JP2018501315A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018501315A5 JP2018501315A5 JP2017552007A JP2017552007A JP2018501315A5 JP 2018501315 A5 JP2018501315 A5 JP 2018501315A5 JP 2017552007 A JP2017552007 A JP 2017552007A JP 2017552007 A JP2017552007 A JP 2017552007A JP 2018501315 A5 JP2018501315 A5 JP 2018501315A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- pyridin
- halogen
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 109
- 239000001257 hydrogen Substances 0.000 claims 109
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 54
- 125000004093 cyano group Chemical group *C#N 0.000 claims 48
- 229910052736 halogen Inorganic materials 0.000 claims 48
- 150000002367 halogens Chemical group 0.000 claims 48
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 43
- 150000002431 hydrogen Chemical group 0.000 claims 39
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 36
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- -1 —OH Chemical group 0.000 claims 12
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 8
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 8
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 7
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical group C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 6
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical group C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000052185 transforming growth factor beta receptor activity proteins Human genes 0.000 claims 4
- 108700015056 transforming growth factor beta receptor activity proteins Proteins 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 3
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Chemical group CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 3
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Chemical group C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- XODSKPZUYKGNMW-UHFFFAOYSA-N N-[4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound COC1=CC=C(C=N1)C1=C(NC=2C1=NC=CC=2)C1=CC(=NC=C1)NC(C)=O XODSKPZUYKGNMW-UHFFFAOYSA-N 0.000 claims 1
- VWSFKHLXKXHRDY-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2)C1=CC(=NC=C1)NC(C)=O)F VWSFKHLXKXHRDY-UHFFFAOYSA-N 0.000 claims 1
- LZIKYNOAPPEQMG-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-6-ethoxy-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=C(C=2)OCC)C1=CC(=NC=C1)NC(C)=O)F LZIKYNOAPPEQMG-UHFFFAOYSA-N 0.000 claims 1
- YAURUPNGLRUZTR-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-6-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=C(C=2)OC)C1=CC(=NC=C1)NC(C)=O)F YAURUPNGLRUZTR-UHFFFAOYSA-N 0.000 claims 1
- OLYCUNOTKFNETC-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-(1-hydroxyethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2C(C)O)C1=CC(=NC=C1)NC(C)=O)F OLYCUNOTKFNETC-UHFFFAOYSA-N 0.000 claims 1
- BXHURORUSAJJMH-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-(2-hydroxypropan-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2C(C)(C)O)C1=CC(=NC=C1)NC(C)=O)F BXHURORUSAJJMH-UHFFFAOYSA-N 0.000 claims 1
- CDVFGEXFOAGXJO-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-(methylaminomethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2CNC)C1=CC(=NC=C1)NC(C)=O)F CDVFGEXFOAGXJO-UHFFFAOYSA-N 0.000 claims 1
- OLYCUNOTKFNETC-LLVKDONJSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-[(1R)-1-hydroxyethyl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2[C@@H](C)O)C1=CC(=NC=C1)NC(C)=O)F OLYCUNOTKFNETC-LLVKDONJSA-N 0.000 claims 1
- OLYCUNOTKFNETC-NSHDSACASA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-[(1S)-1-hydroxyethyl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2[C@H](C)O)C1=CC(=NC=C1)NC(C)=O)F OLYCUNOTKFNETC-NSHDSACASA-N 0.000 claims 1
- AQUKDYPRJZEQSG-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-[(dimethylamino)methyl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2CN(C)C)C1=CC(=NC=C1)NC(C)=O)F AQUKDYPRJZEQSG-UHFFFAOYSA-N 0.000 claims 1
- UKJWABCHVCNLAX-UHFFFAOYSA-N N-[4-[3-[6-(difluoromethyl)pyridin-2-yl]-7-ethoxy-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC(C1=CC=CC(=N1)C1=C(NC=2C1=NC=CC=2OCC)C1=CC(=NC=C1)NC(C)=O)F UKJWABCHVCNLAX-UHFFFAOYSA-N 0.000 claims 1
- KBCCSSMKVXTFDE-UHFFFAOYSA-N N-[4-[6-chloro-3-(5-fluoropyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]-2-(3-morpholin-4-ylpropylamino)acetamide Chemical compound ClC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(CNCCCN1CCOCC1)=O)C1=NC=C(C=C1)F KBCCSSMKVXTFDE-UHFFFAOYSA-N 0.000 claims 1
- SDIWHZMLILEDAK-UHFFFAOYSA-N N-[4-[6-chloro-3-(5-methoxypyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound ClC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C1=NC=C(C=C1)OC SDIWHZMLILEDAK-UHFFFAOYSA-N 0.000 claims 1
- SDIWHZMLILEDAK-BMSJAHLVSA-N N-[4-[6-chloro-3-[5-(trideuteriomethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound ClC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C1=NC=C(C=C1)OC([2H])([2H])[2H] SDIWHZMLILEDAK-BMSJAHLVSA-N 0.000 claims 1
- MCOHDLNMMNXGOH-UHFFFAOYSA-N N-[4-[6-fluoro-3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C=1C=NC(=CC=1)OC MCOHDLNMMNXGOH-UHFFFAOYSA-N 0.000 claims 1
- TWGKOZPGDCIKQA-BMSJAHLVSA-N N-[4-[6-fluoro-3-[5-(trideuteriomethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound FC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C1=NC=C(C=C1)OC([2H])([2H])[2H] TWGKOZPGDCIKQA-BMSJAHLVSA-N 0.000 claims 1
- PRIWSHXIEAISOK-UHFFFAOYSA-N N-[4-[6-methoxy-3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound COC=1C=C2C(=NC=1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C=1C=NC(=CC=1)OC PRIWSHXIEAISOK-UHFFFAOYSA-N 0.000 claims 1
- OUXSSNKXGXEJMO-BMSJAHLVSA-N N-[4-[6-methoxy-3-[5-(trideuteriomethoxy)pyridin-2-yl]-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound [2H]C([2H])([2H])OC1=CN=C(C=C1)C1=C(NC2=C1N=CC(OC)=C2)C1=CC(NC(C)=O)=NC=C1 OUXSSNKXGXEJMO-BMSJAHLVSA-N 0.000 claims 1
- IHDQOIQCCCQCNA-UHFFFAOYSA-N N-[4-[7-(1-hydroxyethyl)-3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl]acetamide Chemical compound OC(C)C1=C2C(=NC=C1)C(=C(N2)C1=CC(=NC=C1)NC(C)=O)C=1C=NC(=CC=1)OC IHDQOIQCCCQCNA-UHFFFAOYSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 201000011176 T-cell adult acute lymphocytic leukemia Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical group C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 229930192474 thiophene Chemical group 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095328P | 2014-12-22 | 2014-12-22 | |
| US62/095,328 | 2014-12-22 | ||
| PCT/US2015/067252 WO2016106266A1 (en) | 2014-12-22 | 2015-12-22 | TGFβ RECEPTOR ANTAGONISTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018501315A JP2018501315A (ja) | 2018-01-18 |
| JP2018501315A5 true JP2018501315A5 (https=) | 2019-01-24 |
Family
ID=55135542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552007A Pending JP2018501315A (ja) | 2014-12-22 | 2015-12-22 | ＴＧＦβ受容体アンタゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9708316B2 (https=) |
| EP (1) | EP3237415A1 (https=) |
| JP (1) | JP2018501315A (https=) |
| CN (1) | CN107257798A (https=) |
| AR (1) | AR103232A1 (https=) |
| TW (1) | TW201630907A (https=) |
| WO (1) | WO2016106266A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201384T1 (hr) | 2014-01-01 | 2020-11-27 | Medivation Technologies Llc | Spojevi i postupci njihove upotrebe |
| EP3527570A4 (en) | 2016-10-14 | 2020-04-15 | Jiangsu Hengrui Medicine Co., Ltd. | FIVE-LINKED HETERARYARYLE CYCLE BRIDGE DERIVATIVE, METHOD FOR PREPARING SAME, AND MEDICAL USE THEREOF |
| JP2020500177A (ja) | 2016-11-14 | 2020-01-09 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | ３，４−ビピリジルピラゾール誘導体、およびその製造方法およびその医療応用 |
| WO2018171611A1 (zh) * | 2017-03-22 | 2018-09-27 | 江苏恒瑞医药股份有限公司 | 6-吡唑-[1,2,4]三唑并[4,3-a]吡啶-3-酰胺类衍生物、其制备方法及其在医药上的应用 |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| SI3796975T1 (sl) | 2018-05-22 | 2024-02-29 | Orsobio, Inc. | Derivati sulfonilaminobenzamida |
| TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Ｆｘｒ有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
| CA3128946A1 (en) | 2019-02-07 | 2020-08-13 | Bayer Aktiengesellschaft | 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors |
| CN112694477B (zh) * | 2019-10-22 | 2024-02-06 | 四川科伦博泰生物医药股份有限公司 | 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途 |
| CN110885329B (zh) * | 2019-12-16 | 2020-12-15 | 诚达药业股份有限公司 | 一种1,7-萘啶衍生物的合成方法 |
| WO2022023341A1 (en) | 2020-07-29 | 2022-02-03 | Bayer Aktiengesellschaft | Substituted 1 h-pyrrolo[3,2-b]pyridin compounds and methods of use thereof |
| WO2022040293A1 (en) * | 2020-08-19 | 2022-02-24 | Bristol-Myers Squibb Company | Substituted heteroaryl compounds useful as inhibitors of tlr9 |
| EP4469457A4 (en) * | 2022-01-27 | 2026-01-21 | Broad Inst Inc | CSNK1 SUBSTITUTE HETEROCYCLIC INHIBITORS |
| US20250134888A1 (en) * | 2022-02-07 | 2025-05-01 | Cornell University | Inhibitors of malic enzyme 1 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2221213T3 (es) * | 1997-10-20 | 2004-12-16 | F. Hoffmann-La Roche Ag | Inhibidores de kinasa biciclicos. |
| WO2003037862A1 (en) | 2001-10-30 | 2003-05-08 | Nippon Shinyaku Co., Ltd. | Amide derivatives and drugs |
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| PA8595001A1 (es) * | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| AU2006230099B2 (en) | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| CA2634198C (en) | 2005-12-20 | 2014-06-03 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| GB0708141D0 (en) * | 2007-04-26 | 2007-06-06 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| ES2776406T3 (es) | 2007-07-12 | 2020-07-30 | Gitr Inc | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| US8993615B2 (en) * | 2008-08-08 | 2015-03-31 | The Johns Hopkins University | Compositions and methods for treatment of neurodegenerative disease |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| DE102008052943A1 (de) * | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | Azaindolderivate |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| EP2245936A1 (en) * | 2009-04-27 | 2010-11-03 | Bayer CropScience AG | Use of 4-aza indole derivatives for the reduction of mycotoxin contamination |
| EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| US8722720B2 (en) | 2009-10-28 | 2014-05-13 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
| PH12012500881A1 (en) | 2009-12-10 | 2017-07-26 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
| JP5998060B2 (ja) | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| CA2789076C (en) | 2010-03-05 | 2017-11-21 | F. Hoffmann-La Roche Ag | Antibodies against human colony stimulating factor-1 receptor and uses thereof |
| CN102918061B (zh) | 2010-03-05 | 2016-06-08 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| MX378336B (es) | 2010-05-04 | 2025-03-10 | Five Prime Therapeutics Inc | Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r). |
| PT2614082T (pt) | 2010-09-09 | 2018-12-03 | Pfizer | Moléculas de ligação a 4-1bb |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| BR112014012624A2 (pt) | 2011-12-15 | 2018-10-09 | F Hoffmann-La Roche Ag | anticorpos, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira, método para a produção de um anticorpo recombinante e uso do anticorpo |
| RU2014136332A (ru) | 2012-02-06 | 2016-03-27 | Дженентек, Инк. | Композиции и способы применения ингибиторов csf1r |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| EP2847220A1 (en) | 2012-05-11 | 2015-03-18 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| GB201304527D0 (en) * | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
-
2015
- 2015-12-21 TW TW104142991A patent/TW201630907A/zh unknown
- 2015-12-21 AR ARP150104241A patent/AR103232A1/es unknown
- 2015-12-22 CN CN201580076649.4A patent/CN107257798A/zh active Pending
- 2015-12-22 EP EP15823892.3A patent/EP3237415A1/en not_active Withdrawn
- 2015-12-22 WO PCT/US2015/067252 patent/WO2016106266A1/en not_active Ceased
- 2015-12-22 US US14/977,709 patent/US9708316B2/en active Active
- 2015-12-22 JP JP2017552007A patent/JP2018501315A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018501315A5 (https=) | ||
| ES2360933T3 (es) | Derivados de heteroarilo condensados. | |
| RU2665036C2 (ru) | Гетероароматические соединения-модуляторы фосфоинозидит-3-киназы и способы применения | |
| HRP20200624T1 (hr) | Derivati 2-(2,4,5-supstituiranog-anilino)pirimidina kao modulatori egfr korisni za liječenje raka | |
| CN113316574A (zh) | Shp2抑制剂及其应用 | |
| JP2009529047A5 (https=) | ||
| JP2018531983A (ja) | タンパク質分解誘導キメラ化合物ならびにその調製方法および使用方法 | |
| JP2014513139A5 (https=) | ||
| JP5662321B2 (ja) | 骨髄腫の治療のための置換２，３−ジヒドロイミダゾ［１，２−ｃ］キナゾリンの使用 | |
| JP2014518544A5 (https=) | ||
| RU2016130932A (ru) | Производные хинолона как ингибиторы рецептора фактора роста фибробластов | |
| JP2009513703A5 (https=) | ||
| RU2016141645A (ru) | ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ | |
| JP2017503867A5 (https=) | ||
| JP2019512535A5 (https=) | ||
| JP2012524056A5 (https=) | ||
| JP2008531537A5 (https=) | ||
| JP2010510215A5 (https=) | ||
| RU2015148189A (ru) | ПРОИЗВОДНЫЕ 2-АМИДОПИРИДО[4, 3-d]ПИРИМИДИН-5-ОНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ WEE-1 | |
| IL233739A (en) | Imidazopyrolidinone Compounds | |
| JP2014513110A5 (https=) | ||
| MY167423A (en) | Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators,compositions,and their use | |
| JP2019536768A5 (https=) | ||
| JP2015536986A5 (https=) | ||
| JP2017501983A5 (https=) |