CN111164429B - 预测对fgf-18化合物反应性的炎性生物标志物 - Google Patents
预测对fgf-18化合物反应性的炎性生物标志物 Download PDFInfo
- Publication number
- CN111164429B CN111164429B CN201880063173.4A CN201880063173A CN111164429B CN 111164429 B CN111164429 B CN 111164429B CN 201880063173 A CN201880063173 A CN 201880063173A CN 111164429 B CN111164429 B CN 111164429B
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- fgf
- treatment
- metalloproteinases
- cartilage
- degraded
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17194169 | 2017-09-29 | ||
| EP17194169.3 | 2017-09-29 | ||
| EP18169317 | 2018-04-25 | ||
| EP18169317.7 | 2018-04-25 | ||
| PCT/EP2018/076391 WO2019063756A1 (en) | 2017-09-29 | 2018-09-28 | INFLAMMATORY BIOMARKERS FOR PREDICTING REACTIVITY TO FGF-18 COMPOUND |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111164429A CN111164429A (zh) | 2020-05-15 |
| CN111164429B true CN111164429B (zh) | 2024-08-09 |
Family
ID=63722379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880063173.4A Active CN111164429B (zh) | 2017-09-29 | 2018-09-28 | 预测对fgf-18化合物反应性的炎性生物标志物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11467169B2 (enExample) |
| EP (1) | EP3688468B1 (enExample) |
| JP (1) | JP7418324B2 (enExample) |
| CN (1) | CN111164429B (enExample) |
| AU (1) | AU2018343980B2 (enExample) |
| CA (1) | CA3075713A1 (enExample) |
| DK (1) | DK3688468T3 (enExample) |
| ES (1) | ES2918249T3 (enExample) |
| HR (1) | HRP20220737T1 (enExample) |
| HU (1) | HUE058848T2 (enExample) |
| IL (1) | IL273574B2 (enExample) |
| LT (1) | LT3688468T (enExample) |
| PL (1) | PL3688468T3 (enExample) |
| RS (1) | RS63292B1 (enExample) |
| SI (1) | SI3688468T1 (enExample) |
| WO (1) | WO2019063756A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107209177A (zh) | 2015-01-29 | 2017-09-26 | 阿雷斯贸易股份有限公司 | 用于高正电荷蛋白的免疫测定法 |
| CN111164429B (zh) | 2017-09-29 | 2024-08-09 | 默克专利有限公司 | 预测对fgf-18化合物反应性的炎性生物标志物 |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| HRP20240665T1 (hr) | 2018-09-10 | 2024-08-16 | Merck Patent Gmbh | Markeri korisni u strategijama obogaćivanja za liječenje osteoartritisa |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104736723A (zh) * | 2012-08-06 | 2015-06-24 | 默克专利有限公司 | 用于预测对fgf-18化合物的响应性的遗传标记 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9712348B1 (pt) | 1996-10-16 | 2013-06-18 | vetor de expressão, célula de bactéria ou levedura transformada ou transfectada, processo para produzir um polipeptídeo homólogo de fgf, composição farmacêutica, e, processos para estimular ex vivo células progenitoras de miócitos ou miócitos | |
| JP4754823B2 (ja) | 2002-10-07 | 2011-08-24 | ザイモジェネティクス， インコーポレイテッド | Ｆｇｆ１８の投与方法 |
| CA2502926A1 (en) | 2002-11-08 | 2004-05-27 | Linda J. Sandell | Uncoupled collagen synthesis and degradation assays |
| AU2005314438B2 (en) | 2004-12-10 | 2012-03-29 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
| US8224579B2 (en) | 2005-06-17 | 2012-07-17 | The Brigham And Women's Hospital, Inc. | Method of diagnosing osteoarthritis |
| AR062522A1 (es) | 2006-08-25 | 2008-11-12 | Ares Trading Sa | Tratamiento de desordenes en cartilagos |
| JP2009257842A (ja) | 2008-04-14 | 2009-11-05 | Ttc:Kk | 変形性関節症の検査方法及び診断用キット |
| US20100098775A1 (en) | 2008-05-02 | 2010-04-22 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| US20090299769A1 (en) | 2008-05-29 | 2009-12-03 | Nordic Bioscience Imaging A/S | Prognostic osteoarthritis biomarkers |
| US20120115137A1 (en) | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| WO2014023704A1 (en) | 2012-08-06 | 2014-02-13 | xARES TRADING S.A. | Prognosis biomarkers in cartilage disorders |
| WO2015084883A2 (en) | 2013-12-02 | 2015-06-11 | Abbvie, Inc. | Compositions and methods for treating osteoarthritis |
| CN106029085B (zh) | 2013-12-24 | 2020-08-04 | 阿雷斯贸易股份有限公司 | 木糖葡聚糖凝胶中的fgf-18制剂 |
| SG11201604972TA (en) | 2013-12-24 | 2016-07-28 | Ares Trading Sa | Fgf-18 formulation in alginate/collagen hydrogels |
| MX2016010872A (es) | 2014-02-20 | 2016-11-17 | Merck Patent Gmbh | Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18. |
| LT3107592T (lt) | 2014-02-20 | 2018-12-10 | Merck Patent Gmbh | Implantas, apimantis fgf-18 |
| EP3107591B1 (en) | 2014-02-20 | 2018-04-18 | Merck Patent GmbH | Fgf-18 in graft transplantation and tissue engineering procedures |
| CN107209177A (zh) | 2015-01-29 | 2017-09-26 | 阿雷斯贸易股份有限公司 | 用于高正电荷蛋白的免疫测定法 |
| CN108473491A (zh) | 2015-11-06 | 2018-08-31 | 萨穆梅德有限公司 | 2-(1h-吲唑-3-基)-3h-咪唑并[4,5-c]吡啶以及其抗炎用途 |
| US9983214B2 (en) | 2016-04-15 | 2018-05-29 | Esm Technologies, Llc | Method for evaluating articular joint therapeutics |
| CN111164429B (zh) | 2017-09-29 | 2024-08-09 | 默克专利有限公司 | 预测对fgf-18化合物反应性的炎性生物标志物 |
| CN111163791A (zh) | 2017-09-29 | 2020-05-15 | 默克专利有限公司 | 预测对fgf-18化合物反应性的代谢生物标志物 |
| HRP20240665T1 (hr) | 2018-09-10 | 2024-08-16 | Merck Patent Gmbh | Markeri korisni u strategijama obogaćivanja za liječenje osteoartritisa |
-
2018
- 2018-09-28 CN CN201880063173.4A patent/CN111164429B/zh active Active
- 2018-09-28 AU AU2018343980A patent/AU2018343980B2/en active Active
- 2018-09-28 US US16/650,878 patent/US11467169B2/en active Active
- 2018-09-28 JP JP2020517797A patent/JP7418324B2/ja active Active
- 2018-09-28 WO PCT/EP2018/076391 patent/WO2019063756A1/en not_active Ceased
- 2018-09-28 IL IL273574A patent/IL273574B2/en unknown
- 2018-09-28 HU HUE18782012A patent/HUE058848T2/hu unknown
- 2018-09-28 HR HRP20220737TT patent/HRP20220737T1/hr unknown
- 2018-09-28 LT LTEPPCT/EP2018/076391T patent/LT3688468T/lt unknown
- 2018-09-28 DK DK18782012.1T patent/DK3688468T3/da active
- 2018-09-28 ES ES18782012T patent/ES2918249T3/es active Active
- 2018-09-28 SI SI201830693T patent/SI3688468T1/sl unknown
- 2018-09-28 RS RS20220541A patent/RS63292B1/sr unknown
- 2018-09-28 PL PL18782012.1T patent/PL3688468T3/pl unknown
- 2018-09-28 EP EP18782012.1A patent/EP3688468B1/en active Active
- 2018-09-28 CA CA3075713A patent/CA3075713A1/en active Pending
-
2022
- 2022-09-01 US US17/929,261 patent/US12332250B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104736723A (zh) * | 2012-08-06 | 2015-06-24 | 默克专利有限公司 | 用于预测对fgf-18化合物的响应性的遗传标记 |
Non-Patent Citations (3)
| Title |
|---|
| A.S. Siebuhr et al.Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover.《Osteoarthritis and Cartilage》.2014,第22卷(第1期),第45页. * |
| Clinical Trial Protocol;Merck KGaA et al;Phase II Trial of Sprifermin in Knee OA;第1页 * |
| Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover;A.S. Siebuhr et al;《Osteoarthritis and Cartilage》;20141231;第22卷(第1期);第44-50页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20220737T1 (hr) | 2022-09-02 |
| RS63292B1 (sr) | 2022-06-30 |
| US11467169B2 (en) | 2022-10-11 |
| DK3688468T3 (da) | 2022-06-20 |
| EP3688468A1 (en) | 2020-08-05 |
| CA3075713A1 (en) | 2019-04-04 |
| LT3688468T (lt) | 2022-06-27 |
| EP3688468B1 (en) | 2022-03-16 |
| US20210231680A1 (en) | 2021-07-29 |
| ES2918249T3 (es) | 2022-07-14 |
| US12332250B2 (en) | 2025-06-17 |
| US20230258659A1 (en) | 2023-08-17 |
| IL273574A (en) | 2020-05-31 |
| JP2020535423A (ja) | 2020-12-03 |
| IL273574B2 (en) | 2025-01-01 |
| JP7418324B2 (ja) | 2024-01-19 |
| AU2018343980A1 (en) | 2020-04-02 |
| HUE058848T2 (hu) | 2022-09-28 |
| AU2018343980B2 (en) | 2025-04-10 |
| WO2019063756A1 (en) | 2019-04-04 |
| PL3688468T3 (pl) | 2022-07-18 |
| SI3688468T1 (sl) | 2022-08-31 |
| CN111164429A (zh) | 2020-05-15 |
| IL273574B1 (en) | 2024-09-01 |
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| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |