SG11202001642WA - Cycloolefin substituted heteroaromatic compounds and their use - Google Patents
Cycloolefin substituted heteroaromatic compounds and their useInfo
- Publication number
- SG11202001642WA SG11202001642WA SG11202001642WA SG11202001642WA SG11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA
- Authority
- SG
- Singapore
- Prior art keywords
- substituted heteroaromatic
- heteroaromatic compounds
- cycloolefin
- cycloolefin substituted
- compounds
- Prior art date
Links
- 125000000392 cycloalkenyl group Chemical group 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710801364.3A CN109467538A (en) | 2017-09-07 | 2017-09-07 | The heteroaryl cyclics and application thereof that cycloolefin replaces |
| PCT/CN2018/104531 WO2019047909A1 (en) | 2017-09-07 | 2018-09-07 | Cycloolefin substituted heteroaromatic compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001642WA true SG11202001642WA (en) | 2020-03-30 |
Family
ID=65634832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001642WA SG11202001642WA (en) | 2017-09-07 | 2018-09-07 | Cycloolefin substituted heteroaromatic compounds and their use |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11414390B2 (en) |
| EP (1) | EP3679020A4 (en) |
| JP (2) | JP7273030B6 (en) |
| KR (1) | KR102566237B1 (en) |
| CN (6) | CN109467538A (en) |
| AR (1) | AR112794A1 (en) |
| AU (1) | AU2018329047B2 (en) |
| BR (1) | BR112020004563A2 (en) |
| CA (1) | CA3073782A1 (en) |
| CL (1) | CL2020000553A1 (en) |
| EA (1) | EA202090653A1 (en) |
| IL (1) | IL272923B2 (en) |
| MX (1) | MX2020002505A (en) |
| PE (1) | PE20200727A1 (en) |
| PH (1) | PH12020500408A1 (en) |
| SG (1) | SG11202001642WA (en) |
| TW (1) | TWI816693B (en) |
| WO (1) | WO2019047909A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018329840A1 (en) | 2017-09-07 | 2020-03-19 | Augusta University Research Institute, Inc. | Specific Akt3 activator and uses thereof |
| CN109467538A (en) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | The heteroaryl cyclics and application thereof that cycloolefin replaces |
| CN116209655A (en) * | 2020-11-09 | 2023-06-02 | 贝达药业股份有限公司 | Mutant IDH1 and IDH2 inhibitors and application thereof |
| CN118355008A (en) * | 2022-01-11 | 2024-07-16 | 正大天晴药业集团股份有限公司 | Preparation method of 1,3, 5-triazine derivative |
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| US3555154A (en) * | 1967-08-16 | 1971-01-12 | Armour Pharma | Preparations containing 6 - cycloalkylguanamines and methods for treating inflammatory conditions therewith |
| EP0361489A3 (en) | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | Novel 3,4-diaminoquinoline and pyridine compounds |
| ATE396978T1 (en) | 1999-10-07 | 2008-06-15 | Amgen Inc | TRIAZINE KINASE INHIBITORS |
| AU2005247441A1 (en) | 2004-05-24 | 2005-12-08 | Equusys, Incorporated | Animal instrumentation |
| GB0512324D0 (en) * | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| US8598168B2 (en) | 2006-04-07 | 2013-12-03 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP2066645A2 (en) | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| US20100168077A1 (en) * | 2007-04-04 | 2010-07-01 | Ucb Pharma, S.A. | Novel Pyridine Derivatives, Processes for Preparing Them, Pharmaceutical Compositions Thereof |
| JO3240B1 (en) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | Inhibitors of c-fms Kinase |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CA2765823A1 (en) * | 2009-06-25 | 2010-12-29 | Amgen Inc. | Tricyclic heterocyclic compounds as mediators of p13k activity |
| WO2011078143A1 (en) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | Pyrimidine derivatives and pharmaceutical composition containing same |
| CA2803358A1 (en) | 2010-06-30 | 2012-01-05 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
| CA2826464C (en) * | 2011-03-02 | 2020-07-28 | Lead Discovery Center Gmbh | Pharmaceutically active disubstituted triazine derivatives |
| CN104080782B (en) | 2011-09-12 | 2016-06-01 | 默克专利有限公司 | As the aminoimidazole of modulators of kinase activity |
| KR101992505B1 (en) | 2011-09-12 | 2019-06-24 | 메르크 파텐트 게엠베하 | Aminopyrimidine derivatives for use as modulators of kinase activity |
| CN115521264A (en) | 2012-01-06 | 2022-12-27 | 法国施维雅药厂 | Therapeutically active compounds and methods of use thereof |
| US9549558B2 (en) * | 2012-10-24 | 2017-01-24 | Basf Se | Herbicidal azines |
| CN103044469A (en) | 2012-11-30 | 2013-04-17 | 大连联化化学有限公司 | Method for preparing cyclopentene/cyclohexene-1-boronic acid pinacol ester |
| US9862692B2 (en) | 2013-01-23 | 2018-01-09 | The University Of Toledo | Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EA032070B1 (en) | 2013-07-11 | 2019-04-30 | Аджиос Фармасьютикалз, Инк. | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
| CN105593215B (en) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 2,4- the or 4,6- diaminopyrimidine compounds as IDH2 mutant inhibitor for treating cancer |
| WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN105517996B (en) * | 2013-07-11 | 2019-03-26 | 安吉奥斯医药品有限公司 | Therapeutical active compound and its application method |
| SG10201709187TA (en) | 2013-08-02 | 2017-12-28 | Agios Pharmaceuticals Inc | Therapeutically active compounds and their methods of use |
| SI3063143T1 (en) | 2013-11-01 | 2018-09-28 | Novartis Ag, | Aminoheteroaryl benzamides as kinase inhibitors |
| WO2015187088A1 (en) | 2014-06-04 | 2015-12-10 | Thomas Helledays Stiftelse För Medicinsk Forskning | Mth1 inhibitors for treatment of cancer |
| WO2015187089A1 (en) | 2014-06-04 | 2015-12-10 | Thomas Helledays Stiftelse För Medicinsk Forskning | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CN113307794A (en) | 2015-07-30 | 2021-08-27 | 正大天晴药业集团股份有限公司 | 1,3, 5-triazine derivatives and methods of use thereof |
| WO2017059280A1 (en) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Novel pan-tam inhibitors and mer/axl dual inhibitors |
| MX2018006745A (en) | 2015-12-04 | 2018-09-05 | Agios Pharmaceuticals Inc | Methods of treatment of malignacies. |
| WO2017096945A1 (en) | 2015-12-07 | 2017-06-15 | 北京康美特科技股份有限公司 | Organic silicon compound containing boron, sealant for solar cell assembly and solar cell assembly |
| BR112018071093A2 (en) | 2016-04-15 | 2019-01-29 | Epizyme Inc | compound of formula, pharmaceutical composition, and method for preventing or treating a blood disorder |
| CN107382840B (en) | 2016-05-16 | 2020-09-01 | 四川大学 | Pyridine compound and application thereof as IDH function mutation mutant inhibitor drug |
| CN111818917A (en) | 2017-08-15 | 2020-10-23 | 艾伯维公司 | Macrocyclic MCL-1 inhibitors and methods of use |
| JOP20200030A1 (en) | 2017-09-07 | 2020-02-12 | Eisai R&D Man Co Ltd | Pentacyclic compound |
| CN109467538A (en) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | The heteroaryl cyclics and application thereof that cycloolefin replaces |
-
2017
- 2017-09-07 CN CN201710801364.3A patent/CN109467538A/en active Pending
-
2018
- 2018-09-07 KR KR1020207009621A patent/KR102566237B1/en active IP Right Grant
- 2018-09-07 MX MX2020002505A patent/MX2020002505A/en unknown
- 2018-09-07 CA CA3073782A patent/CA3073782A1/en active Pending
- 2018-09-07 CN CN202311040510.7A patent/CN117024363A/en active Pending
- 2018-09-07 AR ARP180102548A patent/AR112794A1/en unknown
- 2018-09-07 EA EA202090653A patent/EA202090653A1/en unknown
- 2018-09-07 AU AU2018329047A patent/AU2018329047B2/en active Active
- 2018-09-07 EP EP18853366.5A patent/EP3679020A4/en active Pending
- 2018-09-07 BR BR112020004563-2A patent/BR112020004563A2/en unknown
- 2018-09-07 SG SG11202001642WA patent/SG11202001642WA/en unknown
- 2018-09-07 CN CN202311036845.1A patent/CN117257809A/en active Pending
- 2018-09-07 PE PE2020000280A patent/PE20200727A1/en unknown
- 2018-09-07 CN CN202311036829.2A patent/CN117797156A/en active Pending
- 2018-09-07 TW TW107131525A patent/TWI816693B/en active
- 2018-09-07 US US16/645,329 patent/US11414390B2/en active Active
- 2018-09-07 CN CN202311036787.2A patent/CN116999441A/en active Pending
- 2018-09-07 CN CN201880057118.4A patent/CN111132967B/en active Active
- 2018-09-07 JP JP2020513872A patent/JP7273030B6/en active Active
- 2018-09-07 WO PCT/CN2018/104531 patent/WO2019047909A1/en unknown
-
2020
- 2020-02-26 IL IL272923A patent/IL272923B2/en unknown
- 2020-02-28 PH PH12020500408A patent/PH12020500408A1/en unknown
- 2020-03-05 CL CL2020000553A patent/CL2020000553A1/en unknown
-
2022
- 2022-05-18 US US17/747,925 patent/US20220372005A1/en active Pending
-
2023
- 2023-04-26 JP JP2023072737A patent/JP2023103290A/en active Pending
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