HK1217969A1 - 用於生產重組蛋白質的高細胞密度補料-分批發酵方法 - Google Patents

用於生產重組蛋白質的高細胞密度補料-分批發酵方法

Info

Publication number
HK1217969A1
HK1217969A1 HK16105893.9A HK16105893A HK1217969A1 HK 1217969 A1 HK1217969 A1 HK 1217969A1 HK 16105893 A HK16105893 A HK 16105893A HK 1217969 A1 HK1217969 A1 HK 1217969A1
Authority
HK
Hong Kong
Prior art keywords
recombinant protein
cell density
fermentation process
high cell
batch fermentation
Prior art date
Application number
HK16105893.9A
Other languages
English (en)
Inventor
衛强．威利．孫
厄爾．珀塞爾
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HK1217969A1 publication Critical patent/HK1217969A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
HK16105893.9A 2006-07-27 2016-05-24 用於生產重組蛋白質的高細胞密度補料-分批發酵方法 HK1217969A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83347906P 2006-07-27 2006-07-27

Publications (1)

Publication Number Publication Date
HK1217969A1 true HK1217969A1 (zh) 2017-01-27

Family

ID=38982103

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16105893.9A HK1217969A1 (zh) 2006-07-27 2016-05-24 用於生產重組蛋白質的高細胞密度補料-分批發酵方法

Country Status (20)

Country Link
US (3) US8632995B2 (zh)
EP (2) EP2061897B1 (zh)
JP (2) JP2009544321A (zh)
KR (1) KR101419958B1 (zh)
CN (2) CN105463045A (zh)
AU (1) AU2007277081B2 (zh)
BR (1) BRPI0715360B8 (zh)
CA (1) CA2657135C (zh)
DK (1) DK2061897T3 (zh)
ES (1) ES2788001T3 (zh)
HK (1) HK1217969A1 (zh)
HU (1) HUE048973T2 (zh)
IL (1) IL196496A (zh)
MX (1) MX2009000813A (zh)
PL (1) PL2061897T3 (zh)
PT (1) PT2061897T (zh)
RU (1) RU2451070C2 (zh)
SG (1) SG174013A1 (zh)
SI (1) SI2061897T1 (zh)
WO (1) WO2008013943A2 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
BRPI0715360B8 (pt) * 2006-07-27 2022-01-04 Wyeth Corp método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
DK3246044T3 (da) 2010-08-23 2021-01-18 Wyeth Llc Stabile formuleringer af Neisseria-meningitidis-RLP2086-antigener
EP3549601B1 (en) 2010-09-10 2021-02-24 Wyeth LLC Non-lipidated variants of neisseria meningitidis orf2086 antigens
CA2823270A1 (en) * 2011-01-31 2012-08-09 Novozymes A/S Use of browned glucose as a feed substrate
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
SG10201602558UA (en) 2012-03-09 2016-05-30 Pfizer Neisseria meningitidis compositions and methods thereof
EP2825633B1 (en) * 2012-03-12 2019-03-06 Hanmi Science Co., Ltd. Method of culturing e. coli cells for high density
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
KR20180099912A (ko) 2013-09-08 2018-09-05 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
RU2561467C1 (ru) * 2014-04-24 2015-08-27 Сергей Михайлович Юдин Способ получения препарата для повышения мясной и молочной продуктивности сельскохозяйственных животных (варианты) и препарат, полученный на его основе
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10322304B2 (en) * 2015-01-29 2019-06-18 Sandy Kronenberg Nasal air filter
CN107249626A (zh) 2015-02-19 2017-10-13 辉瑞大药厂 脑膜炎奈瑟球菌组合物及其方法
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
BR112019014397A2 (pt) 2017-01-31 2020-02-11 Pfizer Inc. Composições de neisseria meningitidis e métodos das mesmas
US20210127650A1 (en) * 2019-10-30 2021-05-06 Future Fields Cellular Agriculture and Research LTD. Method for producing recombinant proteins in insects
CN117510596A (zh) * 2023-11-13 2024-02-06 中山迈托姆生物技术有限公司 一种大肠杆菌高密度表达犬瘟热抗原的发酵工艺及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414329A (en) * 1980-01-15 1983-11-08 Phillips Petroleum Company Biochemical conversions by yeast fermentation at high cell densities
US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
GB8516415D0 (en) * 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
RU2111246C1 (ru) * 1992-06-03 1998-05-20 Дербышев Виктор Викторович Способ получения биомассы аэробнорастущих микроорганизмов
AUPM772494A0 (en) 1994-08-30 1994-09-22 Austin Research Institute, The Improvements in production of proteins in host cells
AR005035A1 (es) * 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
JP2001500015A (ja) 1996-09-06 2001-01-09 トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Ｔ７ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法
US6692961B1 (en) 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
MXPA02003417A (es) 1999-10-29 2002-08-20 Basf Ag L-pantolactona-hidrolasa y un procedimiento para la obtencion de d-pantolactona.
WO2002042418A2 (en) * 2000-11-20 2002-05-30 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
FI120310B (fi) 2001-02-13 2009-09-15 Valtion Teknillinen Parannettu menetelmä erittyvien proteiinien tuottamiseksi sienissä
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CN1504575A (zh) * 2002-12-03 2004-06-16 怀德生技化学股份有限公司 以左旋阿拉伯糖诱导t7表达系统的控制方法
BR0317243A (pt) * 2002-12-13 2005-11-01 Zymogenetics Inc Vetor de expressão, célula hospedeira, métodos para produzir proteìnas il-21 e para isolar proteìna il-21 insolúvel, e, composição
DE10305774A1 (de) 2003-02-06 2004-08-26 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von L-Methionin
US20070253964A1 (en) 2003-04-16 2007-11-01 Zlotnick Gary W Novel Immunogenic Compositions for the Prevention and Treatment of Meningococcal Disease
CN100384998C (zh) * 2003-11-11 2008-04-30 浙江大学 重组鹅白细胞介素-2蛋白的制备方法及其用途
US8227241B2 (en) * 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
BRPI0715360B8 (pt) 2006-07-27 2022-01-04 Wyeth Corp método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição

Also Published As

Publication number Publication date
AU2007277081A1 (en) 2008-01-31
IL196496A0 (en) 2011-08-01
US10301663B2 (en) 2019-05-28
BRPI0715360A2 (pt) 2013-06-18
CA2657135A1 (en) 2008-01-31
DK2061897T3 (da) 2020-06-02
KR20090034375A (ko) 2009-04-07
KR101419958B1 (ko) 2014-07-16
RU2451070C2 (ru) 2012-05-20
US8632995B2 (en) 2014-01-21
CN105463045A (zh) 2016-04-06
CA2657135C (en) 2016-03-15
RU2008152445A (ru) 2010-09-10
AU2007277081B2 (en) 2014-02-06
US20080026425A1 (en) 2008-01-31
CN101535493A (zh) 2009-09-16
EP2061897A4 (en) 2012-03-07
BRPI0715360B1 (pt) 2021-01-19
SI2061897T1 (sl) 2020-07-31
EP3705579A1 (en) 2020-09-09
JP2014064583A (ja) 2014-04-17
JP5925175B2 (ja) 2016-05-25
US9279000B2 (en) 2016-03-08
BRPI0715360B8 (pt) 2022-01-04
WO2008013943A3 (en) 2009-04-02
EP2061897A2 (en) 2009-05-27
PT2061897T (pt) 2020-05-08
US20140113329A1 (en) 2014-04-24
PL2061897T3 (pl) 2020-09-07
ES2788001T3 (es) 2020-10-20
IL196496A (en) 2016-05-31
HUE048973T2 (hu) 2020-09-28
WO2008013943A2 (en) 2008-01-31
JP2009544321A (ja) 2009-12-17
EP2061897B1 (en) 2020-03-25
US20160289725A1 (en) 2016-10-06
SG174013A1 (en) 2011-09-29
MX2009000813A (es) 2009-02-03

Similar Documents

Publication Publication Date Title
HK1217969A1 (zh) 用於生產重組蛋白質的高細胞密度補料-分批發酵方法
WO2008033517A3 (en) Cell culture improvements
IL196322A0 (en) Improved process for the culturing of cells
EP2011857A4 (en) METHOD FOR PRODUCING A CELL CULTURAL CONTAINER
EP2133943A4 (en) PROCESS FOR PREPARING AN ELECTRODE CATALYST FOR A FUEL CELL
WO2009054433A1 (ja) 異種タンパク質製造のための細胞及びそれを用いた製造方法
GB0617476D0 (en) Improved process for biodiesel production
EP2194126A4 (en) PROCESS FOR CONSTRUCTING CELLS WITH HIGH PRODUCTIVITY OF FOREIGN PROTEIN
EP2041296A4 (en) PROCESS FOR PRODUCING HIGH LEVELS OF RECOMBINANT PROTEINS OF PRODUCING STABLE MICRICULAR CELL LINES
EP1721871A4 (en) PROCESS FOR GENERATING BIOGAS
IL209617A (en) Methods for enhancing secreted protein production in cell culture
EP2189529A4 (en) RECOMBINANT MAMMALIAN CELLS, PROCESS FOR PRODUCING RECOMBINANT MAMMALIAN CELLS, AND METHOD FOR PRODUCING TARGET PROTEIN
IL218957A0 (en) Dna construct , and process for production of recombinant cho cell using same
EP2053926A4 (en) PROCESS FOR THE PREPARATION OF HYBRID PROTEINS
EP1939283A4 (en) PROCESS FOR PRODUCING RECOMBINANT HUMAN THROMBIN BY A CULTIVATED CELL
EP2274418A4 (en) HUMAN HOST CELL FOR PRODUCING RECOMBINANT PROTEINS WITH HIGH QUALITY AND LARGE QUANTITY
EP2006302A4 (en) PROTEIN COMPLEX AND METHOD FOR THE PRODUCTION THEREOF
EP1935981A4 (en) PROCESS FOR PRODUCING RECOMBINANT PROTEIN
PL1930368T3 (pl) Sposób wytwarzania tworzyw piankowych o powiększonych komórkach
GB0708430D0 (en) Process for producing fermentable sugars