AR080974A1 - Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. - Google Patents

Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras.

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Publication number
AR080974A1
AR080974A1 ARP110101456A ARP110101456A AR080974A1 AR 080974 A1 AR080974 A1 AR 080974A1 AR P110101456 A ARP110101456 A AR P110101456A AR P110101456 A ARP110101456 A AR P110101456A AR 080974 A1 AR080974 A1 AR 080974A1
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AR
Argentina
Prior art keywords
alkyl
aryl
piridinic
piperazinic
soc
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ARP110101456A
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English (en)
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Calcimedica Inc
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Publication date
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Publication of AR080974A1 publication Critical patent/AR080974A1/es

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Abstract

Reivindicacion 1: Un compuesto que tiene la estructura de formula (1) donde X es CR3 o N; L1 es O, S, o NR11 donde R11 es H, alquenilo C2-6 o alquilo C1-6; L2 es -NH-C(=O)-, o -C(=O)NH-; R1 es arilo o heteroarilo; donde arilo o heteroarilo es opcionalmente sustituido con por lo menos un R3 o forma un sistema bicíclico; R2 es alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, alquilen C1-4-heterocicloalquilo C2-8, arilo o heteroarilo donde alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, alquilen C1-4-heterocicloalquilo C2-8, ariIo o heteroarilo es opcionalmente sustituido con por lo menos un R3; R3 se selecciona independientemente entre H, D, F, CI, Br, I, -CN, -NO2, -OH, -CF3, -OCF3, -OR5, -NR5R5, alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, arilo opcionalmente sustituido, O-arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -NHS(=O)2R4, -S(=O)2N(R5)2, -N(R5)S(=O)2N(R5)2, -C(=O)CF3, -C(=O)NHS(=O)2R4, -S(=O)2NHC(=O)R4, -N(R5)2, -N(R5)C(=O)R5, -N(R5)C(=O)N(R5)2, -N(R5)C(=O)OR4, -CO2R5, -C(=O)R5, -OC(=O)R4, -OC(=O)N(R5)2, -CON(R5)2, -SR5, -S(=O)R4, y -S(=O)2R4; cada R4 se selecciona independientemente entre alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-8, fenilo y bencilo; cada R5 se selecciona independientemente entre H, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-5, fenilo y bencilo; n es un numero entero seleccionado entre 0 y 2; o una sal farmacéuticamente aceptable, un solvato farmacéuticamente aceptable, o profármaco farmacéuticamente aceptable del mismo.
ARP110101456A 2010-04-27 2011-04-27 Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. AR080974A1 (es)

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