JP2020515557A5 - - Google Patents
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- Publication number
- JP2020515557A5 JP2020515557A5 JP2019552891A JP2019552891A JP2020515557A5 JP 2020515557 A5 JP2020515557 A5 JP 2020515557A5 JP 2019552891 A JP2019552891 A JP 2019552891A JP 2019552891 A JP2019552891 A JP 2019552891A JP 2020515557 A5 JP2020515557 A5 JP 2020515557A5
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- JP
- Japan
- Prior art keywords
- salt
- compound selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479493P | 2017-03-31 | 2017-03-31 | |
| US62/479,493 | 2017-03-31 | ||
| PCT/EP2018/058056 WO2018178227A1 (en) | 2017-03-31 | 2018-03-29 | Synthesis of mcl-1 inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515557A JP2020515557A (ja) | 2020-05-28 |
| JP2020515557A5 true JP2020515557A5 (ja) | 2021-03-11 |
| JP7032428B2 JP7032428B2 (ja) | 2022-03-08 |
Family
ID=61827753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552891A Active JP7032428B2 (ja) | 2017-03-31 | 2018-03-29 | Ｍｃｌ－１阻害剤の合成 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11149024B2 (ja) |
| EP (1) | EP3601230B1 (ja) |
| JP (1) | JP7032428B2 (ja) |
| KR (1) | KR102604876B1 (ja) |
| CN (1) | CN110536884B (ja) |
| AR (1) | AR111304A1 (ja) |
| AU (1) | AU2018244180B2 (ja) |
| BR (1) | BR112019019686A2 (ja) |
| CA (1) | CA3056712A1 (ja) |
| CO (1) | CO2019010035A2 (ja) |
| EA (1) | EA038226B1 (ja) |
| ES (1) | ES2909751T3 (ja) |
| IL (1) | IL269410B2 (ja) |
| MX (1) | MX2019011468A (ja) |
| TW (1) | TWI781996B (ja) |
| WO (1) | WO2018178227A1 (ja) |
| ZA (1) | ZA201905645B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3781570A4 (en) * | 2018-11-22 | 2021-06-02 | Ascentage Pharma (Suzhou) Co., Ltd. | MACROCYCLIC INDOLES AS MCL-1 INHIBITORS |
| TWI760685B (zh) * | 2019-01-23 | 2022-04-11 | 大陸商蘇州亞盛藥業有限公司 | 作為mcl-1抑制劑的大環稠合的吡唑 |
| CN114641481A (zh) | 2019-06-21 | 2022-06-17 | 詹森药业有限公司 | Mcl-1的大环抑制剂 |
| KR20220034136A (ko) | 2019-07-09 | 2022-03-17 | 얀센 파마슈티카 엔.브이. | Mcl-1 억제제로서의 거대환식 스피로사이클 유도체 |
| WO2021092053A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| CA3157731A1 (en) | 2019-11-21 | 2021-05-27 | Frederik Jan Rita Rombouts | Macrocyclic indole derivatives as mcl-1 inhibitors |
| CA3157590A1 (en) | 2019-11-21 | 2021-05-27 | Janssen Pharmaceutica Nv | Macrocyclic sulfonyl derivatives as mcl-1 inhibitors |
| KR20220143906A (ko) | 2020-02-21 | 2022-10-25 | 얀센 파마슈티카 엔.브이. | Mcl-1의 억제제로서의 거대환식 인돌 유도체 |
| US20230265105A1 (en) | 2020-05-29 | 2023-08-24 | Janssen Pharmaceutica Nv | Macrocyclic 7-pyrazol-5-yl-indole derivatives as inhibitors of mcl-1 |
| JP2023530985A (ja) | 2020-06-19 | 2023-07-20 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍｃｌ－１の阻害剤としてのｎ結合大環状７－（ピラゾール－５－イル）－インドール誘導体 |
| JP2023530148A (ja) | 2020-06-19 | 2023-07-13 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍｃｌ－１阻害剤としてのｎ－結合大環状４－（ピラゾール－５－イル）－インドール誘導体 |
| BR112023000212A2 (pt) | 2020-07-08 | 2023-01-31 | Janssen Pharmaceutica Nv | Éter macrocíclico contendo derivados de indol como inibidores de mcl-1 |
| WO2022032284A1 (en) * | 2020-08-07 | 2022-02-10 | Zeno Management, Inc. | Macrocyclic compounds |
| MX2023007291A (es) | 2020-12-17 | 2023-07-04 | Janssen Pharmaceutica Nv | Derivados de 4-(pirazol-5-il)-indol macrociclicos ramificados como inhibidores de mcl-1. |
| MX2023009475A (es) | 2021-02-12 | 2023-08-22 | Janssen Pharmaceutica Nv | Derivados macrociclicos 1,3-con puente 6-cloro-7-pirazol-4-il-1h-i ndol-2-carboxilato y 6-cloro-7-pirimidina-5-il-1h-indol-2-carboxil ato como inhibidores de mcl-1 para el tratamiento del cancer. |
| US11931424B2 (en) | 2021-06-11 | 2024-03-19 | Gilead Sciences, Inc. | Combination MCL-1 inhibitors with anti-body drug conjugates |
| TW202315637A (zh) | 2021-06-11 | 2023-04-16 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗癌劑之組合 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2915811A1 (en) * | 2014-03-04 | 2015-09-09 | Centre Régional de Lutte contre le Cancer - Centre François Baclesse | MCL-1 modulating compounds for cancer treatment |
| US9949965B2 (en) * | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
| CN105061315B (zh) * | 2015-08-06 | 2017-10-24 | 大连理工大学 | 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用 |
| CR20180499A (es) | 2016-04-22 | 2019-01-25 | Astrazeneca Ab | Inhibidores de mcl1 macrocicliclos para tratar el cancer |
| CN106478606B (zh) * | 2016-09-21 | 2019-05-10 | 沈阳药科大学 | N-取代吲哚类衍生物及其应用 |
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2018
- 2018-03-26 TW TW107110205A patent/TWI781996B/zh active
- 2018-03-28 AR ARP180100757A patent/AR111304A1/es unknown
- 2018-03-29 MX MX2019011468A patent/MX2019011468A/es unknown
- 2018-03-29 JP JP2019552891A patent/JP7032428B2/ja active Active
- 2018-03-29 BR BR112019019686A patent/BR112019019686A2/pt unknown
- 2018-03-29 EA EA201992235A patent/EA038226B1/ru unknown
- 2018-03-29 US US16/497,919 patent/US11149024B2/en active Active
- 2018-03-29 AU AU2018244180A patent/AU2018244180B2/en active Active
- 2018-03-29 WO PCT/EP2018/058056 patent/WO2018178227A1/en active Application Filing
- 2018-03-29 ES ES18714249T patent/ES2909751T3/es active Active
- 2018-03-29 CA CA3056712A patent/CA3056712A1/en active Pending
- 2018-03-29 CN CN201880021146.0A patent/CN110536884B/zh active Active
- 2018-03-29 KR KR1020197031979A patent/KR102604876B1/ko active IP Right Grant
- 2018-03-29 EP EP18714249.2A patent/EP3601230B1/en active Active
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2019
- 2019-08-27 ZA ZA2019/05645A patent/ZA201905645B/en unknown
- 2019-09-16 CO CONC2019/0010035A patent/CO2019010035A2/es unknown
- 2019-09-17 IL IL269410A patent/IL269410B2/en unknown