|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
CA1271477A
(en)
|
1983-11-18 |
1990-07-10 |
John F. Gerster |
1h-imidazo[4,5-c]quinolin-4-amines
|
|
US5389640A
(en)
|
1991-03-01 |
1995-02-14 |
Minnesota Mining And Manufacturing Company |
1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
|
|
US6608201B2
(en)
|
1992-08-28 |
2003-08-19 |
3M Innovative Properties Company |
Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
|
|
US5352784A
(en)
|
1993-07-15 |
1994-10-04 |
Minnesota Mining And Manufacturing Company |
Fused cycloalkylimidazopyridines
|
|
US5482936A
(en)
|
1995-01-12 |
1996-01-09 |
Minnesota Mining And Manufacturing Company |
Imidazo[4,5-C]quinoline amines
|
|
UA67760C2
(uk)
|
1997-12-11 |
2004-07-15 |
Міннесота Майнінг Енд Мануфакчурінг Компані |
Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
|
|
US6110929A
(en)
|
1998-07-28 |
2000-08-29 |
3M Innovative Properties Company |
Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
|
|
US6451810B1
(en)
|
1999-06-10 |
2002-09-17 |
3M Innovative Properties Company |
Amide substituted imidazoquinolines
|
|
US6331539B1
(en)
|
1999-06-10 |
2001-12-18 |
3M Innovative Properties Company |
Sulfonamide and sulfamide substituted imidazoquinolines
|
|
HU230586B1
(hu)
|
1999-06-25 |
2017-02-28 |
Genentech, Inc. |
Anti-ErbB antitest/maytansinoid konjugátumok alkalmazása rákos betegségek kezelésére szolgáló gyógyszer előállítására
|
|
US6635677B2
(en)
|
1999-08-13 |
2003-10-21 |
Case Western Reserve University |
Methoxyamine combinations in the treatment of cancer
|
|
US6376669B1
(en)
|
1999-11-05 |
2002-04-23 |
3M Innovative Properties Company |
Dye labeled imidazoquinoline compounds
|
|
US7097840B2
(en)
|
2000-03-16 |
2006-08-29 |
Genentech, Inc. |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
|
|
US6664264B2
(en)
|
2000-12-08 |
2003-12-16 |
3M Innovative Properties Company |
Thioether substituted imidazoquinolines
|
|
UA74852C2
(en)
|
2000-12-08 |
2006-02-15 |
3M Innovative Properties Co |
Urea-substituted imidazoquinoline ethers
|
|
JP2008531580A
(ja)
|
2000-12-08 |
2008-08-14 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答修飾因子の標的化送達のための組成物および方法
|
|
UA74593C2
(en)
|
2000-12-08 |
2006-01-16 |
3M Innovative Properties Co |
Substituted imidazopyridines
|
|
US20060057651A1
(en)
|
2000-12-08 |
2006-03-16 |
Bowdish Katherine S |
Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
|
|
US20030139364A1
(en)
|
2001-10-12 |
2003-07-24 |
University Of Iowa Research Foundation |
Methods and products for enhancing immune responses using imidazoquinoline compounds
|
|
EP1455700A4
(en)
|
2001-11-16 |
2007-02-14 |
3M Innovative Properties Co |
METHODS AND COMPOSITIONS RELATED TO MRI COMPOUNDS AND TO TOLL-TYPE RECEPTOR (TLR) PATHWAYS
|
|
NZ533628A
(en)
|
2001-11-27 |
2006-07-28 |
Anadys Pharmaceuticals Inc |
3-beta-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and uses thereof
|
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
|
US7595048B2
(en)
|
2002-07-03 |
2009-09-29 |
Ono Pharmaceutical Co., Ltd. |
Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
|
|
EP1413316A1
(en)
|
2002-09-27 |
2004-04-28 |
Bruno Robert |
Bifunctional conjugates or fusion proteins
|
|
EP1590348A1
(en)
|
2002-12-20 |
2005-11-02 |
3M Innovative Properties Company |
Aryl / hetaryl substituted imidazoquinolines
|
|
WO2004056875A1
(en)
|
2002-12-23 |
2004-07-08 |
Wyeth |
Antibodies against pd-1 and uses therefor
|
|
WO2004062603A2
(en)
|
2003-01-09 |
2004-07-29 |
Arizeke Pharmaceuticals Inc. |
Methods of treating lung diseases
|
|
US9259459B2
(en)
|
2003-01-31 |
2016-02-16 |
Celldex Therapeutics Inc. |
Antibody vaccine conjugates and uses therefor
|
|
US7375180B2
(en)
|
2003-02-13 |
2008-05-20 |
3M Innovative Properties Company |
Methods and compositions related to IRM compounds and Toll-like receptor 8
|
|
WO2005025583A2
(en)
|
2003-09-05 |
2005-03-24 |
Anadys Pharmaceuticals, Inc. |
Tlr7 ligands for the treatment of hepatitis c
|
|
US8871782B2
(en)
|
2003-10-03 |
2014-10-28 |
3M Innovative Properties Company |
Alkoxy substituted imidazoquinolines
|
|
EP1696912B1
(en)
|
2003-10-03 |
2016-05-11 |
3M Innovative Properties Company |
Pyrazolopyridines and analogs thereof
|
|
RU2426734C2
(ru)
|
2003-10-03 |
2011-08-20 |
Зм Инновейтив Пропертиз Компани |
Пиразолопиридины и их аналоги
|
|
CA2542099A1
(en)
|
2003-10-11 |
2005-04-21 |
Inex Pharmaceuticals Corporation |
Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
|
|
SG149815A1
(en)
|
2003-11-06 |
2009-02-27 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
JP2007517055A
(ja)
|
2003-12-30 |
2007-06-28 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答の増強
|
|
WO2005092893A1
(ja)
|
2004-03-26 |
2005-10-06 |
Dainippon Sumitomo Pharma Co., Ltd. |
９置換−８−オキソアデニン化合物
|
|
EP1776105A2
(en)
|
2004-07-18 |
2007-04-25 |
Coley Pharmaceutical Group, Ltd |
Methods and compositions for inducing innate immune responses
|
|
EP1809671B1
(en)
|
2004-11-09 |
2014-07-16 |
University Of Southern California |
CpG/antibody conjugate against cancer
|
|
US8461174B2
(en)
|
2004-12-30 |
2013-06-11 |
3M Innovative Properties Company |
Treatment for cutaneous metastases
|
|
JP2008531590A
(ja)
|
2005-02-24 |
2008-08-14 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
カリウムイオンチャンネル開口薬としての新規なキノリン誘導体
|
|
RU2007141067A
(ru)
|
2005-04-14 |
2009-05-20 |
Мерк Патент ГмбХ (DE) |
Терапия с помощью антител к egfr, основанная на повышенном числе копий гена egfr в опухолевых тканях
|
|
CN101203241B
(zh)
|
2005-04-19 |
2012-02-22 |
西雅图基因公司 |
人源化抗-cd70结合物和其应用
|
|
JP5185813B2
(ja)
|
2005-04-26 |
2013-04-17 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
癌免疫治療のための組成物および方法
|
|
DK2161336T4
(en)
|
2005-05-09 |
2017-04-24 |
Ono Pharmaceutical Co |
Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies
|
|
RS54271B1
(sr)
|
2005-07-01 |
2016-02-29 |
E. R. Squibb & Sons, L.L.C. |
Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1)
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
|
|
TWI404537B
(zh)
|
2005-08-19 |
2013-08-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
|
|
CA2621502A1
(en)
|
2005-09-07 |
2007-03-15 |
Medimmune, Inc. |
Toxin conjugated eph receptor antibodies
|
|
ZA200803029B
(en)
|
2005-09-09 |
2009-02-25 |
Coley Pharm Group Inc |
Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
|
|
US8951528B2
(en)
|
2006-02-22 |
2015-02-10 |
3M Innovative Properties Company |
Immune response modifier conjugates
|
|
WO2007103048A2
(en)
|
2006-03-01 |
2007-09-13 |
Regents Of The University Of Colorado |
Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity
|
|
US20080031887A1
(en)
|
2006-06-30 |
2008-02-07 |
Joseph Lustgarten |
Conjugates for inducing targeted immune responses and methods of making and using same
|
|
US8138172B2
(en)
|
2006-07-05 |
2012-03-20 |
Astrazeneca Ab |
8-oxoadenine derivatives acting as modulators of TLR7
|
|
PT2845866T
(pt)
|
2006-10-27 |
2017-08-09 |
Genentech Inc |
Anticorpos e imunoconjugados e utilizações dos mesmos
|
|
NZ577440A
(en)
|
2006-12-21 |
2011-12-22 |
Hoffmann La Roche |
Polymorphs of a mglur5 receptor antagonist
|
|
US20080149123A1
(en)
|
2006-12-22 |
2008-06-26 |
Mckay William D |
Particulate material dispensing hairbrush with combination bristles
|
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
|
|
PL2125007T3
(pl)
|
2007-02-07 |
2014-07-31 |
Univ California |
Koniugaty syntetycznych agonistów TLR i ich zastosowania
|
|
PT2155743E
(pt)
|
2007-05-08 |
2012-10-30 |
Astrazeneca Ab |
Imidazoquinolinas com propriedades imunomoduladoras
|
|
WO2009018500A1
(en)
|
2007-07-31 |
2009-02-05 |
The Johns Hopkins University |
Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
|
|
GB0715428D0
(en)
*
|
2007-08-08 |
2007-09-19 |
Imp Innovations Ltd |
Compositions and uses thereof
|
|
JP5410434B2
(ja)
|
2007-09-28 |
2014-02-05 |
バインド セラピューティックス インコーポレイテッド |
ナノ粒子を用いた癌細胞の標的化
|
|
MX2010007699A
(es)
|
2008-01-15 |
2010-08-04 |
Meda Ab |
Tratamiento de enfermedades del colon o prevencion de carcinoma colorrectal con derivados de imidazoquinolina.
|
|
CA2713137C
(en)
|
2008-01-25 |
2017-10-24 |
Hadasit Medical Research Services And Development Ltd. |
Targeting of innate immune response to tumor site
|
|
US20090202626A1
(en)
|
2008-02-07 |
2009-08-13 |
Carson Dennis A |
Treatment of bladder diseases with a tlr7 activator
|
|
HUE035182T2
(hu)
|
2008-03-18 |
2018-05-02 |
Genentech Inc |
Anti-HER2 antitest-hatóanyag-konjugátum és pertuzumab kombinációi
|
|
EP2316032A1
(en)
|
2008-08-20 |
2011-05-04 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
|
|
MX2011003195A
(es)
|
2008-09-26 |
2011-08-12 |
Dana Farber Cancer Inst Inc |
Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos.
|
|
PE20120106A1
(es)
|
2008-12-09 |
2012-02-20 |
Gilead Sciences Inc |
Moduladores de receptores tipo toll
|
|
PL2427485T3
(pl)
|
2009-05-07 |
2017-10-31 |
Immunocellular Therapeutics Ltd |
Epitopy CD133
|
|
WO2010132622A2
(en)
|
2009-05-14 |
2010-11-18 |
The Regents Of The University Of California |
Anticd20-cpg conjugates and methods of treating b cell malignancies
|
|
US20110077263A1
(en)
|
2009-09-29 |
2011-03-31 |
University Of Southern California |
Methods and Compositions of Toll-Like Receptor (TLR) Agonists
|
|
PT2504364T
(pt)
|
2009-11-24 |
2017-11-14 |
Medimmune Ltd |
Agentes de ligação direcionados contra b7-h1
|
|
WO2011084725A1
(en)
|
2009-12-21 |
2011-07-14 |
3M Innovative Properties Company |
4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM 1-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS
|
|
WO2011084726A1
(en)
|
2009-12-21 |
2011-07-14 |
3M Innovative Properties Company |
BIS [4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM] 4-[(3-CARBOXYLATO-2-HYDROXYNAPHTHALEN-1-YL)METHYL]-3-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS
|
|
ES2608475T3
(es)
|
2010-04-13 |
2017-04-11 |
Celldex Therapeutics, Inc. |
Anticuerpos que se unen a cd27 humana y usos de los mismos
|
|
NO2575876T3
(enExample)
|
2010-05-26 |
2018-05-05 |
|
|
|
AR082686A1
(es)
|
2010-08-13 |
2012-12-26 |
Baylor Res Inst |
Adyuvantes de vacuna que direccionan a los adyuvantes de anticuerpos directamente hacia las celulas presentadoras de antigenos
|
|
NZ608673A
(en)
|
2010-10-01 |
2015-04-24 |
Univ Pennsylvania |
Therapeutic use of a tlr agonist and combination therapy
|
|
EP2648719A1
(en)
|
2010-12-09 |
2013-10-16 |
F.Hoffmann-La Roche Ag |
Treatment of her2-positive cancer with paclitaxel and trastuzumab-mcc-dm1
|
|
EP3207930A1
(en)
|
2011-01-12 |
2017-08-23 |
VentiRx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
CN103458930B
(zh)
|
2011-02-01 |
2019-10-15 |
健玛保 |
针对cd74的人抗体和抗体-药物缀合物
|
|
TW201247706A
(en)
|
2011-03-08 |
2012-12-01 |
Baylor Res Inst |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
|
|
CA2833636A1
(en)
|
2011-04-20 |
2012-10-26 |
Amplimmune, Inc. |
Antibodies and other molecules that bind b7-h1 and pd-1
|
|
KR101649610B1
(ko)
|
2011-04-21 |
2016-08-19 |
오리제니스 게엠베하 |
키나아제 억제제로서의 헤테로사이클릭 화합물
|
|
UY34032A
(es)
*
|
2011-04-21 |
2012-11-30 |
Origenis Gmbh |
Nuevos inhibidores de quinasa
|
|
US8728486B2
(en)
|
2011-05-18 |
2014-05-20 |
University Of Kansas |
Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
|
|
EP2734551B1
(en)
|
2011-07-24 |
2018-01-10 |
Cure Tech Ltd. |
Variants of humanized immunomodulatory monoclonal antibodies
|
|
AU2012290121B2
(en)
|
2011-08-01 |
2015-11-26 |
Genentech, Inc. |
Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
|
|
US9120763B2
(en)
|
2011-08-11 |
2015-09-01 |
Huntsman Advanced Materials Americas Llc |
Method for producing benzoxazine compounds
|
|
CN103957939A
(zh)
|
2011-09-19 |
2014-07-30 |
约翰霍普金斯大学 |
癌症免疫治疗
|
|
WO2013063277A1
(en)
|
2011-10-25 |
2013-05-02 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
CN104661683A
(zh)
|
2011-11-09 |
2015-05-27 |
埃森德生物制药有限公司 |
免疫调节缀合物
|
|
WO2013166110A1
(en)
|
2012-05-02 |
2013-11-07 |
Yale University |
Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
|
|
CA2873402C
(en)
|
2012-05-15 |
2023-10-24 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
CN112587658A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
WO2014022758A1
(en)
|
2012-08-03 |
2014-02-06 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-pd-l1 and pd-l2 dual binding antibodies and methods of use
|
|
AR092219A1
(es)
|
2012-08-23 |
2015-04-08 |
Seattle Genetics Inc |
Conjugados anticuerpo-farmaco (adc) que se unen a proteinas 158p1d7
|
|
US9637491B2
(en)
*
|
2012-10-19 |
2017-05-02 |
Origenis Gmbh |
Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
|
|
US10000482B2
(en)
*
|
2012-10-19 |
2018-06-19 |
Origenis Gmbh |
Kinase inhibitors
|
|
EP2787005A1
(en)
|
2013-04-02 |
2014-10-08 |
Activartis Biotech GmbH |
Targeted cancer immune therapy
|
|
EP3082853A2
(en)
|
2013-12-20 |
2016-10-26 |
The Broad Institute, Inc. |
Combination therapy with neoantigen vaccine
|
|
SG11201605449YA
(en)
|
2014-01-10 |
2016-08-30 |
Birdie Biopharmaceuticals Inc |
Compounds and compositions for immunotherapy
|
|
AU2015279738A1
(en)
|
2014-06-25 |
2016-12-22 |
Selecta Biosciences, Inc. |
Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
|
|
CN112546230A
(zh)
|
2014-07-09 |
2021-03-26 |
博笛生物科技有限公司 |
用于治疗癌症的联合治疗组合物和联合治疗方法
|
|
EP4001311B1
(en)
|
2014-07-09 |
2025-11-05 |
Birdie Biopharmaceuticals Inc. |
Anti-pd-l1/pd-1 combinations for treating tumors
|
|
CN112546238A
(zh)
|
2014-09-01 |
2021-03-26 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-pd-l1结合物
|
|
CN105732635A
(zh)
|
2014-12-29 |
2016-07-06 |
南京明德新药研发股份有限公司 |
一类Toll样受体7激动剂
|
|
DK3345907T3
(da)
|
2015-09-01 |
2020-06-22 |
Taiho Pharmaceutical Co Ltd |
Pyrazolo[3,4-d]pyrimidinforbindelser eller salte deraf
|
|
US10821127B2
(en)
|
2015-11-09 |
2020-11-03 |
Shaperon Inc. |
Composition for inhibiting myeloid-derived suppressor cells comprising decitabine or its pharmaceutically acceptable salt as active ingredient
|
|
CN106943597A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-egfr组合
|
|
CN106943596A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-cd20组合
|
|
CN115350279A
(zh)
|
2016-01-07 |
2022-11-18 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-her2组合
|
|
CN118515666A
(zh)
|
2017-04-27 |
2024-08-20 |
博笛生物科技有限公司 |
2-氨基-喹啉衍生物
|
|
US11517567B2
(en)
|
2017-06-23 |
2022-12-06 |
Birdie Biopharmaceuticals, Inc. |
Pharmaceutical compositions
|
|
EP3846807B1
(en)
|
2018-09-07 |
2023-08-02 |
Birdie Biopharmaceuticals, Inc. |
Imidazoquinoline compounds and uses thereof
|
|
CN113613641A
(zh)
|
2018-12-26 |
2021-11-05 |
博笛生物科技有限公司 |
用于治疗癌症的免疫调节组合和方法
|
|
US20220175762A1
(en)
|
2019-03-15 |
2022-06-09 |
Birdie Biopharmaceuticals, Inc. |
Immune modulatory compositions and methods for treating cancers
|
|
WO2022047083A1
(en)
|
2020-08-26 |
2022-03-03 |
Birdie Pharmaceuticals, Inc. |
Cancer treatment with tlr agonist
|