BRPI0715360B8 - método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição - Google Patents
método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composiçãoInfo
- Publication number
- BRPI0715360B8 BRPI0715360B8 BRPI0715360A BRPI0715360A BRPI0715360B8 BR PI0715360 B8 BRPI0715360 B8 BR PI0715360B8 BR PI0715360 A BRPI0715360 A BR PI0715360A BR PI0715360 A BRPI0715360 A BR PI0715360A BR PI0715360 B8 BRPI0715360 B8 BR PI0715360B8
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- protein
- recombinant
- composition
- meningococcal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição. apresentam-se métodos para a produção de proteínas, por exemplo, proteínas 2086 meningocócícas recombinantes, usando fermentação por batelada alimentada com entrada contínua de um indutor depois de se atingir um parâmetro de limiar e, opcionalmente, a entrada contínua de uma fonte de carbono, por exemplo, uma entrada a taxa constante, para melhorar os rendimentos de proteína, assim como composições de proteínas de alta densidade e composições para uso nos métodos da presente invenção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83347906P | 2006-07-27 | 2006-07-27 | |
| US833,479 | 2006-07-27 | ||
| PCT/US2007/016917 WO2008013943A2 (en) | 2006-07-27 | 2007-07-21 | High-cell density fed-batch fermentation process for producing recombinant protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0715360A2 BRPI0715360A2 (pt) | 2013-06-18 |
| BRPI0715360B1 BRPI0715360B1 (pt) | 2021-01-19 |
| BRPI0715360B8 true BRPI0715360B8 (pt) | 2022-01-04 |
Family
ID=38982103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0715360A BRPI0715360B8 (pt) | 2006-07-27 | 2007-07-21 | método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8632995B2 (pt) |
| EP (2) | EP2061897B1 (pt) |
| JP (2) | JP2009544321A (pt) |
| KR (1) | KR101419958B1 (pt) |
| CN (2) | CN101535493A (pt) |
| AU (1) | AU2007277081B2 (pt) |
| BR (1) | BRPI0715360B8 (pt) |
| CA (1) | CA2657135C (pt) |
| DK (1) | DK2061897T3 (pt) |
| ES (1) | ES2788001T3 (pt) |
| HK (1) | HK1217969A1 (pt) |
| HU (1) | HUE048973T2 (pt) |
| IL (1) | IL196496A (pt) |
| MX (1) | MX2009000813A (pt) |
| PL (1) | PL2061897T3 (pt) |
| PT (1) | PT2061897T (pt) |
| RU (1) | RU2451070C2 (pt) |
| SG (1) | SG174013A1 (pt) |
| SI (1) | SI2061897T1 (pt) |
| WO (1) | WO2008013943A2 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| HUE048973T2 (hu) | 2006-07-27 | 2020-09-28 | Wyeth Llc | Nagy sejtsûrûségû, rátáplálásos-szakaszos fermentáló eljárás rekombináns fehérje elõállítására |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| EP3831406B1 (en) | 2010-08-23 | 2024-06-05 | Wyeth LLC | Stable formulations of neisseria meningitidis rlp2086 antigens |
| AU2011300409B2 (en) | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
| WO2012104176A1 (en) * | 2011-01-31 | 2012-08-09 | Novozymes A/S | Use of browned glucose as a feed substrate |
| MX351993B (es) | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| EP2825633B1 (en) * | 2012-03-12 | 2019-03-06 | Hanmi Science Co., Ltd. | Method of culturing e. coli cells for high density |
| CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
| MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
| RU2561467C1 (ru) * | 2014-04-24 | 2015-08-27 | Сергей Михайлович Юдин | Способ получения препарата для повышения мясной и молочной продуктивности сельскохозяйственных животных (варианты) и препарат, полученный на его основе |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10322304B2 (en) * | 2015-01-29 | 2019-06-18 | Sandy Kronenberg | Nasal air filter |
| RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7010961B2 (ja) | 2017-01-31 | 2022-02-10 | ファイザー・インク | 髄膜炎菌組成物およびその方法 |
| WO2021087404A1 (en) * | 2019-10-30 | 2021-05-06 | Future Fields Cellular Agriculture and Research LTD. | Method for producing recombinant proteins in insects |
| CN117510596A (zh) * | 2023-11-13 | 2024-02-06 | 中山迈托姆生物技术有限公司 | 一种大肠杆菌高密度表达犬瘟热抗原的发酵工艺及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414329A (en) * | 1980-01-15 | 1983-11-08 | Phillips Petroleum Company | Biochemical conversions by yeast fermentation at high cell densities |
| GB8516415D0 (en) * | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US5672502A (en) * | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| RU2111246C1 (ru) * | 1992-06-03 | 1998-05-20 | Дербышев Виктор Викторович | Способ получения биомассы аэробнорастущих микроорганизмов |
| AUPM772494A0 (en) | 1994-08-30 | 1994-09-22 | Austin Research Institute, The | Improvements in production of proteins in host cells |
| AR005035A1 (es) * | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
| AU722624B2 (en) | 1996-09-06 | 2000-08-10 | Trustees Of The University Of Pennsylvania, The | An inducible method for production of recombinant adeno-associated viruses utilizing T7 polymerase |
| US6692961B1 (en) | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
| KR20020043254A (ko) * | 1999-10-29 | 2002-06-08 | 스타르크, 카르크 | Ｌ-판토락톤 가수분해 효소 및 ｄ-판토락톤의 제조 방법 |
| MXPA03004324A (es) * | 2000-11-20 | 2004-01-26 | Cargill Inc | Acido 3-hidroxipropionico y otros compuestos organicos. |
| FI120310B (fi) | 2001-02-13 | 2009-09-15 | Valtion Teknillinen | Parannettu menetelmä erittyvien proteiinien tuottamiseksi sienissä |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| CN1504575A (zh) * | 2002-12-03 | 2004-06-16 | 怀德生技化学股份有限公司 | 以左旋阿拉伯糖诱导t7表达系统的控制方法 |
| CA2507817C (en) * | 2002-12-13 | 2014-04-22 | Zymogenetics, Inc. | Il-21 production in prokaryotic hosts |
| DE10305774A1 (de) * | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
| WO2004094596A2 (en) | 2003-04-16 | 2004-11-04 | Wyeth Holdings Corporation | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
| CN100384998C (zh) * | 2003-11-11 | 2008-04-30 | 浙江大学 | 重组鹅白细胞介素-2蛋白的制备方法及其用途 |
| US8227241B2 (en) * | 2004-03-12 | 2012-07-24 | Unigene Laboratories, Inc. | Bacterial host cell for the direct expression of peptides |
| HUE048973T2 (hu) | 2006-07-27 | 2020-09-28 | Wyeth Llc | Nagy sejtsûrûségû, rátáplálásos-szakaszos fermentáló eljárás rekombináns fehérje elõállítására |
-
2007
- 2007-07-21 HU HUE07836299A patent/HUE048973T2/hu unknown
- 2007-07-21 SI SI200732152T patent/SI2061897T1/sl unknown
- 2007-07-21 DK DK07836299.3T patent/DK2061897T3/da active
- 2007-07-21 PT PT78362993T patent/PT2061897T/pt unknown
- 2007-07-21 AU AU2007277081A patent/AU2007277081B2/en active Active
- 2007-07-21 RU RU2008152445/10A patent/RU2451070C2/ru active
- 2007-07-21 KR KR1020097002713A patent/KR101419958B1/ko active IP Right Grant
- 2007-07-21 EP EP07836299.3A patent/EP2061897B1/en active Active
- 2007-07-21 EP EP20164873.0A patent/EP3705579A1/en active Pending
- 2007-07-21 SG SG2011054384A patent/SG174013A1/en unknown
- 2007-07-21 WO PCT/US2007/016917 patent/WO2008013943A2/en active Application Filing
- 2007-07-21 PL PL07836299T patent/PL2061897T3/pl unknown
- 2007-07-21 CA CA2657135A patent/CA2657135C/en active Active
- 2007-07-21 ES ES07836299T patent/ES2788001T3/es active Active
- 2007-07-21 JP JP2009521856A patent/JP2009544321A/ja active Pending
- 2007-07-21 CN CNA200780027778XA patent/CN101535493A/zh active Pending
- 2007-07-21 CN CN201511016493.9A patent/CN105463045A/zh active Pending
- 2007-07-21 MX MX2009000813A patent/MX2009000813A/es active IP Right Grant
- 2007-07-21 BR BRPI0715360A patent/BRPI0715360B8/pt active IP Right Grant
- 2007-07-27 US US11/829,703 patent/US8632995B2/en active Active
-
2009
- 2009-01-13 IL IL196496A patent/IL196496A/en active IP Right Grant
-
2013
- 2013-12-04 JP JP2013250901A patent/JP5925175B2/ja active Active
- 2013-12-19 US US14/135,434 patent/US9279000B2/en active Active
-
2016
- 2016-02-01 US US15/011,815 patent/US10301663B2/en active Active
- 2016-05-24 HK HK16105893.9A patent/HK1217969A1/zh unknown
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/01/2021, OBSERVADAS AS CONDICOES LEGAIS. |
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