JP2020522278A5 - - Google Patents
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- JP2020522278A5 JP2020522278A5 JP2020516792A JP2020516792A JP2020522278A5 JP 2020522278 A5 JP2020522278 A5 JP 2020522278A5 JP 2020516792 A JP2020516792 A JP 2020516792A JP 2020516792 A JP2020516792 A JP 2020516792A JP 2020522278 A5 JP2020522278 A5 JP 2020522278A5
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- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 30
- 102000036639 antigens Human genes 0.000 claims 30
- 108091007433 antigens Proteins 0.000 claims 30
- 239000012634 fragment Substances 0.000 claims 27
- 238000000034 method Methods 0.000 claims 10
- 230000035772 mutation Effects 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 206010061598 Immunodeficiency Diseases 0.000 claims 4
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000007813 immunodeficiency Effects 0.000 claims 4
- 230000000903 blocking effect Effects 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 101000989065 Homo sapiens Immunoglobulin heavy variable 7-4-1 Proteins 0.000 claims 2
- 102100029420 Immunoglobulin heavy variable 7-4-1 Human genes 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 230000003325 follicular Effects 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000006386 Bone Resorption Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 101001008315 Homo sapiens Immunoglobulin kappa variable 3D-20 Proteins 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 102100027403 Immunoglobulin kappa variable 3D-20 Human genes 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- 241000590503 Melanitis Species 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 235000011941 Tilia x europaea Nutrition 0.000 claims 1
- 208000031737 Tissue Adhesions Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 230000024279 bone resorption Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 150000004676 glycans Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000000796 hypoacidity effect Effects 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000023589 ischemic disease Diseases 0.000 claims 1
- 208000002741 leukoplakia Diseases 0.000 claims 1
- 239000004571 lime Substances 0.000 claims 1
- 238000002794 lymphocyte assay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762515188P | 2017-06-05 | 2017-06-05 | |
| US62/515,188 | 2017-06-05 | ||
| US201862648114P | 2018-03-26 | 2018-03-26 | |
| US62/648,114 | 2018-03-26 | ||
| US201862673185P | 2018-05-18 | 2018-05-18 | |
| US62/673,185 | 2018-05-18 | ||
| PCT/US2018/035843 WO2018226580A2 (en) | 2017-06-05 | 2018-06-04 | Antibodies that specifically bind pd-1 and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522278A JP2020522278A (ja) | 2020-07-30 |
| JP2020522278A5 true JP2020522278A5 (https=) | 2021-07-26 |
| JP7235733B2 JP7235733B2 (ja) | 2023-03-08 |
Family
ID=64562613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516792A Active JP7235733B2 (ja) | 2017-06-05 | 2018-06-04 | Ｐｄ－１に特異的に結合する抗体、及び使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10995149B2 (https=) |
| EP (1) | EP3634995A4 (https=) |
| JP (1) | JP7235733B2 (https=) |
| KR (1) | KR102692379B1 (https=) |
| CN (1) | CN110997712B (https=) |
| AU (1) | AU2018282094B2 (https=) |
| BR (1) | BR112019025574A2 (https=) |
| CA (1) | CA3065516A1 (https=) |
| CL (1) | CL2019003520A1 (https=) |
| CO (1) | CO2019013935A2 (https=) |
| CR (1) | CR20190550A (https=) |
| EC (1) | ECSP19086810A (https=) |
| IL (1) | IL271009B2 (https=) |
| MA (1) | MA52459A (https=) |
| MX (1) | MX2019014577A (https=) |
| MY (1) | MY199715A (https=) |
| NI (1) | NI201900123A (https=) |
| PE (1) | PE20200294A1 (https=) |
| PH (1) | PH12019502755A1 (https=) |
| TW (1) | TWI806873B (https=) |
| UA (1) | UA128035C2 (https=) |
| UY (1) | UY37761A (https=) |
| WO (1) | WO2018226580A2 (https=) |
| ZA (1) | ZA202000051B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20200859A1 (es) * | 2017-06-02 | 2020-08-25 | Bayer Healthcare Llc | Combinacion farmaceutica que comprende regonafenib y nivolumab como anticancerigeno |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| TWI849895B (zh) | 2018-02-09 | 2024-07-21 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| CN110950953B (zh) * | 2018-09-26 | 2022-05-13 | 福州拓新天成生物科技有限公司 | 抗b7-h3的单克隆抗体及其在细胞治疗中的应用 |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2020163225A1 (en) * | 2019-02-05 | 2020-08-13 | Seattle Genetics, Inc. | Anti-cd228 antibodies and antibody-drug conjugates |
| WO2020247642A1 (en) * | 2019-06-04 | 2020-12-10 | Board Of Regents On Behalf Of Arizona State University Arizona | Plant-produced mabs against chikungunya virus with enhanced effector function and efficacy |
| WO2021006199A1 (ja) | 2019-07-05 | 2021-01-14 | 小野薬品工業株式会社 | Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| WO2021020416A1 (ja) * | 2019-07-30 | 2021-02-04 | 小野薬品工業株式会社 | 二重特異性抗体 |
| EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| KR20220143869A (ko) * | 2020-02-21 | 2022-10-25 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항-il-2 항체, 이의 항원-결합 단편 및 이의 의학적 용도 |
| BR112022023989A2 (pt) | 2020-05-26 | 2023-02-07 | Boehringer Ingelheim Int | Anticorpos anti-pd-1 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| WO2022156773A1 (en) * | 2021-01-21 | 2022-07-28 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd | Protein complexes targeting il12 pathway |
| IL307887A (en) | 2021-05-13 | 2023-12-01 | Foundation For Biomedical Res And Innovation At Kobe | Anti-human pd-1 agonist antibody and pharmaceutical composition comprising the antibody for treating or preventing inflammatory diseases |
| AU2022294106A1 (en) * | 2021-06-18 | 2024-01-25 | Therini Bio, Inc. | ANTIBODIES WHICH BIND HUMAN FIBRIN OR FIBRINOGEN γC DOMAIN AND METHODS OF USE |
| EP4419566A4 (en) * | 2021-10-21 | 2025-09-17 | Seismic Therapeutic Inc | DUAL-TARGETED IMMUNE REGULATORY COMPOSITIONS |
| PE20241755A1 (es) | 2021-11-19 | 2024-08-28 | Mirobio Ltd | Anticuerpos pd-1 disenados por ingenieria y usos de estos |
| JP2025504020A (ja) * | 2022-01-28 | 2025-02-06 | ジョージアミューン・インコーポレイテッド | Ｐｄ－１アゴニストであるプログラム細胞死タンパク質１に対する抗体 |
| WO2024010861A2 (en) * | 2022-07-06 | 2024-01-11 | Santa Ana Bio, Inc. | Methods and compositions for treating autoimmune, allergic and inflammatory diseases |
| WO2024076990A1 (en) * | 2022-10-03 | 2024-04-11 | Therini Bio, Inc. | Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use |
| WO2024076993A2 (en) * | 2022-10-03 | 2024-04-11 | Therini Bio, Inc. | Multi-specific antigen binding proteins which bind human fibrin or fibrinogen ?c domain and vascular endothelial growth factor and methods of use |
| WO2024081686A2 (en) * | 2022-10-11 | 2024-04-18 | Ibio, Inc. | Epidermal growth factor receptor variant iii antibodies |
| WO2024092031A1 (en) | 2022-10-25 | 2024-05-02 | Seismic Therapeutic, Inc. | VARIANT IgG FC POLYPEPTIDES AND USES THEREOF |
| CN116854820B (zh) * | 2023-06-26 | 2024-02-06 | 华中科技大学同济医学院附属协和医院 | Pd-1非阻断性清除抗体及其用途 |
| WO2025151607A1 (en) * | 2024-01-10 | 2025-07-17 | Santa Ana Bio, Inc. | Methods and compositions for treating autoimmune, allergic and inflammatory diseases |
| WO2026008664A1 (en) | 2024-07-01 | 2026-01-08 | Vib Vzw | Allosteric modulators of inhibitory immune receptor complexes |
| WO2026008009A1 (en) * | 2024-07-04 | 2026-01-08 | Xiamen Jiuheyipin Biopharmaceutical Co., Ltd. | Pd-1 targeting antibodies and uses thereof |
| CN120040594B (zh) * | 2025-02-21 | 2025-09-23 | 四川大学 | 一种靶向flt3基因编辑通用型car-t细胞的制备方法和应用 |
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| CN104558177B (zh) * | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
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| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| WO2017019846A1 (en) | 2015-07-30 | 2017-02-02 | Macrogenics, Inc. | Pd-1-binding molecules and methods use thereof |
| KR102055396B1 (ko) | 2015-08-11 | 2019-12-12 | 우시 바이올로직스 (케이만) 인코포레이티드 | 신규한 항-pd-1 항체 |
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| EA201890790A1 (ru) | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| RU2656181C1 (ru) | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Анти-pd-1-антитела, способ их получения и способ применения |
| KR102561356B1 (ko) | 2016-09-14 | 2023-08-03 | 애브비 바이오테라퓨틱스 인크. | 항-pd-1 항체 및 이의 용도 |
| BR112019004733A2 (pt) | 2016-09-19 | 2019-05-28 | Celgene Corp | métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1 |
| CN110799213A (zh) | 2017-06-01 | 2020-02-14 | 康姆普根有限公司 | 三联组合抗体疗法 |
| CN118909118A (zh) | 2017-09-07 | 2024-11-08 | 奥古斯塔大学研究所公司 | 程序性细胞死亡蛋白1抗体 |
| AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
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2018
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- 2018-06-04 JP JP2020516792A patent/JP7235733B2/ja active Active
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- 2018-06-04 WO PCT/US2018/035843 patent/WO2018226580A2/en not_active Ceased
- 2018-06-04 KR KR1020207000242A patent/KR102692379B1/ko active Active
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2019
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2020
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2023
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