JP2021066727A5 - - Google Patents

Info

Publication number

JP2021066727A5

JP2021066727A5 JP2020160424A JP2020160424A JP2021066727A5 JP 2021066727 A5 JP2021066727 A5 JP 2021066727A5 JP 2020160424 A JP2020160424 A JP 2020160424A JP 2020160424 A JP2020160424 A JP 2020160424A JP 2021066727 A5 JP2021066727 A5 JP 2021066727A5

Authority

JP

Japan

Prior art keywords

composition

meningococcal

composition according

dose

serotype

Prior art date

2020-09-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 93
• 230000028993 immune response Effects 0.000 claims description 24
• 229920001184 polypeptide Polymers 0.000 claims description 22
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
• 150000004676 glycans Chemical class 0.000 claims description 16
• 229920001282 polysaccharide Polymers 0.000 claims description 16
• 239000005017 polysaccharide Substances 0.000 claims description 16
• 230000000844 anti-bacterial effect Effects 0.000 claims description 14
• 150000001720 carbohydrates Chemical class 0.000 claims description 14
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
• 210000002966 serum Anatomy 0.000 claims description 11
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 10
• 229910052782 aluminium Inorganic materials 0.000 claims description 10
• 241000588650 Neisseria meningitidis Species 0.000 claims description 9
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 8
• 229940068968 polysorbate 80 Drugs 0.000 claims description 8
• 229920000053 polysorbate 80 Polymers 0.000 claims description 8
• 229960005486 vaccine Drugs 0.000 claims description 8
• -1 tetrafluoroborate Chemical compound 0.000 claims description 7
• 239000002671 adjuvant Substances 0.000 claims description 6
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 6
• 230000001939 inductive effect Effects 0.000 claims description 6
• 239000011780 sodium chloride Substances 0.000 claims description 6
• 229960000814 tetanus toxoid Drugs 0.000 claims description 6
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 5
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 5
• 230000004044 response Effects 0.000 claims description 5
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
• 229930006000 Sucrose Natural products 0.000 claims description 4
• 150000001413 amino acids Chemical group 0.000 claims description 4
• 239000005720 sucrose Substances 0.000 claims description 4
• 150000001718 carbodiimides Chemical class 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 229940124951 Menveo Drugs 0.000 claims description 2
• IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 claims description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
• 239000007788 liquid Substances 0.000 claims description 2
• 229940035144 trumenba Drugs 0.000 claims description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
• 239000002775 capsule Substances 0.000 claims 2
• 229960002885 histidine Drugs 0.000 description 3
• 230000002163 immunogen Effects 0.000 description 2
• 229940009859 aluminum phosphate Drugs 0.000 description 1
• 229960002668 sodium chloride Drugs 0.000 description 1
• 229960004793 sucrose Drugs 0.000 description 1