|
US3480613A
(en)
*
|
1967-07-03 |
1969-11-25 |
Merck & Co Inc |
2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
|
|
US4182623A
(en)
*
|
1977-07-27 |
1980-01-08 |
Monsanto Company |
Bicyclothiadiazinones
|
|
US5206382A
(en)
*
|
1991-06-27 |
1993-04-27 |
Fidia Georgetown Institute For The Neurosciences |
Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
|
|
IT1278077B1
(it)
|
1995-05-25 |
1997-11-17 |
Angeletti P Ist Richerche Bio |
Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
|
|
US6128582A
(en)
|
1996-04-30 |
2000-10-03 |
Vertex Pharmaceuticals Incorporated |
Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
|
IL134232A0
(en)
|
1997-08-11 |
2001-04-30 |
Boehringer Ingelheim Ca Ltd |
Hepatitis c inhibitor peptides
|
|
PT1012180E
(pt)
|
1997-08-11 |
2005-04-29 |
Boehringer Ingelheim Ca Ltd |
Analogos de peptidos inibidores da hepatite c
|
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
|
US6348587B1
(en)
|
1998-02-25 |
2002-02-19 |
Emory University |
2′-Fluoronucleosides
|
|
GB9806815D0
(en)
|
1998-03-30 |
1998-05-27 |
Hoffmann La Roche |
Amino acid derivatives
|
|
JP4690545B2
(ja)
|
1998-03-31 |
2011-06-01 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
セリンプロテアーゼ、特にc型肝炎ウイルスns3プロテアーゼの阻害因子
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
US6602982B1
(en)
|
1998-08-10 |
2003-08-05 |
Hokkaido Electric Power Company, Incorporated |
Process for the preparation of regular glycopeptides
|
|
US6323180B1
(en)
*
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
JP2002528499A
(ja)
|
1998-10-29 |
2002-09-03 |
ブリストル−マイヤーズ スクイブ カンパニー |
Impdh酵素のインヒビターであるアミノ核誘導化合物
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
US6608027B1
(en)
*
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
|
ES2156725B1
(es)
|
1999-05-07 |
2002-03-01 |
Consejo Superior Investigacion |
Derivados de dioxidos n,n- y n,x-disustituidos de 1,2,6-tiadiazina fusionadas y procedimiento de obtencion.
|
|
MXPA02000294A
(es)
|
1999-06-25 |
2002-06-21 |
Vertex Pharma |
Profarmacos de carbamatos inhibidores de impdh.
|
|
RU2223761C2
(ru)
|
1999-12-27 |
2004-02-20 |
Джапан Тобакко Инк. |
Соединения с конденсированным кольцом и их использование в качестве лекарственных средств
|
|
US6455508B1
(en)
|
2000-02-15 |
2002-09-24 |
Kanda S. Ramasamy |
Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
AU2001235278A1
(en)
*
|
2000-02-18 |
2001-08-27 |
Shire Biochem Inc |
Method for the treatment or prevention of flavivirus infections using nucleoside analogues
|
|
NZ521455A
(en)
|
2000-04-05 |
2004-06-25 |
Schering Corp |
Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising N-Cyclic P2 Moieties
|
|
WO2001077091A2
(en)
|
2000-04-05 |
2001-10-18 |
Tularik Inc. |
Ns5b hcv polymerase inhibitors
|
|
KR100974917B1
(ko)
|
2000-04-13 |
2010-08-09 |
파마셋 인코포레이티드 |
간염 바이러스 감염 치료를 위한 3'- 또는2'-하이드록시메틸 치환된 뉴클레오시드 유도체
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
AU2001272923A1
(en)
|
2000-05-26 |
2001-12-11 |
Idenix (Cayman) Limited |
Methods and compositions for treating flaviviruses and pestiviruses
|
|
US6448281B1
(en)
|
2000-07-06 |
2002-09-10 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
GB0017676D0
(en)
|
2000-07-19 |
2000-09-06 |
Angeletti P Ist Richerche Bio |
Inhibitors of viral polymerase
|
|
WO2002014376A2
(en)
*
|
2000-08-10 |
2002-02-21 |
Trustees Of Boston College |
Recyclable metathesis catalysts
|
|
US6955174B2
(en)
*
|
2000-08-18 |
2005-10-18 |
Uryovascular Systems, Inc. |
Cryotherapy method for detecting and treating vulnerable plaque
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
WO2002020497A1
(en)
|
2000-09-01 |
2002-03-14 |
Shionogi & Co., Ltd. |
Compounds having anti-hepatitis c virus effect
|
|
EP1411954B1
(en)
|
2000-10-18 |
2010-12-15 |
Pharmasset, Inc. |
Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
|
|
EP1343807B1
(en)
|
2000-12-12 |
2009-04-29 |
Schering Corporation |
Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus
|
|
AU2002230763A1
(en)
|
2000-12-13 |
2008-01-03 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
WO2002048165A2
(en)
|
2000-12-15 |
2002-06-20 |
Pharmasset Ltd. |
Antiviral agents for treatment of flaviviridae infections
|
|
EP1346724A4
(en)
|
2000-12-26 |
2004-11-17 |
Mitsubishi Pharma Corp |
AGENT FOR TREATING HEPATITIS C
|
|
JP2004532184A
(ja)
|
2001-01-22 |
2004-10-21 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
|
|
WO2002059321A2
(en)
|
2001-01-23 |
2002-08-01 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Hepatitis c virus replicons and replicon enhanced cells
|
|
GB0114286D0
(en)
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
KR20040037062A
(ko)
|
2001-08-14 |
2004-05-04 |
텔 아비브 유니버시티 퓨쳐 테크날러지 디벨로프멘트 엘피 |
지질화된 글리코스아미노글리칸 입자 및 그의 진단 및치료용 약물 및 유전자 송달 용도
|
|
EP1435974A4
(en)
*
|
2001-09-28 |
2006-09-06 |
Idenix Cayman Ltd |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES
|
|
EP1438054A4
(en)
|
2001-09-28 |
2006-07-26 |
Idenix Cayman Ltd |
METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
|
|
US7282512B2
(en)
|
2002-01-17 |
2007-10-16 |
Smithkline Beecham Corporation |
Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
|
|
GB0201179D0
(en)
|
2002-01-18 |
2002-03-06 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
US7323453B2
(en)
|
2002-02-13 |
2008-01-29 |
Merck & Co., Inc. |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds
|
|
CA2484921A1
(en)
*
|
2002-05-06 |
2003-11-13 |
Genelabs Technologies, Inc. |
Nucleoside derivatives for treating hepatitis c virus infection
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
TW200400963A
(en)
|
2002-05-21 |
2004-01-16 |
Wyeth Corp |
R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
|
|
AU2003269890A1
(en)
|
2002-06-21 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
EP1572945A2
(en)
|
2002-06-27 |
2005-09-14 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
KR20050035194A
(ko)
|
2002-06-28 |
2005-04-15 |
이데닉스 (케이만) 리미티드 |
플라비비리다에 감염 치료용 2'-c-메틸-3'-o-l-발린에스테르 리보푸라노실 사이티딘
|
|
AP2005003211A0
(en)
|
2002-06-28 |
2005-03-31 |
Idenix Cayman Ltd |
1'-,2'-and 3'-modified nucleoside derivatives for treating flaviviridae infections.
|
|
CA2490191C
(en)
|
2002-06-28 |
2010-08-03 |
Idenix (Cayman) Limited |
Modified 2' and 3' -nucleoside prodrugs for treating flaviviridae infections
|
|
WO2004007512A2
(en)
|
2002-07-16 |
2004-01-22 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
AU2003254657A1
(en)
|
2002-07-25 |
2004-02-16 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza d-nucleosides and uses thereof
|
|
WO2004013300A2
(en)
|
2002-08-01 |
2004-02-12 |
Pharmasset Inc. |
Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
|
|
NZ538457A
(en)
|
2002-09-30 |
2008-04-30 |
Genelabs Tech Inc |
Nucleoside derivatives for treating hepatitis C virus infection
|
|
WO2004041201A2
(en)
|
2002-11-01 |
2004-05-21 |
Viropharma Incorporated |
Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US20040254159A1
(en)
*
|
2003-02-27 |
2004-12-16 |
Hasvold Lisa A. |
Heterocyclic kinase inhibitors
|
|
WO2004101605A1
(en)
*
|
2003-03-05 |
2004-11-25 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibiting compounds
|
|
KR20050108420A
(ko)
|
2003-04-02 |
2005-11-16 |
베링거 인겔하임 인터내셔날 게엠베하 |
C형 간염 바이러스 프로테아제 억제제를 위한 약제학적조성물
|
|
GB0307891D0
(en)
|
2003-04-04 |
2003-05-14 |
Angeletti P Ist Richerche Bio |
Chemical compounds,compositions and uses
|
|
JP4733023B2
(ja)
*
|
2003-04-16 |
2011-07-27 |
ブリストル−マイヤーズ スクイブ カンパニー |
C型肝炎ウイルスの大環状イソキノリンペプチド阻害剤
|
|
US7176208B2
(en)
*
|
2003-04-18 |
2007-02-13 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
|
AU2004240704B9
(en)
|
2003-05-21 |
2009-10-22 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor compounds
|
|
US6955184B2
(en)
|
2003-05-29 |
2005-10-18 |
Honeywell International, Inc. |
Pneumatic generator system for simulating operating conditions of an aircraft
|
|
KR100883703B1
(ko)
|
2003-05-30 |
2009-02-12 |
파마셋 인코포레이티드 |
변형 불소화 뉴클레오시드 유사체
|
|
GB0313250D0
(en)
|
2003-06-09 |
2003-07-16 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
DK1644395T3
(da)
*
|
2003-06-19 |
2007-04-02 |
Hoffmann La Roche |
Fremgangsmåde til fremstilling af 4azido-nukleosidderivater
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
GB0321003D0
(en)
|
2003-09-09 |
2003-10-08 |
Angeletti P Ist Richerche Bio |
Compounds, compositions and uses
|
|
GB0323845D0
(en)
|
2003-10-10 |
2003-11-12 |
Angeletti P Ist Richerche Bio |
Chemical compounds,compositions and uses
|
|
US20050239767A1
(en)
*
|
2003-10-28 |
2005-10-27 |
Chan Michael K |
Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands
|
|
US20050119318A1
(en)
*
|
2003-10-31 |
2005-06-02 |
Hudyma Thomas W. |
Inhibitors of HCV replication
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CA2549851C
(en)
|
2004-01-21 |
2012-09-11 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis c virus
|
|
RS52931B
(sr)
|
2004-02-20 |
2014-02-28 |
Boehringer Ingelheim International Gmbh |
Inhibitori virusne polimeraze
|
|
PT1719773E
(pt)
|
2004-02-24 |
2009-06-03 |
Japan Tobacco Inc |
Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv
|
|
US20070049593A1
(en)
*
|
2004-02-24 |
2007-03-01 |
Japan Tobacco Inc. |
Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
|
|
GB0413087D0
(en)
|
2004-06-11 |
2004-07-14 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
UY29017A1
(es)
|
2004-07-16 |
2006-02-24 |
Boehringer Ingelheim Int |
Inhibidores de polimerasa viral
|
|
GB0416396D0
(en)
|
2004-07-22 |
2004-08-25 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
US7348425B2
(en)
*
|
2004-08-09 |
2008-03-25 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7153848B2
(en)
*
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
JP2008510748A
(ja)
|
2004-08-23 |
2008-04-10 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗ウイルス4’−アジド−ヌクレオシド
|
|
GB0419850D0
(en)
|
2004-09-07 |
2004-10-13 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
US7795247B2
(en)
*
|
2004-10-26 |
2010-09-14 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Tetracyclic indole derivatives as antiviral agents
|
|
JP2008517986A
(ja)
|
2004-10-26 |
2008-05-29 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
抗ウイルス薬としての四環式インドール誘導体
|
|
US7659263B2
(en)
|
2004-11-12 |
2010-02-09 |
Japan Tobacco Inc. |
Thienopyrrole compound and use thereof as HCV polymerase inhibitor
|
|
US7879797B2
(en)
*
|
2005-05-02 |
2011-02-01 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
|
GB0509326D0
(en)
|
2005-05-09 |
2005-06-15 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US7470664B2
(en)
*
|
2005-07-20 |
2008-12-30 |
Merck & Co., Inc. |
HCV NS3 protease inhibitors
|
|
AU2006275605B2
(en)
|
2005-08-01 |
2011-01-06 |
Merck Sharp & Dohme Corp. |
Macrocyclic peptides as HCV NS3 protease inhibitors
|
|
WO2007028789A1
(en)
|
2005-09-07 |
2007-03-15 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Quinazoline derivatives as antiviral agents
|
|
GB0518390D0
(en)
*
|
2005-09-09 |
2005-10-19 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US7399758B2
(en)
*
|
2005-09-12 |
2008-07-15 |
Meanwell Nicholas A |
Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
|
|
US7473688B2
(en)
|
2005-09-13 |
2009-01-06 |
Bristol-Myers Squibb Company |
Indolobenzazepine HCV NS5B inhibitors
|
|
GB0519797D0
(en)
|
2005-09-29 |
2005-11-09 |
Istituto Di Ricerche D Biolog |
Therapeutic agents
|
|
GB0522881D0
(en)
*
|
2005-11-10 |
2005-12-21 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
GB0608928D0
(en)
|
2006-05-08 |
2006-06-14 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
GB0609492D0
(en)
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
EP2029741A4
(en)
|
2006-06-08 |
2011-03-16 |
Merck Sharp & Dohme |
QUICK PROCEDURE FOR DETERMINING THE HEMMERSENSITIVITY OF NS3 / 4A PROTEASE SEQUENCES CLONED FROM CLINICAL SAMPLES
|
|
GB0612423D0
(en)
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
JP5345941B2
(ja)
|
2006-10-24 |
2013-11-20 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Hcvns3プロテアーゼ阻害剤
|
|
CA2667165A1
(en)
|
2006-10-24 |
2008-05-02 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
CA2667146C
(en)
|
2006-10-24 |
2016-01-19 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
US20100099695A1
(en)
|
2006-10-27 |
2010-04-22 |
Liverton Nigel J |
HCV NS3 Protease Inhibitors
|
|
ES2444575T3
(es)
|
2006-10-27 |
2014-02-25 |
Merck Sharp & Dohme Corp. |
Inhibidores de la proteasa NS3 del VHC
|
|
US9061360B2
(en)
|
2006-11-09 |
2015-06-23 |
Twinblade Technolgies Holding Sweden AB |
Hub device
|
|
GB0625349D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
JP2010513450A
(ja)
*
|
2006-12-20 |
2010-04-30 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
抗ウイルス性インドール
|
|
GB0625345D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
BRPI0807887A2
(pt)
|
2007-02-20 |
2014-06-17 |
Novartis Ag |
Compostos macrocíclicos como inibidores de hcv ns3 protease.
|
|
EP2481807A3
(en)
|
2007-03-09 |
2013-04-03 |
Merck Sharp & Dohme Corp. |
In vivo HCV resistance to anti-viral inhibitors
|
|
ES2541434T3
(es)
|
2007-06-29 |
2015-07-20 |
Gilead Sciences, Inc. |
Derivados de purina y su uso como moduladores del receptor de tipo Toll 7
|
|
CN101754970B
(zh)
*
|
2007-07-17 |
2013-07-10 |
P.安杰莱蒂分子生物学研究所 |
用于治疗丙型肝炎的大环吲哚衍生物
|
|
WO2009010804A1
(en)
|
2007-07-19 |
2009-01-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic compounds as antiviral agents
|
|
CL2008003384A1
(es)
|
2007-11-14 |
2009-12-11 |
Enanta Pharm Inc |
Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
|
|
JP2011503201A
(ja)
|
2007-11-14 |
2011-01-27 |
エナンタ ファーマシューティカルズ インコーポレイテッド |
大環状テトラゾリルc型肝炎セリンプロテアーゼ阻害剤
|