JP2021501203A5 - - Google Patents

Download PDF

Info

Publication number
JP2021501203A5
JP2021501203A5 JP2020543260A JP2020543260A JP2021501203A5 JP 2021501203 A5 JP2021501203 A5 JP 2021501203A5 JP 2020543260 A JP2020543260 A JP 2020543260A JP 2020543260 A JP2020543260 A JP 2020543260A JP 2021501203 A5 JP2021501203 A5 JP 2021501203A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
cancer
composition according
subject
brca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020543260A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021501203A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/058103 external-priority patent/WO2019089511A1/en
Publication of JP2021501203A publication Critical patent/JP2021501203A/ja
Publication of JP2021501203A5 publication Critical patent/JP2021501203A5/ja
Pending legal-status Critical Current

Links

JP2020543260A 2017-10-30 2018-10-30 がん治療用のアリールイミダゾール Pending JP2021501203A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762578938P 2017-10-30 2017-10-30
US62/578,938 2017-10-30
PCT/US2018/058103 WO2019089511A1 (en) 2017-10-30 2018-10-30 Aryl imidazoles for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2021501203A JP2021501203A (ja) 2021-01-14
JP2021501203A5 true JP2021501203A5 (enExample) 2021-12-09

Family

ID=66333658

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020543260A Pending JP2021501203A (ja) 2017-10-30 2018-10-30 がん治療用のアリールイミダゾール

Country Status (9)

Country Link
US (1) US11149047B2 (enExample)
EP (1) EP3703685A4 (enExample)
JP (1) JP2021501203A (enExample)
KR (1) KR20200096914A (enExample)
CN (1) CN111417395A (enExample)
AU (1) AU2018360477A1 (enExample)
CA (1) CA3081261A1 (enExample)
TW (1) TW201936190A (enExample)
WO (1) WO2019089511A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3052102B1 (en) 2013-10-04 2019-12-04 Aptose Biosciences Inc. Compositions for treating cancers
JP2021501203A (ja) 2017-10-30 2021-01-14 アプトース バイオサイエンシズ インコーポレイテッド がん治療用のアリールイミダゾール
US20210380586A1 (en) * 2020-06-02 2021-12-09 Aptose Biosciences Inc. 2-indolyl imidazo[4,5-d]phenanthroline polymorphs and compositions regarding the same
CN115919873B (zh) * 2023-03-07 2023-09-29 信义核新(北京)生物科技有限公司 一种化合物及其盐在癌症治疗药物中的应用

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE585555A (enExample) 1960-03-31
US3297710A (en) 1963-04-09 1967-01-10 Du Pont Oxoarylidene-imidazoles
US3714181A (en) 1970-12-31 1973-01-30 American Cyanamid Co 2-aryl-5,10-diphenylphenanthro(9,10-d)azoles
US4089747A (en) 1976-08-09 1978-05-16 Eastman Kodak Company Compositions for the detection of hydrogen peroxide
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
DE3141063A1 (de) 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4423046A (en) 1982-04-05 1983-12-27 Sterling Drug Inc. Antibacterial and antiprotozoal 1-methyl-5-nitro-2-(2-phenylvinyl)imidazoles
DE3422175A1 (de) 1984-06-04 1985-12-19 Julius Dr. 8000 München Kern Verfahren zur beimischung von ammoniak zu saure schadstoffe enthaltenden abgasen oder luft
WO1987003591A1 (fr) 1985-12-12 1987-06-18 Ube Industries, Ltd. Nouveaux derives d'imidazole, bactericides les contenant et procede permettant leur preparation
JPS614960A (ja) 1984-06-19 1986-01-10 Fuji Photo Film Co Ltd 分析試薬および多層化学分析要素
US4762706A (en) 1984-10-17 1988-08-09 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
US5443956A (en) 1985-01-29 1995-08-22 Oncogene Science, Inc. Detection, quantitation and classification of RAS proteins in body fluids and tissues
US5081230A (en) 1987-07-08 1992-01-14 E. I. Dupont Denemours And Company Monoclonal antibodies reactive with normal and oncogenic forms of the ras p21 protein
US4720459A (en) 1985-02-14 1988-01-19 Medical College Of Wisconsin Research Foundation, Inc. Myelomas for producing human/human hybridomas
US4758421A (en) 1985-03-15 1988-07-19 The Board Of Trustees Of The Leland Stanford Junior University Bleomycin conjugates and method
IT1214597B (it) 1985-04-15 1990-01-18 Rorer Italiana Spa Derivati dell'imidazolo adattivita' antimicotica, procedimento ed intermedi per laloro preparazione e composizioni che li contengono.
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5024935A (en) 1987-12-18 1991-06-18 Eastman Kodak Company Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor
US5047318A (en) 1988-06-13 1991-09-10 Eastman Kodak Company Imidazole leuco dye composition containing 4'-hydroxyacetanilide, diagnostic kit and method using same
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5501959A (en) 1989-01-17 1996-03-26 Alamar Biosciences Laboratory, Inc. Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents
US5514550A (en) 1989-02-03 1996-05-07 Johnson & Johnson Clinical Diagnostics, Inc. Nucleic acid test article and its use to detect a predetermined nucleic acid
EP0462226B1 (en) 1989-03-08 1995-05-10 Rocky Research Method and apparatus for achieving high reaction rates in solid-gas reactor systems
US5441716A (en) 1989-03-08 1995-08-15 Rocky Research Method and apparatus for achieving high reaction rates
JPH02258017A (ja) 1989-03-31 1990-10-18 Babcock Hitachi Kk 固体還元剤を用いた排ガス脱硝装置
US4970226A (en) 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5161389A (en) 1990-11-13 1992-11-10 Rocky Research Appliance for rapid sorption cooling and freezing
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
AU7629594A (en) 1993-07-21 1995-02-20 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US5496702A (en) 1994-09-01 1996-03-05 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay elements having stable leuco dye coatings
ATE252094T1 (de) 1994-12-13 2003-11-15 Hoffmann La Roche Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung
TW424172B (en) 1995-04-19 2001-03-01 Hitachi Chemical Co Ltd Photosensitive resin composition and photosensitive element using the same
US5700826A (en) 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
US5753687A (en) 1995-06-19 1998-05-19 Ontogen Corporation Modulators of proteins with phosphotryrosine recognition units
JP2000504023A (ja) 1996-04-03 2000-04-04 メルク エンド カンパニー インコーポレーテッド 癌治療方法
US5693589A (en) 1996-05-08 1997-12-02 Eastman Kodak Company Thermal imaging recording element
EP0812829A1 (en) 1996-06-14 1997-12-17 Ontogen Corporation Substituted imidazoles as modulators of multi-drug resistance
IT240917Y1 (it) 1996-10-01 2001-04-11 Stefcom Spa Scarpa con tomaia avente porzione per la traspirazione dell'internodella scarpa
EP0946587A2 (en) 1996-12-16 1999-10-06 Fujisawa Pharmaceutical Co., Ltd. New amide compounds
AU740425B2 (en) 1996-12-16 2001-11-01 Ontogen Corporation Modulators of proteins with phosphotyrosine recognition units
US5945418A (en) 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5809775A (en) 1997-04-02 1998-09-22 Clean Diesel Technologies, Inc. Reducing NOx emissions from an engine by selective catalytic reduction utilizing solid reagents
HUP0002842A3 (en) 1997-04-24 2002-01-28 Ortho Mcneil Pharm Inc Substituted imidazoles, process for producing them, pharmaceutical compositions containing them, their use and their intermediates
JPH10319584A (ja) 1997-05-21 1998-12-04 Brother Ind Ltd マイクロカプセルを用いた感光性記録材料
DE19728343C5 (de) 1997-07-03 2013-02-21 Robert Bosch Gmbh Verfahren und Vorrichtung zur selektiven katalytischen NOx-Reduktion
US6121260A (en) 1997-07-03 2000-09-19 Neurogen Corporation Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives
US5840721A (en) 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
WO1999007701A1 (en) 1997-08-05 1999-02-18 Sugen, Inc. Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
JPH11199582A (ja) 1998-01-05 1999-07-27 Sagami Chem Res Center 4(5)−(3−インドリル)イミダゾール誘導体
EP1064264A4 (en) 1998-03-18 2002-06-26 Univ Wake Forest CYTOTOXIC METAL CHELATORS AND METHOD FOR THEIR PRODUCTION AND USE
US6288212B1 (en) 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
AU2164300A (en) 1998-12-04 2000-06-26 N.V. Organon Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin
JP2000273088A (ja) 1999-01-18 2000-10-03 Nippon Soda Co Ltd トリフェニルイミダゾール化合物および農園芸用殺菌剤
JP2000281588A (ja) 1999-03-30 2000-10-10 Sankyo Co Ltd ガンの予防又は治療薬及びそのスクリーニング方法
DE19920936A1 (de) 1999-05-07 2000-11-09 Basf Ag Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
WO2000068266A1 (en) 1999-05-11 2000-11-16 Eli Lilly And Company Amyloid precursor protein protease and related nucleic acid compounds
US7364868B2 (en) 1999-05-19 2008-04-29 The Uab Research Foundation Krüppel-like transcriptional factor KLF4/GKLF and uses thereof
DE19925631A1 (de) 1999-06-04 2000-12-07 Georg Gros Beschichtungsverfahren und Beschichtungsgemisch
WO2000078761A1 (en) 1999-06-23 2000-12-28 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
US6266955B1 (en) 1999-08-20 2001-07-31 Caterpillar Inc. Diagnostic system for an emissions control on an engine
CN1087744C (zh) 1999-09-24 2002-07-17 中国科学院化学研究所 一种钌(ⅱ)多吡啶配合物及其制备方法
CN1088713C (zh) 1999-09-24 2002-08-07 中国科学院化学研究所 用于二级pH传感的钌(Ⅱ)多吡啶配合物及其制备方法
JP2003511396A (ja) 1999-10-08 2003-03-25 オントジエン・コーポレイシヨン 化学療法を増強する方法
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
EP1274861B1 (en) 2000-03-27 2009-12-23 Thomas Jefferson University Compositions and methods for identifying and targeting cancer cells
WO2002024680A1 (en) 2000-09-21 2002-03-28 Smithkline Beecham P.L.C. Imidazole derivatives as raf kinase inhibitors
US6458816B1 (en) 2000-10-13 2002-10-01 Vion Pharmaceuticals, Inc. Modified prodrug forms of AP/AMP
JP2004515496A (ja) 2000-12-07 2004-05-27 アストラゼネカ・アクチエボラーグ ベンズイミダゾール治療剤
WO2002072576A1 (en) 2001-03-09 2002-09-19 Pfizer Products Inc. Benzimidazole anti-inflammatory compounds
JP2002275458A (ja) 2001-03-21 2002-09-25 Fukuoka Prefecture フォトクロミックアモルファス材料及び高密度光記録媒体
CZ20032829A3 (cs) 2001-04-16 2005-03-16 Tanabe Seiyaku Co., Ltd. Heterocyklické sloučeniny
US6916440B2 (en) 2001-05-31 2005-07-12 3M Innovative Properties Company Processes and apparatus for making transversely drawn films with substantially uniaxial character
JP3759882B2 (ja) 2001-06-01 2006-03-29 株式会社日立製作所 ポンプ装置
DE10134775A1 (de) 2001-07-06 2003-01-30 Schering Ag 1-Alkyl-2.aryl-benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
CA2455181C (en) 2001-08-01 2010-04-06 Merck & Co., Inc. Benzimidazo[4,5-f]isoquinolinone derivatives
JP4637481B2 (ja) 2001-10-19 2011-02-23 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Cds1/chk2阻害剤および癌治療における化学療法または放射線療法の補助剤としての2−フェニルベンズイミダゾールおよびイミダゾ−[4,5]−ピリジン
JP2005517007A (ja) 2002-02-07 2005-06-09 アクシス・ファーマスーティカルズ ヒストンデアセチラーゼ阻害剤としての新規二環式ヒドロキサメート
US6790852B2 (en) 2002-04-18 2004-09-14 Hoffmann-La Roche Inc. 2-(2,6-dichlorophenyl)-diarylimidazoles
WO2004000857A1 (ja) 2002-06-19 2003-12-31 Kurita Water Industries Ltd. 水素貯蔵方法、水素包接化合物及びその製造方法
EP1532118A2 (en) 2002-07-05 2005-05-25 Axxima Pharmaceuticals Aktiengesellschaft Imidazole compounds for the treatment of hepatitis c virus infections
CN101870691A (zh) 2002-08-19 2010-10-27 劳洛斯治疗公司 2,4,5-三取代的咪唑及其作为抗菌剂的用途
DE10251472A1 (de) 2002-11-06 2004-05-19 Robert Bosch Gmbh Verfahren zur Nachbehandlung von Abgasen und Anordnung hierzu
WO2004071464A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
CA2425797C (en) 2003-04-17 2013-10-15 Xerox Corporation Organic light emitting devices
US7989089B2 (en) 2003-04-17 2011-08-02 Lg Display Co., Ltd. Organic luminescent compounds and methods of making and using same
DE10323591A1 (de) 2003-05-16 2004-12-02 E.G.O. Elektro-Gerätebau GmbH Verfahren und Vorrichtung zur Erzeugung eines Gases aus einem Sublimationsgut
AU2004289539C1 (en) 2003-11-14 2012-06-07 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
US20050195793A1 (en) 2004-03-05 2005-09-08 Lockheed Martin Corporation System for locally synchronizing a group of mobile devices
US20050282285A1 (en) 2004-06-21 2005-12-22 Eaton Corporation Strategy for controlling NOx emissions and ammonia slip in an SCR system using a nonselective NOx/NH3
JP2008508186A (ja) 2004-08-03 2008-03-21 アムミネクス・アー/エス 固体アンモニア貯蔵及び移送材料
AU2006209949B2 (en) 2005-02-03 2011-09-29 Amminex Emissions Technology A/S High density storage of ammonia
CA2611032C (en) * 2005-05-25 2012-01-17 Genesense Technologies Inc. 2-indolyl imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer
JP5334575B2 (ja) * 2005-05-25 2013-11-06 ローラス セラピューティクス インコーポレーテッド 2−インドリルイミダゾ[4,5‐d]フェナントロリン派生物および癌治療におけるそれらの使用
EP1901831B1 (en) 2005-06-29 2012-12-19 Amminex A/S Method and device for safe and controlled delivery of ammonia from a solid ammonia storage medium
KR100694181B1 (ko) 2005-11-25 2007-03-12 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
EP3207941B3 (en) 2006-09-07 2020-08-19 Scott & White Memorial Hospital Methods and compositions based on diphtheria toxin-interleukin-3 conjugates
WO2008125883A1 (en) 2007-04-16 2008-10-23 Cancer Research Technology Limited Cancer markers for prognosis and screening of anti-cancer agents
EP2137166B1 (en) 2007-04-24 2012-05-30 Ingenium Pharmaceuticals GmbH 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
US20100311683A1 (en) 2007-11-01 2010-12-09 Beach C L Cytidine analogs for treatment of myelodysplastic syndromes
WO2009151503A2 (en) 2008-04-10 2009-12-17 University Of Florida Research Foundation, Inc. Compositions and methods for the treatment of a neoplasia
CA2695590C (en) 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010102393A1 (en) 2009-03-12 2010-09-16 Lorus Therapeutics Inc. 2-indolyl imidazo [4,5-d]phenanthroline derivatives and their use to inhibit angiogenesis
EP2239580B1 (en) 2009-04-09 2013-03-27 Lga Biotecnologie Srl Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis
US8647623B2 (en) 2009-04-10 2014-02-11 Kyowa Hakko Kirin Co., Ltd Method for treatment of blood tumor using anti-TIM-3 antibody
WO2011066048A1 (en) 2009-10-22 2011-06-03 Thomas Jefferson University Cell-based anti-cancer compositions and methods of making and using the same
US8524240B2 (en) 2009-10-26 2013-09-03 Djordje Atanackovic Diagnosis and therapy of hematological malignancies
US20130011411A1 (en) 2010-01-06 2013-01-10 Pestell Richard G Methods and compositions for the diagnosis, prognosis, and treatment of cancer
KR101317513B1 (ko) 2010-05-17 2013-10-15 가톨릭대학교 산학협력단 대장암 또는 난소암 진단용 조성물, 진단키트 및 진단방법
AU2011276590A1 (en) 2010-06-28 2013-01-31 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
US20120172244A1 (en) 2010-12-20 2012-07-05 Steven Buechler Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease
EP3388535B1 (en) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
TW201343920A (zh) 2012-03-29 2013-11-01 財團法人國家衛生研究院 預測前列腺癌預後之分子標記、方法與套組
EP3052102B1 (en) * 2013-10-04 2019-12-04 Aptose Biosciences Inc. Compositions for treating cancers
JP6663350B2 (ja) * 2014-01-16 2020-03-11 クロヴィス・オンコロジー,インコーポレーテッド ヘテロ接合性の喪失を示す乳癌または卵巣癌の患者を治療するためのparp阻害剤の使用
JP2021501203A (ja) 2017-10-30 2021-01-14 アプトース バイオサイエンシズ インコーポレイテッド がん治療用のアリールイミダゾール

Similar Documents

Publication Publication Date Title
JP2025512780A5 (enExample)
JP2023512175A5 (enExample)
JP2008521928A5 (enExample)
US9370535B2 (en) Method for treatment of advanced solid tumors
JP2021513965A5 (enExample)
JP2023546362A5 (enExample)
JP2023500391A5 (enExample)
Gupta et al. Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer
JP2022502450A5 (enExample)
Wani et al. Gold and its complexes in anticancer chemotherapy
JP2024502446A5 (enExample)
JP2020515582A5 (enExample)
CN101484443A (zh) 放射线治疗增强剂
TW201039817A (en) Pyrrolidine substituted flavones as radio sensitizers
TW201936190A (zh) 用於治療癌症之芳基咪唑
JP2022544559A5 (enExample)
US7919486B2 (en) Use of gallium(III) complexes for the treatment of melanomas
JP2013523867A5 (enExample)
EP0819430A1 (en) Inhibitor of tumor metastasis or recurrence
TW202448458A (zh) 雌激素受體降解劑與akt抑制劑之組合
JP5103170B2 (ja) ピリジン誘導体を有効成分とする放射線治療増強剤
JPWO2005120480A1 (ja) 抗腫瘍効果増強剤、抗腫瘍剤及び癌治療方法
CN118436793A (zh) 一种双官能化合物及其用途
CN102319260A (zh) 顺铂联合伊曲康唑异构体在制备治疗肺癌药物中的应用
EP3492082B1 (en) Anticancer pharmaceutical composition