUJNLDKCRQQ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-benzoxazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1OC2=C(N=1)C=CC(=C2)C(=O)O ZSSCUJNLDKCRQQ-UHFFFAOYSA-N 0.000 claims 2
SGUJKFFAWLLIGZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-oxazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1OC=C(N=1)C(=O)O SGUJKFFAWLLIGZ-UHFFFAOYSA-N 0.000 claims 2
PNYIICMNDMXEGB-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC=C(N=1)C(=O)O PNYIICMNDMXEGB-UHFFFAOYSA-N 0.000 claims 2
CYCLZAVSVDDBDM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C=1SC(=C(N=1)C)C(=O)O CYCLZAVSVDDBDM-UHFFFAOYSA-N 0.000 claims 2
YXVSTHAINMSHLT-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(=N1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 YXVSTHAINMSHLT-UHFFFAOYSA-N 0.000 claims 2
DIOMJYZUMUEJOD-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F DIOMJYZUMUEJOD-UHFFFAOYSA-N 0.000 claims 2
XKJVRZKELVRCDG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=C(C=C2C(=O)O)C(F)(F)F XKJVRZKELVRCDG-UHFFFAOYSA-N 0.000 claims 2
BGRBSSFDFYXYPH-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-5-(trifluoromethyl)quinoline-7-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=CC(=N2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=C1)C(F)(F)F BGRBSSFDFYXYPH-UHFFFAOYSA-N 0.000 claims 2
DXUBXDHUOMYKBZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-fluoro-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2C(=O)O)F DXUBXDHUOMYKBZ-UHFFFAOYSA-N 0.000 claims 2
VZLGSTKSUYAQNZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-6-methoxyquinoline-5-carboxylic acid Chemical compound COC1=C(C(O)=O)C2=C(C=C1)N=C(C=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 VZLGSTKSUYAQNZ-UHFFFAOYSA-N 0.000 claims 2
WZDQHEVIWLCSLF-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-7-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC(=CC2=C1C=CC(=N2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F WZDQHEVIWLCSLF-UHFFFAOYSA-N 0.000 claims 2
FKBKIWNUCUBWAN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(2-hydroxy-2-methylpropoxy)quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=2C(=CC=C(C=2C=C1)C(=O)O)OCC(C)(C)O FKBKIWNUCUBWAN-UHFFFAOYSA-N 0.000 claims 2
KUDDWIOSXRMZPP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(3-methoxypropoxy)quinoline-6-carboxylic acid Chemical compound COCCCOC1=CC(=CC2=C1N=C(C=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(O)=O KUDDWIOSXRMZPP-UHFFFAOYSA-N 0.000 claims 2
ISQFLTCJDFBHHA-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(4-methylpiperazin-1-yl)quinoline-5-carboxylic acid Chemical compound CN1CCN(CC1)C1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ISQFLTCJDFBHHA-UHFFFAOYSA-N 0.000 claims 2
YULOLRRJARARHD-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(cyclopropylmethoxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OCC2CC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 YULOLRRJARARHD-UHFFFAOYSA-N 0.000 claims 2
MTNUKQZXOCAOIR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxan-4-yloxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2CCOCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 MTNUKQZXOCAOIR-UHFFFAOYSA-N 0.000 claims 2
AXJWXWHTELKSOZ-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxetan-3-yloxy)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(OC2COC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 AXJWXWHTELKSOZ-UHFFFAOYSA-N 0.000 claims 2
FHBSBBXQLLGBBP-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxetan-3-yloxy)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2COC2)=C1 FHBSBBXQLLGBBP-UHFFFAOYSA-N 0.000 claims 2
MEPPIPGTOKSMRR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(oxolan-3-yloxy)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(C=C2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2CCOC2)=C1 MEPPIPGTOKSMRR-UHFFFAOYSA-N 0.000 claims 2
OIRVTLYUXMHOIV-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C(F)(F)F OIRVTLYUXMHOIV-UHFFFAOYSA-N 0.000 claims 2
PGZFNBBQFNMPQR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=CC=C(N=C2C(=C1)C(F)(F)F)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 PGZFNBBQFNMPQR-UHFFFAOYSA-N 0.000 claims 2
WPYWIOPLTFLQGN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-fluoroquinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=CC=C(N=C2C(F)=C1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WPYWIOPLTFLQGN-UHFFFAOYSA-N 0.000 claims 2
SIRVQDTVVSUCLG-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-hydroxyquinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(O)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 SIRVQDTVVSUCLG-UHFFFAOYSA-N 0.000 claims 2
OXVJUKFVDFFXMA-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-methoxyquinoline-5-carboxylic acid Chemical compound COC1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OXVJUKFVDFFXMA-UHFFFAOYSA-N 0.000 claims 2
OOMFPJKYLUBFCO-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-methylquinoline-5-carboxylic acid Chemical compound CC1=CC=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OOMFPJKYLUBFCO-UHFFFAOYSA-N 0.000 claims 2
PMEZLPBEMUVZTI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-propan-2-yloxyquinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=2C(=CC=C(C=2C=C1)C(=O)O)OC(C)C PMEZLPBEMUVZTI-UHFFFAOYSA-N 0.000 claims 2
WAMGLBALJXEOHI-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-pyrrolidin-1-ylquinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=C(N2CCCC2)C2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 WAMGLBALJXEOHI-UHFFFAOYSA-N 0.000 claims 2
UDSKFKJXXCUHST-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinoline-5-carboxylic acid Chemical compound OC(=O)C1=CC=CC2=NC(=CC=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 UDSKFKJXXCUHST-UHFFFAOYSA-N 0.000 claims 2
FOYMVMLVLIIZOS-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-(dicyclopropylmethyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-7-(trifluoromethyl)quinoline-5-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C(C1CC1)C1CC1)COC12CCC(CC1)(CC2)C1=NC=2C=C(C=C(C=2C=C1)C(=O)O)C(F)(F)F FOYMVMLVLIIZOS-UHFFFAOYSA-N 0.000 claims 2
BSHYILBOKGIEIN-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(S2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 BSHYILBOKGIEIN-UHFFFAOYSA-N 0.000 claims 2
XMRUTTLFGJEBEM-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F XMRUTTLFGJEBEM-UHFFFAOYSA-N 0.000 claims 2
QMYDZSITTJBTTH-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]quinazoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(C=C1)N=C(N=C2)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 QMYDZSITTJBTTH-UHFFFAOYSA-N 0.000 claims 2
PXUKANRLSFFNRC-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C=1SC2=C(N=1)C=CC(=C2)C(=O)O PXUKANRLSFFNRC-UHFFFAOYSA-N 0.000 claims 2
UBJLWZIZLGZQPR-UHFFFAOYSA-N 2-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=C(S2)C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)C(F)=C1 UBJLWZIZLGZQPR-UHFFFAOYSA-N 0.000 claims 2
DLRBUARSOFLKGN-AATRIKPKSA-N 2-[5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridin-2-yl]oxyacetic acid Chemical compound OC(=O)COC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 DLRBUARSOFLKGN-AATRIKPKSA-N 0.000 claims 2
BQZVTXZADJYSTG-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]acetic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)CC(=O)O BQZVTXZADJYSTG-UHFFFAOYSA-N 0.000 claims 2
QVGDSDQMNKCFLT-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1C(C1)C(=O)O QVGDSDQMNKCFLT-UHFFFAOYSA-N 0.000 claims 2
MTBVJYHELGSHOV-UHFFFAOYSA-N 2-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1C(C1)C(=O)O MTBVJYHELGSHOV-UHFFFAOYSA-N 0.000 claims 2
ALUZIFDFSMWCNQ-BQYQJAHWSA-N 2-[[4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]phenyl]methoxy]acetic acid Chemical compound OC(=O)COCC1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 ALUZIFDFSMWCNQ-BQYQJAHWSA-N 0.000 claims 2
KCCDYUTYWQDQRI-ONEGZZNKSA-N 2-[[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluoro-1,3-benzothiazole-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)COC=1SC2=C(N=1)C=C(C=C2C(=O)O)F KCCDYUTYWQDQRI-ONEGZZNKSA-N 0.000 claims 2
QYDJRIBEWYNZSD-UHFFFAOYSA-N 2-[[4-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound OC(=O)C1=CC(F)=C2N=C(OCC34CCC(CC3)(CC4)C=CC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)SC2=C1 QYDJRIBEWYNZSD-UHFFFAOYSA-N 0.000 claims 2
BJAUQRZOTFDMFP-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C=CC(=C2)C(=O)O)O BJAUQRZOTFDMFP-UHFFFAOYSA-N 0.000 claims 2
RRMNLDUMZOJPHY-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluoro-1,3-benzothiazole-6-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C(=CC(=C2)C(=O)N)F)O RRMNLDUMZOJPHY-UHFFFAOYSA-N 0.000 claims 2
DBZIYVDYGIFKFQ-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F)O DBZIYVDYGIFKFQ-UHFFFAOYSA-N 0.000 claims 2
DKLPJMVSLOZBKB-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluoro-1,3-benzothiazole-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1SC2=C(N=1)C(=CC(=C2)C(=O)O)F DKLPJMVSLOZBKB-UHFFFAOYSA-N 0.000 claims 2
AKARZHRKWSJNCE-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrimidine-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=NC=CC(=N1)C(=O)O AKARZHRKWSJNCE-UHFFFAOYSA-N 0.000 claims 2
LQWJTXSONPLUMD-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methyl]-3,4-dihydro-1H-isoquinoline-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)CN1CC2=CC(=CC=C2CC1)C(=O)O LQWJTXSONPLUMD-UHFFFAOYSA-N 0.000 claims 2
PAOITBRBSLDZKC-UHFFFAOYSA-N 2-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]methoxy]-1,3-thiazole-4-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)COC=1SC=C(N=1)C(=O)O PAOITBRBSLDZKC-UHFFFAOYSA-N 0.000 claims 2
DMTLWRBTDNMMPU-UHFFFAOYSA-N 2-cyclopropyl-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=NN1C1CC1 DMTLWRBTDNMMPU-UHFFFAOYSA-N 0.000 claims 2
FIAVPVDRQOFMTF-MDZDMXLPSA-N 3-[(E)-2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)/C=C/C=1C=C(C(=O)O)C=CC=1 FIAVPVDRQOFMTF-MDZDMXLPSA-N 0.000 claims 2
CFTBAAHLIFHVOM-MDZDMXLPSA-N 3-[(E)-2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]ethenyl]benzoic acid Chemical compound OC(=O)C1=CC(\C=C\C23CCC(COCC4=C(ON=C4C4=C(Cl)C=CC=C4Cl)C4CC4)(CC2)CO3)=CC=C1 CFTBAAHLIFHVOM-MDZDMXLPSA-N 0.000 claims 2
TUHGQIBMTUQNRU-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-2-hydroxyethyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(CC=1C=C(C(=O)O)C=CC=1)O TUHGQIBMTUQNRU-UHFFFAOYSA-N 0.000 claims 2
XUKKVJLGZVCGLP-UHFFFAOYSA-N 3-[2-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C#CC=1C=C(C(=O)O)C=CC=1 XUKKVJLGZVCGLP-UHFFFAOYSA-N 0.000 claims 2
VMFAKWFEPOEJNC-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VMFAKWFEPOEJNC-UHFFFAOYSA-N 0.000 claims 2
OFRLZPLBXIKXMQ-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 OFRLZPLBXIKXMQ-UHFFFAOYSA-N 0.000 claims 2
BFWJNSGEBQVPJR-UHFFFAOYSA-N 3-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C=1C=C(C(=O)O)C=CC=1 BFWJNSGEBQVPJR-UHFFFAOYSA-N 0.000 claims 2
WPNCTCCEACQUDU-UHFFFAOYSA-N 3-[4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]triazol-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C=1N=NN(C=1)C=1C=C(C(=O)O)C=CC=1 WPNCTCCEACQUDU-UHFFFAOYSA-N 0.000 claims 2
LADYWUOKVAOOOU-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=CC=1 LADYWUOKVAOOOU-UHFFFAOYSA-N 0.000 claims 2
WHVBWQWYTWCBEJ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F WHVBWQWYTWCBEJ-UHFFFAOYSA-N 0.000 claims 2
WIPJOIYNJSLXMU-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-5-(trifluoromethyl)benzonitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C#N)C=C(C=1)C(F)(F)F WIPJOIYNJSLXMU-UHFFFAOYSA-N 0.000 claims 2
BONYTGCCCNCUJZ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12COC(CC1)(CC2)C=1C=C(C(=O)O)C=CC=1 BONYTGCCCNCUJZ-UHFFFAOYSA-N 0.000 claims 2
ONZMWFFNQYDXJQ-UHFFFAOYSA-N 3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound OC(=O)c1cccc(c1)C12CCC(COCc3c(onc3-c3ccccc3OC(F)(F)F)C3CC3)(CC1)CO2 ONZMWFFNQYDXJQ-UHFFFAOYSA-N 0.000 claims 2
HXULRUBKXIGJRK-UHFFFAOYSA-N 3-[5-[3-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[1.1.1]pentanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CC(C1)(C2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 HXULRUBKXIGJRK-UHFFFAOYSA-N 0.000 claims 2
ZBLAVCXWEDBPGW-BQYQJAHWSA-N 3-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=CC=1)OC ZBLAVCXWEDBPGW-BQYQJAHWSA-N 0.000 claims 2
KCKINKDKHFRCCF-ONEGZZNKSA-N 3-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F KCKINKDKHFRCCF-ONEGZZNKSA-N 0.000 claims 2
XRQLLCDZAFIYMP-ONEGZZNKSA-N 3-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)F XRQLLCDZAFIYMP-ONEGZZNKSA-N 0.000 claims 2
NPLRKCYKCYMSBD-VOTSOKGWSA-N 3-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 NPLRKCYKCYMSBD-VOTSOKGWSA-N 0.000 claims 2
MWOZFTAXBUAODT-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,6-difluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)F)F MWOZFTAXBUAODT-UHFFFAOYSA-N 0.000 claims 2
VFLGTLCZFLXKHK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VFLGTLCZFLXKHK-UHFFFAOYSA-N 0.000 claims 2
BWOXSMAZSDLVLL-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-oxadiazol-2-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NN=C(O1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 BWOXSMAZSDLVLL-UHFFFAOYSA-N 0.000 claims 2
NADGBATYYSICMD-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-thiadiazol-2-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NN=C(S1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 NADGBATYYSICMD-UHFFFAOYSA-N 0.000 claims 2
STNYJQLDNCURKZ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12COC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 STNYJQLDNCURKZ-UHFFFAOYSA-N 0.000 claims 2
KPNRGTCZVFGEMY-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 KPNRGTCZVFGEMY-UHFFFAOYSA-N 0.000 claims 2
OJDZFOAVUNYLCO-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]cuban-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12C3C4C5(C(C14)C2C53)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 OJDZFOAVUNYLCO-UHFFFAOYSA-N 0.000 claims 2
JCMOMIMABYTFMJ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)triazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(N=NN1C1=C(Cl)C=CC=C1Cl)C1CC1 JCMOMIMABYTFMJ-UHFFFAOYSA-N 0.000 claims 2
LIQADTAOIWSMRQ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2,6-difluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)F)F LIQADTAOIWSMRQ-UHFFFAOYSA-N 0.000 claims 2
KMTRQYIVCJCUDB-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-5-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=C(C=1)OC)F KMTRQYIVCJCUDB-UHFFFAOYSA-N 0.000 claims 2
XSBQAINLOLSXCK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-6-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C(=CC=1)OC)F XSBQAINLOLSXCK-UHFFFAOYSA-N 0.000 claims 2
ZSVDAFBKKBTVNK-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=CC=1)F ZSVDAFBKKBTVNK-UHFFFAOYSA-N 0.000 claims 2
BZODDLTWRLDJFC-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1F BZODDLTWRLDJFC-UHFFFAOYSA-N 0.000 claims 2
AZXOSCPIMLOMEF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1OC AZXOSCPIMLOMEF-UHFFFAOYSA-N 0.000 claims 2
URSGZIHPVYJOGW-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-fluoro-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C(=C(C(=O)O)C=C(C=1)F)OC URSGZIHPVYJOGW-UHFFFAOYSA-N 0.000 claims 2
IWHOFALWOUHSFZ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)F IWHOFALWOUHSFZ-UHFFFAOYSA-N 0.000 claims 2
DROAEAYQUOSWBU-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)OC DROAEAYQUOSWBU-UHFFFAOYSA-N 0.000 claims 2
ZNYPZGSPXJORTF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-propan-2-yloxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)OC(C)C ZNYPZGSPXJORTF-UHFFFAOYSA-N 0.000 claims 2
HFVDBDMXBCHOML-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 HFVDBDMXBCHOML-UHFFFAOYSA-N 0.000 claims 2
SKGHKCOLDJYBOG-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 SKGHKCOLDJYBOG-UHFFFAOYSA-N 0.000 claims 2
NLWIZKXHMCCCIF-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1F NLWIZKXHMCCCIF-UHFFFAOYSA-N 0.000 claims 2
NPJLZPMCBSKGOG-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-4-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1OC NPJLZPMCBSKGOG-UHFFFAOYSA-N 0.000 claims 2
ANMWGNOVKKRRFP-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=C(C=1)C(F)(F)F ANMWGNOVKKRRFP-UHFFFAOYSA-N 0.000 claims 2
KJTHTTUKYWWIQM-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-(3-fluoropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 KJTHTTUKYWWIQM-UHFFFAOYSA-N 0.000 claims 2
MCNALCXWQXEAJX-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 MCNALCXWQXEAJX-UHFFFAOYSA-N 0.000 claims 2
PXVJVPSOOURVKX-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-oxadiazol-2-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NN=C(O1)C=1C=C(C(=O)O)C=CC=1 PXVJVPSOOURVKX-UHFFFAOYSA-N 0.000 claims 2
HJHBACFCTKJTOW-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,3,4-thiadiazol-2-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NN=C(S1)C=1C=C(C(=O)O)C=CC=1 HJHBACFCTKJTOW-UHFFFAOYSA-N 0.000 claims 2
OXRWPZWNYCYSBJ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC(=CC=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=C(OC(F)(F)F)C=CC=C3)C3CC3)(CC1)CO2 OXRWPZWNYCYSBJ-UHFFFAOYSA-N 0.000 claims 2
YGCYIHIJUANYDQ-UHFFFAOYSA-N 3-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 YGCYIHIJUANYDQ-UHFFFAOYSA-N 0.000 claims 2
JKMJWOGBGIGBGG-UHFFFAOYSA-N 3-[5-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=O)O)C=CC=1 JKMJWOGBGIGBGG-UHFFFAOYSA-N 0.000 claims 2
CZMNMNVOPADVKJ-ONEGZZNKSA-N 3-[[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-5-(trifluoromethyl)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)C(F)(F)F CZMNMNVOPADVKJ-ONEGZZNKSA-N 0.000 claims 2
LYUQTVQFXODQEH-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C=1C=C(C(=O)O)C=CC=1F)O LYUQTVQFXODQEH-UHFFFAOYSA-N 0.000 claims 2
SVXNWHRRXDBJAY-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-methylbenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C(=C(C(=O)O)C=CC=1)C SVXNWHRRXDBJAY-UHFFFAOYSA-N 0.000 claims 2
GDCAJVAYZJYLTR-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-4-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1F GDCAJVAYZJYLTR-UHFFFAOYSA-N 0.000 claims 2
UOTYJVXOVGITDR-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-5-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=C(C=1)F UOTYJVXOVGITDR-UHFFFAOYSA-N 0.000 claims 2
QWCKCBLCIJXSPP-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C(=O)O)C=CC=1 QWCKCBLCIJXSPP-UHFFFAOYSA-N 0.000 claims 2
BWCRCWHVDZGJSG-UHFFFAOYSA-N 3-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzonitrile Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=C(C#N)C=CC=1 BWCRCWHVDZGJSG-UHFFFAOYSA-N 0.000 claims 2
RVNRQGDQWVLPNS-UHFFFAOYSA-N 3-cyclobutyloxy-5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=C(OC2CCC2)C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 RVNRQGDQWVLPNS-UHFFFAOYSA-N 0.000 claims 2
FGMDFCILNHZMHB-UHFFFAOYSA-N 4-(cyclobutylmethoxy)-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OCC2CCC2)=C1 FGMDFCILNHZMHB-UHFFFAOYSA-N 0.000 claims 2
MWGLJKWWPIPPFU-BQYQJAHWSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-methylindole-2-carboxylic acid Chemical compound CN1C(=CC2=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=CC=C12)C(O)=O MWGLJKWWPIPPFU-BQYQJAHWSA-N 0.000 claims 2
RSTHOGFJRGIBNW-BQYQJAHWSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]benzoic acid Chemical compound OC(=O)C1=CC=C(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=C1 RSTHOGFJRGIBNW-BQYQJAHWSA-N 0.000 claims 2
MCGUGGTZDFCMEC-HWKANZROSA-N 4-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 MCGUGGTZDFCMEC-HWKANZROSA-N 0.000 claims 2
GIWJDTCXTLGCDY-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 GIWJDTCXTLGCDY-UHFFFAOYSA-N 0.000 claims 2
ZRVBOYFDBQSGOI-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC(=NC=C1)C(=O)O ZRVBOYFDBQSGOI-UHFFFAOYSA-N 0.000 claims 2
PZVQMSBIHKPIAA-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 PZVQMSBIHKPIAA-UHFFFAOYSA-N 0.000 claims 2
WMURSFMOBYNJQS-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 WMURSFMOBYNJQS-UHFFFAOYSA-N 0.000 claims 2
CMPUCDNLNFAGBQ-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC=C(C(=O)O)C=C1 CMPUCDNLNFAGBQ-UHFFFAOYSA-N 0.000 claims 2
HTWAKCUDAAATHL-UHFFFAOYSA-N 4-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 HTWAKCUDAAATHL-UHFFFAOYSA-N 0.000 claims 2
YIYQGXGZPYLUAG-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COCC12CCC(CC1)(CC2)C1=CC=C(C(=O)O)C=C1 YIYQGXGZPYLUAG-UHFFFAOYSA-N 0.000 claims 2
OARCYHJFTQEWHN-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 OARCYHJFTQEWHN-UHFFFAOYSA-N 0.000 claims 2
WEIJCVCCSSGFFL-UHFFFAOYSA-N 4-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-8-(trifluoromethyl)quinoline-6-carboxylic acid Chemical compound OC(=O)C1=CC2=C(N=CC=C2C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(=C1)C(F)(F)F WEIJCVCCSSGFFL-UHFFFAOYSA-N 0.000 claims 2
AEJICVPURLCZSH-UHFFFAOYSA-N 4-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-2-oxabicyclo[2.2.2]octan-1-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)NCC12COC(CC1)(CC2)C1=CC=C(C(=O)O)C=C1 AEJICVPURLCZSH-UHFFFAOYSA-N 0.000 claims 2
FOFXFNYIVXFEAT-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 FOFXFNYIVXFEAT-UHFFFAOYSA-N 0.000 claims 2
AJQUFYGEEBGKRH-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC(=NC=C1)C(=O)O AJQUFYGEEBGKRH-UHFFFAOYSA-N 0.000 claims 2
MWORYOAEBQFXDR-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CC2 MWORYOAEBQFXDR-UHFFFAOYSA-N 0.000 claims 2
BLWSFOHIXSETRP-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)triazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(N=NN1C1=C(Cl)C=CC=C1Cl)C1CC1 BLWSFOHIXSETRP-UHFFFAOYSA-N 0.000 claims 2
ROQSCVHIZWPAQX-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CO2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 ROQSCVHIZWPAQX-UHFFFAOYSA-N 0.000 claims 2
AJHHQPYCALNQJL-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 AJHHQPYCALNQJL-UHFFFAOYSA-N 0.000 claims 2
OPWPEQHRUFBAMC-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 OPWPEQHRUFBAMC-UHFFFAOYSA-N 0.000 claims 2
OGENKUKIJQYNGK-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COCC12COC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=O)O)C=C1 OGENKUKIJQYNGK-UHFFFAOYSA-N 0.000 claims 2
JEXYEJHTRXRUMP-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 JEXYEJHTRXRUMP-UHFFFAOYSA-N 0.000 claims 2
OEHBBTWYSFNXKA-UHFFFAOYSA-N 4-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 OEHBBTWYSFNXKA-UHFFFAOYSA-N 0.000 claims 2
SIFRMFSRTSVHJF-UHFFFAOYSA-N 4-[5-[4-[[5-propan-2-yl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound CC(C)C1=C(COC23CCC(CC2)(CC3)C2=NC(=NO2)C2=CC=C(C=C2)C(O)=O)C(=NO1)C1=CC=CC=C1OC(F)(F)F SIFRMFSRTSVHJF-UHFFFAOYSA-N 0.000 claims 2
GWVFONNDXDMUIX-UHFFFAOYSA-N 4-[5-[4-[[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]amino]methyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]benzoic acid Chemical compound OC(=O)C1=CC=C(C=C1)C1=NOC(=N1)C12CCC(CNC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CC2 GWVFONNDXDMUIX-UHFFFAOYSA-N 0.000 claims 2
RFEIIXLAOOMNFT-SNAWJCMRSA-N 4-[[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoro-2-methylquinoline-6-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)COC1=CC(=NC2=C(C=C(C=C12)C(=O)O)F)C RFEIIXLAOOMNFT-SNAWJCMRSA-N 0.000 claims 2
QUKDBOMNJLPTSZ-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]-3-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C1=C(C=C(C(=O)O)C=C1)F)O QUKDBOMNJLPTSZ-UHFFFAOYSA-N 0.000 claims 2
BJPAPGXPJJWCSW-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-hydroxymethyl]quinoline-7-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C(C1=CC=NC2=CC(=CC=C12)C(=O)O)O BJPAPGXPJJWCSW-UHFFFAOYSA-N 0.000 claims 2
PWFHKZKKGCMAME-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC1=CC=C(C(=O)O)C=C1 PWFHKZKKGCMAME-UHFFFAOYSA-N 0.000 claims 2
FQIZYXUKQARSKS-UHFFFAOYSA-N 4-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]isoquinoline-1-carboxylic acid Chemical compound OC(=O)C1=C2C=CC=CC2=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)C=N1 FQIZYXUKQARSKS-UHFFFAOYSA-N 0.000 claims 2
FPODYWBPWRTPBY-UHFFFAOYSA-N 4-cyclobutyloxy-6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C(C=C2)C#CC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C(OC2CCC2)=C1 FPODYWBPWRTPBY-UHFFFAOYSA-N 0.000 claims 2
KSGCZEYUPFFYGI-UHFFFAOYSA-N 4-cyclobutyloxy-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoroquinoline-2-carboxylic acid Chemical compound C1(CCC1)OC1=CC(=NC2=C(C=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)F)C(=O)O KSGCZEYUPFFYGI-UHFFFAOYSA-N 0.000 claims 2
AIOLYNAVGXTJAS-UHFFFAOYSA-N 4-cyclobutyloxy-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(OCC34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2C(OC2CCC2)=C1 AIOLYNAVGXTJAS-UHFFFAOYSA-N 0.000 claims 2
KZNMJSLLSRSUOV-MDZDMXLPSA-N 4-cyclopentyloxy-6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C(\C=C\C34CCC(CC3)(CC4)OCC3=C(ON=C3C3=C(Cl)C=NC=C3Cl)C3CC3)C=C2)C(OC2CCCC2)=C1 KZNMJSLLSRSUOV-MDZDMXLPSA-N 0.000 claims 2
CDCFRCQSTWSJEV-UHFFFAOYSA-N 4-cyclopropyl-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-8-fluoroquinoline-2-carboxylic acid Chemical compound C1(CC1)C1=CC(=NC2=C(C=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)F)C(=O)O CDCFRCQSTWSJEV-UHFFFAOYSA-N 0.000 claims 2
RPJVJLNMEAKYTJ-UHFFFAOYSA-N 4-cyclopropyl-6-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=CC(=NC2=CC=C(C=C12)OCC12CCC(CC1)(CC2)OCC=1C(=NOC=1C1CC1)C1=C(C=NC=C1Cl)Cl)C(=O)O RPJVJLNMEAKYTJ-UHFFFAOYSA-N 0.000 claims 2
ZZVZUHIALJOOAG-ONEGZZNKSA-N 5-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(\C=C\C23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)=C1 ZZVZUHIALJOOAG-ONEGZZNKSA-N 0.000 claims 2
BHBFVDMFPOJDNC-UHFFFAOYSA-N 5-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]-2-methylpyrazole-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=NN(C(=C1)C(=O)O)C BHBFVDMFPOJDNC-UHFFFAOYSA-N 0.000 claims 2
RWXJVDQCJRWGRT-UHFFFAOYSA-N 5-[3-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NOC(=N1)C=1C=CC(=C(C(=O)O)C=1)OC RWXJVDQCJRWGRT-UHFFFAOYSA-N 0.000 claims 2
JDAOYDDDSNTGHH-UHFFFAOYSA-N 5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazole-3-carboxamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C(=O)N JDAOYDDDSNTGHH-UHFFFAOYSA-N 0.000 claims 2
RSRGOYBWOBFVLU-UHFFFAOYSA-N 5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxymethyl]-2-oxabicyclo[2.2.2]octan-1-yl]-2-fluorobenzoic acid Chemical compound OC(=O)C1=C(F)C=CC(=C1)C12CCC(COCC3=C(ON=C3C3=C(Cl)C=CC=C3Cl)C3CC3)(CC1)CO2 RSRGOYBWOBFVLU-UHFFFAOYSA-N 0.000 claims 2
IRIFQDKBNFFKJY-AATRIKPKSA-N 5-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-(difluoromethoxy)benzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC(F)F IRIFQDKBNFFKJY-AATRIKPKSA-N 0.000 claims 2
GIFYBJNFLVLYDG-VOTSOKGWSA-N 5-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC GIFYBJNFLVLYDG-VOTSOKGWSA-N 0.000 claims 2
BSRCTFQJGQGIBJ-CMDGGOBGSA-N 5-[5-[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-N-cyclopropylsulfonyl-2-methoxybenzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)NS(=O)(=O)C2CC2)C=1)OC BSRCTFQJGQGIBJ-CMDGGOBGSA-N 0.000 claims 2
JRVUMRYYCKYECS-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)F JRVUMRYYCKYECS-UHFFFAOYSA-N 0.000 claims 2
DIEZEEGCLMMFQD-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound COC1=C(C=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1)C(O)=O DIEZEEGCLMMFQD-UHFFFAOYSA-N 0.000 claims 2
QRLMUZGBVACLIR-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 QRLMUZGBVACLIR-UHFFFAOYSA-N 0.000 claims 2
NLNAQGCGEJRVNM-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzamide Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)N)C=1)OC NLNAQGCGEJRVNM-UHFFFAOYSA-N 0.000 claims 2
LCSVEGBYCMYDKD-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC LCSVEGBYCMYDKD-UHFFFAOYSA-N 0.000 claims 2
OLQGSCLODSDUHN-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxypyridine-3-carboxylic acid Chemical compound COC1=NC=C(C=C1C(O)=O)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OLQGSCLODSDUHN-UHFFFAOYSA-N 0.000 claims 2
ZVYCIBWSDREYGY-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-3-fluoro-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=C(C(=C(C(=O)O)C=1)OC)F ZVYCIBWSDREYGY-UHFFFAOYSA-N 0.000 claims 2
DWZYVFYSQDDYMA-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-2-oxabicyclo[2.2.2]octan-1-yl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12COC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC DWZYVFYSQDDYMA-UHFFFAOYSA-N 0.000 claims 2
BXIKWFBTWHVRFY-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=C(C(=O)O)C=1)OC BXIKWFBTWHVRFY-UHFFFAOYSA-N 0.000 claims 2
VVYCSMMIVOYHDI-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)OC(F)(F)F)COC12CCC(CC1)(CC2)C1=NC(=NO1)C=1C=CC(=NC=1)C(=O)O VVYCSMMIVOYHDI-UHFFFAOYSA-N 0.000 claims 2
WTNPWTUTRJHPAM-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=CC(=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 WTNPWTUTRJHPAM-UHFFFAOYSA-N 0.000 claims 2
YCGGCEABKZAAJT-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-2-methoxybenzoic acid Chemical compound COC1=C(C=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1)C(O)=O YCGGCEABKZAAJT-UHFFFAOYSA-N 0.000 claims 2
ULQXKUPCZCEAAN-UHFFFAOYSA-N 5-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=NC=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 ULQXKUPCZCEAAN-UHFFFAOYSA-N 0.000 claims 2
LMRCIZRWNVSOGK-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=CC(=C(C(=O)O)C=1)F LMRCIZRWNVSOGK-UHFFFAOYSA-N 0.000 claims 2
ABFMZSZMWTXJCO-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)COC=1C=NC=C(C(=O)O)C=1 ABFMZSZMWTXJCO-UHFFFAOYSA-N 0.000 claims 2
CMMRGCPKNDCTPD-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methylamino]-2-methylpyrazole-3-carboxylic acid Chemical compound Cn1nc(NCC23CCC(CC2)(CC3)OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1C(O)=O CMMRGCPKNDCTPD-UHFFFAOYSA-N 0.000 claims 2
BRCIBDPAOCHJJV-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-cyclopropyloxypyridine-2-carboxylic acid Chemical compound OC(=O)C1=C(OC2CC2)C=C(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=C(Cl)C=NC=C2Cl)C2CC2)C=N1 BRCIBDPAOCHJJV-UHFFFAOYSA-N 0.000 claims 2
NGAMUSYLUKWVFP-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-2-fluorobenzoic acid Chemical compound OC(=O)C1=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=CC=C1F NGAMUSYLUKWVFP-UHFFFAOYSA-N 0.000 claims 2
RCUKLBOMCGLIRX-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxamide Chemical compound CCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=C1)C(N)=O RCUKLBOMCGLIRX-UHFFFAOYSA-N 0.000 claims 2
SFATYYDKFQXOFL-UHFFFAOYSA-N 5-[[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]methoxy]-3-ethoxypyridine-2-carboxylic acid Chemical compound CCOC1=C(N=CC(OCC23CCC(CC2)(CC3)OCC2=C(ON=C2C2=CC=CC=C2C(F)(F)F)C2CC2)=C1)C(O)=O SFATYYDKFQXOFL-UHFFFAOYSA-N 0.000 claims 2
WPEGGCDSUBAHHX-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[1-[3-(2H-tetrazol-5-yl)phenyl]-2-oxabicyclo[2.2.2]octan-4-yl]methoxymethyl]-1,2-oxazole Chemical compound N1N=NN=C1C=1C=C(C=CC=1)C12OCC(CC1)(CC2)COCC=1C(=NOC=1C1CC1)C1=C(C=CC=C1Cl)Cl WPEGGCDSUBAHHX-UHFFFAOYSA-N 0.000 claims 2
TWOYCPCUYQNBGB-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[4-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound N1N=NN=C1C1=CC2=C(N=C(S2)C23CCC(CC2)(CC3)OCC=2C(=NOC=2C2CC2)C2=C(C=CC=C2Cl)Cl)C=C1 TWOYCPCUYQNBGB-UHFFFAOYSA-N 0.000 claims 2
VISHNRLBZQHURE-UHFFFAOYSA-N 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-[[4-[[3-(2H-tetrazol-5-yl)phenoxy]methyl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound N=1NN=NC=1C=1C=C(OCC23CCC(CC2)(CC3)OCC=2C(=NOC=2C2CC2)C2=C(C=CC=C2Cl)Cl)C=CC=1 VISHNRLBZQHURE-UHFFFAOYSA-N 0.000 claims 2
UAISDRDPOMMDTE-BQYQJAHWSA-N 5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-4-[[4-[(E)-2-[4-(2H-tetrazol-5-ylmethyl)phenyl]ethenyl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-1,2-oxazole Chemical compound ClC1=CN=CC(Cl)=C1C1=NOC(C2CC2)=C1COC12CCC(CC1)(CC2)\C=C\C1=CC=C(CC2=NNN=N2)C=C1 UAISDRDPOMMDTE-BQYQJAHWSA-N 0.000 claims 2
QYMHJEPSMXHZIG-ZHACJKMWSA-N 5-cyclopropyl-4-[[4-[(E)-2-[3-(2H-tetrazol-5-yl)phenyl]ethenyl]-1-bicyclo[2.2.2]octanyl]oxymethyl]-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazole Chemical compound N1N=NN=C1C=1C=C(/C=C/C23CCC(CC2)(CC3)OCC=2C(=NOC=2C2CC2)C2=C(C=CC=C2)OC(F)(F)F)C=CC=1 QYMHJEPSMXHZIG-ZHACJKMWSA-N 0.000 claims 2
OTPPXGVHWDQPCH-UHFFFAOYSA-N 6-(azetidin-1-yl)-5-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethynyl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(N2CCC2)C(=C1)C#CC12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 OTPPXGVHWDQPCH-UHFFFAOYSA-N 0.000 claims 2
STEFUOFHVMYJLH-VOTSOKGWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-1-methylindole-2-carboxylic acid Chemical compound CN1C(=CC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O STEFUOFHVMYJLH-VOTSOKGWSA-N 0.000 claims 2
IHHXTFZSKFIHQX-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-ethoxyquinoline-2-carboxylic acid Chemical compound CCOC1=CC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O IHHXTFZSKFIHQX-BQYQJAHWSA-N 0.000 claims 2
OCBYPFJVLBHLAY-VOTSOKGWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-methoxyquinazoline-2-carboxylic acid Chemical compound COC1=NC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O OCBYPFJVLBHLAY-VOTSOKGWSA-N 0.000 claims 2
XMHVVIZKDIEWNV-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound CC(C)OC1=CC(=NC2=C1C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O XMHVVIZKDIEWNV-BQYQJAHWSA-N 0.000 claims 2
JYRFKQFUBIKIRL-BQYQJAHWSA-N 6-[(E)-2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethenyl]quinoline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=C(C=C1)C=C(\C=C\C13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2 JYRFKQFUBIKIRL-BQYQJAHWSA-N 0.000 claims 2
OHJIDDZOPJSSLT-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)CCC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)C(F)(F)F OHJIDDZOPJSSLT-UHFFFAOYSA-N 0.000 claims 2
KUVGDRNPGBBSQX-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]-4-propan-2-yloxyquinoline-2-carboxylic acid Chemical compound CC(C)OC1=CC(=NC2=C1C=C(CCC13CCC(CC1)(CC3)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1)C=C2)C(O)=O KUVGDRNPGBBSQX-UHFFFAOYSA-N 0.000 claims 2
KGHFOIQKADFXOR-UHFFFAOYSA-N 6-[2-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]ethyl]quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)CCC=1C=C2C=CC(=NC2=CC=1)C(=O)O KGHFOIQKADFXOR-UHFFFAOYSA-N 0.000 claims 2
VBGZNCZTIODECK-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=CC=C1Cl)C1CC1 VBGZNCZTIODECK-UHFFFAOYSA-N 0.000 claims 2
UZGHOHSXZJBXCY-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NC(=NO1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 UZGHOHSXZJBXCY-UHFFFAOYSA-N 0.000 claims 2
QDCSPAMDZWYZGW-UHFFFAOYSA-N 6-[3-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-5-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1)C(F)(F)F)COC12CCC(CC1)(CC2)C1=NOC(=N1)C1=CC=CC(=N1)C(=O)O QDCSPAMDZWYZGW-UHFFFAOYSA-N 0.000 claims 2
MJHFNWJSCIZWMS-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-methylpyrrolo[2,3-b]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=CC=C2C(=N1)N(C=C2C(=O)O)C MJHFNWJSCIZWMS-UHFFFAOYSA-N 0.000 claims 2
XIQUUUJGRSAHID-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]pyridine-3-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC=C(C(=O)O)C=C1 XIQUUUJGRSAHID-UHFFFAOYSA-N 0.000 claims 2
JUOLNUVICVSFOF-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-ethylpyrazolo[3,4-b]pyridine-3-carboxylic acid Chemical compound CCN1N=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 JUOLNUVICVSFOF-UHFFFAOYSA-N 0.000 claims 2
URZCSQZZYMCUTH-UHFFFAOYSA-N 6-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1-methylpyrazolo[3,4-b]pyridine-3-carboxylic acid Chemical compound CN1N=C(C(O)=O)C2=CC=C(N=C12)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=C(Cl)C=NC=C1Cl)C1CC1 URZCSQZZYMCUTH-UHFFFAOYSA-N 0.000 claims 2
LXOJWNYSHPQEMU-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=CC(=N1)C(=O)O LXOJWNYSHPQEMU-UHFFFAOYSA-N 0.000 claims 2
DHOWRLMYESJZOE-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]-3-methoxypyridine-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)COC12CCC(CC1)(CC2)C1=NC(=NO1)C1=CC=C(C(=N1)C(=O)O)OC DHOWRLMYESJZOE-UHFFFAOYSA-N 0.000 claims 2
CMJQZWWRGNZDMC-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 CMJQZWWRGNZDMC-UHFFFAOYSA-N 0.000 claims 2
AOYIMGUJDVAAOL-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CN=C(C=C1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1OC(F)(F)F)C1CC1 AOYIMGUJDVAAOL-UHFFFAOYSA-N 0.000 claims 2
DZPUBFBGNVJPJQ-UHFFFAOYSA-N 6-[5-[4-[[5-cyclopropyl-3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-4-yl]methoxy]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazol-3-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(=N1)C1=NOC(=N1)C12CCC(CC1)(CC2)OCC1=C(ON=C1C1=CC=CC=C1C(F)(F)F)C1CC1 DZPUBFBGNVJPJQ-UHFFFAOYSA-N 0.000 claims 2
WPNTWEJXPJOBCX-AATRIKPKSA-N 6-[[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(difluoromethoxy)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)OC(F)F WPNTWEJXPJOBCX-AATRIKPKSA-N 0.000 claims 2
HNOMCMXRVKWLGX-AATRIKPKSA-N 6-[[4-[(E)-2-[5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)-1,2-oxazol-4-yl]ethenyl]-1-bicyclo[2.2.2]octanyl]methoxy]-4-(trifluoromethyl)quinoline-2-carboxylic acid Chemical compound C1(CC1)C1=C(C(=NO1)C1=C(C=NC=C1Cl)Cl)/C=C/C12CCC(CC1)(CC2)COC=1C=C2C(=CC(=NC2=CC=1)C(=O)O)C(F)(F)F HNOMCMXRVKWLGX-AATRIKPKSA-N 0.000 claims 2
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125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
125000004193 piperazinyl group Chemical group 0.000 claims 1
125000003386 piperidinyl group Chemical group 0.000 claims 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
125000003373 pyrazinyl group Chemical group 0.000 claims 1
125000002098 pyridazinyl group Chemical group 0.000 claims 1
125000000714 pyrimidinyl group Chemical group 0.000 claims 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
201000002793 renal fibrosis Diseases 0.000 claims 1
208000010157 sclerosing cholangitis Diseases 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1
125000001113 thiadiazolyl group Chemical group 0.000 claims 1
125000001425 triazolyl group Chemical group 0.000 claims 1

JP2020544333A 2017-11-01 2018-10-31 ファルネソイドｘ受容体モジュレーターとしての架橋二環化合物 Active JP7212693B2 (ja)