PL1828239T3 - Produkcja FGF18 w organizmach prokariotycznych - Google Patents
Produkcja FGF18 w organizmach prokariotycznychInfo
- Publication number
- PL1828239T3 PL1828239T3 PL05853969T PL05853969T PL1828239T3 PL 1828239 T3 PL1828239 T3 PL 1828239T3 PL 05853969 T PL05853969 T PL 05853969T PL 05853969 T PL05853969 T PL 05853969T PL 1828239 T3 PL1828239 T3 PL 1828239T3
- Authority
- PL
- Poland
- Prior art keywords
- fgf18
- coli
- production
- expression
- ompt
- Prior art date
Links
- 101150106178 FGF18 gene Proteins 0.000 title abstract 2
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title 1
- 241000588724 Escherichia coli Species 0.000 abstract 4
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 abstract 3
- 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 abstract 3
- 239000013604 expression vector Substances 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108020004705 Codon Proteins 0.000 abstract 1
- 101100390711 Escherichia coli (strain K12) fhuA gene Proteins 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63502304P | 2004-12-10 | 2004-12-10 | |
| PCT/US2005/045166 WO2006063362A1 (en) | 2004-12-10 | 2005-12-12 | Fgf18 production in prokaryotic hosts |
| EP05853969A EP1828239B1 (en) | 2004-12-10 | 2005-12-12 | Fgf18 production in prokaryotic hosts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1828239T3 true PL1828239T3 (pl) | 2012-01-31 |
Family
ID=36061577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05853969T PL1828239T3 (pl) | 2004-12-10 | 2005-12-12 | Produkcja FGF18 w organizmach prokariotycznych |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7858341B2 (pl) |
| EP (1) | EP1828239B1 (pl) |
| AT (1) | ATE521633T1 (pl) |
| AU (1) | AU2005314438B2 (pl) |
| CA (1) | CA2592261C (pl) |
| CY (1) | CY1112394T1 (pl) |
| DK (1) | DK1828239T3 (pl) |
| ES (1) | ES2371219T3 (pl) |
| PL (1) | PL1828239T3 (pl) |
| PT (1) | PT1828239E (pl) |
| SI (1) | SI1828239T1 (pl) |
| WO (1) | WO2006063362A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006018969D1 (de) | 2005-10-04 | 2011-01-27 | Bristol Myers Squibb Co | Herstellung und reinigung von il-29 |
| ZA200900426B (en) * | 2006-08-25 | 2010-04-28 | Ares Trading Sa | Treatment of cartilage disorders with FGF-18 |
| CA2658511C (en) * | 2006-08-25 | 2019-02-19 | Ares Trading S.A. | Use of fgf-18 compound to treat cartilage disorders |
| CN102482321B (zh) | 2009-06-22 | 2015-06-17 | 安姆根有限公司 | 使用化学控制的氧化还原态重折叠蛋白质 |
| WO2010151688A2 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
| WO2012038953A2 (en) | 2010-09-21 | 2012-03-29 | Hepacore Ltd. | Fgf-18 truncated variants having increased receptor specificity and uses thereof |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| TW201307563A (zh) * | 2011-05-19 | 2013-02-16 | Shire Human Genetic Therapies | 純化乙醯肝素－ｎ－硫酸酯酶之方法 |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| US9580692B2 (en) * | 2012-02-29 | 2017-02-28 | Ge Healthcare Bioprocess R&D Ab | Method for endotoxin removal |
| US10041050B2 (en) | 2012-02-29 | 2018-08-07 | Ge Healthcare Bioprocess R&D Ab | Method for endotoxin removal |
| CN104736723B (zh) | 2012-08-06 | 2017-10-31 | 默克专利有限公司 | 用于预测对fgf‑18化合物的响应性的遗传标记 |
| BR112016018681B1 (pt) * | 2014-02-20 | 2021-01-05 | Merck Patent Gmbh | sistema de distribuição de substâncias que compreende pelo menos um material polimérico formador de uma matriz e um fármaco anabólico, processo de produção do mesmo e artigo de manufatura |
| KR101608734B1 (ko) | 2014-03-21 | 2016-04-04 | 씨제이제일제당 주식회사 | L-아미노산을 생산하는 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법 |
| WO2016120387A1 (en) | 2015-01-29 | 2016-08-04 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| EP3322736B1 (en) * | 2015-07-15 | 2021-09-01 | Prosit Sole Biotechnology (Beijing) Co., Ltd | Fusion polypeptides and methods of use |
| PL3688468T3 (pl) | 2017-09-29 | 2022-07-18 | Merck Patent Gmbh | Biomarkery stanu zapalnego do przewidywania odpowiedzi na związek fgf-18 |
| DK3687558T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| CN110759986B (zh) * | 2019-10-18 | 2023-01-31 | 大连工业大学 | 一种可逆自组装蛋白的高效制备方法 |
| CN114181321B (zh) * | 2021-12-10 | 2023-04-11 | 中国海洋大学 | 花鲈fgf6a、fgf6b以及fgf18重组蛋白及其制备方法和应用 |
| JPWO2024084807A1 (pl) * | 2022-10-19 | 2024-04-25 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5439818A (en) | 1985-09-12 | 1995-08-08 | Scios Nova Inc. | DNA encoding human recombinant basic fibroblast growth factor |
| US5604293A (en) | 1985-09-12 | 1997-02-18 | Scios Inc. | Recombinant human basic fibroblast growth factor |
| US5773252A (en) | 1995-06-05 | 1998-06-30 | Human Genome Sciences, Inc. | Fibroblast growth factor 15 |
| US7135459B2 (en) | 1996-10-16 | 2006-11-14 | Zymogenetics, Inc. | Methods of use of FGF homologs |
| IL129379A (en) | 1996-10-16 | 2008-12-29 | Zymogenetics Inc | Fibroblast growth factor homologues |
| US20050043234A1 (en) | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| US6518236B1 (en) | 1996-10-16 | 2003-02-11 | Zymogenetics, Inc. | FGF homologs |
| JP5209161B2 (ja) | 1999-12-02 | 2013-06-12 | ザイモジェネティクス， インコーポレイテッド | 腺維芽細胞成長受容体−３又は−２を発現する細胞を標的化するための方法 |
| US20040136970A1 (en) * | 2002-10-07 | 2004-07-15 | Ellsworth Jeff L. | Methods for administering FGF18 |
| US20040229292A1 (en) | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
-
2005
- 2005-12-12 PL PL05853969T patent/PL1828239T3/pl unknown
- 2005-12-12 EP EP05853969A patent/EP1828239B1/en not_active Expired - Lifetime
- 2005-12-12 AU AU2005314438A patent/AU2005314438B2/en not_active Expired
- 2005-12-12 ES ES05853969T patent/ES2371219T3/es not_active Expired - Lifetime
- 2005-12-12 DK DK05853969.3T patent/DK1828239T3/da active
- 2005-12-12 US US11/301,383 patent/US7858341B2/en not_active Expired - Lifetime
- 2005-12-12 SI SI200531396T patent/SI1828239T1/sl unknown
- 2005-12-12 PT PT05853969T patent/PT1828239E/pt unknown
- 2005-12-12 AT AT05853969T patent/ATE521633T1/de active
- 2005-12-12 CA CA2592261A patent/CA2592261C/en not_active Expired - Lifetime
- 2005-12-12 WO PCT/US2005/045166 patent/WO2006063362A1/en not_active Ceased
-
2011
- 2011-11-24 CY CY20111101149T patent/CY1112394T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005314438A1 (en) | 2006-06-15 |
| DK1828239T3 (da) | 2011-12-19 |
| CY1112394T1 (el) | 2015-12-09 |
| WO2006063362A1 (en) | 2006-06-15 |
| ES2371219T3 (es) | 2011-12-28 |
| US7858341B2 (en) | 2010-12-28 |
| EP1828239B1 (en) | 2011-08-24 |
| ATE521633T1 (de) | 2011-09-15 |
| EP1828239A1 (en) | 2007-09-05 |
| US20060172384A1 (en) | 2006-08-03 |
| CA2592261A1 (en) | 2006-06-15 |
| PT1828239E (pt) | 2011-10-27 |
| SI1828239T1 (sl) | 2011-11-30 |
| HK1113161A1 (en) | 2008-09-26 |
| CA2592261C (en) | 2015-11-24 |
| AU2005314438B2 (en) | 2012-03-29 |
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