JP2009515814A5 - - Google Patents
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- Publication number
- JP2009515814A5 JP2009515814A5 JP2008503187A JP2008503187A JP2009515814A5 JP 2009515814 A5 JP2009515814 A5 JP 2009515814A5 JP 2008503187 A JP2008503187 A JP 2008503187A JP 2008503187 A JP2008503187 A JP 2008503187A JP 2009515814 A5 JP2009515814 A5 JP 2009515814A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- amino
- membered
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66438105P | 2005-03-22 | 2005-03-22 | |
| US60/664,381 | 2005-03-22 | ||
| US11/386,271 | 2006-03-21 | ||
| US11/386,271 US20060216288A1 (en) | 2005-03-22 | 2006-03-21 | Combinations for the treatment of cancer |
| PCT/US2006/010582 WO2006102504A2 (en) | 2005-03-22 | 2006-03-22 | Combinations for the treatment of cancer comprising anti-egfr antibody and vegfr inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515814A JP2009515814A (ja) | 2009-04-16 |
| JP2009515814A5 true JP2009515814A5 (https=) | 2009-05-28 |
| JP5142981B2 JP5142981B2 (ja) | 2013-02-13 |
Family
ID=37035437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503187A Expired - Fee Related JP5142981B2 (ja) | 2005-03-22 | 2006-03-22 | 抗egfr抗体およびvegfr阻害剤を含む、癌の治療のための組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060216288A1 (https=) |
| EP (1) | EP1915151B1 (https=) |
| JP (1) | JP5142981B2 (https=) |
| AU (1) | AU2006226897B2 (https=) |
| CA (1) | CA2600195C (https=) |
| MX (1) | MX2007011545A (https=) |
| WO (1) | WO2006102504A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2539324A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| JP4974903B2 (ja) | 2005-02-09 | 2012-07-11 | 参天製薬株式会社 | 疾患または状態を処置するための液体処方物 |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| KR20070121754A (ko) * | 2005-03-21 | 2007-12-27 | 마커사이트, 인코포레이티드 | 질환 또는 상태의 치료를 위한 약물 송달 시스템 |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| WO2007092620A2 (en) | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| PL2001466T3 (pl) | 2006-03-23 | 2016-06-30 | Santen Pharmaceutical Co Ltd | Rapamycyna w małej dawce do leczenia chorób związanych z przepuszczalnością naczyń |
| EP2081553B1 (en) * | 2006-10-06 | 2020-08-12 | Amgen Inc. | Stable antibody formulations |
| JP2010508277A (ja) * | 2006-11-01 | 2010-03-18 | ジョージ メイソン インテレクチュアル プロパティーズ,インコーポレイテッド オブ フェアファックス,バージニア | 癌を検出および抑制するための方法 |
| CN101675075B (zh) | 2007-03-01 | 2014-06-18 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| US8609640B2 (en) | 2007-07-25 | 2013-12-17 | Eisai, Inc. | Multikinase inhibitors for use in the treatment of cancer |
| WO2009023877A2 (en) * | 2007-08-16 | 2009-02-19 | Macusight, Inc. | Formulations for treatment of ocular diseases or conditions |
| TWI436775B (zh) * | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| FR2921657A1 (fr) * | 2007-09-28 | 2009-04-03 | Sanofi Aventis Sa | Derives de nicotinamide, leur preparation et leur application en therapeutique |
| AU2008318690B2 (en) * | 2007-10-29 | 2015-08-13 | Eisai R & D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
| WO2009062199A1 (en) * | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
| US20130331294A1 (en) | 2007-11-09 | 2013-12-12 | Fox Chase Cancer Center | Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders |
| RU2601892C2 (ru) * | 2008-03-06 | 2016-11-10 | Дженентек, Инк. | Комбинированная терапия антагонистами с-мет и egfr |
| EP2260056A1 (en) * | 2008-03-06 | 2010-12-15 | Genentech, Inc. | Combination therapy with c-met and her antagonists |
| US20120035183A1 (en) * | 2008-03-19 | 2012-02-09 | Gilmer Tona M | Cancer Treatment Method |
| US8663640B2 (en) | 2008-08-29 | 2014-03-04 | Symphogen A/S | Methods using recombinant anti-epidermal growth factor receptor antibody compositions |
| JP6013359B2 (ja) | 2010-12-17 | 2016-10-25 | ノバルティス アーゲー | 組合せ |
| WO2012099968A1 (en) * | 2011-01-19 | 2012-07-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating skin cancer associated diseases |
| JP2014504638A (ja) * | 2011-02-01 | 2014-02-24 | グラクソスミスクライン インテレクチュアル プロパティ リミテッド | 組合せ |
| RU2013155695A (ru) | 2011-06-30 | 2015-08-10 | Дженентек, Инк. | Препараты антител против с-мет |
| WO2013173255A2 (en) | 2012-05-17 | 2013-11-21 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind egfr |
| DK2884979T3 (da) | 2012-08-17 | 2019-09-02 | Hoffmann La Roche | Kombinationsbehandlinger mod melanom omfattende indgivelse af cobimetinib og vemurafenib |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US20050241006A1 (en) * | 1995-04-27 | 2005-10-27 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| RS49779B (sr) * | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| ATE538794T1 (de) * | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| JP3789066B2 (ja) * | 1999-12-08 | 2006-06-21 | 三菱電機株式会社 | 液晶表示装置 |
| US6515004B1 (en) * | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US8725620B2 (en) * | 2000-07-10 | 2014-05-13 | Nobuyoshi Morimoto | System and method for negotiating improved terms for products and services being purchased through the internet |
| GB0017635D0 (en) * | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
| US6630500B2 (en) * | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| CA2466762A1 (en) * | 2001-12-04 | 2003-06-12 | Onyx Pharmaceuticals, Inc. | Raf-mek-erk pathway inhibitors to treat cancer |
| CN1625602A (zh) * | 2002-03-13 | 2005-06-08 | 霍夫曼-拉罗奇有限公司 | 选择药物敏感性决定因子的方法和利用所选择的因子预测药物敏感性的方法 |
| WO2003099205A2 (en) * | 2002-05-20 | 2003-12-04 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
| US20040147428A1 (en) * | 2002-11-15 | 2004-07-29 | Pluenneke John D. | Methods of treatment using an inhibitor of epidermal growth factor receptor |
| EA010485B1 (ru) * | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
| CA2555306A1 (en) * | 2004-02-06 | 2005-08-18 | Nymox Corporation | Humanized antibody |
-
2006
- 2006-03-21 US US11/386,271 patent/US20060216288A1/en not_active Abandoned
- 2006-03-22 JP JP2008503187A patent/JP5142981B2/ja not_active Expired - Fee Related
- 2006-03-22 CA CA2600195A patent/CA2600195C/en not_active Expired - Fee Related
- 2006-03-22 EP EP06739398A patent/EP1915151B1/en not_active Expired - Lifetime
- 2006-03-22 AU AU2006226897A patent/AU2006226897B2/en not_active Ceased
- 2006-03-22 MX MX2007011545A patent/MX2007011545A/es active IP Right Grant
- 2006-03-22 WO PCT/US2006/010582 patent/WO2006102504A2/en not_active Ceased
-
2009
- 2009-11-19 US US12/592,103 patent/US20100074909A1/en not_active Abandoned
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