DK1638551T3 - Immunosuppressive forbindelser og sammensætninger - Google Patents
Immunosuppressive forbindelser og sammensætningerInfo
- Publication number
- DK1638551T3 DK1638551T3 DK04752678.5T DK04752678T DK1638551T3 DK 1638551 T3 DK1638551 T3 DK 1638551T3 DK 04752678 T DK04752678 T DK 04752678T DK 1638551 T3 DK1638551 T3 DK 1638551T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- immunosuppressive compounds
- diseases
- immunosuppressant
- prevention
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47193103P | 2003-05-19 | 2003-05-19 | |
PCT/US2004/015701 WO2004103309A2 (en) | 2003-05-19 | 2004-05-19 | Immunosuppressant compounds and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1638551T3 true DK1638551T3 (da) | 2012-04-02 |
Family
ID=33476902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04752678.5T DK1638551T3 (da) | 2003-05-19 | 2004-05-19 | Immunosuppressive forbindelser og sammensætninger |
Country Status (18)
Country | Link |
---|---|
US (2) | US7060697B2 (da) |
EP (1) | EP1638551B1 (da) |
JP (1) | JP4575920B2 (da) |
CN (4) | CN1787817B (da) |
AT (1) | ATE537825T1 (da) |
AU (2) | AU2004240649A1 (da) |
BR (1) | BRPI0410454A (da) |
CA (1) | CA2524054C (da) |
CY (1) | CY1112505T1 (da) |
DK (1) | DK1638551T3 (da) |
ES (1) | ES2379169T3 (da) |
HK (1) | HK1090559A1 (da) |
MX (1) | MXPA05012459A (da) |
PL (1) | PL1638551T3 (da) |
PT (1) | PT1638551E (da) |
SI (1) | SI1638551T1 (da) |
WO (1) | WO2004103309A2 (da) |
ZA (1) | ZA200508203B (da) |
Families Citing this family (104)
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CA2533587A1 (en) * | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Compounds active in sphingosine 1-phosphate signaling |
KR20110140139A (ko) * | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | S1p 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
WO2005041899A2 (en) * | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
US7718704B2 (en) * | 2004-02-24 | 2010-05-18 | Irm Llc | Immunosuppressant compounds and compositions |
CN101884781B (zh) | 2004-07-16 | 2012-07-18 | 杏林制药株式会社 | 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物 |
KR101181090B1 (ko) | 2004-10-12 | 2012-09-07 | 교린 세이야꾸 가부시키 가이샤 | 2-아미노-2-[2-[4-(3-벤질옥시페닐티오)-2-클로로페닐]에틸]-1,3-프로판디올 염산염 또는 그 수화물의 제조방법 및 그 제조 중간체 |
US7888527B2 (en) * | 2004-12-06 | 2011-02-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
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MX2007009848A (es) | 2005-02-14 | 2008-03-10 | Univ Virginia | Agonistas de esfingosina 1-fosfato comprendiendo cicloalcanos y heterociclos de 5 miembros substituidos por grupos amino y fenilo. |
NZ563522A (en) * | 2005-04-22 | 2010-01-29 | Daiichi Sankyo Co Ltd | Heterocyclic compound with immunosuppressive activity |
CN101291908A (zh) * | 2005-08-23 | 2008-10-22 | Irm责任有限公司 | 免疫抑制剂化合物和组合物 |
CA2624909C (en) * | 2005-10-07 | 2013-10-01 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease |
AU2007209961A1 (en) * | 2006-01-27 | 2007-08-09 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
JP2009526073A (ja) * | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−1−リン酸受容体アナログ |
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MX2009001457A (es) * | 2006-08-08 | 2009-02-19 | Kyorin Seiyaku Kk | Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo. |
WO2008064320A2 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
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CA2669102A1 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
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EP3892616A4 (en) * | 2018-12-06 | 2022-07-27 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND MANUFACTURING METHOD AND APPLICATION OF AN AROMATIC RING DERIVATIVE |
WO2020114477A1 (zh) * | 2018-12-06 | 2020-06-11 | 上海济煜医药科技有限公司 | 作为免疫调节剂的化合物及其制备方法和应用 |
CN111484434A (zh) * | 2019-01-29 | 2020-08-04 | 东莞市东阳光仿制药研发有限公司 | 一种辛波莫德晶型及其制备方法 |
CN113382982B (zh) * | 2019-02-25 | 2023-01-31 | 广东东阳光药业有限公司 | 一种辛波莫德的制备方法 |
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CH540247A (de) | 1967-04-21 | 1973-09-28 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen |
IL109161A0 (en) * | 1993-03-31 | 1994-06-24 | Cell Therapeutics Inc | Amino alcohol derivatives, methods for the preparation thereof, and pharmaceutical compositions containing the same |
AU3325295A (en) * | 1994-08-24 | 1996-03-14 | Eli Lilly And Company | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists |
US6110922A (en) * | 1998-12-29 | 2000-08-29 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
WO2001003739A1 (fr) * | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
US20040235794A1 (en) * | 2001-09-04 | 2004-11-25 | Shinji Nakade | Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller |
WO2003037271A2 (en) * | 2001-10-30 | 2003-05-08 | Millennium Pharmaceuticals,Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
NZ533430A (en) * | 2001-12-14 | 2005-12-23 | Zentaris Gmbh | Tetrahydrocarbozole derivatives as ligands for G-protein coupled receptors (GPCR) |
WO2003061567A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
EP1470137B1 (en) * | 2002-01-18 | 2009-09-02 | Merck & Co., Inc. | Edg receptor agonists |
DE10207844A1 (de) * | 2002-02-15 | 2003-09-04 | Schering Ag | 1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
US20030207924A1 (en) * | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
BR0309562A (pt) * | 2002-04-26 | 2005-02-15 | Hoffmann La Roche | Derivados de isoquinolina |
JP2007186422A (ja) * | 2004-01-28 | 2007-07-26 | Astellas Pharma Inc | アリールスルフィド誘導体 |
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- 2004-05-19 CN CN2004800188602A patent/CN1816544B/zh not_active Expired - Fee Related
- 2004-05-19 ES ES04752678T patent/ES2379169T3/es not_active Expired - Lifetime
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- 2004-05-19 PL PL04752678T patent/PL1638551T3/pl unknown
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- 2004-05-19 AU AU2004240649A patent/AU2004240649A1/en not_active Abandoned
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CN1791395A (zh) | 2006-06-21 |
US20050009786A1 (en) | 2005-01-13 |
ZA200508203B (en) | 2007-02-28 |
CN1787817B (zh) | 2011-09-07 |
JP2006528987A (ja) | 2006-12-28 |
CN1816544B (zh) | 2011-06-08 |
US20050014724A1 (en) | 2005-01-20 |
CN1791395B (zh) | 2012-09-26 |
CA2524054A1 (en) | 2004-12-02 |
CN1791592A (zh) | 2006-06-21 |
US7060697B2 (en) | 2006-06-13 |
WO2004103309A3 (en) | 2005-03-03 |
HK1090559A1 (en) | 2006-12-29 |
EP1638551A2 (en) | 2006-03-29 |
CN1787817A (zh) | 2006-06-14 |
CN1791592B (zh) | 2012-07-04 |
SI1638551T1 (sl) | 2012-04-30 |
CY1112505T1 (el) | 2015-12-09 |
ATE537825T1 (de) | 2012-01-15 |
JP4575920B2 (ja) | 2010-11-04 |
AU2004240649A1 (en) | 2004-12-02 |
PT1638551E (pt) | 2012-03-28 |
EP1638551A4 (en) | 2008-12-31 |
CN1816544A (zh) | 2006-08-09 |
CA2524054C (en) | 2012-04-24 |
WO2004103309A2 (en) | 2004-12-02 |
AU2008203088A1 (en) | 2008-08-07 |
PL1638551T3 (pl) | 2012-05-31 |
US7462629B2 (en) | 2008-12-09 |
EP1638551B1 (en) | 2011-12-21 |
ES2379169T3 (es) | 2012-04-23 |
BRPI0410454A (pt) | 2006-06-13 |
MXPA05012459A (es) | 2006-02-22 |
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