EA202090653A1 - Циклоолефиновые замещённые гетероароматические соединения и их применение - Google Patents
Циклоолефиновые замещённые гетероароматические соединения и их применениеInfo
- Publication number
- EA202090653A1 EA202090653A1 EA202090653A EA202090653A EA202090653A1 EA 202090653 A1 EA202090653 A1 EA 202090653A1 EA 202090653 A EA202090653 A EA 202090653A EA 202090653 A EA202090653 A EA 202090653A EA 202090653 A1 EA202090653 A1 EA 202090653A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyclolefin
- application
- substituted heteroaromatic
- heteroaromatic compounds
- present
- Prior art date
Links
- 150000002390 heteroarenes Chemical class 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710801364.3A CN109467538A (zh) | 2017-09-07 | 2017-09-07 | 环烯烃取代的杂芳环类化合物及其用途 |
| PCT/CN2018/104531 WO2019047909A1 (en) | 2017-09-07 | 2018-09-07 | HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090653A1 true EA202090653A1 (ru) | 2021-02-03 |
Family
ID=65634832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090653A EA202090653A1 (ru) | 2017-09-07 | 2018-09-07 | Циклоолефиновые замещённые гетероароматические соединения и их применение |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11414390B2 (enExample) |
| EP (1) | EP3679020A4 (enExample) |
| JP (2) | JP7273030B6 (enExample) |
| KR (1) | KR102566237B1 (enExample) |
| CN (6) | CN109467538A (enExample) |
| AR (1) | AR112794A1 (enExample) |
| AU (1) | AU2018329047B2 (enExample) |
| BR (1) | BR112020004563A2 (enExample) |
| CA (1) | CA3073782A1 (enExample) |
| CL (1) | CL2020000553A1 (enExample) |
| EA (1) | EA202090653A1 (enExample) |
| IL (1) | IL272923B2 (enExample) |
| MX (1) | MX2020002505A (enExample) |
| PE (1) | PE20200727A1 (enExample) |
| PH (1) | PH12020500408A1 (enExample) |
| SG (1) | SG11202001642WA (enExample) |
| TW (1) | TWI816693B (enExample) |
| UA (1) | UA129118C2 (enExample) |
| WO (1) | WO2019047909A1 (enExample) |
| ZA (1) | ZA202001448B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| CA3074641A1 (en) | 2017-09-07 | 2019-03-14 | Augusta University Research Institute, Inc. | Specific akt3 activator and uses thereof |
| WO2022095756A1 (zh) * | 2020-11-09 | 2022-05-12 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
| CN118355008A (zh) * | 2022-01-11 | 2024-07-16 | 正大天晴药业集团股份有限公司 | 一种1,3,5-三嗪衍生物的制备方法 |
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| US3555154A (en) * | 1967-08-16 | 1971-01-12 | Armour Pharma | Preparations containing 6 - cycloalkylguanamines and methods for treating inflammatory conditions therewith |
| EP0361489A3 (en) | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | Novel 3,4-diaminoquinoline and pyridine compounds |
| CA2386218A1 (en) | 1999-10-07 | 2001-04-12 | Amgen Inc. | Triazine kinase inhibitors |
| NZ551559A (en) | 2004-05-24 | 2008-10-31 | Equusys Inc | Animal instrumentation |
| GB0512324D0 (en) * | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| CN101466670B (zh) * | 2006-04-07 | 2013-04-17 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| EP2066645A2 (en) * | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| WO2008122378A1 (en) * | 2007-04-04 | 2008-10-16 | Ucb Pharma, S.A. | Novel pyridine derivatives, processes for preparing them, pharmaceutical compositions thereof |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EA201270051A1 (ru) | 2009-06-25 | 2012-05-30 | Амген Инк. | Гетероциклические соединения и их применения |
| WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
| WO2012003283A1 (en) * | 2010-06-30 | 2012-01-05 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
| US9226929B2 (en) | 2011-03-02 | 2016-01-05 | Bayer Intellectual Property Gmbh | Pharmaceutically active disubstituted triazine derivatives |
| CN106946796B (zh) * | 2011-09-12 | 2020-05-08 | 默克专利有限公司 | 用作激酶活性调节剂的氨基嘧啶衍生物 |
| MX346095B (es) | 2011-09-12 | 2017-03-07 | Merck Patent Gmbh | Nuevas imidazol-aminas como moduladores de la actividad de cinasas. |
| MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
| ES2675760T3 (es) | 2012-01-06 | 2018-07-12 | Agios Pharmaceuticals, Inc. | Compuestos terapéuticamente activos y métodos de uso de los mismos |
| EP2912024B1 (en) * | 2012-10-24 | 2016-07-20 | Basf Se | Herbicidal azines |
| CN103044469A (zh) * | 2012-11-30 | 2013-04-17 | 大连联化化学有限公司 | 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法 |
| WO2014116594A1 (en) | 2013-01-23 | 2014-07-31 | The University Of Toledo | Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN105517996B (zh) * | 2013-07-11 | 2019-03-26 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| AU2014287121B2 (en) | 2013-07-11 | 2018-11-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| KR102302091B1 (ko) * | 2013-07-11 | 2021-09-16 | 아지오스 파마슈티컬스 아이엔씨. | 암 치료용의 ｉｄｈ２ 돌연변이체 억제제로서의 ｎ,６-비스(아릴 또는 헤테로아릴)-１，３，５-트리아진-２,４-디아민 화합물 |
| ES2886211T3 (es) | 2013-08-02 | 2021-12-16 | Agios Pharmaceuticals Inc | Compuestos terapéuticamente activos y sus métodos de uso |
| SG11201601467SA (en) | 2013-11-01 | 2016-05-30 | Novartis Ag | Aminoheteroaryl benzamides as kinase inhibitors |
| SG11201609981RA (en) * | 2014-06-04 | 2016-12-29 | Thomas Helledays Stiftelse För Medicinsk Forskning | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
| US10179790B2 (en) | 2014-06-04 | 2019-01-15 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of cancer |
| HUE056537T2 (hu) * | 2015-07-30 | 2022-02-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 1,3,5-triazinszármazék és annak alkalmazási módszere |
| WO2017059280A1 (en) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Novel pan-tam inhibitors and mer/axl dual inhibitors |
| IL299563A (en) | 2015-12-04 | 2023-02-01 | Agios Pharmaceuticals Inc | Methods of treatment of acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras |
| WO2017096945A1 (zh) * | 2015-12-07 | 2017-06-15 | 北京康美特科技股份有限公司 | 含硼有机硅化合物、太阳能电池组件用密封剂以及太阳能电池组件 |
| LT3442947T (lt) | 2016-04-15 | 2023-09-11 | Epizyme, Inc. | Aminu pakeisti arilo arba heteroarilo junginiai, kaip ehmt1 ir ehmt2 inhibitoriai |
| CN107382840B (zh) | 2016-05-16 | 2020-09-01 | 四川大学 | 吡啶类化合物及其作为idh功能变异突变体抑制剂类药物的用途 |
| SG11202001182QA (en) | 2017-08-15 | 2020-03-30 | Abbvie Inc | Macrocyclic mcl-1 inhibitors and methods of use |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| SMT202200004T1 (it) | 2017-09-07 | 2022-03-21 | Eisai R&D Man Co Ltd | Composto pentaciclico |
-
2017
- 2017-09-07 CN CN201710801364.3A patent/CN109467538A/zh active Pending
-
2018
- 2018-09-07 WO PCT/CN2018/104531 patent/WO2019047909A1/en not_active Ceased
- 2018-09-07 CN CN201880057118.4A patent/CN111132967B/zh active Active
- 2018-09-07 CA CA3073782A patent/CA3073782A1/en active Pending
- 2018-09-07 UA UAA202002089A patent/UA129118C2/uk unknown
- 2018-09-07 CN CN202311036787.2A patent/CN116999441A/zh active Pending
- 2018-09-07 CN CN202311036845.1A patent/CN117257809A/zh active Pending
- 2018-09-07 KR KR1020207009621A patent/KR102566237B1/ko active Active
- 2018-09-07 US US16/645,329 patent/US11414390B2/en active Active
- 2018-09-07 BR BR112020004563-2A patent/BR112020004563A2/pt active IP Right Grant
- 2018-09-07 CN CN202311036829.2A patent/CN117797156A/zh active Pending
- 2018-09-07 JP JP2020513872A patent/JP7273030B6/ja active Active
- 2018-09-07 EA EA202090653A patent/EA202090653A1/ru unknown
- 2018-09-07 SG SG11202001642WA patent/SG11202001642WA/en unknown
- 2018-09-07 TW TW107131525A patent/TWI816693B/zh active
- 2018-09-07 AR ARP180102548A patent/AR112794A1/es unknown
- 2018-09-07 EP EP18853366.5A patent/EP3679020A4/en active Pending
- 2018-09-07 AU AU2018329047A patent/AU2018329047B2/en active Active
- 2018-09-07 CN CN202311040510.7A patent/CN117024363A/zh active Pending
- 2018-09-07 MX MX2020002505A patent/MX2020002505A/es unknown
- 2018-09-07 PE PE2020000280A patent/PE20200727A1/es unknown
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2020
- 2020-02-26 IL IL272923A patent/IL272923B2/en unknown
- 2020-02-28 PH PH12020500408A patent/PH12020500408A1/en unknown
- 2020-03-05 CL CL2020000553A patent/CL2020000553A1/es unknown
- 2020-03-06 ZA ZA2020/01448A patent/ZA202001448B/en unknown
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2022
- 2022-05-18 US US17/747,925 patent/US12234211B2/en active Active
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2023
- 2023-04-26 JP JP2023072737A patent/JP7603740B2/ja active Active
-
2025
- 2025-02-11 US US19/050,772 patent/US20250223267A1/en active Pending
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