|
EP0903341A1
(en)
|
1997-07-22 |
1999-03-24 |
Akzo Nobel N.V. |
"Novel ortho-mercaptoaniline compounds"
|
|
AU2001282941C1
(en)
|
2000-07-21 |
2016-12-22 |
Gilead Sciences, Inc. |
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
|
|
WO2004087720A1
(en)
|
2003-03-10 |
2004-10-14 |
Pfizer Inc. |
Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1)
|
|
CA2523083C
(en)
|
2003-04-25 |
2014-07-08 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
JP2008508291A
(ja)
|
2004-07-27 |
2008-03-21 |
ギリアード サイエンシーズ, インコーポレイテッド |
抗hiv剤としてのヌクレオシドホスホネート結合体
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯
|
|
TWI404537B
(zh)
|
2005-08-19 |
2013-08-11 |
Array Biopharma Inc |
作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯
|
|
EA021463B1
(ru)
|
2007-06-29 |
2015-06-30 |
Джилид Сайэнс, Инк. |
Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7
|
|
KR20100097156A
(ko)
|
2007-11-16 |
2010-09-02 |
베링거 인겔하임 인터내셔날 게엠베하 |
사람 면역결핍 바이러스 복제의 억제제
|
|
SG10201805844QA
(en)
|
2008-07-08 |
2018-08-30 |
Incyte Holdings Corp |
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
|
|
PT2313111E
(pt)
|
2008-08-01 |
2013-12-05 |
Ventirx Pharmaceuticals Inc |
Formulações de agonista de receptor do tipo toll e seus usos
|
|
TW201639852A
(zh)
|
2008-12-09 |
2016-11-16 |
吉李德科學股份有限公司 |
用於製備可用作類鐸受體調節劑之化合物的中間體化合物
|
|
JP5690286B2
(ja)
*
|
2009-03-04 |
2015-03-25 |
イデニク プハルマセウティカルス,インコーポレイテッド |
ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
WO2011022509A2
(en)
|
2009-08-18 |
2011-02-24 |
Ventirx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
PL2467377T3
(pl)
|
2009-08-18 |
2017-10-31 |
Ventirx Pharmaceuticals Inc |
Podstawione benzoazepiny jako modulatory receptora toll-podobnego
|
|
WO2011049825A1
(en)
|
2009-10-22 |
2011-04-28 |
Gilead Sciences, Inc. |
Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
|
|
US9186337B2
(en)
|
2010-02-24 |
2015-11-17 |
Oryzon Genomics S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
|
|
US20130165489A1
(en)
|
2010-05-03 |
2013-06-27 |
The Trustees Of The University Of Pennsylvania |
Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof
|
|
MY169745A
(en)
|
2010-05-31 |
2019-05-14 |
Ono Pharmaceutical Co |
Purinone derivative
|
|
US20120149708A1
(en)
|
2010-06-17 |
2012-06-14 |
George Mason University |
Modulators of viral transcription, and methods and compositions therewith
|
|
SG186820A1
(en)
|
2010-07-02 |
2013-02-28 |
Gilead Sciences Inc |
Napht- 2 -ylacetic acid derivatives to treat aids
|
|
BR112012033689A2
(pt)
|
2010-07-02 |
2019-09-24 |
Gilead Sciences Inc |
derivados de ácido 2-quinolinil-acético como compostos de hiv antivirais
|
|
SG188362A1
(en)
*
|
2010-09-01 |
2013-04-30 |
Arena Pharm Inc |
Modified-release dosage forms of 5-ht2c agonists useful for weight management
|
|
US9102668B2
(en)
|
2010-09-08 |
2015-08-11 |
Glaxo Group Limited |
Polymorphs and salts
|
|
HUE026059T2
(en)
|
2010-09-08 |
2016-05-30 |
Glaxosmithkline Ip Dev Ltd |
N- [5- [4- (5 - {[(2R, 6S) -2,6-dimethyl-4-morpholinyl] methyl} -1,3-oxazol-2-yl) -1H-indazol-6-yl ] Polymorphs and salts of 2 - (methyloxy) -3-pyridinyl] methanesulfonamide
|
|
BR112013007678A2
(pt)
|
2010-10-01 |
2017-07-04 |
Ventirx Pharmaceuticals Inc |
método para tratamento de doenças alérgicas
|
|
MX340290B
(es)
|
2010-10-01 |
2016-07-04 |
Ventirx Pharmaceuticals Inc |
Uso terapéutico de un agonista de receptor tipo toll y terapia de combinación.
|
|
AR084217A1
(es)
|
2010-12-10 |
2013-05-02 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
|
US9718796B2
(en)
|
2011-01-12 |
2017-08-01 |
Ventirx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
BR112013017947A2
(pt)
|
2011-01-12 |
2018-12-18 |
Array Biopharma Inc |
benzoazepinas substituídas como moduladores de receptor toll-like
|
|
CN103476426B
(zh)
|
2011-02-12 |
2021-08-10 |
全球免疫股份有限公司 |
用于慢性乙型肝炎病毒感染的基于酵母的治疗剂
|
|
LT3590928T
(lt)
|
2011-04-08 |
2021-08-25 |
Janssen Sciences Ireland Unlimited Company |
Pirimidino dariniai, skirti virusinės infekcijos gydymui
|
|
ES2615734T3
(es)
|
2011-04-21 |
2017-06-08 |
Gilead Sciences, Inc. |
Compuestos de benzotiazol y su uso farmacéutico
|
|
US8916575B2
(en)
|
2011-05-18 |
2014-12-23 |
Janssen R&D Ireland |
Quinazoline derivatives for the treatment of viral infections and further diseases
|
|
EP2729448B1
(en)
|
2011-07-06 |
2015-09-09 |
Gilead Sciences, Inc. |
Compounds for the treatment of hiv
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
DK2744810T4
(da)
*
|
2011-08-16 |
2023-11-20 |
Gilead Sciences Inc |
Tenofovir-alafenamid-hemifumarat
|
|
NZ626750A
(en)
|
2011-11-29 |
2015-08-28 |
Ono Pharmaceutical Co |
Purinone derivative hydrochloride
|
|
EP2794613B1
(en)
|
2011-12-20 |
2017-03-29 |
Boehringer Ingelheim International GmbH |
Condensed triclyclic compounds as inhibitors of hiv replication
|
|
KR101699822B1
(ko)
|
2011-12-21 |
2017-01-25 |
노비라 테라퓨틱스, 인코포레이티드 |
B형 간염의 항바이러스성 제제
|
|
DK2794624T3
(da)
|
2011-12-22 |
2019-07-22 |
Geron Corp |
Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
|
|
BR112014019699B1
(pt)
|
2012-02-08 |
2021-12-07 |
Janssen Sciences Ireland Uc |
Derivados de piperidino-pirimidina, seu uso no tratamento de infecções virais e composição farmacêutica que os compreende
|
|
US20130267517A1
(en)
|
2012-03-31 |
2013-10-10 |
Hoffmann-La Roche Inc. |
Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
MX2014011749A
(es)
|
2012-03-31 |
2015-01-22 |
Hoffmann La Roche |
4-metil-dihidropirimidinas novedosas para el tratamiento y la prolifaxis de la infeccion por el virus de la hepatitis b.
|
|
MX2014005002A
(es)
|
2012-04-20 |
2014-07-09 |
Gilead Sciences Inc |
Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih.
|
|
WO2013185103A1
(en)
|
2012-06-08 |
2013-12-12 |
Gilead Sciences, Inc. |
Macrocyclic inhibitors of flaviviridae viruses
|
|
NZ724616A
(en)
|
2012-06-08 |
2018-06-29 |
Gilead Sciences Inc |
Macrocyclic inhibitors of flaviviridae viruses
|
|
AR091279A1
(es)
|
2012-06-08 |
2015-01-21 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
|
BR112015002524B1
(pt)
|
2012-08-10 |
2021-11-03 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina, composição farmacêutica que os compreende e uso dos mesmos
|
|
AR092269A1
(es)
|
2012-08-28 |
2015-04-08 |
Janssen R&D Ireland |
Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
|
|
CN104797561B
(zh)
|
2012-08-28 |
2017-03-01 |
爱尔兰詹森科学公司 |
稠合二环的氨磺酰基衍生物及其作为药物用于治疗乙型肝炎的用途
|
|
CN103665043B
(zh)
|
2012-08-30 |
2017-11-10 |
江苏豪森药业集团有限公司 |
一种替诺福韦前药及其在医药上的应用
|
|
EP2892893B2
(en)
|
2012-09-10 |
2019-10-16 |
F.Hoffmann-La Roche Ag |
6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
KR102160320B1
(ko)
|
2012-10-02 |
2020-09-28 |
에피테라퓨틱스 에이피에스 |
히스톤 탈메틸효소의 저해제
|
|
SI2906563T1
(en)
|
2012-10-10 |
2018-06-29 |
Janssen Sciences Ireland Uc |
Derivatives of pyrrolo (3,2-d) pyrimidine for the treatment of viral infections and other diseases
|
|
KR101268466B1
(ko)
|
2012-11-12 |
2013-06-04 |
유병수 |
사축형 윈드 터빈
|
|
MY171115A
(en)
|
2012-11-16 |
2019-09-26 |
Janssen Sciences Ireland Uc |
Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
|
|
ES2834959T3
(es)
|
2012-12-06 |
2021-06-21 |
Celgene Quanticel Res Inc |
Inhibidores de histona desmetilasa
|
|
PT2934145T
(pt)
|
2012-12-19 |
2018-02-13 |
Celgene Quanticel Res Inc |
Inibidores de histona demetilase
|
|
PE20151417A1
(es)
|
2012-12-21 |
2015-10-10 |
Quanticel Pharmaceuticals Inc |
Inhibidores de histona desmetilasa
|
|
MX344879B
(es)
|
2012-12-21 |
2017-01-11 |
Gilead Sciences Inc |
Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico.
|
|
RU2015131006A
(ru)
|
2012-12-27 |
2017-01-30 |
Джапан Тобакко Инк. |
ЗАМЕЩЕННОЕ ПРОИЗВОДНОЕ СПИРОПИРИДО[1,2-a]ПИРАЗИНА И ЕГО ПРИМЕНЕНИЕ В МЕДИЦИНЕ В КАЧЕСТВЕ ИНГИБИТОРА ИНТЕГРАЗЫ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ)
|
|
UA118751C2
(uk)
|
2013-02-21 |
2019-03-11 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Похідні 2-амінопіримідину для лікування вірусних інфекцій
|
|
SI2961736T1
(en)
|
2013-02-27 |
2018-06-29 |
Gilead Sciences, Inc. |
Histone demethylase inhibitors
|
|
SI2961732T1
(sl)
|
2013-02-28 |
2017-07-31 |
Janssen Sciences Ireland Uc |
Sulfamoil-arilamidi in njihova uporaba kot zdravila za zdravljenje hepatitisa B
|
|
EP2968282B1
(en)
|
2013-03-12 |
2018-05-09 |
Celgene Quanticel Research, Inc. |
Histone dementhylase inhibitors
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
US10035801B2
(en)
|
2013-03-13 |
2018-07-31 |
Genentech, Inc. |
Pyrazolo compounds and uses thereof
|
|
US9133166B2
(en)
|
2013-03-14 |
2015-09-15 |
Quanticel Pharmaceuticals, Inc. |
Histone demethylase inhibitors
|
|
SI2970211T1
(sl)
|
2013-03-15 |
2017-12-29 |
Quanticel Pharmaceuticals Inc. |
Inhibitorji histon demetilaze
|
|
HUE033542T2
(en)
|
2013-04-03 |
2017-12-28 |
Janssen Sciences Ireland Uc |
Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B
|
|
BR112015026252B1
(pt)
*
|
2013-04-15 |
2022-03-22 |
Becton, Dickinson And Company |
Dispositivo de coleta de fluido biológico e sistema de coleta e teste de fluido biológico
|
|
CN105209470B
(zh)
|
2013-05-17 |
2018-02-06 |
豪夫迈·罗氏有限公司 |
用于治疗和预防乙型肝炎病毒感染的6‑桥连的杂芳基二氢嘧啶
|
|
US10160743B2
(en)
|
2013-05-17 |
2018-12-25 |
Janssen Sciences Ireland Uc |
Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
JO3603B1
(ar)
|
2013-05-17 |
2020-07-05 |
Janssen Sciences Ireland Uc |
مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
|
|
US9676803B2
(en)
|
2013-06-07 |
2017-06-13 |
Cipla Limited |
Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
|
|
WO2015002434A1
(en)
|
2013-07-03 |
2015-01-08 |
Dong-A St Co.,Ltd |
Novel tenofovir disoproxil salt and the preparation method thereof
|
|
SG10201805033XA
(en)
|
2013-07-25 |
2018-07-30 |
Janssen Sciences Ireland Uc |
Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
|
|
KR20150025993A
(ko)
|
2013-08-30 |
2015-03-11 |
동아에스티 주식회사 |
테노포비어 디소프록실 산부가염 및 이의 제조방법
|
|
DK3043865T3
(da)
|
2013-09-11 |
2021-02-01 |
Univ Claude Bernard Lyon |
Fremgangsmåder og farmaceutiske sammensætningr til behandlingen af hepatitis b-virusinfektion
|
|
WO2015040640A2
(en)
|
2013-09-20 |
2015-03-26 |
Laurus Labs Private Limited |
An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof
|
|
JP6452119B2
(ja)
|
2013-10-23 |
2019-01-16 |
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー |
カルボキサミド誘導体およびb型肝炎の処置のための医薬品としてのその使用
|
|
KR20160127714A
(ko)
|
2013-11-14 |
2016-11-04 |
노비라 테라퓨틱스, 인코포레이티드 |
아제판 유도체 및 b형 간염 감염의 치료 방법
|
|
EP3077404B1
(en)
*
|
2014-01-14 |
2020-10-07 |
Mylan Laboratories Ltd. |
Purification of tenofovir alafenamide and its intermediates
|
|
US9181288B2
(en)
|
2014-01-16 |
2015-11-10 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
CA2931329A1
(en)
|
2014-01-30 |
2015-08-06 |
F. Hoffmann-La Roche Ag |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
US11078193B2
(en)
|
2014-02-06 |
2021-08-03 |
Janssen Sciences Ireland Uc |
Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
KR101926243B1
(ko)
|
2014-03-07 |
2018-12-06 |
에프. 호프만-라 로슈 아게 |
B형 간염 바이러스 감염의 치료 및 예방을 위한 6-융합된 헤테로아릴다이하이드로피리미딘
|
|
US9400280B2
(en)
|
2014-03-27 |
2016-07-26 |
Novira Therapeutics, Inc. |
Piperidine derivatives and methods of treating hepatitis B infections
|
|
FR3020810B1
(fr)
*
|
2014-05-06 |
2016-05-06 |
Servier Lab |
Nouveau sel de l'ivabradine et son procede de preparation.
|
|
CN106459032B
(zh)
|
2014-05-13 |
2019-04-05 |
豪夫迈·罗氏有限公司 |
治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类
|
|
CN105085571A
(zh)
|
2014-05-20 |
2015-11-25 |
四川海思科制药有限公司 |
替诺福韦艾拉酚胺复合物及其制备方法和用途
|
|
CN106535884A
(zh)
|
2014-06-06 |
2017-03-22 |
弗雷克萨斯生物科学公司 |
免疫调节剂
|
|
WO2016012470A1
(en)
|
2014-07-25 |
2016-01-28 |
F. Hoffmann-La Roche Ag |
New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
|
|
JP6506836B2
(ja)
|
2014-08-14 |
2019-04-24 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
B型肝炎ウイルス感染症の処置および予防のための新規ピリダゾンおよびトリアジノン
|
|
MX2017002451A
(es)
|
2014-08-27 |
2017-05-23 |
Gilead Sciences Inc |
Compuestos y metodos para inhibir histona desmetilasas.
|
|
CN107912040B
(zh)
|
2014-10-10 |
2021-04-06 |
基因泰克公司 |
作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
UY36390A
(es)
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
WO2016081940A1
(en)
*
|
2014-11-21 |
2016-05-26 |
Huntington Alloys Corporation |
Ni-Cr-Mo-Ta-Nb WELDING FILLER METALS, WELDING FILLER METAL CONSUMABLES, WELD DEPOSITS, METHODS OF MAKING WELD DEPOSITS, AND WELDMENTS THEREOF
|
|
CN104558036A
(zh)
|
2014-12-11 |
2015-04-29 |
杭州和泽医药科技有限公司 |
一种替诺福韦艾拉酚胺半反丁烯二酸盐晶型及其制备方法
|
|
AR103222A1
(es)
|
2014-12-23 |
2017-04-26 |
Hoffmann La Roche |
Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
|
|
US9676793B2
(en)
|
2014-12-23 |
2017-06-13 |
Hoffmann-Laroche Inc. |
Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
|
|
JP6506845B2
(ja)
|
2014-12-30 |
2019-04-24 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
B型肝炎ウイルス感染症の治療及び予防のための新規テトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
|
|
JP2018504891A
(ja)
|
2014-12-31 |
2018-02-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
リアルタイムPCRによる細胞溶解物からのHBV cccDNA定量化のための新規ハイスループット法
|
|
MA41338B1
(fr)
|
2015-01-16 |
2019-07-31 |
Hoffmann La Roche |
Composés de pyrazine pour le traitement de maladies infectieuses
|
|
EP3250685A1
(en)
|
2015-01-27 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Recombinant hbv cccdna, the method to generate thereof and the use thereof
|
|
HK1244281B
(zh)
|
2015-02-11 |
2020-02-07 |
F. Hoffmann-La Roche Ag |
治疗和预防乙型肝炎病毒感染的2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物
|
|
CZ2015384A3
(cs)
|
2015-06-05 |
2016-12-14 |
Zentiva, K.S. |
Pevné formy Tenofovir alafenamidu
|
|
HK1252631A1
(zh)
*
|
2015-06-17 |
2019-05-31 |
Gilead Sciences, Inc. |
替诺福韦艾拉酚胺的共晶体,盐和固体形式
|
|
CA2921336A1
(en)
*
|
2015-06-30 |
2016-12-30 |
Gilead Sciences, Inc. |
Pharmaceutical formulations
|
|
TWI714820B
(zh)
|
2017-01-31 |
2021-01-01 |
美商基利科學股份有限公司 |
替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型
|