JP2020514419A5 - - Google Patents
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- JP2020514419A5 JP2020514419A5 JP2020500010A JP2020500010A JP2020514419A5 JP 2020514419 A5 JP2020514419 A5 JP 2020514419A5 JP 2020500010 A JP2020500010 A JP 2020500010A JP 2020500010 A JP2020500010 A JP 2020500010A JP 2020514419 A5 JP2020514419 A5 JP 2020514419A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- alkyl
- substituted
- alkenyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc1cccc(C(*)=O)c1)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc1cccc(C(*)=O)c1)=O)=O 0.000 description 3
- QVSQMRFWFRSZMS-UHFFFAOYSA-N CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CC1)CCC1O)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CC1)CCC1O)=O)=O QVSQMRFWFRSZMS-UHFFFAOYSA-N 0.000 description 1
- APUDKOSUPNXOIR-UHFFFAOYSA-N CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CCC1)CC1O)=O)=O Chemical compound CCCN(CCC)C(C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)ccc1N(CCC1)CC1O)=O)=O APUDKOSUPNXOIR-UHFFFAOYSA-N 0.000 description 1
- JGQSALJLSDESHS-UHFFFAOYSA-N CCCN(CCC)C1OC1C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)cnc1N(CCC1)CC1NOC(c1ccccc1)=O)=O Chemical compound CCCN(CCC)C1OC1C(CC(N)=Nc1c2)=Cc1ccc2C(Nc(cc1)cnc1N(CCC1)CC1NOC(c1ccccc1)=O)=O JGQSALJLSDESHS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471886P | 2017-03-15 | 2017-03-15 | |
| US62/471,886 | 2017-03-15 | ||
| US201762573630P | 2017-10-17 | 2017-10-17 | |
| US62/573,630 | 2017-10-17 | ||
| US201862622780P | 2018-01-26 | 2018-01-26 | |
| US62/622,780 | 2018-01-26 | ||
| PCT/US2018/022510 WO2018170179A1 (en) | 2017-03-15 | 2018-03-14 | Benzazepine compounds, conjugates, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514419A JP2020514419A (ja) | 2020-05-21 |
| JP2020514419A5 true JP2020514419A5 (https=) | 2021-04-30 |
Family
ID=63523998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500010A Ceased JP2020514419A (ja) | 2017-03-15 | 2018-03-14 | ベンズアゼピン化合物、そのコンジュゲート及び使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10239862B2 (https=) |
| EP (2) | EP3949969A3 (https=) |
| JP (1) | JP2020514419A (https=) |
| KR (1) | KR20200031560A (https=) |
| CN (1) | CN110612104A (https=) |
| AU (1) | AU2018236272B2 (https=) |
| BR (1) | BR112019019116A2 (https=) |
| CA (1) | CA3055652A1 (https=) |
| DK (1) | DK3595668T3 (https=) |
| ES (1) | ES2894731T3 (https=) |
| HU (1) | HUE056427T2 (https=) |
| IL (1) | IL269283B2 (https=) |
| MX (1) | MX2019010804A (https=) |
| PT (1) | PT3595668T (https=) |
| SG (5) | SG10202110182PA (https=) |
| WO (1) | WO2018170179A1 (https=) |
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| CN109311854B (zh) * | 2016-05-23 | 2021-08-10 | 豪夫迈·罗氏有限公司 | 具有仲酰胺官能团的苯并氮杂卓二甲酰胺化合物 |
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| SG10202110182PA (en) | 2017-03-15 | 2021-10-28 | Silverback Therapeutics Inc | Benzazepine compounds, conjugates, and uses thereof |
| JP2021506827A (ja) * | 2017-12-15 | 2021-02-22 | シルバーバック セラピューティックス インコーポレイテッド | 肝炎の治療用の抗体コンストラクト−薬物コンジュゲート |
| CA3100544A1 (en) | 2018-05-17 | 2019-11-21 | Bolt Biotherapeutics, Inc. | Immunoconjugates |
| KR20210025522A (ko) | 2018-06-25 | 2021-03-09 | 유니버시티 오브 워싱톤 | 강력하고 선택적인 인터루킨 모방체의 드 노보 디자인 |
| MX2021002764A (es) * | 2018-09-12 | 2021-05-12 | Silverback Therapeutics Inc | Composiciones para el tratamiento de enfermedades con conjugados inmunoestimuladores. |
| WO2020056194A1 (en) * | 2018-09-12 | 2020-03-19 | Silverback Therapeutics, Inc. | Benzazepine compounds, conjugates, and uses thereof |
| AU2019337654A1 (en) * | 2018-09-12 | 2021-04-08 | Silverback Therapeutics, Inc. | Substituted benzazepine compounds, conjugates, and uses thereof |
| JP2022511390A (ja) | 2018-11-20 | 2022-01-31 | ユニバーシティ オブ ワシントン | 分割インターロイキン模倣体およびその使用 |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| EP3966248A4 (en) * | 2019-05-08 | 2023-04-12 | Memorial Sloan Kettering Cancer Center | HUMAN ANTIBODIES TO FEL MUCIN-16 AND THEIR METHODS OF USE |
| JP7558205B2 (ja) * | 2019-06-13 | 2024-09-30 | ボルト バイオセラピューティクス、インコーポレーテッド | 高分子支持アミノベンズアピン化合物 |
| US20200390899A1 (en) * | 2019-06-13 | 2020-12-17 | Bolt Biotherapeutics, Inc. | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
| KR20220035908A (ko) | 2019-06-19 | 2022-03-22 | 실버백 테라퓨틱스, 인크. | 항-메소텔린 항체 및 이의 면역접합체 |
| CN114667134A (zh) * | 2019-08-15 | 2022-06-24 | 希沃尔拜克治疗公司 | 苯并氮杂䓬缀合物的制剂及其用途 |
| US20220347310A1 (en) * | 2019-09-30 | 2022-11-03 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
| CA3151322A1 (en) * | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| WO2021072203A1 (en) | 2019-10-09 | 2021-04-15 | Silverback Therapeutics, Inc. | Tgfbetar1 inhibitor-asgr antibody conjugates and uses thereof |
| WO2021072330A1 (en) | 2019-10-09 | 2021-04-15 | Silverback Therapeutics, Inc. | Galnac-tgfbr1 inhibitor conjugates for the treatment of liver diseases |
| US11554999B2 (en) | 2019-11-15 | 2023-01-17 | Goodrich Corporation | Inflation systems for evacuation slides and life rafts |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| US20230340071A1 (en) | 2020-03-16 | 2023-10-26 | Neoleukin Therapeutics, Inc. | Interleukin-2 Receptor Beta (IL-2RB) Binding Polypeptides |
| CN115515972A (zh) | 2020-04-07 | 2022-12-23 | 尼尔路金治疗公司 | 血管紧张素转换酶2(ace2)的从头蛋白诱饵 |
| JP2023532304A (ja) | 2020-07-01 | 2023-07-27 | エーアールエス ファーマシューティカルズ オペレーションズ，インク． | 抗ａｓｇｒ１抗体コンジュゲートおよびその使用 |
| US20230303699A1 (en) * | 2020-08-04 | 2023-09-28 | Exelixis, Inc. | Pd-l1 binding agents and uses thereof |
| WO2022031680A1 (en) * | 2020-08-04 | 2022-02-10 | Exelixis, Inc. | Cd47 binding agents and uses thereof |
| IL300316A (en) * | 2020-08-13 | 2023-04-01 | Bolt Biotherapeutics Inc | Immune conjugates of pyrazolozapines and their uses |
| US20220195066A1 (en) * | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
| KR102917231B1 (ko) * | 2021-03-08 | 2026-01-26 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항체 면역 작용제 접합체 및 이의 적용 |
| US20240209080A1 (en) | 2021-04-10 | 2024-06-27 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| AU2022279185A1 (en) | 2021-05-19 | 2024-01-04 | Shanghai De Novo Pharmatech Co., Ltd. | Nitrogen-containing compound, conjugate containing said compound, and application thereof |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| WO2023044318A2 (en) | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| WO2023154318A1 (en) * | 2022-02-09 | 2023-08-17 | Bolt Biotherapeutics, Inc. | Anti-tr0p2, aminobenzazepine immunoconjugates, and uses thereof |
| WO2024067841A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海迪诺医药科技有限公司 | 苯并氮杂卓衍生物、含其的偶联物及其应用 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
| WO2025149661A1 (en) | 2024-01-10 | 2025-07-17 | Genmab A/S | Slitrk6 binding agents, conjugates thereof and methods of using the same |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| TW202547884A (zh) * | 2024-03-15 | 2025-12-16 | 美商艾爾維克醫療公司 | Ｍｕｃ１６／ｎａｐｉ－２ｂ抗體及使用方法 |
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| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
| ES2173391T3 (es) | 1996-08-16 | 2002-10-16 | Pfizer | Derivados de 2-aminobenzazepina y su uso para el tratamiento de la inmunodepresion. |
| US20040141983A1 (en) | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| US7585326B2 (en) | 2004-08-06 | 2009-09-08 | Spinalmotion, Inc. | Methods and apparatus for intervertebral disc prosthesis insertion |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| TW201402124A (zh) * | 2005-08-19 | 2014-01-16 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| RU2016108987A (ru) | 2009-08-18 | 2018-11-26 | Вентиркс Фармасьютикалз, Инк. | Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора |
| CN105669553A (zh) | 2009-08-18 | 2016-06-15 | 文蒂雷克斯药品公司 | 作为toll样受体调节剂的取代的苯并氮杂* |
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| DK2663555T3 (en) | 2011-01-12 | 2017-03-27 | Ventirx Pharmaceuticals Inc | SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS |
| US9034336B2 (en) * | 2011-08-30 | 2015-05-19 | Regents Of The University Of Minnesota | Immunomodulators and immunomodulator conjugates |
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| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
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| HUE047952T2 (hu) | 2014-04-25 | 2020-05-28 | Pf Medicament | Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra |
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| CA2970358A1 (en) | 2014-12-16 | 2016-06-23 | Celgene Corporation | Solid forms comprising (1e, 4e)-2-amino-n,n-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3h-benzo[b]azepine-4-carboxamide, compositions thereof, and uses thereof |
| JP6644792B2 (ja) | 2014-12-18 | 2020-02-12 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンザゼピンスルホンアミド化合物 |
| BR112017014937A2 (pt) * | 2015-01-14 | 2018-03-13 | Bristol-Myers Squibb Company | dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso |
| PT3265458T (pt) * | 2015-03-06 | 2019-02-13 | Hoffmann La Roche | Compostos de dicarboxamida de benzazepina |
| US9943416B2 (en) | 2015-03-10 | 2018-04-17 | Simplify Medical Pty Limited | Intervertebral spacer that dynamically promotes bone growth |
| EP4071131A1 (en) | 2016-04-13 | 2022-10-12 | Lummus Technology LLC | Apparatus and method for exchanging heat |
| CN107344931B (zh) | 2016-05-06 | 2020-09-15 | 上海迪诺医药科技有限公司 | 苯并氮杂卓衍生物、其制备方法、药物组合物及应用 |
| CN109311854B (zh) | 2016-05-23 | 2021-08-10 | 豪夫迈·罗氏有限公司 | 具有仲酰胺官能团的苯并氮杂卓二甲酰胺化合物 |
| JP6918838B2 (ja) * | 2016-05-23 | 2021-08-11 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 第三級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
| JP7012668B2 (ja) * | 2016-06-12 | 2022-02-14 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物 |
| US20190336615A1 (en) * | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| EP3576782A4 (en) | 2017-02-02 | 2020-12-30 | Silverback Therapeutics, Inc. | COMPOSITIONS OF RECOMBINATION PRODUCT-PEPTIDE AND THEIR METHODS OF USE |
| SG10202110182PA (en) | 2017-03-15 | 2021-10-28 | Silverback Therapeutics Inc | Benzazepine compounds, conjugates, and uses thereof |
-
2018
- 2018-03-14 SG SG10202110182P patent/SG10202110182PA/en unknown
- 2018-03-14 JP JP2020500010A patent/JP2020514419A/ja not_active Ceased
- 2018-03-14 CN CN201880030959.6A patent/CN110612104A/zh active Pending
- 2018-03-14 EP EP21179495.3A patent/EP3949969A3/en not_active Withdrawn
- 2018-03-14 SG SG10202110184X patent/SG10202110184XA/en unknown
- 2018-03-14 PT PT187670120T patent/PT3595668T/pt unknown
- 2018-03-14 KR KR1020197030167A patent/KR20200031560A/ko not_active Withdrawn
- 2018-03-14 SG SG11201908131R patent/SG11201908131RA/en unknown
- 2018-03-14 MX MX2019010804A patent/MX2019010804A/es unknown
- 2018-03-14 SG SG10202110183V patent/SG10202110183VA/en unknown
- 2018-03-14 DK DK18767012.0T patent/DK3595668T3/da active
- 2018-03-14 AU AU2018236272A patent/AU2018236272B2/en not_active Ceased
- 2018-03-14 EP EP18767012.0A patent/EP3595668B1/en active Active
- 2018-03-14 CA CA3055652A patent/CA3055652A1/en active Pending
- 2018-03-14 WO PCT/US2018/022510 patent/WO2018170179A1/en not_active Ceased
- 2018-03-14 SG SG10202110181R patent/SG10202110181RA/en unknown
- 2018-03-14 HU HUE18767012A patent/HUE056427T2/hu unknown
- 2018-03-14 BR BR112019019116A patent/BR112019019116A2/pt not_active IP Right Cessation
- 2018-03-14 ES ES18767012T patent/ES2894731T3/es active Active
- 2018-03-14 US US15/774,262 patent/US10239862B2/en active Active
- 2018-05-07 US US15/973,506 patent/US10519131B2/en not_active Expired - Fee Related
-
2019
- 2019-02-12 US US16/274,132 patent/US10442790B2/en active Active
- 2019-02-12 US US16/274,130 patent/US10428045B2/en active Active
- 2019-08-07 US US16/534,903 patent/US20200031798A1/en not_active Abandoned
- 2019-09-11 IL IL269283A patent/IL269283B2/en unknown
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