|
US3480613A
(en)
*
|
1967-07-03 |
1969-11-25 |
Merck & Co Inc |
2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
|
|
US4182623A
(en)
*
|
1977-07-27 |
1980-01-08 |
Monsanto Company |
Bicyclothiadiazinones
|
|
US5206382A
(en)
*
|
1991-06-27 |
1993-04-27 |
Fidia Georgetown Institute For The Neurosciences |
Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
|
|
IT1278077B1
(it)
|
1995-05-25 |
1997-11-17 |
Angeletti P Ist Richerche Bio |
Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
|
|
US6128582A
(en)
|
1996-04-30 |
2000-10-03 |
Vertex Pharmaceuticals Incorporated |
Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
|
DE69829381T2
(de)
|
1997-08-11 |
2006-04-13 |
Boehringer Ingelheim (Canada) Ltd., Laval |
Hepatitis c inhibitor peptide
|
|
EP1012180B1
(en)
|
1997-08-11 |
2004-12-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor peptide analogues
|
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
|
EA008609B1
(ru)
|
1998-02-25 |
2007-06-29 |
Эмори Юниверсити |
2'-фторнуклеозиды
|
|
GB9806815D0
(en)
|
1998-03-30 |
1998-05-27 |
Hoffmann La Roche |
Amino acid derivatives
|
|
ES2281170T3
(es)
|
1998-03-31 |
2007-09-16 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de serina proteasas, particularmente proteasa ns3 del virus de la hepatitis c.
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
WO2000009546A1
(fr)
|
1998-08-10 |
2000-02-24 |
Hokkaido Electric Power Company, Incorporated |
Preparation de glycopeptides ordinaires
|
|
US6323180B1
(en)
*
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
EP1126843A4
(en)
|
1998-10-29 |
2005-06-15 |
Bristol Myers Squibb Co |
AMINO-CELL DERIVATIVE COMPOUNDS INHIBITORS OF ENZYME IMPDH
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
US6608027B1
(en)
*
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
|
ES2156725B1
(es)
|
1999-05-07 |
2002-03-01 |
Consejo Superior Investigacion |
Derivados de dioxidos n,n- y n,x-disustituidos de 1,2,6-tiadiazina fusionadas y procedimiento de obtencion.
|
|
PT1196414E
(pt)
|
1999-06-25 |
2003-12-31 |
Vertex Pharma |
Pro-farmacos de inibidores carbamato de impdh
|
|
IL145071A0
(en)
|
1999-12-27 |
2002-06-30 |
Japan Tobacco Inc |
Fused ring compounds and pharmaceutical compositions containing the same
|
|
US6455508B1
(en)
|
2000-02-15 |
2002-09-24 |
Kanda S. Ramasamy |
Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
MXPA02008078A
(es)
*
|
2000-02-18 |
2002-11-29 |
Julio Javier Cristiani |
Metodo para el tratamiento o prevencion de infecciones por flavivirus utilizando analogos de nucleosidos.
|
|
DE60137207D1
(de)
|
2000-04-05 |
2009-02-12 |
Schering Corp |
Makrozyklische inhibitoren der ns3-serinprotease des hepatitis c-virus mit stickstoffhaltigen zyklischen p2-gruppen
|
|
WO2001077091A2
(en)
|
2000-04-05 |
2001-10-18 |
Tularik Inc. |
Ns5b hcv polymerase inhibitors
|
|
KR20100003313A
(ko)
|
2000-04-13 |
2010-01-07 |
파마셋 인코포레이티드 |
간염 바이러스 감염 치료를 위한 3'- 또는 2'-하이드록시메틸 치환된 뉴클레오시드 유도체
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
EA200601591A1
(ru)
|
2000-05-26 |
2007-02-27 |
Айденикс (Кайман) Лимитед |
Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций
|
|
US6448281B1
(en)
|
2000-07-06 |
2002-09-10 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
GB0017676D0
(en)
|
2000-07-19 |
2000-09-06 |
Angeletti P Ist Richerche Bio |
Inhibitors of viral polymerase
|
|
DE60140455D1
(de)
*
|
2000-08-10 |
2009-12-24 |
Trustees Boston College |
Wiederverwendbare methathese-katalysatoren
|
|
US6955174B2
(en)
*
|
2000-08-18 |
2005-10-18 |
Uryovascular Systems, Inc. |
Cryotherapy method for detecting and treating vulnerable plaque
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
AU2001282528A1
(en)
|
2000-09-01 |
2002-03-22 |
Shionogi And Co., Ltd. |
Compounds having anti-hepatitis c virus effect
|
|
CA2426187C
(en)
|
2000-10-18 |
2011-08-16 |
Pharmasset Limited |
Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
|
|
US6911428B2
(en)
|
2000-12-12 |
2005-06-28 |
Schering Corporation |
Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
AU2002230763A1
(en)
|
2000-12-13 |
2008-01-03 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
JP2005502580A
(ja)
|
2000-12-15 |
2005-01-27 |
フアーマセツト・リミテツド |
フラビウィルス感染治療用抗ウィルス薬
|
|
CN1482914A
(zh)
|
2000-12-26 |
2004-03-17 |
三菱制药株式会社 |
丙型肝炎治疗剂
|
|
CN1267446C
(zh)
|
2001-01-22 |
2006-08-02 |
默克公司 |
作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物
|
|
EP1423522A2
(en)
|
2001-01-23 |
2004-06-02 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Hepatitis c virus replicons and replicon enhanced cells
|
|
GB0114286D0
(en)
*
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
KR20040037062A
(ko)
|
2001-08-14 |
2004-05-04 |
텔 아비브 유니버시티 퓨쳐 테크날러지 디벨로프멘트 엘피 |
지질화된 글리코스아미노글리칸 입자 및 그의 진단 및치료용 약물 및 유전자 송달 용도
|
|
EP1438054A4
(en)
|
2001-09-28 |
2006-07-26 |
Idenix Cayman Ltd |
METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
|
|
US7138376B2
(en)
*
|
2001-09-28 |
2006-11-21 |
Idenix Pharmaceuticals, Inc. |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
|
|
US7282512B2
(en)
|
2002-01-17 |
2007-10-16 |
Smithkline Beecham Corporation |
Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
|
|
GB0201179D0
(en)
|
2002-01-18 |
2002-03-06 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
EP1476169B1
(en)
|
2002-02-13 |
2013-03-20 |
Merck Sharp & Dohme Corp. |
Inhibiting orthopoxvirus replication with nucleoside compounds
|
|
US20040063658A1
(en)
|
2002-05-06 |
2004-04-01 |
Roberts Christopher Don |
Nucleoside derivatives for treating hepatitis C virus infection
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
TW200400963A
(en)
|
2002-05-21 |
2004-01-16 |
Wyeth Corp |
R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
|
|
WO2004000858A2
(en)
|
2002-06-21 |
2003-12-31 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
WO2004003138A2
(en)
|
2002-06-27 |
2004-01-08 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
AU2003247084B9
(en)
|
2002-06-28 |
2018-07-26 |
Centre National De La Recherche Scientifique |
Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections
|
|
RS114104A
(sr)
|
2002-06-28 |
2007-02-05 |
Idenix (Cayman) Limited, |
2'i 3'-nukleozidni prolekovi za lečenje flaviviridae infekcija
|
|
CA2489552A1
(en)
|
2002-06-28 |
2004-01-08 |
Idenix (Cayman) Limited |
2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
CA2490666A1
(en)
|
2002-07-16 |
2004-01-22 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
US20050026853A1
(en)
|
2002-07-25 |
2005-02-03 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza D-nucleosides and uses thereof
|
|
US8093380B2
(en)
|
2002-08-01 |
2012-01-10 |
Pharmasset, Inc. |
Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections
|
|
WO2004028481A2
(en)
|
2002-09-30 |
2004-04-08 |
Genelabs Technologies, Inc. |
Nucleoside derivatives for treating hepatitis c virus infection
|
|
KR20050065661A
(ko)
|
2002-11-01 |
2005-06-29 |
비로파마 인코포레이티드 |
벤조푸란 화합물, 조성물 및 c형 간염 바이러스 감염 및관련 질병의 치료 및 예방 방법
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US20040254159A1
(en)
*
|
2003-02-27 |
2004-12-16 |
Hasvold Lisa A. |
Heterocyclic kinase inhibitors
|
|
EP1601685A1
(en)
*
|
2003-03-05 |
2005-12-07 |
Boehringer Ingelheim International GmbH |
Hepatitis c inhibiting compounds
|
|
CA2520886A1
(en)
|
2003-04-02 |
2004-11-04 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for hepatitis c viral protease inhibitors
|
|
GB0307891D0
(en)
|
2003-04-04 |
2003-05-14 |
Angeletti P Ist Richerche Bio |
Chemical compounds,compositions and uses
|
|
ES2320771T3
(es)
*
|
2003-04-16 |
2009-05-28 |
Bristol-Myers Squibb Company |
Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c.
|
|
US7176208B2
(en)
*
|
2003-04-18 |
2007-02-13 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
|
UY28323A1
(es)
*
|
2003-05-21 |
2004-12-31 |
Boehringer Ingelheim Int |
Compuestos inhibidores de la hepatitis c
|
|
US6955184B2
(en)
|
2003-05-29 |
2005-10-18 |
Honeywell International, Inc. |
Pneumatic generator system for simulating operating conditions of an aircraft
|
|
HUE029877T2
(en)
|
2003-05-30 |
2017-04-28 |
Gilead Pharmasset Llc |
Modified fluorinated nucleoside analogues
|
|
GB0313250D0
(en)
|
2003-06-09 |
2003-07-16 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
EP1644395B1
(en)
*
|
2003-06-19 |
2006-11-22 |
F. Hoffmann-La Roche Ag |
Processes for preparing 4'azido nucleoside derivatives
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
GB0321003D0
(en)
|
2003-09-09 |
2003-10-08 |
Angeletti P Ist Richerche Bio |
Compounds, compositions and uses
|
|
GB0323845D0
(en)
|
2003-10-10 |
2003-11-12 |
Angeletti P Ist Richerche Bio |
Chemical compounds,compositions and uses
|
|
US20050239767A1
(en)
*
|
2003-10-28 |
2005-10-27 |
Chan Michael K |
Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands
|
|
US20050119318A1
(en)
*
|
2003-10-31 |
2005-06-02 |
Hudyma Thomas W. |
Inhibitors of HCV replication
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
JP4682155B2
(ja)
|
2004-01-21 |
2011-05-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎ウイルスに対して活性な大環状ペプチド
|
|
ES2431314T3
(es)
|
2004-02-20 |
2013-11-26 |
Boehringer Ingelheim International Gmbh |
Inhibidores de polimerasa vírica
|
|
EP2206715A1
(en)
|
2004-02-24 |
2010-07-14 |
Japan Tobacco, Inc. |
Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor
|
|
US20070049593A1
(en)
*
|
2004-02-24 |
2007-03-01 |
Japan Tobacco Inc. |
Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
|
|
GB0413087D0
(en)
|
2004-06-11 |
2004-07-14 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
PE20060569A1
(es)
|
2004-07-16 |
2006-06-22 |
Boehringer Ingelheim Int |
Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc
|
|
GB0416396D0
(en)
|
2004-07-22 |
2004-08-25 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
US7348425B2
(en)
*
|
2004-08-09 |
2008-03-25 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7153848B2
(en)
*
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
CN101044151B
(zh)
|
2004-08-23 |
2011-01-19 |
弗·哈夫曼-拉罗切有限公司 |
抗病毒的4'-叠氮基-核苷
|
|
GB0419850D0
(en)
|
2004-09-07 |
2004-10-13 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
US7795247B2
(en)
*
|
2004-10-26 |
2010-09-14 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Tetracyclic indole derivatives as antiviral agents
|
|
RU2007119562A
(ru)
|
2004-10-26 |
2008-12-10 |
Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) |
Тетрациклические производные индолов в качестве противовирусных агентов
|
|
US7659263B2
(en)
|
2004-11-12 |
2010-02-09 |
Japan Tobacco Inc. |
Thienopyrrole compound and use thereof as HCV polymerase inhibitor
|
|
AU2006242475B2
(en)
*
|
2005-05-02 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
|
GB0509326D0
(en)
|
2005-05-09 |
2005-06-15 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US7470664B2
(en)
*
|
2005-07-20 |
2008-12-30 |
Merck & Co., Inc. |
HCV NS3 protease inhibitors
|
|
JP4705984B2
(ja)
|
2005-08-01 |
2011-06-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Hcvns3プロテアーゼ阻害剤としての大環状ペプチド
|
|
WO2007028789A1
(en)
|
2005-09-07 |
2007-03-15 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Quinazoline derivatives as antiviral agents
|
|
GB0518390D0
(en)
*
|
2005-09-09 |
2005-10-19 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US7399758B2
(en)
*
|
2005-09-12 |
2008-07-15 |
Meanwell Nicholas A |
Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
|
|
US7473688B2
(en)
|
2005-09-13 |
2009-01-06 |
Bristol-Myers Squibb Company |
Indolobenzazepine HCV NS5B inhibitors
|
|
GB0519797D0
(en)
|
2005-09-29 |
2005-11-09 |
Istituto Di Ricerche D Biolog |
Therapeutic agents
|
|
GB0522881D0
(en)
*
|
2005-11-10 |
2005-12-21 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
GB0608928D0
(en)
|
2006-05-08 |
2006-06-14 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
GB0609492D0
(en)
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
EP2029741A4
(en)
|
2006-06-08 |
2011-03-16 |
Merck Sharp & Dohme |
QUICK PROCEDURE FOR DETERMINING THE HEMMERSENSITIVITY OF NS3 / 4A PROTEASE SEQUENCES CLONED FROM CLINICAL SAMPLES
|
|
GB0612423D0
(en)
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
AU2007309546A1
(en)
|
2006-10-24 |
2008-05-02 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
HCV NS3 protease inhibitors
|
|
CN101583372A
(zh)
|
2006-10-24 |
2009-11-18 |
默克公司 |
Hcv ns3蛋白酶抑制剂
|
|
US8138164B2
(en)
|
2006-10-24 |
2012-03-20 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
|
CA2667032A1
(en)
|
2006-10-27 |
2008-05-15 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
EP2086982B1
(en)
|
2006-10-27 |
2018-08-29 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
WO2008057028A1
(en)
|
2006-11-09 |
2008-05-15 |
Twinblade Technologies Holding Sweden Ab |
Hub device
|
|
GB0625349D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
WO2008075103A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Antiviral indoles
|
|
GB0625345D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
JP2010519266A
(ja)
|
2007-02-20 |
2010-06-03 |
ノバルティス アーゲー |
Hcvns3プロテアーゼ阻害剤としての大員環化合物
|
|
EP2118301A4
(en)
|
2007-03-09 |
2011-04-20 |
Merck Sharp & Dohme |
IN VIVO HCV RESISTANCE TO ANTI-VIRAL HEMMER
|
|
CA2691444C
(en)
|
2007-06-29 |
2016-06-14 |
Gilead Sciences, Inc. |
Purine derivatives and their use as modulators of toll-like receptor 7
|
|
WO2009010785A1
(en)
*
|
2007-07-17 |
2009-01-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Macrocyclic indole derivatives for the treatment of hepatitis c infections
|
|
US8927569B2
(en)
|
2007-07-19 |
2015-01-06 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as antiviral agents
|
|
CL2008003384A1
(es)
|
2007-11-14 |
2009-12-11 |
Enanta Pharm Inc |
Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
|
|
MX2010005261A
(es)
|
2007-11-14 |
2010-10-15 |
Enanta Pharm Inc |
Inhibidores macrocíclicos de proteasa de serina de hepatitis c de tetrazolilo.
|