JP2020533319A5 - - Google Patents
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- Publication number
- JP2020533319A5 JP2020533319A5 JP2020513872A JP2020513872A JP2020533319A5 JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5 JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020513872 A JP2020513872 A JP 2020513872A JP 2020533319 A5 JP2020533319 A5 JP 2020533319A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- halo
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023072737A JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710801364.3 | 2017-09-07 | ||
| CN201710801364.3A CN109467538A (zh) | 2017-09-07 | 2017-09-07 | 环烯烃取代的杂芳环类化合物及其用途 |
| PCT/CN2018/104531 WO2019047909A1 (en) | 2017-09-07 | 2018-09-07 | HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023072737A Division JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020533319A JP2020533319A (ja) | 2020-11-19 |
| JP2020533319A5 true JP2020533319A5 (enExample) | 2021-10-14 |
| JP7273030B2 JP7273030B2 (ja) | 2023-05-12 |
| JP7273030B6 JP7273030B6 (ja) | 2024-02-15 |
Family
ID=65634832
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513872A Active JP7273030B6 (ja) | 2017-09-07 | 2018-09-07 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
| JP2023072737A Active JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023072737A Active JP7603740B2 (ja) | 2017-09-07 | 2023-04-26 | シクロオレフィン置換複素芳香族化合物およびそれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11414390B2 (enExample) |
| EP (1) | EP3679020A4 (enExample) |
| JP (2) | JP7273030B6 (enExample) |
| KR (1) | KR102566237B1 (enExample) |
| CN (6) | CN109467538A (enExample) |
| AR (1) | AR112794A1 (enExample) |
| AU (1) | AU2018329047B2 (enExample) |
| BR (1) | BR112020004563A2 (enExample) |
| CA (1) | CA3073782A1 (enExample) |
| CL (1) | CL2020000553A1 (enExample) |
| EA (1) | EA202090653A1 (enExample) |
| IL (1) | IL272923B2 (enExample) |
| MX (1) | MX2020002505A (enExample) |
| PE (1) | PE20200727A1 (enExample) |
| PH (1) | PH12020500408A1 (enExample) |
| SG (1) | SG11202001642WA (enExample) |
| TW (1) | TWI816693B (enExample) |
| UA (1) | UA129118C2 (enExample) |
| WO (1) | WO2019047909A1 (enExample) |
| ZA (1) | ZA202001448B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| BR112020003494A2 (pt) | 2017-09-07 | 2020-08-25 | Augusta University Research Institute, Inc | composto, métodos para aumentar uma resposta imunossupressora, para tratar um distúrbio inflamatório, uma doença autoimune, doença do enxerto contra hospedeiro, infecção crônica e obesidade e para inibir ou reduzir a rejeição a um transplante, e, composição farmacêutica |
| CN116209655A (zh) * | 2020-11-09 | 2023-06-02 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
| WO2023134686A1 (zh) * | 2022-01-11 | 2023-07-20 | 正大天晴药业集团股份有限公司 | 一种1,3,5-三嗪衍生物的制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3555154A (en) | 1967-08-16 | 1971-01-12 | Armour Pharma | Preparations containing 6 - cycloalkylguanamines and methods for treating inflammatory conditions therewith |
| US5019574A (en) | 1988-09-30 | 1991-05-28 | Chugai Seiyaku Kabushiki Kaisha | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function |
| ATE396978T1 (de) | 1999-10-07 | 2008-06-15 | Amgen Inc | Triazin-kinase-hemmer |
| NZ551559A (en) | 2004-05-24 | 2008-10-31 | Equusys Inc | Animal instrumentation |
| GB0512324D0 (en) * | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CN101466670B (zh) | 2006-04-07 | 2013-04-17 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| EP2066645A2 (en) * | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| WO2008122378A1 (en) | 2007-04-04 | 2008-10-16 | Ucb Pharma, S.A. | Novel pyridine derivatives, processes for preparing them, pharmaceutical compositions thereof |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| JP2011507910A (ja) | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
| UY32742A (es) | 2009-06-25 | 2010-12-31 | Amgen Inc | Compuestos heterocíclicos y sus usos |
| WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| WO2012003283A1 (en) | 2010-06-30 | 2012-01-05 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
| JP6010557B2 (ja) | 2011-03-02 | 2016-10-19 | リード ディスカバリー センター ゲーエムベーハー | 薬学的活性化二置換トリアジン誘導体 |
| SI2755958T1 (sl) | 2011-09-12 | 2017-12-29 | Merck Patent Gmbh | Aminopirimidinski derivati za uporabo kot modulatorji kinazne aktivnosti |
| SG10201606301YA (en) | 2011-09-12 | 2016-09-29 | Merck Patent Gmbh | Novel imidazole amines as modulators of kinase activity |
| TWI547493B (zh) | 2011-09-27 | 2016-09-01 | 諾華公司 | 作為突變ｉｄｈ之抑制劑之３－嘧啶－４－基－唑啶－２－酮 |
| UA117451C2 (uk) | 2012-01-06 | 2018-08-10 | Аджиос Фармасьютікалз, Інк. | Терапевтично активні сполуки і способи їх застосування |
| EP2912024B1 (en) | 2012-10-24 | 2016-07-20 | Basf Se | Herbicidal azines |
| CN103044469A (zh) * | 2012-11-30 | 2013-04-17 | 大连联化化学有限公司 | 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法 |
| WO2014116594A1 (en) | 2013-01-23 | 2014-07-31 | The University Of Toledo | Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9724350B2 (en) * | 2013-07-11 | 2017-08-08 | Agios Pharmaceuticals, Inc. | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015006591A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| CN105517996B (zh) * | 2013-07-11 | 2019-03-26 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| CN110386922A (zh) | 2013-08-02 | 2019-10-29 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| CA2922532C (en) | 2013-11-01 | 2023-09-19 | Novartis Ag | Aminoheteroaryl benzamides as kinase inhibitors |
| JP6635949B2 (ja) | 2014-06-04 | 2020-01-29 | トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング | 炎症性および自己免疫性の病気の処置のためのｍｔｈ１阻害剤 |
| AU2015268961B9 (en) | 2014-06-04 | 2019-10-10 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of cancer |
| KR102303011B1 (ko) | 2015-07-30 | 2021-09-16 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 1,3,5-트라이아진 유도체 및 이의 사용 방법 |
| US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
| CA3007218A1 (en) | 2015-12-04 | 2017-06-08 | Agios Pharmaceuticals, Inc. | Methods of treatment of malignancies |
| WO2017096945A1 (zh) | 2015-12-07 | 2017-06-15 | 北京康美特科技股份有限公司 | 含硼有机硅化合物、太阳能电池组件用密封剂以及太阳能电池组件 |
| JP7041070B2 (ja) | 2016-04-15 | 2022-03-23 | エピザイム，インコーポレイティド | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
| CN107382840B (zh) | 2016-05-16 | 2020-09-01 | 四川大学 | 吡啶类化合物及其作为idh功能变异突变体抑制剂类药物的用途 |
| EP3652184A4 (en) | 2017-08-15 | 2020-05-20 | AbbVie Inc. | MACROCYCLIC INHIBITORS OF MCL-1 AND METHODS OF USE |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| AU2018330578B2 (en) | 2017-09-07 | 2022-11-10 | Eisai R&D Management Co., Ltd. | Pentacyclic compound |
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2017
- 2017-09-07 CN CN201710801364.3A patent/CN109467538A/zh active Pending
-
2018
- 2018-09-07 BR BR112020004563-2A patent/BR112020004563A2/pt active IP Right Grant
- 2018-09-07 KR KR1020207009621A patent/KR102566237B1/ko active Active
- 2018-09-07 AR ARP180102548A patent/AR112794A1/es unknown
- 2018-09-07 AU AU2018329047A patent/AU2018329047B2/en active Active
- 2018-09-07 CN CN201880057118.4A patent/CN111132967B/zh active Active
- 2018-09-07 PE PE2020000280A patent/PE20200727A1/es unknown
- 2018-09-07 EP EP18853366.5A patent/EP3679020A4/en active Pending
- 2018-09-07 CN CN202311036829.2A patent/CN117797156A/zh active Pending
- 2018-09-07 CA CA3073782A patent/CA3073782A1/en active Pending
- 2018-09-07 US US16/645,329 patent/US11414390B2/en active Active
- 2018-09-07 CN CN202311040510.7A patent/CN117024363A/zh active Pending
- 2018-09-07 UA UAA202002089A patent/UA129118C2/uk unknown
- 2018-09-07 TW TW107131525A patent/TWI816693B/zh active
- 2018-09-07 EA EA202090653A patent/EA202090653A1/ru unknown
- 2018-09-07 CN CN202311036845.1A patent/CN117257809A/zh active Pending
- 2018-09-07 WO PCT/CN2018/104531 patent/WO2019047909A1/en not_active Ceased
- 2018-09-07 JP JP2020513872A patent/JP7273030B6/ja active Active
- 2018-09-07 CN CN202311036787.2A patent/CN116999441A/zh active Pending
- 2018-09-07 MX MX2020002505A patent/MX2020002505A/es unknown
- 2018-09-07 SG SG11202001642WA patent/SG11202001642WA/en unknown
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2020
- 2020-02-26 IL IL272923A patent/IL272923B2/en unknown
- 2020-02-28 PH PH12020500408A patent/PH12020500408A1/en unknown
- 2020-03-05 CL CL2020000553A patent/CL2020000553A1/es unknown
- 2020-03-06 ZA ZA2020/01448A patent/ZA202001448B/en unknown
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2022
- 2022-05-18 US US17/747,925 patent/US12234211B2/en active Active
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2023
- 2023-04-26 JP JP2023072737A patent/JP7603740B2/ja active Active
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2025
- 2025-02-11 US US19/050,772 patent/US20250223267A1/en active Pending