JP2021119158A5 - - Google Patents
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- JP2021119158A5 JP2021119158A5 JP2021071253A JP2021071253A JP2021119158A5 JP 2021119158 A5 JP2021119158 A5 JP 2021119158A5 JP 2021071253 A JP2021071253 A JP 2021071253A JP 2021071253 A JP2021071253 A JP 2021071253A JP 2021119158 A5 JP2021119158 A5 JP 2021119158A5
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- 239000000203 mixture Substances 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 13
- 229940122849 Autotaxin inhibitor Drugs 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 12
- 238000011282 treatment Methods 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000004410 intraocular pressure Effects 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- 208000023504 respiratory system disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940126062 Compound A Drugs 0.000 claims 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 2
- JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 102000029791 ADAM Human genes 0.000 claims 1
- 108091022885 ADAM Proteins 0.000 claims 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 1
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims 1
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 1
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 229940100688 oral solution Drugs 0.000 claims 1
- 229940100692 oral suspension Drugs 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229960003073 pirfenidone Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 claims 1
- 229960005342 tranilast Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562167216P | 2015-05-27 | 2015-05-27 | |
| US62/167,216 | 2015-05-27 | ||
| JP2017560309A JP6873919B2 (ja) | 2015-05-27 | 2016-05-24 | オートタキシン阻害剤とその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560309A Division JP6873919B2 (ja) | 2015-05-27 | 2016-05-24 | オートタキシン阻害剤とその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021119158A JP2021119158A (ja) | 2021-08-12 |
| JP2021119158A5 true JP2021119158A5 (enExample) | 2022-04-21 |
| JP7274521B2 JP7274521B2 (ja) | 2023-05-16 |
Family
ID=57393709
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560309A Active JP6873919B2 (ja) | 2015-05-27 | 2016-05-24 | オートタキシン阻害剤とその使用 |
| JP2021071253A Active JP7274521B2 (ja) | 2015-05-27 | 2021-04-20 | オートタキシン阻害剤とその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560309A Active JP6873919B2 (ja) | 2015-05-27 | 2016-05-24 | オートタキシン阻害剤とその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10632104B2 (enExample) |
| EP (2) | EP3302490B1 (enExample) |
| JP (2) | JP6873919B2 (enExample) |
| KR (2) | KR20240060887A (enExample) |
| CN (2) | CN107921048A (enExample) |
| AU (4) | AU2016268250B2 (enExample) |
| BR (1) | BR122023011445B1 (enExample) |
| CA (1) | CA2986759C (enExample) |
| EA (2) | EA039684B1 (enExample) |
| ES (1) | ES2915267T3 (enExample) |
| IL (2) | IL280863B2 (enExample) |
| MX (2) | MX2017015225A (enExample) |
| SG (1) | SG10201911204WA (enExample) |
| WO (1) | WO2016191427A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015077503A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| AU2016268250B2 (en) | 2015-05-27 | 2020-08-27 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| CN107021915A (zh) * | 2017-04-27 | 2017-08-08 | 李亚庆 | 一种治疗妇科炎症的化合物及制备方法和应用 |
| EP3668993A4 (en) * | 2017-08-14 | 2021-05-12 | Camp4 Therapeutics Corporation | HEPATIC DISEASE TREATMENT METHODS |
| WO2019172651A1 (ko) | 2018-03-06 | 2019-09-12 | 주식회사 엘지화학 | 편광판 및 이를 포함하는 화상 표시 장치 |
| CN113056266A (zh) * | 2018-09-18 | 2021-06-29 | 梅塔科林公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| CN117018202A (zh) * | 2019-07-08 | 2023-11-10 | 上海交通大学医学院附属瑞金医院 | 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用 |
| IL313660A (en) | 2021-12-22 | 2024-08-01 | Camp4 Therapeutics Corp | Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs |
| CN114767863B (zh) * | 2022-04-29 | 2024-01-30 | 西北工业大学 | 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用 |
| CA3251769A1 (en) * | 2022-05-03 | 2023-11-09 | Sabre Therapeutics Llc | POLYMORPHIC AND SALINE FORMS OF THE AUTOTAXIN INHIBITOR CUDETAXESTAT |
| US20250281486A1 (en) * | 2022-05-05 | 2025-09-11 | The Trustees Of Indiana University | Therapeutic strategies to manage facial contractures post injury |
| GR1010570B (el) | 2022-12-22 | 2023-11-17 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Α.Β.Ε.Ε., | 4-(2-(4-((2,4-διοξοθειαζολιδιν-5-υλ)μεθυλ)φαινοξυ) παραγωγα με δραση αναστολης της αυτοταξινης |
| TW202502735A (zh) * | 2023-03-02 | 2025-01-16 | 印度商吉德斯生命科學有限公司 | 新穎atx抑制劑 |
| CN116239577A (zh) * | 2023-03-27 | 2023-06-09 | 沈阳药科大学 | 一种制备Cudetaxestat的方法 |
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-
2016
- 2016-05-24 AU AU2016268250A patent/AU2016268250B2/en active Active
- 2016-05-24 KR KR1020247014437A patent/KR20240060887A/ko not_active Ceased
- 2016-05-24 SG SG10201911204WA patent/SG10201911204WA/en unknown
- 2016-05-24 EP EP16800640.1A patent/EP3302490B1/en active Active
- 2016-05-24 IL IL280863A patent/IL280863B2/en unknown
- 2016-05-24 MX MX2017015225A patent/MX2017015225A/es unknown
- 2016-05-24 CN CN201680044106.9A patent/CN107921048A/zh active Pending
- 2016-05-24 EP EP22159828.7A patent/EP4026549A1/en active Pending
- 2016-05-24 JP JP2017560309A patent/JP6873919B2/ja active Active
- 2016-05-24 ES ES16800640T patent/ES2915267T3/es active Active
- 2016-05-24 CN CN202211516732.7A patent/CN116059203A/zh active Pending
- 2016-05-24 EA EA202091731A patent/EA039684B1/ru unknown
- 2016-05-24 CA CA2986759A patent/CA2986759C/en active Active
- 2016-05-24 EA EA201792604A patent/EA036337B1/ru unknown
- 2016-05-24 WO PCT/US2016/033933 patent/WO2016191427A1/en not_active Ceased
- 2016-05-24 US US15/574,769 patent/US10632104B2/en active Active
- 2016-05-24 KR KR1020177036376A patent/KR102663569B1/ko active Active
- 2016-05-24 BR BR122023011445-0A patent/BR122023011445B1/pt active IP Right Grant
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2017
- 2017-11-20 IL IL255764A patent/IL255764B/en active IP Right Grant
- 2017-11-27 MX MX2022007436A patent/MX2022007436A/es unknown
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2020
- 2020-03-17 US US16/821,365 patent/US12458627B2/en active Active
- 2020-09-22 AU AU2020239656A patent/AU2020239656B2/en active Active
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2021
- 2021-04-20 JP JP2021071253A patent/JP7274521B2/ja active Active
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2022
- 2022-09-06 AU AU2022228098A patent/AU2022228098A1/en not_active Abandoned
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2024
- 2024-11-12 AU AU2024264577A patent/AU2024264577A1/en active Pending
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