JP2016512214A5 - - Google Patents
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- Publication number
- JP2016512214A5 JP2016512214A5 JP2015562176A JP2015562176A JP2016512214A5 JP 2016512214 A5 JP2016512214 A5 JP 2016512214A5 JP 2015562176 A JP2015562176 A JP 2015562176A JP 2015562176 A JP2015562176 A JP 2015562176A JP 2016512214 A5 JP2016512214 A5 JP 2016512214A5
- Authority
- JP
- Japan
- Prior art keywords
- bispecific antibody
- epitope
- amino acid
- tfpi
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000539 amino acid group Chemical group 0.000 claims 13
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 12
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 12
- 102000002262 Thromboplastin Human genes 0.000 claims 10
- 108010000499 Thromboplastin Proteins 0.000 claims 10
- 239000003130 blood coagulation factor inhibitor Substances 0.000 claims 10
- 230000027455 binding Effects 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 101001038335 Homo sapiens Serine/threonine-protein kinase LMTK2 Proteins 0.000 claims 3
- 102100040292 Serine/threonine-protein kinase LMTK2 Human genes 0.000 claims 3
- 230000009870 specific binding Effects 0.000 claims 2
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789274P | 2013-03-15 | 2013-03-15 | |
| EP13159515.9 | 2013-03-15 | ||
| EP13159515 | 2013-03-15 | ||
| US61/789,274 | 2013-03-15 | ||
| PCT/EP2014/055055 WO2014140240A1 (en) | 2013-03-15 | 2014-03-14 | Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512214A JP2016512214A (ja) | 2016-04-25 |
| JP2016512214A5 true JP2016512214A5 (enExample) | 2017-04-20 |
| JP6586016B2 JP6586016B2 (ja) | 2019-10-02 |
Family
ID=47877935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562176A Active JP6586016B2 (ja) | 2013-03-15 | 2014-03-14 | 組織因子系凝固インヒビター上の２つのエピトープに特異的に結合することが可能な抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9896513B2 (enExample) |
| EP (1) | EP2970499B1 (enExample) |
| JP (1) | JP6586016B2 (enExample) |
| CN (1) | CN105209497B (enExample) |
| ES (1) | ES2926773T3 (enExample) |
| WO (1) | WO2014140240A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101745394B1 (ko) | 2008-12-22 | 2017-06-09 | 노보 노르디스크 에이/에스 | 조직 인자 경로 억제자에 대한 항체 |
| CN110066339A (zh) * | 2010-04-20 | 2019-07-30 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| US10457743B2 (en) * | 2013-07-19 | 2019-10-29 | Novo Nordisk A/S | Antibodies recognizing the N-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity |
| PE20160953A1 (es) * | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| SG10201909173PA (en) | 2015-04-01 | 2019-11-28 | Anaptysbio Inc | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| PE20240142A1 (es) * | 2015-08-19 | 2024-02-01 | Pfizer | Anticuerpos inhibidores via del factor tisular y usos de los mismos |
| CN106554420A (zh) * | 2015-09-30 | 2017-04-05 | 上海众合医药科技股份有限公司 | Pcsk9抗体、其抗原结合片段及其医药用途 |
| EP3388838B1 (en) * | 2016-01-29 | 2022-02-16 | Sony Group Corporation | Blood coagulation analysis |
| EP3689419A1 (en) | 2016-11-01 | 2020-08-05 | AnaptysBio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| CN110382000A (zh) | 2017-01-09 | 2019-10-25 | 泰萨罗公司 | 用抗tim-3抗体治疗癌症的方法 |
| CN113645995A (zh) | 2018-10-11 | 2021-11-12 | 辉瑞公司 | Tfpi拮抗剂的剂量方案 |
| JP2022506696A (ja) * | 2018-11-07 | 2022-01-17 | ボーダックス バイオ インコーポレーテッド | Ｉｖメロキシカムにより血小板機能異常症の対象を治療する方法 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| CN110156890B (zh) * | 2019-04-09 | 2021-02-02 | 苏州大学 | Semaphorin7A单克隆抗体及其在制备用于治疗炎症疾病药物方面的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| AU5526690A (en) | 1989-04-19 | 1990-11-29 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP0539975A1 (en) * | 1991-10-31 | 1993-05-05 | Teijin Limited | Method for immunological assay of free lipoprotein-associated coagulation inhibitor (LACI) and kit therefor |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| WO1998048837A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| ES2561985T3 (es) | 2001-10-10 | 2016-03-01 | Ratiopharm Gmbh | Remodelación y glicoconjugación de anticuerpos |
| SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
| JP2007534631A (ja) | 2003-10-28 | 2007-11-29 | ノボ ノルディスク アクティーゼルスカブ | ラミニン−５γ２結合性ペプチド、その関連組成物およびその使用 |
| BRPI0611570A2 (pt) | 2005-06-15 | 2011-02-22 | Novo Nordisk Healthcare Ag | métodos para fixar covalentemente peg a um polipeptìdeo e para modificar propriedades farmacológicas de hormÈnio de crescimento, composto e sais, pró-drogas ou solvatos farmaceuticamente aceitáveis do mesmo, hormÈnio de crescimento humano, composição farmacêutica, método para tratamento de doença e, uso de um composto |
| KR101745394B1 (ko) * | 2008-12-22 | 2017-06-09 | 노보 노르디스크 에이/에스 | 조직 인자 경로 억제자에 대한 항체 |
| CN102300876A (zh) | 2008-12-22 | 2011-12-28 | 诺沃—诺迪斯克有限公司 | 针对组织因子途径抑制剂(tfpi)的抗体 |
| CN103080135B (zh) | 2010-06-30 | 2017-06-13 | 诺沃—诺迪斯克有限公司 | 能够特异性结合组织因子途径抑制剂的抗体 |
| CA2831907C (en) * | 2011-04-01 | 2020-03-24 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
-
2014
- 2014-03-14 EP EP14710541.5A patent/EP2970499B1/en active Active
- 2014-03-14 JP JP2015562176A patent/JP6586016B2/ja active Active
- 2014-03-14 US US14/775,108 patent/US9896513B2/en active Active
- 2014-03-14 CN CN201480027370.2A patent/CN105209497B/zh active Active
- 2014-03-14 ES ES14710541T patent/ES2926773T3/es active Active
- 2014-03-14 WO PCT/EP2014/055055 patent/WO2014140240A1/en not_active Ceased
-
2018
- 2018-01-09 US US15/866,007 patent/US10717784B2/en active Active
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