PL3688468T3 - Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18 - Google Patents
Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18Info
- Publication number
- PL3688468T3 PL3688468T3 PL18782012.1T PL18782012T PL3688468T3 PL 3688468 T3 PL3688468 T3 PL 3688468T3 PL 18782012 T PL18782012 T PL 18782012T PL 3688468 T3 PL3688468 T3 PL 3688468T3
- Authority
- PL
- Poland
- Prior art keywords
- fgf
- compound
- predicting responsiveness
- inflammatory biomarkers
- biomarkers
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title 1
- 108090000370 fibroblast growth factor 18 Proteins 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 230000004043 responsiveness Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17194169 | 2017-09-29 | ||
| EP18169317 | 2018-04-25 | ||
| PCT/EP2018/076391 WO2019063756A1 (en) | 2017-09-29 | 2018-09-28 | INFLAMMATORY BIOMARKERS FOR PREDICTING REACTIVITY TO FGF-18 COMPOUND |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3688468T3 true PL3688468T3 (pl) | 2022-07-18 |
Family
ID=63722379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18782012.1T PL3688468T3 (pl) | 2017-09-29 | 2018-09-28 | Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11467169B2 (pl) |
| EP (1) | EP3688468B1 (pl) |
| JP (1) | JP7418324B2 (pl) |
| CN (1) | CN111164429B (pl) |
| AU (1) | AU2018343980B2 (pl) |
| CA (1) | CA3075713A1 (pl) |
| DK (1) | DK3688468T3 (pl) |
| ES (1) | ES2918249T3 (pl) |
| HR (1) | HRP20220737T1 (pl) |
| HU (1) | HUE058848T2 (pl) |
| IL (1) | IL273574B2 (pl) |
| LT (1) | LT3688468T (pl) |
| PL (1) | PL3688468T3 (pl) |
| RS (1) | RS63292B1 (pl) |
| SI (1) | SI3688468T1 (pl) |
| WO (1) | WO2019063756A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| PL3688468T3 (pl) | 2017-09-29 | 2022-07-18 | Merck Patent Gmbh | Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18 |
| DK3687558T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL129379A (en) | 1996-10-16 | 2008-12-29 | Zymogenetics Inc | Fibroblast growth factor homologues |
| US20040136970A1 (en) | 2002-10-07 | 2004-07-15 | Ellsworth Jeff L. | Methods for administering FGF18 |
| EP1558932A2 (en) | 2002-11-08 | 2005-08-03 | Barnes-Jewish Hospital | Uncoupled collagen synthesis and degradation assays |
| PL1828239T3 (pl) | 2004-12-10 | 2012-01-31 | Zymogenetics Inc | Produkcja FGF18 w organizmach prokariotycznych |
| US8224579B2 (en) | 2005-06-17 | 2012-07-17 | The Brigham And Women's Hospital, Inc. | Method of diagnosing osteoarthritis |
| CA2658511C (en) | 2006-08-25 | 2019-02-19 | Ares Trading S.A. | Use of fgf-18 compound to treat cartilage disorders |
| JP2009257842A (ja) | 2008-04-14 | 2009-11-05 | Ttc:Kk | 変形性関節症の検査方法及び診断用キット |
| EP2283156B1 (en) | 2008-05-02 | 2015-11-11 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| US20090299769A1 (en) | 2008-05-29 | 2009-12-03 | Nordic Bioscience Imaging A/S | Prognostic osteoarthritis biomarkers |
| US20120115137A1 (en) | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| CN104736723B (zh) * | 2012-08-06 | 2017-10-31 | 默克专利有限公司 | 用于预测对fgf‑18化合物的响应性的遗传标记 |
| PL2880181T3 (pl) | 2012-08-06 | 2019-03-29 | Merck Patent Gmbh | Biomarkery prognostyczne w zaburzeniach chrząstki |
| CA2931978A1 (en) | 2013-12-02 | 2015-06-11 | Abbvie Inc. | Compositions and methods for treating osteoarthritis |
| BR112016014717B1 (pt) | 2013-12-24 | 2020-12-01 | Ares Trading S.A. | sistema de gelificação de dois componentes, método para produção de um hidrogel homogêneo, e artigo de produção |
| JP6791754B2 (ja) | 2013-12-24 | 2020-11-25 | アレス トレーディング ソシエテ アノニム | キシログルカンゲル中のｆｇｆ−１８製剤 |
| EP3107559B1 (en) * | 2014-02-20 | 2018-07-11 | Merck Patent GmbH | Fgf-18 compound dosing regimen |
| BR112016018681B1 (pt) | 2014-02-20 | 2021-01-05 | Merck Patent Gmbh | sistema de distribuição de substâncias que compreende pelo menos um material polimérico formador de uma matriz e um fármaco anabólico, processo de produção do mesmo e artigo de manufatura |
| AU2015220781B2 (en) | 2014-02-20 | 2018-05-24 | Merck Patent Gmbh | FGF-18 in graft transplantation and tissue engineering procedures |
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| NZ742200A (en) | 2015-11-06 | 2023-01-27 | Samumed Llc | Treatment of osteoarthritis |
| US9983214B2 (en) | 2016-04-15 | 2018-05-29 | Esm Technologies, Llc | Method for evaluating articular joint therapeutics |
| PL3688468T3 (pl) | 2017-09-29 | 2022-07-18 | Merck Patent Gmbh | Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18 |
| DK3687558T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
-
2018
- 2018-09-28 PL PL18782012.1T patent/PL3688468T3/pl unknown
- 2018-09-28 CA CA3075713A patent/CA3075713A1/en active Pending
- 2018-09-28 HU HUE18782012A patent/HUE058848T2/hu unknown
- 2018-09-28 DK DK18782012.1T patent/DK3688468T3/da active
- 2018-09-28 RS RS20220541A patent/RS63292B1/sr unknown
- 2018-09-28 SI SI201830693T patent/SI3688468T1/sl unknown
- 2018-09-28 US US16/650,878 patent/US11467169B2/en active Active
- 2018-09-28 LT LTEPPCT/EP2018/076391T patent/LT3688468T/lt unknown
- 2018-09-28 HR HRP20220737TT patent/HRP20220737T1/hr unknown
- 2018-09-28 JP JP2020517797A patent/JP7418324B2/ja active Active
- 2018-09-28 IL IL273574A patent/IL273574B2/en unknown
- 2018-09-28 ES ES18782012T patent/ES2918249T3/es active Active
- 2018-09-28 WO PCT/EP2018/076391 patent/WO2019063756A1/en not_active Ceased
- 2018-09-28 EP EP18782012.1A patent/EP3688468B1/en active Active
- 2018-09-28 AU AU2018343980A patent/AU2018343980B2/en active Active
- 2018-09-28 CN CN201880063173.4A patent/CN111164429B/zh active Active
-
2022
- 2022-09-01 US US17/929,261 patent/US12332250B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HUE058848T2 (hu) | 2022-09-28 |
| ES2918249T3 (es) | 2022-07-14 |
| IL273574B1 (en) | 2024-09-01 |
| US20230258659A1 (en) | 2023-08-17 |
| JP2020535423A (ja) | 2020-12-03 |
| RS63292B1 (sr) | 2022-06-30 |
| US12332250B2 (en) | 2025-06-17 |
| HRP20220737T1 (hr) | 2022-09-02 |
| EP3688468A1 (en) | 2020-08-05 |
| AU2018343980B2 (en) | 2025-04-10 |
| CN111164429A (zh) | 2020-05-15 |
| SI3688468T1 (sl) | 2022-08-31 |
| CA3075713A1 (en) | 2019-04-04 |
| DK3688468T3 (da) | 2022-06-20 |
| IL273574A (en) | 2020-05-31 |
| JP7418324B2 (ja) | 2024-01-19 |
| US20210231680A1 (en) | 2021-07-29 |
| CN111164429B (zh) | 2024-08-09 |
| IL273574B2 (en) | 2025-01-01 |
| WO2019063756A1 (en) | 2019-04-04 |
| EP3688468B1 (en) | 2022-03-16 |
| US11467169B2 (en) | 2022-10-11 |
| LT3688468T (lt) | 2022-06-27 |
| AU2018343980A1 (en) | 2020-04-02 |
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