JP2020533319A5 - - Google Patents
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- Publication number
- JP2020533319A5 JP2020533319A5 JP2020513872A JP2020513872A JP2020533319A5 JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5 JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- halo
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023072737A JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710801364.3A CN109467538A (zh) | 2017-09-07 | 2017-09-07 | 环烯烃取代的杂芳环类化合物及其用途 |
| CN201710801364.3 | 2017-09-07 | ||
| PCT/CN2018/104531 WO2019047909A1 (en) | 2017-09-07 | 2018-09-07 | HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023072737A Division JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020533319A JP2020533319A (ja) | 2020-11-19 |
| JP2020533319A5 true JP2020533319A5 (enExample) | 2021-10-14 |
| JP7273030B2 JP7273030B2 (ja) | 2023-05-12 |
| JP7273030B6 JP7273030B6 (ja) | 2024-02-15 |
Family
ID=65634832
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513872A Active JP7273030B6 (ja) | 2017-09-07 | 2018-09-07 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
| JP2023072737A Active JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023072737A Active JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11414390B2 (enExample) |
| EP (1) | EP3679020A4 (enExample) |
| JP (2) | JP7273030B6 (enExample) |
| KR (1) | KR102566237B1 (enExample) |
| CN (6) | CN109467538A (enExample) |
| AR (1) | AR112794A1 (enExample) |
| AU (1) | AU2018329047B2 (enExample) |
| CA (1) | CA3073782A1 (enExample) |
| CL (1) | CL2020000553A1 (enExample) |
| EA (1) | EA202090653A1 (enExample) |
| IL (1) | IL272923B2 (enExample) |
| MX (1) | MX2020002505A (enExample) |
| PE (1) | PE20200727A1 (enExample) |
| PH (1) | PH12020500408A1 (enExample) |
| SG (1) | SG11202001642WA (enExample) |
| TW (1) | TWI816693B (enExample) |
| UA (1) | UA129118C2 (enExample) |
| WO (1) | WO2019047909A1 (enExample) |
| ZA (1) | ZA202001448B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3678666B1 (en) | 2017-09-07 | 2025-07-09 | Augusta University Research Institute, Inc. | Specific akt3 activator and uses thereof |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| CN116209655A (zh) * | 2020-11-09 | 2023-06-02 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
| CN118355008A (zh) * | 2022-01-11 | 2024-07-16 | 正大天晴药业集团股份有限公司 | 一种1,3,5-三嗪衍生物的制备方法 |
| WO2026026904A1 (en) * | 2024-08-01 | 2026-02-05 | Hutchmed Limited | The crystalline forms of a compound |
Family Cites Families (41)
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| US3555154A (en) * | 1967-08-16 | 1971-01-12 | Armour Pharma | Preparations containing 6 - cycloalkylguanamines and methods for treating inflammatory conditions therewith |
| EP0361489A3 (en) | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | Novel 3,4-diaminoquinoline and pyridine compounds |
| MXPA02003436A (es) | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| US7467603B2 (en) | 2004-05-24 | 2008-12-23 | Equusys, Incorporated | Animal instrumentation |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CA2648804C (en) | 2006-04-07 | 2014-05-27 | Methylgene Inc. | Benzamide derivatives as inhibitors of histone deacetylase |
| EP2066645A2 (en) | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| WO2008122378A1 (en) * | 2007-04-04 | 2008-10-16 | Ucb Pharma, S.A. | Novel pyridine derivatives, processes for preparing them, pharmaceutical compositions thereof |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CN102625799A (zh) | 2009-06-25 | 2012-08-01 | 安姆根有限公司 | 杂环化合物及其用途 |
| WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| EP2588471A1 (en) | 2010-06-30 | 2013-05-08 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
| WO2012117048A1 (en) | 2011-03-02 | 2012-09-07 | Lead Discovery Center Gmbh | Pharmaceutically active disubstituted triazine derivatives |
| HRP20171554T1 (hr) | 2011-09-12 | 2017-11-17 | Merck Patent Gmbh | Novi imidazol amini kao modulatori aktivnosti kinaze |
| ES2646759T3 (es) | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
| SMT201800334T1 (it) | 2012-01-06 | 2018-09-13 | Agios Pharmaceuticals Inc | Composti terapeuticamente attivi e loro metodi di utilizzo |
| JP6479667B2 (ja) * | 2012-10-24 | 2019-03-06 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 除草性アジン |
| CN103044469A (zh) | 2012-11-30 | 2013-04-17 | 大连联化化学有限公司 | 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法 |
| US9862692B2 (en) | 2013-01-23 | 2018-01-09 | The University Of Toledo | Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer |
| CN105593215B (zh) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| MX375030B (es) * | 2013-07-11 | 2025-03-06 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer. |
| CN105916507A (zh) | 2013-08-02 | 2016-08-31 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| DK3063143T3 (en) | 2013-11-01 | 2018-08-20 | Novartis Ag | Amino heteroaryl benzamides as kinase inhibitors |
| WO2015187088A1 (en) | 2014-06-04 | 2015-12-10 | Thomas Helledays Stiftelse För Medicinsk Forskning | Mth1 inhibitors for treatment of cancer |
| CN106794181A (zh) | 2014-06-04 | 2017-05-31 | 托马斯·黑勒戴药物研究基金会 | 用于治疗炎性和自身免疫性病况的mth1抑制剂 |
| KR102526632B1 (ko) * | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드 |
| WO2016119707A1 (en) * | 2015-01-29 | 2016-08-04 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
| AU2016299092B2 (en) | 2015-07-30 | 2020-08-20 | Centaurus Biopharma Co., Ltd. | 1, 3, 5-triazine derivative and method of using same |
| WO2017059280A1 (en) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Novel pan-tam inhibitors and mer/axl dual inhibitors |
| MA43374A (fr) | 2015-12-04 | 2018-10-10 | Agios Pharmaceuticals Inc | Méthodes de traitement de tumeurs malignes |
| WO2017096945A1 (zh) | 2015-12-07 | 2017-06-15 | 北京康美特科技股份有限公司 | 含硼有机硅化合物、太阳能电池组件用密封剂以及太阳能电池组件 |
| IL307931A (en) | 2016-04-15 | 2023-12-01 | Epizyme Inc | Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors |
| CN107382840B (zh) | 2016-05-16 | 2020-09-01 | 四川大学 | 吡啶类化合物及其作为idh功能变异突变体抑制剂类药物的用途 |
| CR20200124A (es) | 2017-08-15 | 2020-09-28 | Abbvie Inc | Inhibidores macrocíclicos de mcl-1 y métodos de uso |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| TWI707859B (zh) | 2017-09-07 | 2020-10-21 | 日商衛材R&D企管股份有限公司 | 五環化合物 |
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2017
- 2017-09-07 CN CN201710801364.3A patent/CN109467538A/zh active Pending
-
2018
- 2018-09-07 PE PE2020000280A patent/PE20200727A1/es unknown
- 2018-09-07 EP EP18853366.5A patent/EP3679020A4/en active Pending
- 2018-09-07 US US16/645,329 patent/US11414390B2/en active Active
- 2018-09-07 CA CA3073782A patent/CA3073782A1/en active Pending
- 2018-09-07 KR KR1020207009621A patent/KR102566237B1/ko active Active
- 2018-09-07 CN CN202311040510.7A patent/CN117024363A/zh active Pending
- 2018-09-07 CN CN202311036845.1A patent/CN117257809B/zh active Active
- 2018-09-07 CN CN201880057118.4A patent/CN111132967B/zh active Active
- 2018-09-07 AU AU2018329047A patent/AU2018329047B2/en active Active
- 2018-09-07 MX MX2020002505A patent/MX2020002505A/es unknown
- 2018-09-07 CN CN202311036787.2A patent/CN116999441B/zh active Active
- 2018-09-07 SG SG11202001642WA patent/SG11202001642WA/en unknown
- 2018-09-07 UA UAA202002089A patent/UA129118C2/uk unknown
- 2018-09-07 CN CN202311036829.2A patent/CN117797156A/zh active Pending
- 2018-09-07 JP JP2020513872A patent/JP7273030B6/ja active Active
- 2018-09-07 WO PCT/CN2018/104531 patent/WO2019047909A1/en not_active Ceased
- 2018-09-07 EA EA202090653A patent/EA202090653A1/ru unknown
- 2018-09-07 AR ARP180102548A patent/AR112794A1/es active IP Right Grant
- 2018-09-07 TW TW107131525A patent/TWI816693B/zh active
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2020
- 2020-02-26 IL IL272923A patent/IL272923B2/en unknown
- 2020-02-28 PH PH12020500408A patent/PH12020500408A1/en unknown
- 2020-03-05 CL CL2020000553A patent/CL2020000553A1/es unknown
- 2020-03-06 ZA ZA2020/01448A patent/ZA202001448B/en unknown
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2022
- 2022-05-18 US US17/747,925 patent/US12234211B2/en active Active
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2023
- 2023-04-26 JP JP2023072737A patent/JP7603740B2/ja active Active
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2025
- 2025-02-11 US US19/050,772 patent/US20250223267A1/en active Pending