JP2020535423A5 - - Google Patents
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- Publication number
- JP2020535423A5 JP2020535423A5 JP2020517797A JP2020517797A JP2020535423A5 JP 2020535423 A5 JP2020535423 A5 JP 2020535423A5 JP 2020517797 A JP2020517797 A JP 2020517797A JP 2020517797 A JP2020517797 A JP 2020517797A JP 2020535423 A5 JP2020535423 A5 JP 2020535423A5
- Authority
- JP
- Japan
- Prior art keywords
- fgf
- 2sdng
- compound
- subject
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000003977 fibroblast growth factor 18 Human genes 0.000 claims 26
- 108090000370 fibroblast growth factor 18 Proteins 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 23
- 238000000034 method Methods 0.000 claims 12
- 108010017322 catch-relaxing peptide (Mytilus) Proteins 0.000 claims 11
- 208000015100 cartilage disease Diseases 0.000 claims 7
- 210000001188 articular cartilage Anatomy 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010061762 Chondropathy Diseases 0.000 claims 4
- 206010007710 Cartilage injury Diseases 0.000 claims 3
- 206010017076 Fracture Diseases 0.000 claims 3
- 208000013201 Stress fracture Diseases 0.000 claims 3
- 239000000090 biomarker Substances 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 238000001356 surgical procedure Methods 0.000 claims 3
- 230000007717 exclusion Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17194169 | 2017-09-29 | ||
| EP17194169.3 | 2017-09-29 | ||
| EP18169317 | 2018-04-25 | ||
| EP18169317.7 | 2018-04-25 | ||
| PCT/EP2018/076391 WO2019063756A1 (en) | 2017-09-29 | 2018-09-28 | INFLAMMATORY BIOMARKERS FOR PREDICTING REACTIVITY TO FGF-18 COMPOUND |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535423A JP2020535423A (ja) | 2020-12-03 |
| JP2020535423A5 true JP2020535423A5 (enExample) | 2021-11-04 |
| JP7418324B2 JP7418324B2 (ja) | 2024-01-19 |
Family
ID=63722379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517797A Active JP7418324B2 (ja) | 2017-09-29 | 2018-09-28 | Ｆｇｆ－１８化合物に対する反応性を予測する炎症バイオマーカー |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11467169B2 (enExample) |
| EP (1) | EP3688468B1 (enExample) |
| JP (1) | JP7418324B2 (enExample) |
| CN (1) | CN111164429B (enExample) |
| AU (1) | AU2018343980B2 (enExample) |
| CA (1) | CA3075713A1 (enExample) |
| DK (1) | DK3688468T3 (enExample) |
| ES (1) | ES2918249T3 (enExample) |
| HR (1) | HRP20220737T1 (enExample) |
| HU (1) | HUE058848T2 (enExample) |
| IL (1) | IL273574B2 (enExample) |
| LT (1) | LT3688468T (enExample) |
| PL (1) | PL3688468T3 (enExample) |
| RS (1) | RS63292B1 (enExample) |
| SI (1) | SI3688468T1 (enExample) |
| WO (1) | WO2019063756A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3250925B1 (en) | 2015-01-29 | 2019-04-10 | Ares Trading S.A. | Immunoassays for highly positively charged proteins |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| LT3688468T (lt) | 2017-09-29 | 2022-06-27 | Merck Patent Gmbh | Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui |
| KR20210057764A (ko) | 2018-09-10 | 2021-05-21 | 메르크 파텐트 게엠베하 | 골관절염의 치료를 위한 강화 전략에 유용한 마커 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2264175B1 (en) | 1996-10-16 | 2012-11-21 | ZymoGenetics, Inc. | Fibroblast growth factor homologs |
| CA2500742C (en) | 2002-10-07 | 2014-02-18 | Zymogenetics, Inc. | Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis |
| EP1558932A2 (en) | 2002-11-08 | 2005-08-03 | Barnes-Jewish Hospital | Uncoupled collagen synthesis and degradation assays |
| AU2005314438B2 (en) | 2004-12-10 | 2012-03-29 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
| US8224579B2 (en) | 2005-06-17 | 2012-07-17 | The Brigham And Women's Hospital, Inc. | Method of diagnosing osteoarthritis |
| EA015644B1 (ru) * | 2006-08-25 | 2011-10-31 | Арес Трейдинг С.А. | Способ лечения заболеваний хряща |
| JP2009257842A (ja) | 2008-04-14 | 2009-11-05 | Ttc:Kk | 変形性関節症の検査方法及び診断用キット |
| ES2708826T3 (es) | 2008-05-02 | 2019-04-11 | Orig3N Inc | Detección de la predisposición genética a afecciones asociadas a la osteoartritis |
| US20090299769A1 (en) | 2008-05-29 | 2009-12-03 | Nordic Bioscience Imaging A/S | Prognostic osteoarthritis biomarkers |
| US20120115137A1 (en) | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| JP6262731B2 (ja) | 2012-08-06 | 2018-01-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｇｆ−１８化合物に対する応答性を予測するための遺伝子マーカー |
| WO2014023704A1 (en) | 2012-08-06 | 2014-02-13 | xARES TRADING S.A. | Prognosis biomarkers in cartilage disorders |
| TW201536320A (zh) * | 2013-12-02 | 2015-10-01 | Abbvie Inc | 治療骨性關節炎之組合物及方法 |
| AU2014372575B2 (en) | 2013-12-24 | 2020-07-09 | Ares Trading S.A | FGF-18 formulation in xyloglucan gels |
| RU2698210C2 (ru) | 2013-12-24 | 2019-08-23 | Арес Трейдинг С.А. | Состав fgf-18 в альгинатных/коллагеновых гидрогелях |
| US9889179B2 (en) | 2014-02-20 | 2018-02-13 | Merck Patent Gmbh | FGF-18 compound dosing regimen |
| JP6510547B2 (ja) | 2014-02-20 | 2019-05-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｇｆ−１８を含むインプラント |
| ES2676318T3 (es) | 2014-02-20 | 2018-07-18 | Merck Patent Gmbh | FGF-18 en procedimientos de trasplante de injertos y de ingeniería tisular |
| EP3250925B1 (en) | 2015-01-29 | 2019-04-10 | Ares Trading S.A. | Immunoassays for highly positively charged proteins |
| WO2017079759A1 (en) | 2015-11-06 | 2017-05-11 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-c]pyridines and their anti-inflammatory uses thereof |
| US9983214B2 (en) | 2016-04-15 | 2018-05-29 | Esm Technologies, Llc | Method for evaluating articular joint therapeutics |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| LT3688468T (lt) | 2017-09-29 | 2022-06-27 | Merck Patent Gmbh | Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui |
| KR20210057764A (ko) | 2018-09-10 | 2021-05-21 | 메르크 파텐트 게엠베하 | 골관절염의 치료를 위한 강화 전략에 유용한 마커 |
-
2018
- 2018-09-28 LT LTEPPCT/EP2018/076391T patent/LT3688468T/lt unknown
- 2018-09-28 EP EP18782012.1A patent/EP3688468B1/en active Active
- 2018-09-28 SI SI201830693T patent/SI3688468T1/sl unknown
- 2018-09-28 RS RS20220541A patent/RS63292B1/sr unknown
- 2018-09-28 WO PCT/EP2018/076391 patent/WO2019063756A1/en not_active Ceased
- 2018-09-28 JP JP2020517797A patent/JP7418324B2/ja active Active
- 2018-09-28 DK DK18782012.1T patent/DK3688468T3/da active
- 2018-09-28 US US16/650,878 patent/US11467169B2/en active Active
- 2018-09-28 CA CA3075713A patent/CA3075713A1/en active Pending
- 2018-09-28 IL IL273574A patent/IL273574B2/en unknown
- 2018-09-28 CN CN201880063173.4A patent/CN111164429B/zh active Active
- 2018-09-28 ES ES18782012T patent/ES2918249T3/es active Active
- 2018-09-28 PL PL18782012.1T patent/PL3688468T3/pl unknown
- 2018-09-28 AU AU2018343980A patent/AU2018343980B2/en active Active
- 2018-09-28 HR HRP20220737TT patent/HRP20220737T1/hr unknown
- 2018-09-28 HU HUE18782012A patent/HUE058848T2/hu unknown
-
2022
- 2022-09-01 US US17/929,261 patent/US12332250B2/en active Active