JP2018521020A5 - - Google Patents
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- Publication number
- JP2018521020A5 JP2018521020A5 JP2017563311A JP2017563311A JP2018521020A5 JP 2018521020 A5 JP2018521020 A5 JP 2018521020A5 JP 2017563311 A JP2017563311 A JP 2017563311A JP 2017563311 A JP2017563311 A JP 2017563311A JP 2018521020 A5 JP2018521020 A5 JP 2018521020A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- following formula
- pharmaceutically acceptable
- acceptable salt
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- MNEOHCYSHVKLIC-UHFFFAOYSA-N OC(CC(CC1)CCN1C(c(c(Cl)c1C[n](cc2)c3c2cc(C(F)(F)F)cc3Cl)ccc1Cl)=O)=O Chemical compound OC(CC(CC1)CCN1C(c(c(Cl)c1C[n](cc2)c3c2cc(C(F)(F)F)cc3Cl)ccc1Cl)=O)=O MNEOHCYSHVKLIC-UHFFFAOYSA-N 0.000 description 1
Claims (4)
- 以下の式：
- 以下の式：
- 以下の式：
- 以下の式：
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/001693 WO2016198908A1 (en) | 2015-06-09 | 2015-06-09 | Ror nuclear receptor modulators |
| IBPCT/IB2015/001693 | 2015-06-09 | ||
| US201562257806P | 2015-11-20 | 2015-11-20 | |
| US62/257,806 | 2015-11-20 | ||
| US201662343905P | 2016-06-01 | 2016-06-01 | |
| US62/343,905 | 2016-06-01 | ||
| PCT/US2016/036283 WO2016200851A1 (en) | 2015-06-09 | 2016-06-08 | Nuclear receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019118167A Division JP2019178159A (ja) | 2015-06-09 | 2019-06-26 | 核内受容体調節剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521020A JP2018521020A (ja) | 2018-08-02 |
| JP2018521020A5 true JP2018521020A5 (ja) | 2019-02-28 |
| JP6549735B2 JP6549735B2 (ja) | 2019-07-24 |
Family
ID=56194583
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563311A Active JP6549735B2 (ja) | 2015-06-09 | 2016-06-08 | 核内受容体調節剤 |
| JP2019118167A Ceased JP2019178159A (ja) | 2015-06-09 | 2019-06-26 | 核内受容体調節剤 |
| JP2020135558A Active JP6938737B2 (ja) | 2015-06-09 | 2020-08-11 | 核内受容体調節剤 |
| JP2021140781A Active JP7235816B2 (ja) | 2015-06-09 | 2021-08-31 | 核内受容体調節剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019118167A Ceased JP2019178159A (ja) | 2015-06-09 | 2019-06-26 | 核内受容体調節剤 |
| JP2020135558A Active JP6938737B2 (ja) | 2015-06-09 | 2020-08-11 | 核内受容体調節剤 |
| JP2021140781A Active JP7235816B2 (ja) | 2015-06-09 | 2021-08-31 | 核内受容体調節剤 |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US10106501B2 (ja) |
| EP (2) | EP3636643A1 (ja) |
| JP (4) | JP6549735B2 (ja) |
| KR (1) | KR20180014433A (ja) |
| CN (1) | CN107820494B (ja) |
| AU (3) | AU2016276316B2 (ja) |
| BR (1) | BR112017026452A2 (ja) |
| CA (1) | CA2988502A1 (ja) |
| CL (1) | CL2017003147A1 (ja) |
| CO (1) | CO2017012594A2 (ja) |
| CR (1) | CR20170594A (ja) |
| CY (1) | CY1122495T1 (ja) |
| DK (1) | DK3307734T3 (ja) |
| DO (1) | DOP2017000289A (ja) |
| EC (1) | ECSP18001225A (ja) |
| ES (1) | ES2774517T3 (ja) |
| HK (1) | HK1248678A1 (ja) |
| HR (1) | HRP20200064T1 (ja) |
| HU (1) | HUE047988T2 (ja) |
| IL (2) | IL256043B (ja) |
| LT (1) | LT3307734T (ja) |
| MA (1) | MA51556A (ja) |
| MX (2) | MX2017015980A (ja) |
| MY (1) | MY193715A (ja) |
| PE (1) | PE20230683A1 (ja) |
| PH (1) | PH12017502237A1 (ja) |
| PL (1) | PL3307734T3 (ja) |
| PT (1) | PT3307734T (ja) |
| RS (1) | RS59934B1 (ja) |
| RU (1) | RU2715897C2 (ja) |
| SG (1) | SG10201911849SA (ja) |
| SI (1) | SI3307734T1 (ja) |
| TW (2) | TW202128619A (ja) |
| UA (1) | UA120651C2 (ja) |
| UY (1) | UY36716A (ja) |
| WO (1) | WO2016200851A1 (ja) |
| ZA (1) | ZA201708285B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| LT3307734T (lt) * | 2015-06-09 | 2020-05-11 | Abbvie Inc. | Branduolinio receptoriaus moduliatoriai (ror), skirti uždegiminių ir autoimuninių ligų gydymui |
| US10435403B2 (en) | 2015-06-09 | 2019-10-08 | Bayer Pharma Aktiengesellschaft | Positive allosteric modulators of muscarinic M2 receptor |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| JP2019524722A (ja) | 2016-07-11 | 2019-09-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | ７−置換１−ピリジル−ナフチリジン−３−カルボン酸アミドおよびその使用 |
| JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
| CN108689942B (zh) * | 2017-04-11 | 2023-06-09 | 广东东阳光药业有限公司 | 含氮双环化合物及其制备方法和用途 |
| US11427596B2 (en) * | 2019-07-19 | 2022-08-30 | Indian Institute of Technology Indore | Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications |
| CN110407863B (zh) * | 2019-08-24 | 2021-08-17 | 中国科学院兰州化学物理研究所 | 一种通过转移硼化反应合成烯基硼酸酯类化合物的方法 |
| CN110483561B (zh) * | 2019-08-24 | 2021-07-23 | 中国科学院兰州化学物理研究所 | 一种烯基硼酸酯类化合物的合成方法 |
| CN114436833A (zh) * | 2021-12-27 | 2022-05-06 | 南京红太阳医药研究院有限公司 | 一种替米沙坦关键中间体4′-甲基联苯-2-羧酸酯的制备方法 |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
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| CA2091257A1 (en) | 1990-09-10 | 1992-03-11 | Fu-Chih Huang | Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonists activity |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| JP3457694B2 (ja) | 1993-02-04 | 2003-10-20 | 第一製薬株式会社 | インフルエンザ感染予防・治療薬 |
| US5589482A (en) | 1994-12-14 | 1996-12-31 | Pfizer Inc. | Benzo-thiophene estrogen agonists to treat prostatic hyperplasia |
| US6124463A (en) | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| CA2430978C (en) | 2000-12-28 | 2012-05-15 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| US20070129334A1 (en) | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
| AU2003220896A1 (en) | 2002-03-28 | 2003-11-10 | Sumitomo Pharmaceuticals Co., Ltd. | Novel heteroaryl compounds |
| AU2003297431A1 (en) | 2002-12-20 | 2004-07-22 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
| WO2004099192A2 (en) | 2003-04-30 | 2004-11-18 | The Institutes Of Pharmaceutical Discovery, Llc | Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
| KR101149379B1 (ko) | 2003-07-28 | 2012-06-28 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸, 벤즈티아졸 및 벤즈옥사졸 유도체 및ｌｔａ4 ｈ 조정자로서의 그의 용도 |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| US7417063B2 (en) | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
| US20080269284A1 (en) | 2004-06-24 | 2008-10-30 | Eli Lilly And Company | Compounds and Methods for Treating Dyslipidemia |
| US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| US7713979B2 (en) | 2004-10-29 | 2010-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP1893612B1 (en) * | 2005-06-22 | 2011-08-03 | Plexxikon, Inc. | Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors |
| FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| AU2007227681A1 (en) | 2006-03-15 | 2007-09-27 | Wyeth | N-substituted-azacyclylamines as histamine-3 antagonists |
| US8026257B2 (en) | 2007-07-11 | 2011-09-27 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
| CN101855221B (zh) * | 2007-11-15 | 2013-10-30 | P.安杰莱蒂分子生物学研究所 | 作为parp抑制剂的哒嗪酮衍生物 |
| SG173584A1 (en) | 2009-02-06 | 2011-09-29 | Elan Pharm Inc | Inhibitors of jun n-terminal kinase |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| CN102762534A (zh) | 2009-09-18 | 2012-10-31 | 扎里卡斯药品有限公司 | 作为钙通道阻断剂的芳基砜衍生物 |
| US20130310379A1 (en) | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US8466186B2 (en) * | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| MX336578B (es) | 2011-07-25 | 2016-01-25 | Allergan Inc | Derivados de n-(imidazolidin-2-ilideno)-heterociclopenta[b] pirididina como moduladores de receptores de alfa 2 adrenergicos. |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| UA111754C2 (uk) * | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
| JP6073343B2 (ja) | 2011-10-20 | 2017-02-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ |
| EP2647628A1 (en) | 2012-04-02 | 2013-10-09 | Almirall, S.A. | Substituted tricyclic compounds with activity towards ep1 receptors |
| WO2014026328A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| EP2991994B1 (en) | 2013-05-01 | 2018-08-15 | Vitae Pharmaceuticals, Inc. | Thiazolopyrrolidine inhibitors of ror-gamma |
| LT3027603T (lt) * | 2013-08-02 | 2018-08-10 | Pfizer Inc. | Heterobicikloarilo rorc2 inhibitoriai ir jų panaudojimo būdai |
| EP3044224A1 (en) | 2013-09-11 | 2016-07-20 | F. Hoffmann-La Roche AG | KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS |
| SG11201606080SA (en) | 2014-02-03 | 2016-08-30 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
| PT3207043T (pt) | 2014-10-14 | 2019-03-25 | Vitae Pharmaceuticals Llc | Inibidores de di-hidropirrolopiridina de ror-gama |
| LT3307734T (lt) * | 2015-06-09 | 2020-05-11 | Abbvie Inc. | Branduolinio receptoriaus moduliatoriai (ror), skirti uždegiminių ir autoimuninių ligų gydymui |
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2016
- 2016-06-08 LT LTEP16731721.3T patent/LT3307734T/lt unknown
- 2016-06-08 EP EP19203418.9A patent/EP3636643A1/en not_active Withdrawn
- 2016-06-08 AU AU2016276316A patent/AU2016276316B2/en active Active
- 2016-06-08 PL PL16731721T patent/PL3307734T3/pl unknown
- 2016-06-08 KR KR1020187000451A patent/KR20180014433A/ko not_active Application Discontinuation
- 2016-06-08 TW TW110113121A patent/TW202128619A/zh unknown
- 2016-06-08 MY MYPI2017704687A patent/MY193715A/en unknown
- 2016-06-08 RS RS20200097A patent/RS59934B1/sr unknown
- 2016-06-08 JP JP2017563311A patent/JP6549735B2/ja active Active
- 2016-06-08 CN CN201680036750.1A patent/CN107820494B/zh active Active
- 2016-06-08 DK DK16731721.3T patent/DK3307734T3/da active
- 2016-06-08 MX MX2017015980A patent/MX2017015980A/es active IP Right Grant
- 2016-06-08 PE PE2022000685A patent/PE20230683A1/es unknown
- 2016-06-08 WO PCT/US2016/036283 patent/WO2016200851A1/en active Application Filing
- 2016-06-08 CR CR20170594A patent/CR20170594A/es unknown
- 2016-06-08 TW TW105118235A patent/TWI726888B/zh active
- 2016-06-08 ES ES16731721T patent/ES2774517T3/es active Active
- 2016-06-08 UA UAA201713051A patent/UA120651C2/uk unknown
- 2016-06-08 MA MA051556A patent/MA51556A/fr unknown
- 2016-06-08 SI SI201630618T patent/SI3307734T1/sl unknown
- 2016-06-08 US US15/176,309 patent/US10106501B2/en active Active
- 2016-06-08 SG SG10201911849SA patent/SG10201911849SA/en unknown
- 2016-06-08 BR BR112017026452-8A patent/BR112017026452A2/pt active Search and Examination
- 2016-06-08 PT PT167317213T patent/PT3307734T/pt unknown
- 2016-06-08 EP EP16731721.3A patent/EP3307734B1/en active Active
- 2016-06-08 HU HUE16731721A patent/HUE047988T2/hu unknown
- 2016-06-08 CA CA2988502A patent/CA2988502A1/en not_active Abandoned
- 2016-06-08 RU RU2017146835A patent/RU2715897C2/ru active
- 2016-06-08 UY UY0001036716A patent/UY36716A/es unknown
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2017
- 2017-12-01 IL IL256043A patent/IL256043B/en active IP Right Grant
- 2017-12-06 ZA ZA2017/08285A patent/ZA201708285B/en unknown
- 2017-12-06 CO CONC2017/0012594A patent/CO2017012594A2/es unknown
- 2017-12-07 MX MX2020003224A patent/MX2020003224A/es unknown
- 2017-12-07 CL CL2017003147A patent/CL2017003147A1/es unknown
- 2017-12-07 DO DO2017000289A patent/DOP2017000289A/es unknown
- 2017-12-07 PH PH12017502237A patent/PH12017502237A1/en unknown
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2018
- 2018-01-08 EC ECIEPI20181225A patent/ECSP18001225A/es unknown
- 2018-06-25 HK HK18108102.8A patent/HK1248678A1/zh unknown
- 2018-08-22 US US16/108,230 patent/US20190055196A1/en not_active Abandoned
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2019
- 2019-06-26 JP JP2019118167A patent/JP2019178159A/ja not_active Ceased
- 2019-10-16 US US16/654,141 patent/US20210130293A1/en not_active Abandoned
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2020
- 2020-01-16 HR HRP20200064TT patent/HRP20200064T1/hr unknown
- 2020-01-21 CY CY20201100043T patent/CY1122495T1/el unknown
- 2020-04-16 AU AU2020202584A patent/AU2020202584A1/en not_active Abandoned
- 2020-05-08 IL IL274537A patent/IL274537A/en unknown
- 2020-08-11 JP JP2020135558A patent/JP6938737B2/ja active Active
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2021
- 2021-07-23 US US17/443,264 patent/US20230066771A1/en not_active Abandoned
- 2021-08-31 JP JP2021140781A patent/JP7235816B2/ja active Active
- 2021-09-15 AU AU2021232727A patent/AU2021232727A1/en not_active Abandoned