DK2563776T3 - Forbindelser, der modulerer intracellulært calcium - Google Patents
Forbindelser, der modulerer intracellulært calcium Download PDFInfo
- Publication number
- DK2563776T3 DK2563776T3 DK11777791.2T DK11777791T DK2563776T3 DK 2563776 T3 DK2563776 T3 DK 2563776T3 DK 11777791 T DK11777791 T DK 11777791T DK 2563776 T3 DK2563776 T3 DK 2563776T3
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- DK
- Denmark
- Prior art keywords
- calcium
- compound
- pharmaceutically acceptable
- heteroaryl
- aryl
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Claims (15)
1. Forbindelse med formel (VI):
Formula (VI);
hvor: R' i er eller L2 er -NH-C(=0)- eller -C(=0)NH-; X er CR3 eller N; Y er udvalgt uafhængigt blandt CR9 eller N; R2 er Ci-C6alkyl, Ci-Cgheteroalkyl, Ci-Cghalogenalkyl, C2- Csheterocycloalkyl, Ci-C4alkylenC2-C8heterocycloalkyl, aryl, heteroaryl, fusioneret aryl eller fusioneret heteroaryl; hvor Ci-C6alkyl, Ci-Cgheteroalkyl, Ci-Cghalogenalkyl, C2- Csheterocycloalkyl, Ci-C4alkylenC2-C8heterocycloalkyl, aryl, heteroaryl, fusioneret aryl eller fusioneret heteroaryl eventuelt er substitueret med mindst én R3; R3 er udvalgt uafhængigt blandt H, F, D, Cl, Br, I, -CN, -N02, -OH, -CF3, -OCF3, -OR5, Ci-C6alkyl, C3-C8cycloalkyl, Ci~ Cgheteroalkyl, Ci-Cghalogenalkyl, C2-C8heterocycloalkyl, eventuelt substitueret aryl, eventuelt substitueret 0-aryl, eventuelt substitueret heteroaryl, n er et helt tal udvalgt blandt 0-2; Rg er udvalgt uafhængigt blandt H, D, halogen, Ci-Cgalkyl, Ci~ Cghalogenalkyl, -0R5, -0CF3, Ci-Cgcarbonylalkyl, eller -CF3; eller to Rg, der er bundet til det samme carbonatom, danner en oxetanring; Rio er udvalgt blandt halogen, Cg-Cgalkyl, Ci-Cghalogenalkyl, -OR5, -OCF3, Ci-Cgcarbonylalkyl eller -CF3; R5 er udvalgt uafhængigt blandt H, Cg-Cgalkyl, C2- Cghalogenalkyl, Cs-Cscycloalkyl, phenyl og benzyl; eller et farmaceutisk acceptabelt salt eller farmaceutisk acceptabelt solvat deraf.
2. Forbindelse ifølge krav 1, hvor X er N.
3. Forbindelse ifølge krav 2, hvor aryl er phenyl.
4. Forbindelse ifølge krav 3, hvor phenyl er substitueret med mindst én R3 udvalgt blandt Cl, Br, F, I, CF3, Ci-C6alkyl eller 0Ci-C6alkyl.
5. Forbindelse ifølge krav 4, hvor Ci-C6alkyl er methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl eller tert- butyl.
6. Forbindelse ifølge krav 3, hvor phenyl er substitueret med mindst én R3 udvalgt blandt Cl, Br, F og I.
7. Forbindelse ifølge krav 1, hvor Ri0 er et halogen.
8. Forbindelse ifølge krav 1, hvor R2 er heteroaryl udvalgt blandt thienyl, thianthrenyl, furyl, pyranyl, thiadiazolyl, benzothiadiazolyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathiinyl, pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolizinyl, isoindolyl, 3i7-indolyl, indolyl, indazolyl, purinyl, 4H-quinolizinyl, isoquinolyl, quinolyl, phthalazinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, oxazolyl, cinnolinyl, pteridinyl, 4ai7-carbazolyl, carbazolyl, carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl, phenazinyl, phenarsazinyl, phenothiazinyl, furazanyl og phenoxazinyl.
9. Forbindelse ifølge krav 8, hvor heteroaryl er substitueret med mindst én R3 udvalgt blandt F, Cl, Br, I, -OH, -CN, N02 og Ci-C6alkyl.
10. Forbindelse ifølge krav 9, hvor heteroaryl er substitueret med mindst én F.
11. Forbindelse ifølge krav 1, hvor R'i er
og Rg er H, D, Ci-Cgalkyl, halogen, Ci-Cgcarbonylalkyl eller CF3.
12. Forbindelse ifølge krav 11, hvor Ri0 er halogen udvalgt blandt F, Cl, Br og I.
13. Forbindelse udvalgt blandt
eller et farmaceutisk acceptabelt salt eller farmaceutisk acceptabelt solvat deraf.
14. Forbindelse ifølge krav 1 med formel (VIA):
Formula (VIA) hvor R'i, R2, R3, L2 og n er som defineret i krav 1.
15. Farmaceutisk sammensætning, der omfatter et farmaceutisk acceptabelt fortyndingsmiddel, excipiens eller bindemiddel og en forbindelse ifølge krav 1 eller et farmaceutisk acceptabelt salt eller farmaceutisk acceptabelt solvat deraf.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32856910P | 2010-04-27 | 2010-04-27 | |
US37782510P | 2010-08-27 | 2010-08-27 | |
US40781910P | 2010-10-28 | 2010-10-28 | |
US42208810P | 2010-12-10 | 2010-12-10 | |
US201161430894P | 2011-01-07 | 2011-01-07 | |
US201161439786P | 2011-02-04 | 2011-02-04 | |
PCT/US2011/031992 WO2011139489A2 (en) | 2010-04-27 | 2011-04-11 | Compounds that modulate intracellular calcium |
Publications (1)
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US20130345240A1 (en) | 2013-12-26 |
AU2011248877A1 (en) | 2012-12-06 |
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PL2563776T3 (pl) | 2017-01-31 |
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AR080974A1 (es) | 2012-05-23 |
JP2017101044A (ja) | 2017-06-08 |
US8980629B2 (en) | 2015-03-17 |
WO2011139489A2 (en) | 2011-11-10 |
JP2020114824A (ja) | 2020-07-30 |
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AU2011248877B2 (en) | 2015-06-25 |
JP7066768B2 (ja) | 2022-05-13 |
TW201141855A (en) | 2011-12-01 |
ES2591004T3 (es) | 2016-11-24 |
EP2563776A2 (en) | 2013-03-06 |
PT2563776T (pt) | 2016-09-19 |
CA2797663A1 (en) | 2011-11-10 |
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