ATE537825T1 - Immunosuppressive verbindungen und zusammensetzungen - Google Patents

Immunosuppressive verbindungen und zusammensetzungen

Info

Publication number
ATE537825T1
ATE537825T1 AT04752678T AT04752678T ATE537825T1 AT E537825 T1 ATE537825 T1 AT E537825T1 AT 04752678 T AT04752678 T AT 04752678T AT 04752678 T AT04752678 T AT 04752678T AT E537825 T1 ATE537825 T1 AT E537825T1
Authority
AT
Austria
Prior art keywords
compositions
immunosuppressive compounds
diseases
immunosuppressant
prevention
Prior art date
Application number
AT04752678T
Other languages
English (en)
Inventor
Thomas Marsilje
Nathanael Gray
Tao Jiang
Wenshuo Lu
Shifeng Pan
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Application granted granted Critical
Publication of ATE537825T1 publication Critical patent/ATE537825T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04752678T 2003-05-19 2004-05-19 Immunosuppressive verbindungen und zusammensetzungen ATE537825T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47193103P 2003-05-19 2003-05-19
PCT/US2004/015701 WO2004103309A2 (en) 2003-05-19 2004-05-19 Immunosuppressant compounds and compositions

Publications (1)

Publication Number Publication Date
ATE537825T1 true ATE537825T1 (de) 2012-01-15

Family

ID=33476902

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04752678T ATE537825T1 (de) 2003-05-19 2004-05-19 Immunosuppressive verbindungen und zusammensetzungen

Country Status (17)

Country Link
US (2) US7060697B2 (de)
EP (1) EP1638551B1 (de)
JP (1) JP4575920B2 (de)
CN (4) CN1787817B (de)
AT (1) ATE537825T1 (de)
AU (2) AU2004240649A1 (de)
BR (1) BRPI0410454A (de)
CA (1) CA2524054C (de)
CY (1) CY1112505T1 (de)
DK (1) DK1638551T3 (de)
ES (1) ES2379169T3 (de)
MX (1) MXPA05012459A (de)
PL (1) PL1638551T3 (de)
PT (1) PT1638551E (de)
SI (1) SI1638551T1 (de)
WO (1) WO2004103309A2 (de)
ZA (1) ZA200508203B (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003259296A1 (en) * 2002-07-30 2004-02-16 University Of Virginia Patent Foundation Compounds active in spinigosine 1-phosphate signaling
JP4947406B2 (ja) * 2003-08-29 2012-06-06 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途
WO2005041899A2 (en) * 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
EP1718604A4 (de) * 2004-02-24 2008-02-13 Irm Llc Die immunreaktion unterdrückende verbindungen und zusammensetzungen
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
EP1772145B1 (de) 2004-07-16 2011-03-23 Kyorin Pharmaceutical Co., Ltd. Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen
ES2615498T3 (es) 2004-10-12 2017-06-07 Kyorin Pharmaceutical Co., Ltd. Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol
JP2008522977A (ja) * 2004-12-06 2008-07-03 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−リン酸のアリールアミドアナログ
EP2371811B1 (de) * 2004-12-13 2014-10-08 Ono Pharmaceutical Co., Ltd. Azetidincarboxylsäurederivat und medizinische Verwendung davon
MX2007009534A (es) * 2005-02-08 2007-09-21 Novartis Ag Induccion de anticuerpo antilinfocito mediante la combinacion de un agonista/ modulador del receptor s1p y de farmacos inmunosupresivos.
US7754703B2 (en) * 2005-02-14 2010-07-13 University Of Virginia Patent Foundation Cycloalkane-containing sphingosine 1-phosphate agonists
KR20070121013A (ko) * 2005-04-22 2007-12-26 다이이찌 산쿄 가부시키가이샤 헤테로 고리 화합물
WO2007024922A1 (en) * 2005-08-23 2007-03-01 Irm Llc Immunosuppressant compounds and compositions
KR101297302B1 (ko) * 2005-10-07 2013-08-19 교린 세이야꾸 가부시키 가이샤 2-아미노-1,3-프로판디올 유도체를 유효성분으로 하는간장질환 치료제 및 간장질환 치료방법
EP1986623A2 (de) * 2006-01-27 2008-11-05 University Of Virginia Patent Foundation Verfahren zur behandlung von neuropathischem schmerz
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
WO2007092638A1 (en) * 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
PL2058317T3 (pl) 2006-08-08 2014-03-31 Kyorin Seiyaku Kk Aminowa pochodna estru kwasu fosforowego i modulator receptora S1P zawierający ją jako składnik aktywny
WO2008018447A1 (en) 2006-08-08 2008-02-14 Kyorin Pharmaceutical Co., Ltd. Aminoalcohol derivative and immunosuppressant containing the same as active ingredient
EP2099741A2 (de) * 2006-11-21 2009-09-16 University Of Virginia Patent Foundation Hydrindan-analoga mit sphingosin-1-phosphatrezeptoragonistenaktivität
EP2097397A1 (de) * 2006-11-21 2009-09-09 University Of Virginia Patent Foundation Tetralin-analoge mit sphingosin-1-phosphat-agonisten-aktivität
WO2008064337A2 (en) * 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
CA2699157A1 (en) 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2009060278A1 (en) * 2007-11-08 2009-05-14 Pfizer Inc. Cyclobutyl carboxylic acid derivatives
GB0725101D0 (en) * 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
GB0725104D0 (en) * 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
JP5452237B2 (ja) 2008-02-07 2014-03-26 杏林製薬株式会社 アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
WO2009131090A1 (ja) * 2008-04-21 2009-10-29 旭化成ファーマ株式会社 アミノ酸化合物
GB0807910D0 (en) * 2008-04-30 2008-06-04 Glaxo Group Ltd Compounds
CN104311472B9 (zh) 2008-07-23 2020-03-17 艾尼纳制药公司 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物
US9149459B2 (en) * 2008-07-23 2015-10-06 Novartis Ag Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation
EP2321303B1 (de) 2008-08-27 2019-11-27 Calcimedica, Inc. Verbindungen als modulatoren von intrazellulärem calcium
US8415484B2 (en) * 2008-08-27 2013-04-09 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
AU2009304598B2 (en) * 2008-10-17 2015-01-29 Akaal Pharma Pty Ltd S1P receptors modulators and their use thereof
CN103204794A (zh) * 2008-12-18 2013-07-17 诺瓦提斯公司 新的盐
RU2011129230A (ru) * 2008-12-18 2013-01-27 Новартис Аг Новая полиморфная форма 1-[4-[1-(4-циклогексил-3-трифторметилбензилоксиимино)этил]-2-этилбензил]азетидин-3-карбоновой кислоты
US8741923B2 (en) * 2008-12-18 2014-06-03 Merck Serono Sa Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis
JP2013501064A (ja) 2009-08-04 2013-01-10 アミラ ファーマシューティカルス，インコーポレーテッド リゾホスファチジン酸受容体アンタゴニストとしての化合物
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
RU2012125184A (ru) * 2009-11-24 2013-12-27 Аллерган, Инк. Новые соединения в качестве модуляторов рецепторов с терапевтическим действием
TWI517851B (zh) * 2010-01-13 2016-01-21 賽諾菲阿凡提斯公司 含２，５，７－經取代唑并嘧啶環之雜環羧酸衍生物
TWI478929B (zh) * 2010-01-13 2015-04-01 Sanofi Aventis 含２，５，７－經取代唑并嘧啶環之羧酸衍生物
MY156476A (en) * 2010-01-14 2016-02-26 Sanofi Sa Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
SG182484A1 (en) * 2010-01-14 2012-08-30 Sanofi Sa Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
WO2011086081A1 (de) * 2010-01-14 2011-07-21 Sanofi-Aventis 2,5-substituierte oxazolopyrimidinderivate
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
EP2542554B1 (de) 2010-03-03 2015-11-04 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von s1p1-rezeptormodulatoren und kristallinen formen davon
EP2560969B1 (de) 2010-04-23 2015-08-12 Bristol-Myers Squibb Company 4-(5-isoxazolyl und 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelsäureamide als sphingosin-1-phosphate 1 rezeptor agonisten
CA2797533A1 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
PT2563776T (pt) 2010-04-27 2016-09-19 Calcimedica Inc Compostos que modulam o cálcio intracelular
PT2592933T (pt) * 2010-07-16 2017-05-23 Gaweco Anderson Inibidores de mif e suas utilizações
CN106905311A (zh) 2010-08-27 2017-06-30 钙医学公司 调节细胞内钙的化合物
ES2548258T3 (es) 2010-09-24 2015-10-15 Bristol-Myers Squibb Company Compuestos de oxadiazol sustituidos y su uso como agonistas de S1P1
KR20130129232A (ko) * 2010-12-03 2013-11-27 알러간, 인코포레이티드 스핑고신 1-포스페이트 (s1p) 수용체 조절제로서의 신규한 아제티딘 유도체
EP2646018B1 (de) * 2010-12-03 2014-10-22 Allergan, Inc. Neue oximazetidinderivate als sphingosin-1-phosphat (s1p)-rezeptormodulatoren
MX347544B (es) 2010-12-07 2017-05-02 Bristol Myers Squibb Co Antagonista de acido lisofostatidico 1 (lpa1) policiclico y usos del mismo.
EA201390821A1 (ru) 2010-12-07 2013-10-30 Амира Фармасьютикалс, Инк. Антагонисты рецепторов лизофосфатидной кислоты и их применение
PT2672823T (pt) 2011-02-07 2016-11-21 Biogen Ma Inc Agentes que modulam s1p
US8541587B2 (en) 2011-04-05 2013-09-24 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonists
JP2014511878A (ja) * 2011-04-14 2014-05-19 アラーガン インコーポレイテッド スフィンゴシン−１リン酸受容体調節剤としてのフェニル二環式メチルアミン誘導体
US8735402B2 (en) * 2011-07-07 2014-05-27 Sanofi Cycloalkyloxycarboxylic acid derivatives
US8580816B2 (en) * 2011-07-07 2013-11-12 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring
MX2014004813A (es) * 2011-10-21 2014-05-20 Novartis Ag Regimen de dosificacion para un modulador o agonista del receptor s1p.
BR112014018756A8 (pt) * 2012-02-03 2017-07-11 Novartis Ag Processo para preparo de etil éster de ácido n-(4-ciclo-hexil-3-trifluorometil-benziloxi)-acetimídico
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
DK2767532T3 (en) 2012-12-21 2016-09-12 Nat Inst For Quantum And Radiological Science And Tech New connection for reproduction of tau protein heavy in the brain.
US8957061B2 (en) 2013-02-13 2015-02-17 Allergan, Inc. Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators
ES2733920T3 (es) 2013-04-26 2019-12-03 Univ Kyoto Composición que comprende un agonista del receptor 1 de esfingosina-1-fosfato para inhibir la formación y/o el aumento de tamaño de un aneurisma cerebral o para reducirlo
CN103408501B (zh) * 2013-08-14 2016-03-09 合肥医工医药有限公司 苄基嘧啶衍生物、其制备方法及其医药用途
US9951026B2 (en) 2013-09-17 2018-04-24 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
WO2015042053A1 (en) 2013-09-17 2015-03-26 Pharmakea, Inc. Vinyl autotaxin inhibitor compounds
EP3049405A4 (de) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin-inhibitorverbindungen
HRP20210957T1 (hr) 2013-11-22 2021-09-17 Sabre Therapeutics Llc Spojevi inhibitori autotaksina
EA031804B1 (ru) 2014-02-03 2019-02-28 Вайтаи Фармасьютиклз, Инк. Дигидропирролопиридиновые ингибиторы ror-гамма
SI3207043T1 (sl) 2014-10-14 2019-04-30 Vitae Pharmaceuticals, Inc. Dihidropirolopiridinovi inhibitorji za ROR-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
ES2995737T3 (en) 2015-01-06 2025-02-11 Arena Pharm Inc Compound for use in treating conditions related to the s1p1 receptor
KR102594441B1 (ko) 2015-03-06 2023-10-25 파마케아, 인크. 플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도
EP4026549A1 (de) 2015-05-27 2022-07-13 Sabre Therapeutics LLC Autotaxin-inhibitoren und verwendungen davon
MA42807A (fr) 2015-06-22 2018-07-25 Arena Pharm Inc Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
BR112018003776A2 (pt) * 2015-08-28 2018-09-25 Abbvie Deutschland compostos heterocíclicos fundidos como moduladores s1p
CN108463458B (zh) 2015-11-20 2022-02-01 生命医药有限责任公司 ROR-γ的调节剂
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3468600A4 (de) * 2016-06-10 2019-11-13 IO Therapeutics, Inc. Rezeptorselektive retinoid- und rexinoidverbindungen und immunmodulatoren zur krebsimmuntherapie
AU2017324445A1 (en) 2016-09-07 2019-04-11 Pharmakea, Inc. Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
BR112019004513A2 (pt) 2016-09-07 2019-06-18 Pharmakea Inc usos de um inibidor de lisil oxidase-like 2
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2019023207A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of rorϒ
JP7293343B2 (ja) * 2018-05-09 2023-06-19 アプリノイア セラピューティクス リミテッド ヘテロアリール化合物及びその使用
EP3801459B1 (de) 2018-06-06 2024-08-07 Arena Pharmaceuticals, Inc. Verfahren zur behandlung von erkrankungen im zusammenhang mit dem s1p1-rezeptor
CN110776450B (zh) * 2018-07-27 2022-09-27 广东东阳光药业有限公司 一种辛波莫德晶型及其制备方法
WO2020051378A1 (en) 2018-09-06 2020-03-12 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CN111630029B (zh) * 2018-12-06 2021-04-30 上海济煜医药科技有限公司 作为免疫调节剂的化合物及其制备方法和应用
TWI846774B (zh) * 2018-12-06 2024-07-01 大陸商上海濟煜醫藥科技有限公司 作為免疫調節的芳環衍生物及其製備方法和應用
CN111484434A (zh) * 2019-01-29 2020-08-04 东莞市东阳光仿制药研发有限公司 一种辛波莫德晶型及其制备方法
CN113382982B (zh) * 2019-02-25 2023-01-31 广东东阳光药业有限公司 一种辛波莫德的制备方法
AU2020383593A1 (en) 2019-11-13 2022-06-09 Aprinoia Therapeutics Limited Compounds for degrading Tau protein aggregates and uses thereof
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
CN119776509A (zh) * 2023-10-08 2025-04-08 华东师范大学 Ndufa10基因和S1pr4基因突变在肌病诊断、预测和治疗中的用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540247A (de) 1967-04-21 1973-09-28 Ciba Geigy Ag Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
IL109161A0 (en) * 1993-03-31 1994-06-24 Cell Therapeutics Inc Amino alcohol derivatives, methods for the preparation thereof, and pharmaceutical compositions containing the same
JPH10504569A (ja) * 1994-08-24 1998-05-06 イーライ・リリー・アンド・カンパニー 向代謝性グルタメート受容体拮抗剤としてのピロリジニルジカルボン酸誘導体
US6110922A (en) * 1998-12-29 2000-08-29 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
KR20020027463A (ko) * 1999-07-12 2002-04-13 우에노 도시오 스핀고신-1-인산 수용체 아고니스트 또는스핀고신-1-인산을 유효 성분으로서 함유하는 선유화 억제제
JPWO2003020313A1 (ja) * 2001-09-04 2004-12-16 小野薬品工業株式会社 スフィンゴシン−１−リン酸受容体調節剤からなる呼吸器疾患治療剤
AU2002363236A1 (en) * 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
CA2468880A1 (en) * 2001-12-14 2003-06-26 Zentaris Gmbh Tetrahydrocarbazole derivatives as ligands for g-protein coupled receptors (gpcr)
WO2003061567A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
WO2003062252A1 (en) * 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
DE10207844A1 (de) * 2002-02-15 2003-09-04 Schering Ag 1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
US20030207924A1 (en) * 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
RU2318812C2 (ru) * 2002-04-26 2008-03-10 Ф.Хоффманн-Ля Рош Аг Производные изохинолина
JP2007186422A (ja) * 2004-01-28 2007-07-26 Astellas Pharma Inc アリールスルフィド誘導体

Also Published As

Publication number Publication date
CA2524054C (en) 2012-04-24
EP1638551B1 (de) 2011-12-21
ZA200508203B (en) 2007-02-28
WO2004103309A3 (en) 2005-03-03
CN1787817B (zh) 2011-09-07
CY1112505T1 (el) 2015-12-09
CN1791592B (zh) 2012-07-04
US20050009786A1 (en) 2005-01-13
JP4575920B2 (ja) 2010-11-04
CN1816544A (zh) 2006-08-09
US7060697B2 (en) 2006-06-13
PL1638551T3 (pl) 2012-05-31
HK1090559A1 (en) 2006-12-29
MXPA05012459A (es) 2006-02-22
CN1816544B (zh) 2011-06-08
EP1638551A4 (de) 2008-12-31
CN1791592A (zh) 2006-06-21
BRPI0410454A (pt) 2006-06-13
EP1638551A2 (de) 2006-03-29
CN1791395B (zh) 2012-09-26
ES2379169T3 (es) 2012-04-23
JP2006528987A (ja) 2006-12-28
WO2004103309A2 (en) 2004-12-02
DK1638551T3 (da) 2012-04-02
CN1787817A (zh) 2006-06-14
SI1638551T1 (sl) 2012-04-30
US20050014724A1 (en) 2005-01-20
PT1638551E (pt) 2012-03-28
AU2004240649A1 (en) 2004-12-02
CA2524054A1 (en) 2004-12-02
US7462629B2 (en) 2008-12-09
AU2008203088A1 (en) 2008-08-07
CN1791395A (zh) 2006-06-21

Similar Documents

Publication Publication Date Title
ATE537825T1 (de) Immunosuppressive verbindungen und zusammensetzungen
TW200505442A (en) Immunosuppressant compounds and compositions
TNSN05294A1 (en) Immunosuppressant compounds and compositions
WO2004113330A8 (en) Immunosuppressant compounds and compositions
WO2005082089A3 (en) Immunosuppressant compounds and compositions
WO2004071442A3 (en) Novel bicyclic compounds and compositions
TW200700068A (en) Phthalazine, aza-and diaza-phthalazine compounds and methods of use
IL190654A (en) Methods of Methyl-Sulfonamido-Propanamido, Processes for Preparation and Medicines Containing Them
ATE384050T1 (de) Benzazepinderivate als histamin-h3-antagonisten
ATE549311T1 (de) Amino-propanolderivative als modulatoren des sphingosin-1-phosphat-rezeptors
TW200611702A (en) Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
ATE433966T1 (de) Methylendipiperidinderivate
ATE478863T1 (de) Heterotetracyclische verbindungen als tpo- mimetica
FR2872165B1 (fr) Nouveaux derives de pyrimido-benzimidazole
MX2007006754A (es) Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
ATE467636T1 (de) Pyrazoloä3 , 4-düazepinderivate als histamin-h3- antagonisten
TW200517382A (en) Imidazole derivatives
ES2333026T3 (es) Derivados de ciclohexil-1,4-diamina sustituidos.
ATE524463T1 (de) 4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung
TW200801005A (en) Acetylenic piperazines as metabotropic glutamate receptor antagonists
ATE417042T1 (de) Substituierte 2,5-diaminomethyl-1h-pyrrole
UA84701C2 (ru) Замещенные индолы, способ их получения, их использования
TW200621255A (en) Novel compounds