JP2020536845A5 - - Google Patents

Download PDF

Info

Publication number
JP2020536845A5
JP2020536845A5 JP2020508523A JP2020508523A JP2020536845A5 JP 2020536845 A5 JP2020536845 A5 JP 2020536845A5 JP 2020508523 A JP2020508523 A JP 2020508523A JP 2020508523 A JP2020508523 A JP 2020508523A JP 2020536845 A5 JP2020536845 A5 JP 2020536845A5
Authority
JP
Japan
Prior art keywords
independently
appearance
compound according
linker
following structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020508523A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020536845A (ja
JP7403744B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/054648 external-priority patent/WO2019071153A1/en
Publication of JP2020536845A publication Critical patent/JP2020536845A/ja
Publication of JP2020536845A5 publication Critical patent/JP2020536845A5/ja
Application granted granted Critical
Publication of JP7403744B2 publication Critical patent/JP7403744B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020508523A 2017-10-05 2018-10-05 プログラマブルな樹枝状薬物 Active JP7403744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762568681P 2017-10-05 2017-10-05
US62/568,681 2017-10-05
PCT/US2018/054648 WO2019071153A1 (en) 2017-10-05 2018-10-05 PROGRAMMABLE DENDRITIC MEDICINES

Publications (3)

Publication Number Publication Date
JP2020536845A JP2020536845A (ja) 2020-12-17
JP2020536845A5 true JP2020536845A5 (OSRAM) 2021-11-18
JP7403744B2 JP7403744B2 (ja) 2023-12-25

Family

ID=63963607

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020508523A Active JP7403744B2 (ja) 2017-10-05 2018-10-05 プログラマブルな樹枝状薬物

Country Status (6)

Country Link
US (1) US12290571B2 (OSRAM)
EP (1) EP3691689A1 (OSRAM)
JP (1) JP7403744B2 (OSRAM)
KR (1) KR20200064059A (OSRAM)
CN (1) CN111093711A (OSRAM)
WO (1) WO2019071153A1 (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9765220B2 (en) 2013-08-22 2017-09-19 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
CN107454903B (zh) 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
JP6982500B2 (ja) 2015-02-26 2021-12-17 ソニーグループ株式会社 フェニルエチニルナフタレン染料およびそれらの使用方法
EP3294811B1 (en) 2015-05-11 2024-02-28 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
EP3455238A1 (en) 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
EP4616912A3 (en) 2018-01-12 2025-11-19 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
EP3769085B1 (en) 2018-03-19 2022-08-24 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
CN119220109A (zh) 2018-03-30 2024-12-31 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
CN114430738A (zh) * 2019-04-11 2022-05-03 索尼集团公司 可编程的聚合药物
CN113383043A (zh) 2019-09-26 2021-09-10 索尼集团公司 具有连接体基团的聚合物串联染料
CN115103689A (zh) * 2019-12-04 2022-09-23 阿什瓦塔治疗股份有限公司 用于药物递送的树枝状大分子组合物和方法
AU2021259877A1 (en) 2020-04-24 2022-12-08 Ashvattha Therapeutics, Inc. Dendrimer compositions and methods for treatment of severe acute respiratory distress syndrome
CN111521593B (zh) * 2020-05-12 2021-05-11 中国农业大学 一种基于水溶性苝酰亚胺衍生物的快速可视化检测方法
KR102250737B1 (ko) * 2020-06-01 2021-05-11 주식회사 비아이케이테라퓨틱스 약물 전달과 내재화 효율이 강화된 약물복합체
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
EP4267971A4 (en) 2021-04-07 2024-08-07 Becton, Dickinson and Company Water-soluble fluorescent polymeric dyes

Family Cites Families (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450305A (en) 1982-10-25 1984-05-22 American Cyanamid Company Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes
US4476229A (en) 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins
SU1121931A1 (ru) 1983-01-10 1988-04-15 Институт Биологической Химии Ан Бсср Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных
EP0355864A3 (en) 1984-03-15 1991-09-18 Wako Pure Chemical Industries, Ltd. Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter
JPH0665677B2 (ja) 1985-03-09 1994-08-24 三菱化成株式会社 リン脂質類似構造を有するジオ−ルおよびその製造方法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5053054A (en) 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US5318894A (en) 1990-01-30 1994-06-07 Miles Inc. Composition, device and method of assaying for peroxidatively active substances
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JPH04282391A (ja) 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd エタノールアミン誘導体およびその製造法
US5698391A (en) 1991-08-23 1997-12-16 Isis Pharmaceuticals, Inc. Methods for synthetic unrandomization of oligomer fragments
WO1993006482A1 (en) 1991-09-16 1993-04-01 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5565322A (en) 1991-11-07 1996-10-15 Nanogen, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system
WO1994024120A1 (en) 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
JPH09500411A (ja) 1993-07-13 1997-01-14 アボツト・ラボラトリーズ 蛍光性ポリマー標識された接合体および中間体
DE69431669T2 (de) 1993-09-02 2003-10-23 Ribozyme Pharmaceuticals, Inc. Enzymatische nukleiksaüre die nicht-nukleotide enthaltet
US5886177A (en) 1994-01-11 1999-03-23 Isis Pharmaceuticals, Inc. Phosphate linked oligomers
US6171859B1 (en) 1994-03-30 2001-01-09 Mitokor Method of targeting conjugate molecules to mitochondria
US5994143A (en) 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
DE19633268A1 (de) 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
JP2001511128A (ja) 1997-01-28 2001-08-07 ファルマシア・アンド・アップジョン・カンパニー 水不溶性ポルフィリンの脂質錯体の凍結乾燥物
US6893868B2 (en) 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US5986030A (en) 1997-04-15 1999-11-16 Nalco Chemical Company Fluorescent water soluble polymers
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US20020142329A1 (en) 1999-04-30 2002-10-03 Aclara Biosciences, Inc. Compositions and methods employing cleavable electrophoretic tag reagents
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
AU5935300A (en) 1999-07-22 2001-02-13 Nalco Chemical Company Fluorescent water-soluble polymers
US6479650B1 (en) 1999-12-14 2002-11-12 Research Corporation Technologies, Inc. Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
WO2001069254A2 (en) 2000-03-14 2001-09-20 Genigma Corporation Visually detectable dye labelled biomolecules for analysis
AU2001255203A1 (en) 2000-03-28 2001-10-08 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20040067498A1 (en) 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
JP2003532878A (ja) 2000-05-08 2003-11-05 キューティエル・バイオシステムズ・リミテッド・ライアビリティ・カンパニー バイオセンシングに対する蛍光ポリマー−qtlアプローチの改良
WO2001091725A2 (en) 2000-05-31 2001-12-06 Univ Johns Hopkins Biologically useful polyphosphates
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
CA2421582A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
JP4989013B2 (ja) 2000-09-19 2012-08-01 リ−コール インコーポレーティッド シアニン色素
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
GB2372256A (en) 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP3813890B2 (ja) 2002-03-22 2006-08-23 富士写真フイルム株式会社 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法
US20040086914A1 (en) 2002-07-12 2004-05-06 Affymetrix, Inc. Nucleic acid labeling methods
US6806523B2 (en) * 2002-07-15 2004-10-19 Micron Technology, Inc. Magnetoresistive memory devices
WO2004019002A2 (en) 2002-08-23 2004-03-04 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent glycosides and methods for their use
AU2003304043A1 (en) 2002-08-26 2004-11-04 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US20040138467A1 (en) 2002-11-26 2004-07-15 French Roger Harquail Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties
US7759459B2 (en) 2003-01-10 2010-07-20 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
EP1653989B1 (fr) 2003-08-14 2009-07-15 Diatos Composition anti-bacterienne plus particulierement contre les bacteries gram negatif comprenent un peptide et un agent anti-bacterien avantageusement hydrophobe
JP2007534308A (ja) 2003-11-19 2007-11-29 アレロジック・バイオサイエンシズ・コーポレーション 複数のフルオロフォアで標識したオリゴヌクレオチド
WO2005064336A1 (en) 2003-12-09 2005-07-14 Molecular Probes, Inc. Pyrenyloxysulfonic acid fluorescent agents
US7626014B2 (en) 2004-04-27 2009-12-01 Alnylam Pharmaceuticals Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
US20060035302A1 (en) 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
ES2461858T3 (es) 2004-08-13 2014-05-21 Epoch Biosciences, Inc. Colorantes fluorescentes de fosfonato y conjugados
US8586718B2 (en) 2004-09-14 2013-11-19 Applied Biosystems, Llc Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
US8153706B2 (en) 2004-10-25 2012-04-10 Hewlett-Packard Development Company, L.P. Polymeric colorants having pigment and dye components and corresponding ink compositions
DE602004007007T2 (de) 2004-11-09 2008-02-21 Ipagsa Industrial, SL., Rubi Thermisch reaktive, nah-infrarot absorbierende Polymere und ihre Verwendung in wärmeempfindlichen lithographischen Druckplatten
US7897684B2 (en) 2005-01-10 2011-03-01 The Regents Of The University Of California Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
EP1866387B1 (en) 2005-03-09 2013-05-08 Cepheid Polar dyes
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US8158801B2 (en) 2005-09-26 2012-04-17 Life Technologies Corporation Violet laser excitable dyes and their method of use
CN101360997B (zh) 2005-11-18 2013-05-01 美国政府健康及人类服务部,疾病控制和预防中心 改性心磷脂及其应用
EP2573833B1 (en) 2005-12-12 2014-04-02 Basf Se Organic semiconductors, their manufacture and semiconductor devices comprising them
US20070148094A1 (en) 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
WO2007094135A1 (ja) 2006-02-15 2007-08-23 Gifu University オリゴヌクレオチド誘導体及びその利用
ATE517613T1 (de) 2006-04-13 2011-08-15 Midatech Ltd Nanoteilchen mit drei verschiedenen liganden zur auslösung einer immunantwort gegen infektiöse mittel
WO2008021208A2 (en) 2006-08-12 2008-02-21 Stx Aprilis, Inc. Sensitizer dyes for photoacid generating systems using short visible wavelengths
JP5368797B2 (ja) 2006-10-12 2013-12-18 出光興産株式会社 有機薄膜トランジスタ素子及び有機薄膜発光トランジスタ
JP5636189B2 (ja) 2006-10-27 2014-12-03 ライフ テクノロジーズ コーポレーション 蛍光発生性pH感受性色素およびその使用方法
US8053588B2 (en) 2007-03-07 2011-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Organosilane compound and organosilica obtained therefrom
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
ES2516827T3 (es) 2007-04-23 2014-10-31 Deliversir Ltd Un sistema para entregar agentes terapéuticos a células vivas y núcleos de células
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
JP5518697B2 (ja) 2007-05-11 2014-06-11 ビーエーエスエフ ソシエタス・ヨーロピア 高分子色素
EP2014698A1 (en) 2007-07-12 2009-01-14 Crystax Pharmaceuticals S.L. Polymers and their use as fluorescent labels
TWI409280B (zh) 2007-07-31 2013-09-21 American Dye Source Inc 聚合物染料、塗覆層組合物及熱微影印刷板
GB2456298A (en) 2008-01-07 2009-07-15 Anthony Ian Newman Electroluminescent materials comprising oxidation resistant fluorenes
JP5467366B2 (ja) 2008-03-10 2014-04-09 国立大学法人 東京大学 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されたカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用
ES2613844T3 (es) 2008-04-21 2017-05-26 Lawrence Livermore National Security, Llc Ligandos polidentados de alta afinidad selectivos y métodos para producirlos
KR101041446B1 (ko) 2008-07-21 2011-06-14 부산대학교 산학협력단 공액고분자 2단계 fret 시스템 및 바이오센서
JPWO2010026957A1 (ja) 2008-09-03 2012-02-02 国立大学法人富山大学 水溶性ロタキサン型蛍光色素および蛍光性有機分子
US8354515B2 (en) 2008-11-14 2013-01-15 Japan Science And Technology Agency Oligonucleotide derivative, labeling agent and use for labeling agent
JP5798487B2 (ja) 2008-11-20 2015-10-21 ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー Fretに基づく病原体の迅速診断
EP2358770B1 (en) 2008-12-12 2017-03-15 University of Massachusetts Zwitterionic polymers with therapeutic moieties
EP3483610B1 (en) 2009-11-09 2025-09-10 University Of Washington Center For Commercialization Functionalized chromophoric polymer dots and bioconjugates thereof
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
US9221759B2 (en) 2010-01-13 2015-12-29 Rutgers, The State University Of New Jersey Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency
EP2545373B1 (en) 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
US8349308B2 (en) 2010-03-26 2013-01-08 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
EP2577309B1 (en) 2010-05-25 2016-11-23 Carnegie Mellon University Targeted probes of cellular physiology
CN102971283A (zh) 2010-07-08 2013-03-13 旭硝子株式会社 含氟芳香族化合物、有机半导体材料和有机薄膜器件
ES2626437T3 (es) 2010-09-22 2017-07-25 The Board Of Regents Of The University Of Texas System Copolímero en bloque novedoso y composiciones micelares y procedimientos de uso de las mismas
US8846941B2 (en) 2010-12-13 2014-09-30 Quiapeg Ab Functionalized polymers
WO2012086857A1 (ko) 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
CN102174078A (zh) 2011-01-10 2011-09-07 中国药科大学 肿瘤细胞选择性穿膜肽的应用
WO2013012687A2 (en) 2011-07-15 2013-01-24 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
KR20140067070A (ko) 2011-08-31 2014-06-03 말린크로트 엘엘씨 H-포스포네이트에 의한 나노입자 peg 개질
US20130059343A1 (en) 2011-09-06 2013-03-07 Li-Cor, Inc. Nucleotide derivatives
US9085761B1 (en) 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
DK2895607T3 (da) 2012-09-12 2021-05-25 Quark Pharmaceuticals Inc Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf
WO2014055253A1 (en) 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
CN104918639B (zh) 2012-10-22 2018-01-26 萨拜格Rfa公司 用于将治疗剂递送到活细胞和细胞核中的系统
WO2014102806A1 (en) 2012-12-31 2014-07-03 Yeda Research And Development Co. Ltd. Protein biosensors, cross reactive sensor arrays and methods of use thereof
US9545447B2 (en) 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
WO2014175974A2 (en) 2013-03-13 2014-10-30 Elitech Holding B.V. Artificial nucleic acids
WO2014159392A1 (en) 2013-03-14 2014-10-02 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
WO2014147642A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications
CN103319378B (zh) 2013-06-27 2015-06-10 中国科学院宁波材料技术与工程研究所 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途
KR101572901B1 (ko) 2013-07-12 2015-12-15 부산대학교 산학협력단 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서
US9765220B2 (en) 2013-08-22 2017-09-19 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
TWI603305B (zh) * 2013-09-27 2017-10-21 鴻海精密工業股份有限公司 顯示裝置、拼接式顯示器及顯示面板
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
JP5802865B1 (ja) 2013-11-11 2015-11-04 オリンパス株式会社 処置システム
JP6503354B2 (ja) 2013-12-06 2019-04-17 モノソル リミテッド ライアビリティ カンパニー 水溶性フィルムのための蛍光トレーサー、関連方法、及び関連物品
WO2015091953A1 (en) 2013-12-20 2015-06-25 Roche Diagnostics Gmbh Use of compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising peg moieties for stabilization of a cell
WO2015109136A2 (en) 2014-01-16 2015-07-23 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
JP6374172B2 (ja) 2014-01-31 2018-08-15 富士フイルム株式会社 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体
CN104072727A (zh) 2014-06-23 2014-10-01 华南理工大学 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用
WO2016055907A1 (en) 2014-10-10 2016-04-14 Pfizer Inc. Synergistic auristatin combinations
WO2016077625A1 (en) 2014-11-12 2016-05-19 Stayton Patrick S Stabilized polymeric carriers for therapeutic agent delivery
US20170326233A1 (en) 2014-11-14 2017-11-16 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
DK178808B1 (en) 2014-12-12 2017-02-13 Envision Energy Denmark Aps Floating wind turbine structure with reduced tower height and method for optimising the weight thereof
CN107454903B (zh) 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
JP6982500B2 (ja) 2015-02-26 2021-12-17 ソニーグループ株式会社 フェニルエチニルナフタレン染料およびそれらの使用方法
WO2016144652A1 (en) 2015-03-12 2016-09-15 Becton, Dickinson And Company Polymeric bodipy dyes and methods for using the same
EP3294811B1 (en) 2015-05-11 2024-02-28 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
EP3303420B1 (en) 2015-06-02 2022-04-06 University of Washington Free-standing non-fouling polymers, their compositions, and related monomers
CA2991975C (en) 2015-08-10 2021-04-06 Suzhou M-Conj Biotech Co., Ltd. Novel linkers and their uses in specific conjugation of drugs to a biological molecule
US9691615B2 (en) * 2015-08-28 2017-06-27 International Business Machines Corporation Chemoepitaxy-based directed self assembly process with tone inversion for unidirectional wiring
EP3359194A4 (en) 2015-10-06 2019-04-24 Merck Sharp & Dohme Corp. ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
AU2016359230B2 (en) 2015-11-25 2020-04-23 Ligachem Biosciences Inc. Conjugates comprising self-immolative groups and methods related thereto
JP6841430B2 (ja) * 2015-12-04 2021-03-10 全薬工業株式会社 血中滞留性を改善した抗il−17アプタマー
US9913992B2 (en) 2015-12-22 2018-03-13 Colgate-Palmolive Company Oral treatment device
JP2017124994A (ja) 2016-01-15 2017-07-20 靖彦 中村 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
EP3455238A1 (en) 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
JP7216638B2 (ja) 2016-09-01 2023-02-01 ライフ テクノロジーズ コーポレーション 増強された蛍光のための組成物および方法
GB2554666B (en) 2016-09-30 2019-12-18 Sumitomo Chemical Co Composite Particle
CN106589005B (zh) 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
US10834091B2 (en) 2017-02-27 2020-11-10 Ivanti, Inc. Systems and methods for role-based computer security configurations
US12398104B2 (en) 2017-04-27 2025-08-26 The Procter & Gamble Company Odorless thiols for permanent waving, straightening and depilatory applications
CN110869354A (zh) 2017-07-07 2020-03-06 美国政府(由卫生和人类服务部的部长所代表) 脂肪酸衍生物及其用途
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
KR102773157B1 (ko) 2017-12-13 2025-02-27 소니그룹주식회사 생물학적 활성 화합물을 함유하는 이온성 중합체
WO2019126691A1 (en) 2017-12-21 2019-06-27 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
EP4616912A3 (en) 2018-01-12 2025-11-19 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
EP3737419B1 (en) 2018-01-12 2024-04-10 Sony Group Corporation Phosphoalkyl polymers comprising biologically active compounds
EP3769085B1 (en) 2018-03-19 2022-08-24 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
GB201807815D0 (en) 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
WO2020014634A1 (en) 2018-07-13 2020-01-16 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
WO2020210692A1 (en) 2019-04-11 2020-10-15 Sony Corporation Programmable polymeric drugs
CN114072178A (zh) 2019-04-11 2022-02-18 索尼集团公司 可编程的聚合药物
JP7650819B2 (ja) 2019-04-24 2025-03-25 ブイオーアール バイオファーマ インコーポレーテッド 抗-cd45抗体薬物コンジュゲート及びその使用
CN113383043A (zh) 2019-09-26 2021-09-10 索尼集团公司 具有连接体基团的聚合物串联染料
US20220402963A1 (en) 2019-09-30 2022-12-22 Sony Group Corporation Nucleotide probes
EP4251764A1 (en) 2020-11-25 2023-10-04 Sony Group Corporation Polymer dyes
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

Similar Documents

Publication Publication Date Title
JP2020536845A5 (OSRAM)
JP2020536847A5 (OSRAM)
JP2021503450A5 (OSRAM)
JPWO2019140227A5 (OSRAM)
JPWO2019140128A5 (OSRAM)
JPWO2019140301A5 (OSRAM)
JP7103953B2 (ja) 薬物としてアマトキシンの誘導体を有する抗体薬物コンジュゲート
JP5503872B2 (ja) 核酸系代謝拮抗剤の高分子誘導体
JP2005511533A (ja) 標的デリバリ用デントリマ
JP2022515250A (ja) 改善された細胞標的化結合分子
ES2919323T3 (es) Conjugados de compuestos de tubulisina cuaternizados
EP1881020B1 (en) Polymeric derivative of cytidine metabolic antagonist
JP5749273B2 (ja) 抗がん剤送達のためのポリマー系
ES2909486T3 (es) Sistemas de administración para liberación controlada de fármaco
EP2750712A2 (en) Nanoparticle peg modification with h-phosphonates
JP2013532132A (ja) 新規な自己反応性アーム及び同物を含むプロドラッグ
WO2022261504A1 (en) Dendrimer conjugates and methods of use thereof
AU2017279536A1 (en) Non-cleavable polymer conjugated with αvβ3 integrin thyroid antagonists
JP2022552841A (ja) ポリマー薬物送達コンジュゲートならびにそれを作製および使用する方法
ES2784182T3 (es) Composiciones y métodos para inducir la apoptosis
US7026350B2 (en) Water-soluble drugs and methods for their production
Bodyak et al. Delivering more payload (high DAR ADCs)
JP6837962B2 (ja) 活性薬剤の送達のための両親媒性ブロックコポリマー
JP5843086B2 (ja) 治療活性物質の作用を増強するための高分子化環状ニトロキシドラジカル化合物の使用
ES2910659T3 (es) Nuevo derivado de PEG